AT375366B - Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen

Info

Publication number
AT375366B
AT375366B AT0125780A AT125780A AT375366B AT 375366 B AT375366 B AT 375366B AT 0125780 A AT0125780 A AT 0125780A AT 125780 A AT125780 A AT 125780A AT 375366 B AT375366 B AT 375366B
Authority
AT
Austria
Prior art keywords
pharmaceutically acceptable
acid addition
addition salts
acceptable acid
producing new
Prior art date
Application number
AT0125780A
Other languages
English (en)
Other versions
ATA125780A (de
Inventor
Edward Peter Cross
Peter Roger Dickinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to AT0290683A priority Critical patent/AT375932B/de
Publication of ATA125780A publication Critical patent/ATA125780A/de
Application granted granted Critical
Publication of AT375366B publication Critical patent/AT375366B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT0125780A 1979-03-07 1980-03-06 Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen AT375366B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0290683A AT375932B (de) 1979-03-07 1983-08-11 Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7908123 1979-03-07

Publications (2)

Publication Number Publication Date
ATA125780A ATA125780A (de) 1983-12-15
AT375366B true AT375366B (de) 1984-07-25

Family

ID=10503707

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0125780A AT375366B (de) 1979-03-07 1980-03-06 Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen

Country Status (36)

Country Link
US (1) US4273782A (de)
JP (1) JPS55133380A (de)
KR (1) KR850000760B1 (de)
AR (1) AR227015A1 (de)
AT (1) AT375366B (de)
AU (1) AU516957B2 (de)
BE (1) BE882113A (de)
CA (1) CA1120479A (de)
CH (1) CH649546A5 (de)
CS (1) CS253702B2 (de)
DD (1) DD149525A5 (de)
DE (1) DE3008632A1 (de)
DK (1) DK151884C (de)
ES (2) ES489220A0 (de)
FI (1) FI66860C (de)
FR (1) FR2450832A1 (de)
GR (1) GR67237B (de)
HK (1) HK89884A (de)
HU (1) HU184727B (de)
IE (1) IE49542B1 (de)
IL (1) IL59524A (de)
IT (1) IT1218420B (de)
KE (1) KE3467A (de)
LU (1) LU82224A1 (de)
MY (1) MY8500285A (de)
NL (1) NL182959C (de)
NO (1) NO152217C (de)
NZ (1) NZ193052A (de)
PH (1) PH15198A (de)
PL (1) PL128296B1 (de)
PT (1) PT70914A (de)
SE (1) SE440778B (de)
SG (1) SG67284G (de)
SU (1) SU1277894A3 (de)
YU (1) YU41911B (de)
ZA (1) ZA801328B (de)

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US4444775A (en) * 1981-06-22 1984-04-24 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridines
KR840000529A (ko) * 1981-07-07 1984-02-25 콘스탄틴 루이스 클레멘트 인돌 유도체의 제조방법
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4436746A (en) 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4539410A (en) * 1982-09-30 1985-09-03 Ciba-Geigy Corporation N-Substituted-2-(1-imidazolyl)indoles
AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
DE3786030T2 (de) 1986-03-27 1993-12-02 Merck Frosst Canada Inc Tetrahydrocarbazole Ester.
JPH0832679B2 (ja) * 1986-09-05 1996-03-29 理化学研究所 N―フタルイシド誘導体及びその製造法
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
KR920700210A (ko) * 1989-03-31 1992-02-19 기따미 가즈히꼬 신규 이미다졸 유도체, 그의 제법 및 그의 의약용도
MC2210A1 (fr) * 1990-06-07 1992-11-26 Wellcome Found Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer
DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
PT98927A (pt) * 1990-09-13 1992-07-31 Beecham Group Plc Processo para a preparacao de piridil-indolil-ureias
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
US5120749A (en) * 1991-02-20 1992-06-09 Abbott Laboratories Platelet activating antagonists
ZA929788B (en) * 1991-12-18 1993-06-22 Schering Corp Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring.
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
CA2109931A1 (en) * 1992-03-27 1993-10-14 Hiroshi Matsui Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor
JPH0632913U (ja) * 1992-09-18 1994-04-28 三洋電機株式会社 床暖房用パネル
US6214991B1 (en) * 1998-03-31 2001-04-10 The Institute For Pharmaceutical Discovery, Inc. Substituted indolealkanoic acids
RU2296759C2 (ru) * 2002-09-12 2007-04-10 Ф.Хоффманн-Ля Рош Аг N-замещенные 1н-индол-5-пропионовые кислоты, фармацевтическая композиция, содержащая эти соединения, и их применение (варианты)
ES2312819T3 (es) * 2002-11-25 2009-03-01 F. Hoffmann-La Roche Ag Derivados de indolilo.
DK1569899T3 (da) * 2002-12-10 2006-10-23 Wyeth Corp Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
BRPI0510599A (pt) * 2004-05-03 2007-11-20 Hoffmann La Roche compostos, processo para a preparação dos mesmos, composição farmacêutica, uso de um composto, e método para o tratamento e a profilaxia de doenças
KR20070091607A (ko) * 2004-10-12 2007-09-11 디코드 제네틱스, 아이엔씨. 폐쇄성 동맥 질환용의 설폰아미드 주변 치환된바이사이클릭 화합물
AR056043A1 (es) * 2005-08-25 2007-09-12 Schering Corp Agonistas de receptores adrenergicos alfa2c funcionalmente selectivos
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
RU2008149518A (ru) * 2006-05-16 2010-06-27 Декод Дженетикс, Ехф. (Is) Способ получения 7-(акрилоил) индолов
EP2046740B1 (de) 2006-07-22 2012-05-23 Oxagen Limited Verbindungen mit crth2-antagonistischer wirkung
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
AU2008350907A1 (en) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
ES2442717T3 (es) 2008-01-18 2014-02-13 Atopix Therapeutics Limited Compuestos que tienen actividad antagonista de CRTH2
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
WO2009093029A1 (en) * 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
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MX2010012814A (es) * 2008-05-23 2010-12-20 Amira Pharmaceuticals Inc Inhibidor de proteina activadora de 5-lipoxigenasa.
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NL125443C (de) * 1963-06-06
US3370063A (en) * 1964-10-05 1968-02-20 Mcneilab Inc Substituted dimethoxy indoles and method of making the same
US3621027A (en) * 1968-03-18 1971-11-16 Endo Lab 1-aminoalkyl-2,6-diaryl 4,5,6,7 tetrahydro-4-oxindales
US3931229A (en) * 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles
DK376078A (da) * 1977-08-26 1979-02-27 Wellcome Found Fremgangsmaade til fremstilling af amidazoler
US4140858A (en) * 1977-12-19 1979-02-20 Warner-Lambert Company 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production
EP0003901B1 (de) * 1978-02-24 1981-08-05 Pfizer Limited 3-(Imidazol-1-ylalkyl) indole als selektive Thromboxansynthetase Hemmungsmittel, pharmazeutische Zusammensetzungen die diese enthalten und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
ES8104278A1 (es) 1981-04-01
DE3008632A1 (de) 1980-10-16
FI66860B (fi) 1984-08-31
PL222470A1 (de) 1980-12-01
ATA125780A (de) 1983-12-15
MY8500285A (en) 1985-12-31
DK151884B (da) 1988-01-11
DK151884C (da) 1988-06-13
NZ193052A (en) 1984-07-06
HU184727B (en) 1984-10-29
FR2450832B1 (de) 1983-04-22
LU82224A1 (fr) 1980-06-06
DE3008632C2 (de) 1988-02-25
KR830001928A (ko) 1983-05-19
FI800672A7 (fi) 1980-09-08
YU61480A (en) 1983-12-31
SG67284G (en) 1985-03-15
SU1277894A3 (ru) 1986-12-15
ES496889A0 (es) 1982-08-01
IL59524A0 (en) 1980-06-30
IT1218420B (it) 1990-04-19
GR67237B (de) 1981-06-25
JPS55133380A (en) 1980-10-17
NO800650L (no) 1980-09-08
NL182959C (nl) 1988-06-16
CH649546A5 (de) 1985-05-31
IL59524A (en) 1982-11-30
US4273782A (en) 1981-06-16
ES8205789A1 (es) 1982-08-01
FI66860C (fi) 1984-12-10
FR2450832A1 (fr) 1980-10-03
AU5623180A (en) 1980-09-11
CA1120479A (en) 1982-03-23
ZA801328B (en) 1981-03-25
SE8001736L (sv) 1980-09-08
NO152217C (no) 1985-08-21
JPS6141513B2 (de) 1986-09-16
IE800453L (en) 1980-09-07
DK42580A (da) 1980-09-08
NO152217B (no) 1985-05-13
HK89884A (en) 1984-11-23
PH15198A (en) 1982-09-17
ES489220A0 (es) 1981-04-01
DD149525A5 (de) 1981-07-15
IE49542B1 (en) 1985-10-30
PL128296B1 (en) 1984-01-31
PT70914A (en) 1980-04-01
IT8020399A0 (it) 1980-03-06
NL8001351A (nl) 1980-09-09
AR227015A1 (es) 1982-09-15
BE882113A (fr) 1980-09-08
KR850000760B1 (ko) 1985-05-25
AU516957B2 (en) 1981-07-02
SE440778B (sv) 1985-08-19
YU41911B (en) 1988-02-29
KE3467A (en) 1984-11-09
CS253702B2 (en) 1987-12-17

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