AT375366B - Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen

Info

Publication number
AT375366B
AT375366B AT0125780A AT125780A AT375366B AT 375366 B AT375366 B AT 375366B AT 0125780 A AT0125780 A AT 0125780A AT 125780 A AT125780 A AT 125780A AT 375366 B AT375366 B AT 375366B
Authority
AT
Austria
Prior art keywords
pharmaceutically acceptable
acid addition
addition salts
acceptable acid
producing new
Prior art date
Application number
AT0125780A
Other languages
English (en)
Other versions
ATA125780A (de
Inventor
Edward Peter Cross
Peter Roger Dickinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to AT0290683A priority Critical patent/AT375932B/de
Publication of ATA125780A publication Critical patent/ATA125780A/de
Application granted granted Critical
Publication of AT375366B publication Critical patent/AT375366B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT0125780A 1979-03-07 1980-03-06 Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen AT375366B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0290683A AT375932B (de) 1979-03-07 1983-08-11 Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7908123 1979-03-07

Publications (2)

Publication Number Publication Date
ATA125780A ATA125780A (de) 1983-12-15
AT375366B true AT375366B (de) 1984-07-25

Family

ID=10503707

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0125780A AT375366B (de) 1979-03-07 1980-03-06 Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen

Country Status (36)

Country Link
US (1) US4273782A (de)
JP (1) JPS55133380A (de)
KR (1) KR850000760B1 (de)
AR (1) AR227015A1 (de)
AT (1) AT375366B (de)
AU (1) AU516957B2 (de)
BE (1) BE882113A (de)
CA (1) CA1120479A (de)
CH (1) CH649546A5 (de)
CS (1) CS253702B2 (de)
DD (1) DD149525A5 (de)
DE (1) DE3008632A1 (de)
DK (1) DK151884C (de)
ES (2) ES489220A0 (de)
FI (1) FI66860C (de)
FR (1) FR2450832A1 (de)
GR (1) GR67237B (de)
HK (1) HK89884A (de)
HU (1) HU184727B (de)
IE (1) IE49542B1 (de)
IL (1) IL59524A (de)
IT (1) IT1218420B (de)
KE (1) KE3467A (de)
LU (1) LU82224A1 (de)
MY (1) MY8500285A (de)
NL (1) NL182959C (de)
NO (1) NO152217C (de)
NZ (1) NZ193052A (de)
PH (1) PH15198A (de)
PL (1) PL128296B1 (de)
PT (1) PT70914A (de)
SE (1) SE440778B (de)
SG (1) SG67284G (de)
SU (1) SU1277894A3 (de)
YU (1) YU41911B (de)
ZA (1) ZA801328B (de)

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KR840000529A (ko) * 1981-07-07 1984-02-25 콘스탄틴 루이스 클레멘트 인돌 유도체의 제조방법
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4539410A (en) * 1982-09-30 1985-09-03 Ciba-Geigy Corporation N-Substituted-2-(1-imidazolyl)indoles
US4436746A (en) 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
ATE90076T1 (de) 1986-03-27 1993-06-15 Merck Frosst Canada Inc Tetrahydrocarbazole ester.
JPH0832679B2 (ja) * 1986-09-05 1996-03-29 理化学研究所 Ｎ―フタルイシド誘導体及びその製造法
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
AU5279390A (en) * 1989-03-31 1990-11-05 Kyoto Pharmaceutical Industries, Ltd. New imidazole derivatives, production thereof, and uses thereof as medicines
EP0486666B1 (de) * 1990-06-07 1997-08-13 Zeneca Limited Therapeutische heterocyclische verbindungen
DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
KR930702334A (ko) * 1990-09-13 1993-09-08 데이비드 로버트 5 하이드록시트립타민 수용체 길항제로서의 인돌우레아
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
US5120749A (en) * 1991-02-20 1992-06-09 Abbott Laboratories Platelet activating antagonists
IL104125A (en) * 1991-12-18 2000-08-31 Schering Corp Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring and pharmaceutical compositions comprising them
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
EP0597112A4 (en) * 1992-03-27 1994-06-22 Kyoto Pharma Ind Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor.
JPH0632913U (ja) * 1992-09-18 1994-04-28 三洋電機株式会社 床暖房用パネル
AP2000001929A0 (en) * 1998-03-31 2000-09-30 Inst For Pharm Discovery Inc Substituted indolealkanoic acids.
WO2004024726A1 (en) * 2002-09-12 2004-03-25 F. Hoffmann-La Roche Ag N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
CN100343250C (zh) * 2002-11-25 2007-10-17 霍夫曼-拉罗奇有限公司 吲哚衍生物
AU2003297727A1 (en) * 2002-12-10 2004-06-30 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
CA2564563C (en) * 2004-05-03 2011-07-05 F. Hoffmann-La Roche Ag Indolyl derivatives as liver-x-receptor modulators
EP1812388B1 (de) * 2004-10-12 2011-02-23 Decode Genetics, Ehf Peri-substituierte bicyclische sulfonamide gegen arterielle verschlusskrankheit
RU2008110908A (ru) * 2005-08-25 2009-09-27 Шеринг Корпорейшн (US) Производные имидазола в качестве функционально селективных агонистов альфа2с адренорецепторов
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
WO2007137042A2 (en) * 2006-05-16 2007-11-29 Decode Genetics, Ehf. Process for preparing 7- (acryl0yl) -ind0les
ES2391671T3 (es) 2006-07-22 2012-11-28 Oxagen Limited Compuestos con actividad antagonista de CRTH2
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
CA2708281A1 (en) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
SI2250161T1 (sl) 2008-01-18 2014-04-30 Atopix Therapeutics Limited Spojine, ki imajo aktivnost crth2 antagonista
US20100022613A1 (en) * 2008-01-22 2010-01-28 Oxagen Limited Compounds Having CRTH2 Antagonist Activity
WO2009093029A1 (en) * 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
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US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
JP2014518223A (ja) * 2011-06-20 2014-07-28 アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッド 化合物とその治療用途
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US3370063A (en) * 1964-10-05 1968-02-20 Mcneilab Inc Substituted dimethoxy indoles and method of making the same
US3621027A (en) * 1968-03-18 1971-11-16 Endo Lab 1-aminoalkyl-2,6-diaryl 4,5,6,7 tetrahydro-4-oxindales
US3931229A (en) * 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles
DK376078A (da) * 1977-08-26 1979-02-27 Wellcome Found Fremgangsmaade til fremstilling af amidazoler
US4140858A (en) * 1977-12-19 1979-02-20 Warner-Lambert Company 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production
EP0003901B1 (de) * 1978-02-24 1981-08-05 Pfizer Limited 3-(Imidazol-1-ylalkyl) indole als selektive Thromboxansynthetase Hemmungsmittel, pharmazeutische Zusammensetzungen die diese enthalten und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
ES496889A0 (es) 1982-08-01
US4273782A (en) 1981-06-16
NO152217C (no) 1985-08-21
CS253702B2 (en) 1987-12-17
IL59524A0 (en) 1980-06-30
YU61480A (en) 1983-12-31
AU5623180A (en) 1980-09-11
FR2450832B1 (de) 1983-04-22
FI66860B (fi) 1984-08-31
DK151884B (da) 1988-01-11
NO152217B (no) 1985-05-13
CA1120479A (en) 1982-03-23
ES8205789A1 (es) 1982-08-01
DD149525A5 (de) 1981-07-15
JPS55133380A (en) 1980-10-17
LU82224A1 (fr) 1980-06-06
NL8001351A (nl) 1980-09-09
HU184727B (en) 1984-10-29
KR830001928A (ko) 1983-05-19
IT8020399A0 (it) 1980-03-06
SE8001736L (sv) 1980-09-08
AU516957B2 (en) 1981-07-02
IE800453L (en) 1980-09-07
NZ193052A (en) 1984-07-06
DK42580A (da) 1980-09-08
PH15198A (en) 1982-09-17
DK151884C (da) 1988-06-13
FI800672A7 (fi) 1980-09-08
IT1218420B (it) 1990-04-19
ES8104278A1 (es) 1981-04-01
PL128296B1 (en) 1984-01-31
FR2450832A1 (fr) 1980-10-03
NO800650L (no) 1980-09-08
ZA801328B (en) 1981-03-25
NL182959C (nl) 1988-06-16
SU1277894A3 (ru) 1986-12-15
KR850000760B1 (ko) 1985-05-25
BE882113A (fr) 1980-09-08
SE440778B (sv) 1985-08-19
PT70914A (en) 1980-04-01
PL222470A1 (de) 1980-12-01
HK89884A (en) 1984-11-23
GR67237B (de) 1981-06-25
DE3008632C2 (de) 1988-02-25
JPS6141513B2 (de) 1986-09-16
IE49542B1 (en) 1985-10-30
KE3467A (en) 1984-11-09
MY8500285A (en) 1985-12-31
SG67284G (en) 1985-03-15
CH649546A5 (de) 1985-05-31
DE3008632A1 (de) 1980-10-16
ES489220A0 (es) 1981-04-01
IL59524A (en) 1982-11-30
AR227015A1 (es) 1982-09-15
YU41911B (en) 1988-02-29
ATA125780A (de) 1983-12-15
FI66860C (fi) 1984-12-10

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