ATA908381A - Verfahren zur herstellung von neuen carbostyrilverbindungen und deren pharmazeutisch annehmbaren salzen - Google Patents
Verfahren zur herstellung von neuen carbostyrilverbindungen und deren pharmazeutisch annehmbaren salzenInfo
- Publication number
- ATA908381A ATA908381A AT0908381A AT908381A ATA908381A AT A908381 A ATA908381 A AT A908381A AT 0908381 A AT0908381 A AT 0908381A AT 908381 A AT908381 A AT 908381A AT A908381 A ATA908381 A AT A908381A
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutically acceptable
- acceptable salts
- producing new
- carbostyril compounds
- new carbostyril
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/32—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0908381A AT382376B (de) | 1980-11-11 | 1981-11-11 | Verfahren zur herstellung von neuen carbostyrilverbindungen und deren pharmazeutisch annehmbaren salzen |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55159016A JPS5782390A (en) | 1980-11-11 | 1980-11-11 | Carbostyril derivative |
| JP55179950A JPS57102888A (en) | 1980-12-18 | 1980-12-18 | Carbostyril derivative |
| AT0908381A AT382376B (de) | 1980-11-11 | 1981-11-11 | Verfahren zur herstellung von neuen carbostyrilverbindungen und deren pharmazeutisch annehmbaren salzen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA908381A true ATA908381A (de) | 1986-07-15 |
| AT382376B AT382376B (de) | 1987-02-25 |
Family
ID=26485945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0908381A AT382376B (de) | 1980-11-11 | 1981-11-11 | Verfahren zur herstellung von neuen carbostyrilverbindungen und deren pharmazeutisch annehmbaren salzen |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4414390A (de) |
| EP (1) | EP0052016B1 (de) |
| KR (1) | KR880001657B1 (de) |
| AT (1) | AT382376B (de) |
| AU (1) | AU547586B2 (de) |
| CA (1) | CA1164459A (de) |
| CH (1) | CH653684A5 (de) |
| DE (1) | DE3152512T1 (de) |
| DK (1) | DK157193C (de) |
| ES (1) | ES507545A0 (de) |
| FI (1) | FI71145C (de) |
| IT (1) | IT8149680A0 (de) |
| MX (1) | MX6802E (de) |
| NO (1) | NO157819C (de) |
| PH (1) | PH17158A (de) |
| PT (1) | PT73959B (de) |
| SE (1) | SE440653B (de) |
| SU (1) | SU1215621A3 (de) |
| WO (1) | WO1982001706A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636502A (en) * | 1982-12-27 | 1987-01-13 | Eli Lilly And Company | Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines |
| US4537889A (en) * | 1982-12-27 | 1985-08-27 | Eli Lilly And Company | Inotropic agents |
| GB8305245D0 (en) * | 1983-02-25 | 1983-03-30 | Fujisawa Pharmaceutical Co | Imidazo-heterocyclic compounds |
| US4533734A (en) * | 1983-11-10 | 1985-08-06 | Eli Lilly And Company | Inotropic agents |
| PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| ES8608874A1 (es) * | 1984-05-29 | 1986-09-01 | Pfizer | Un procedimiento para la preparacion de una 2-(1h)-quinolona |
| US4721721A (en) * | 1984-12-18 | 1988-01-26 | Rorer Pharmaceutical Corporation | 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses |
| FR2580646A1 (fr) * | 1985-04-19 | 1986-10-24 | Synthelabo | Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique |
| US4666913A (en) * | 1985-11-22 | 1987-05-19 | William H. Rorer, Inc. | Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses |
| GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
| GB8619902D0 (en) * | 1986-08-15 | 1986-09-24 | Pfizer Ltd | Quinolone cardiac stimulants |
| GB8709448D0 (en) * | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
| DE69524598T2 (de) * | 1994-06-20 | 2002-07-11 | Takeda Chemical Industries, Ltd. | Kondensierte imidazolderivate, ihre herstellung und verwendung |
| DE10117184A1 (de) * | 2001-04-05 | 2002-10-17 | Gruenenthal Gmbh | Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen |
| DE10247271A1 (de) * | 2002-10-10 | 2004-08-26 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yle |
| PE20100399A1 (es) * | 2003-04-02 | 2010-06-01 | Novartis Ag | Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas |
| DE102005019181A1 (de) * | 2005-04-25 | 2006-10-26 | Novartis Ag | Peptid-Deformylase (PDF) Inhibitoren 1 |
| CN102216298B (zh) * | 2008-09-16 | 2014-04-16 | Csir公司 | 作为hiv-1逆转录酶抑制剂的咪唑并吡啶和咪唑并嘧啶 |
| ES2362894B1 (es) * | 2009-11-16 | 2012-05-21 | Ferrer Internacional S.A. | Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico. |
| CN107810188B (zh) * | 2015-04-08 | 2020-09-22 | 拜耳作物科学股份公司 | 作为害虫防治剂和中间体产物的稠合双环杂环衍生物 |
| EP3328839A1 (de) | 2015-07-30 | 2018-06-06 | Bristol-Myers Squibb Company | Arylsubstituierte bicyclische heteroarylverbindungen |
| ES2823180T3 (es) * | 2016-07-14 | 2021-05-06 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos con heteroarilo |
| KR102468661B1 (ko) | 2016-07-14 | 2022-11-17 | 브리스톨-마이어스 스큅 컴퍼니 | Par4 억제제로서의 트리시클릭 헤테로아릴-치환된 퀴놀린 및 아자퀴놀린 화합물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1473819A (en) * | 1976-01-28 | 1977-05-18 | Gallardo Antonio Sa | Derivatives of imidazo 1,2-a pyridine |
| ES482438A0 (es) * | 1978-07-18 | 1980-04-01 | Hoechst Ag | Procedimiento para la preparacion de nuevos derivados de 2-(4-aminopiperidino)-3,4-dihidroquinoleina. |
| ES8100016A1 (es) * | 1978-07-18 | 1980-04-01 | Hoechst Ag | Procedimiento para la preparacion de nuevos derivados de 1-(4-aminopiperidino)-3,4-dihidroisoquinoleina. |
| JPS5553284A (en) * | 1978-10-12 | 1980-04-18 | Yoshitomi Pharmaceut Ind Ltd | Pyridazinone derivative |
| GB2031404A (en) * | 1978-10-17 | 1980-04-23 | Yoshitomi Pharmaceutical | Pyridazinone compounds |
-
1981
- 1981-10-29 CA CA000389034A patent/CA1164459A/en not_active Expired
- 1981-11-10 PH PH26478A patent/PH17158A/en unknown
- 1981-11-10 PT PT73959A patent/PT73959B/pt not_active IP Right Cessation
- 1981-11-11 CH CH4324/82A patent/CH653684A5/fr not_active IP Right Cessation
- 1981-11-11 MX MX819760U patent/MX6802E/es unknown
- 1981-11-11 IT IT8149680A patent/IT8149680A0/it unknown
- 1981-11-11 ES ES507545A patent/ES507545A0/es active Granted
- 1981-11-11 EP EP81305344A patent/EP0052016B1/de not_active Expired
- 1981-11-11 KR KR1019810004359A patent/KR880001657B1/ko active
- 1981-11-11 AT AT0908381A patent/AT382376B/de not_active IP Right Cessation
- 1981-11-11 AU AU78085/81A patent/AU547586B2/en not_active Ceased
- 1981-11-11 DE DE813152512T patent/DE3152512T1/de active Granted
- 1981-11-11 US US06/403,582 patent/US4414390A/en not_active Expired - Lifetime
- 1981-11-11 WO PCT/JP1981/000328 patent/WO1982001706A1/ja active IP Right Grant
-
1982
- 1982-07-08 SE SE8204237A patent/SE440653B/sv not_active IP Right Cessation
- 1982-07-08 DK DK307482A patent/DK157193C/da not_active IP Right Cessation
- 1982-07-09 NO NO82822391A patent/NO157819C/no unknown
- 1982-07-11 SU SU823466402A patent/SU1215621A3/ru active
- 1982-07-12 FI FI822471A patent/FI71145C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE8204237D0 (sv) | 1982-07-08 |
| ES8301967A1 (es) | 1983-02-01 |
| NO157819C (no) | 1988-05-25 |
| FI71145C (fi) | 1986-11-24 |
| CH653684A5 (fr) | 1986-01-15 |
| FI71145B (fi) | 1986-08-14 |
| AU7808581A (en) | 1982-06-07 |
| NO822391L (no) | 1982-07-09 |
| KR830007644A (ko) | 1983-11-04 |
| FI822471L (fi) | 1982-07-12 |
| FI822471A0 (fi) | 1982-07-12 |
| DE3152512C2 (de) | 1991-01-03 |
| DK307482A (da) | 1982-07-08 |
| ES507545A0 (es) | 1983-02-01 |
| SU1215621A3 (ru) | 1986-02-28 |
| SE440653B (sv) | 1985-08-12 |
| AT382376B (de) | 1987-02-25 |
| EP0052016A1 (de) | 1982-05-19 |
| NO157819B (no) | 1988-02-15 |
| SE8204237L (sv) | 1982-07-08 |
| PT73959B (en) | 1983-04-18 |
| DE3152512T1 (de) | 1982-11-18 |
| IT8149680A0 (it) | 1981-11-11 |
| DK157193B (da) | 1989-11-20 |
| DK157193C (da) | 1990-04-09 |
| PT73959A (en) | 1981-12-01 |
| PH17158A (en) | 1984-06-13 |
| CA1164459A (en) | 1984-03-27 |
| US4414390A (en) | 1983-11-08 |
| EP0052016B1 (de) | 1984-09-05 |
| KR880001657B1 (ko) | 1988-09-05 |
| MX6802E (es) | 1986-07-29 |
| AU547586B2 (en) | 1985-10-24 |
| WO1982001706A1 (en) | 1982-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |