IL59524A - Indole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

Indole derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL59524A
IL59524A IL59524A IL5952480A IL59524A IL 59524 A IL59524 A IL 59524A IL 59524 A IL59524 A IL 59524A IL 5952480 A IL5952480 A IL 5952480A IL 59524 A IL59524 A IL 59524A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
indole derivatives
indole
Prior art date
Application number
IL59524A
Other languages
English (en)
Other versions
IL59524A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL59524A0 publication Critical patent/IL59524A0/xx
Publication of IL59524A publication Critical patent/IL59524A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL59524A 1979-03-07 1980-03-05 Indole derivatives,their preparation and pharmaceutical compositions containing them IL59524A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7908123 1979-03-07

Publications (2)

Publication Number Publication Date
IL59524A0 IL59524A0 (en) 1980-06-30
IL59524A true IL59524A (en) 1982-11-30

Family

ID=10503707

Family Applications (1)

Application Number Title Priority Date Filing Date
IL59524A IL59524A (en) 1979-03-07 1980-03-05 Indole derivatives,their preparation and pharmaceutical compositions containing them

Country Status (36)

Country Link
US (1) US4273782A (de)
JP (1) JPS55133380A (de)
KR (1) KR850000760B1 (de)
AR (1) AR227015A1 (de)
AT (1) AT375366B (de)
AU (1) AU516957B2 (de)
BE (1) BE882113A (de)
CA (1) CA1120479A (de)
CH (1) CH649546A5 (de)
CS (1) CS253702B2 (de)
DD (1) DD149525A5 (de)
DE (1) DE3008632A1 (de)
DK (1) DK151884C (de)
ES (2) ES489220A0 (de)
FI (1) FI66860C (de)
FR (1) FR2450832A1 (de)
GR (1) GR67237B (de)
HK (1) HK89884A (de)
HU (1) HU184727B (de)
IE (1) IE49542B1 (de)
IL (1) IL59524A (de)
IT (1) IT1218420B (de)
KE (1) KE3467A (de)
LU (1) LU82224A1 (de)
MY (1) MY8500285A (de)
NL (1) NL182959C (de)
NO (1) NO152217C (de)
NZ (1) NZ193052A (de)
PH (1) PH15198A (de)
PL (1) PL128296B1 (de)
PT (1) PT70914A (de)
SE (1) SE440778B (de)
SG (1) SG67284G (de)
SU (1) SU1277894A3 (de)
YU (1) YU41911B (de)
ZA (1) ZA801328B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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US4414159A (en) * 1980-09-26 1983-11-08 E. I. Du Pont De Nemours & Co. Vinyl ether monomers and polymers therefrom
US4444775A (en) * 1981-06-22 1984-04-24 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridines
KR840000529A (ko) * 1981-07-07 1984-02-25 콘스탄틴 루이스 클레멘트 인돌 유도체의 제조방법
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4539410A (en) * 1982-09-30 1985-09-03 Ciba-Geigy Corporation N-Substituted-2-(1-imidazolyl)indoles
US4436746A (en) 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
ATE90076T1 (de) 1986-03-27 1993-06-15 Merck Frosst Canada Inc Tetrahydrocarbazole ester.
JPH0832679B2 (ja) * 1986-09-05 1996-03-29 理化学研究所 Ｎ―フタルイシド誘導体及びその製造法
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
KR920700210A (ko) * 1989-03-31 1992-02-19 기따미 가즈히꼬 신규 이미다졸 유도체, 그의 제법 및 그의 의약용도
ATE204275T1 (de) * 1990-06-07 2001-09-15 Astrazeneca Ab Indolderivate als 5-ht1-like agonisten
DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
KR930702334A (ko) * 1990-09-13 1993-09-08 데이비드 로버트 5 하이드록시트립타민 수용체 길항제로서의 인돌우레아
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
US5120749A (en) * 1991-02-20 1992-06-09 Abbott Laboratories Platelet activating antagonists
AU671092B2 (en) * 1991-12-18 1996-08-15 Schering Corporation Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
AU658729B2 (en) * 1992-03-27 1995-04-27 Kyoto Pharmaceutical Industries, Ltd. 3-(1H-imidazol-1-ylmethyl)-1H-indole derivatives
JPH0632913U (ja) * 1992-09-18 1994-04-28 三洋電機株式会社 床暖房用パネル
SK7522001A3 (en) * 1998-03-31 2002-02-05 Inst For Pharm Discovery Inc Substituted indolealkanoic acids
ATE345340T1 (de) * 2002-09-12 2006-12-15 Hoffmann La Roche N-substituierte-1h-indol-5-propansäure verbindungen als ppar-agonisten zur behandlung von diabetis
AU2003292030B2 (en) * 2002-11-25 2007-01-04 F. Hoffmann-La Roche Ag Indolyl derivatives
US7348351B2 (en) * 2002-12-10 2008-03-25 Wyeth Substituted 3-alkyl and 3-arylalkyl 1H-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
PL1756096T3 (pl) * 2004-05-03 2010-01-29 Hoffmann La Roche Pochodne indolilowe jako modulatory wątrobowych receptorów X
MX2007004525A (es) * 2004-10-12 2007-09-19 Decode Genetics Inc Sulfonamidas biciclicas peri-sustituidas para enfermedad de arteria oclusiva.
WO2007024944A1 (en) * 2005-08-25 2007-03-01 Schering Corporation Imidazole derivatives as functionally selective alpha2c adrenoreceptor agonists
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
RU2008149518A (ru) * 2006-05-16 2010-06-27 Декод Дженетикс, Ехф. (Is) Способ получения 7-(акрилоил) индолов
AU2007279079A1 (en) 2006-07-22 2008-01-31 Oxagen Limited Compounds having CRTH2 antagonist activity
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
EP2234608A2 (de) 2007-12-11 2010-10-06 Viamet Pharmaceuticals, Inc. Metalloenzymhemmer mit metallbindenden teilen in kombination mit targeting-teilen
SI2250161T1 (sl) 2008-01-18 2014-04-30 Atopix Therapeutics Limited Spojine, ki imajo aktivnost crth2 antagonista
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
JP2011509991A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
JP2011509990A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
JP5791500B2 (ja) * 2008-05-23 2015-10-07 パンミラ ファーマシューティカルズ，エルエルシー． ５−リポキシゲナーゼ活性化タンパク質阻害剤
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
CA2877474A1 (en) * 2011-06-20 2012-12-27 Myrexis, Inc. Compounds and therapeutic uses thereof
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
WO2019191410A1 (en) * 2018-03-29 2019-10-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibitors for the β-catenin / t-cell factor protein–protein interaction

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125443C (de) * 1963-06-06
US3370063A (en) * 1964-10-05 1968-02-20 Mcneilab Inc Substituted dimethoxy indoles and method of making the same
US3621027A (en) * 1968-03-18 1971-11-16 Endo Lab 1-aminoalkyl-2,6-diaryl 4,5,6,7 tetrahydro-4-oxindales
US3931229A (en) * 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles
AU523536B2 (en) * 1977-08-26 1982-08-05 Wellcome Foundation Limited, The Imidazoles and methods of preparing them
US4140858A (en) * 1977-12-19 1979-02-20 Warner-Lambert Company 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production
EP0003901B1 (de) * 1978-02-24 1981-08-05 Pfizer Limited 3-(Imidazol-1-ylalkyl) indole als selektive Thromboxansynthetase Hemmungsmittel, pharmazeutische Zusammensetzungen die diese enthalten und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
IE800453L (en) 1980-09-07
IT1218420B (it) 1990-04-19
NO152217B (no) 1985-05-13
ATA125780A (de) 1983-12-15
PL222470A1 (de) 1980-12-01
ZA801328B (en) 1981-03-25
DK151884B (da) 1988-01-11
AR227015A1 (es) 1982-09-15
FR2450832A1 (fr) 1980-10-03
ES8205789A1 (es) 1982-08-01
CH649546A5 (de) 1985-05-31
AT375366B (de) 1984-07-25
YU61480A (en) 1983-12-31
PH15198A (en) 1982-09-17
SU1277894A3 (ru) 1986-12-15
NZ193052A (en) 1984-07-06
NO800650L (no) 1980-09-08
CS253702B2 (en) 1987-12-17
KE3467A (en) 1984-11-09
HU184727B (en) 1984-10-29
DK151884C (da) 1988-06-13
KR850000760B1 (ko) 1985-05-25
ES8104278A1 (es) 1981-04-01
HK89884A (en) 1984-11-23
SE440778B (sv) 1985-08-19
AU5623180A (en) 1980-09-11
AU516957B2 (en) 1981-07-02
FI800672A7 (fi) 1980-09-08
ES496889A0 (es) 1982-08-01
SE8001736L (sv) 1980-09-08
NL182959C (nl) 1988-06-16
IT8020399A0 (it) 1980-03-06
FI66860C (fi) 1984-12-10
FI66860B (fi) 1984-08-31
IL59524A0 (en) 1980-06-30
BE882113A (fr) 1980-09-08
DE3008632C2 (de) 1988-02-25
MY8500285A (en) 1985-12-31
PT70914A (en) 1980-04-01
SG67284G (en) 1985-03-15
YU41911B (en) 1988-02-29
FR2450832B1 (de) 1983-04-22
JPS55133380A (en) 1980-10-17
KR830001928A (ko) 1983-05-19
ES489220A0 (es) 1981-04-01
NO152217C (no) 1985-08-21
GR67237B (de) 1981-06-25
DE3008632A1 (de) 1980-10-16
CA1120479A (en) 1982-03-23
DK42580A (da) 1980-09-08
IE49542B1 (en) 1985-10-30
DD149525A5 (de) 1981-07-15
US4273782A (en) 1981-06-16
LU82224A1 (fr) 1980-06-06
NL8001351A (nl) 1980-09-09
PL128296B1 (en) 1984-01-31
JPS6141513B2 (de) 1986-09-16

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