KR20220045189A - 위장관 기질 종양을 치료하는 방법 - Google Patents

위장관 기질 종양을 치료하는 방법 Download PDF

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Publication number
KR20220045189A
KR20220045189A KR1020227007366A KR20227007366A KR20220045189A KR 20220045189 A KR20220045189 A KR 20220045189A KR 1020227007366 A KR1020227007366 A KR 1020227007366A KR 20227007366 A KR20227007366 A KR 20227007366A KR 20220045189 A KR20220045189 A KR 20220045189A
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South Korea
Prior art keywords
patient
rifretinib
daily
mutation
administration
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Ceased
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KR1020227007366A
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English (en)
Korean (ko)
Inventor
로드리고 뤼즈 소토
올리버 로젠
자마 피트맨
Original Assignee
데시페라 파마슈티칼스, 엘엘씨.
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Application filed by 데시페라 파마슈티칼스, 엘엘씨. filed Critical 데시페라 파마슈티칼스, 엘엘씨.
Priority claimed from PCT/US2020/045876 external-priority patent/WO2021030405A1/en
Publication of KR20220045189A publication Critical patent/KR20220045189A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020227007366A 2019-08-12 2020-08-12 위장관 기질 종양을 치료하는 방법 Ceased KR20220045189A (ko)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US201962885797P 2019-08-12 2019-08-12
US62/885,797 2019-08-12
US201962904198P 2019-09-23 2019-09-23
US62/904,198 2019-09-23
US201962926281P 2019-10-25 2019-10-25
US62/926,281 2019-10-25
US201962936018P 2019-11-15 2019-11-15
US62/936,018 2019-11-15
US202062968927P 2020-01-31 2020-01-31
US202062968945P 2020-01-31 2020-01-31
US62/968,927 2020-01-31
US62/968,945 2020-01-31
US202063023936P 2020-05-13 2020-05-13
US202063023921P 2020-05-13 2020-05-13
US63/023,936 2020-05-13
US63/023,921 2020-05-13
PCT/US2020/045876 WO2021030405A1 (en) 2019-08-12 2020-08-12 Ripretinib for treating gastrointestinal stromal tumors

Publications (1)

Publication Number Publication Date
KR20220045189A true KR20220045189A (ko) 2022-04-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227007366A Ceased KR20220045189A (ko) 2019-08-12 2020-08-12 위장관 기질 종양을 치료하는 방법

Country Status (13)

Country Link
US (16) US10966966B2 (https=)
EP (1) EP4013412B1 (https=)
JP (2) JP7818502B2 (https=)
KR (1) KR20220045189A (https=)
CN (1) CN114615982A (https=)
AU (3) AU2020329956B2 (https=)
BR (1) BR112022002609A2 (https=)
CA (1) CA3150433A1 (https=)
DK (1) DK4013412T3 (https=)
FI (1) FI4013412T3 (https=)
IL (2) IL326329A (https=)
LT (1) LT4013412T (https=)
MX (1) MX2022001863A (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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IL276398B2 (en) 2018-01-31 2026-03-01 Deciphera Pharmaceuticals Llc Combination therapy for mastocytosis
CN118416236A (zh) 2018-01-31 2024-08-02 德西费拉制药有限责任公司 治疗胃肠道间质瘤的组合疗法
WO2020185812A1 (en) 2019-03-11 2020-09-17 Teva Pharmaceuticals International Gmbh Solid state forms of ripretinib
EP4013412B1 (en) 2019-08-12 2026-01-28 Deciphera Pharmaceuticals, LLC Ripretinib for treating gastrointestinal stromal tumors
TWI878335B (zh) 2019-08-12 2025-04-01 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
EP4084779B1 (en) 2019-12-30 2024-10-09 Deciphera Pharmaceuticals, LLC Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
MX2022008103A (es) 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Formulaciones de inhibidores de la cinasa amorfa y metodos de estas.
IL302807A (en) 2020-11-18 2023-07-01 Deciphera Pharmaceuticals Llc Gcn2 and perk kinase inhibitors and methods of use thereof
PE20250609A1 (es) 2021-12-03 2025-02-26 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos
CA3240263A1 (en) 2021-12-09 2023-06-15 Daniel L. Flynn Raf kinase inhibitors and methods of use thereof
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors
TW202440099A (zh) * 2022-12-23 2024-10-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法

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