KR20210149750A - 올리고뉴클레오티드 제조에 유용한 기술 - Google Patents
올리고뉴클레오티드 제조에 유용한 기술 Download PDFInfo
- Publication number
- KR20210149750A KR20210149750A KR1020217033895A KR20217033895A KR20210149750A KR 20210149750 A KR20210149750 A KR 20210149750A KR 1020217033895 A KR1020217033895 A KR 1020217033895A KR 20217033895 A KR20217033895 A KR 20217033895A KR 20210149750 A KR20210149750 A KR 20210149750A
- Authority
- KR
- South Korea
- Prior art keywords
- independently
- oligonucleotide
- oligonucleotides
- capping
- phosphorus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962821423P | 2019-03-20 | 2019-03-20 | |
| US62/821,423 | 2019-03-20 | ||
| PCT/US2020/023735 WO2020191252A1 (en) | 2019-03-20 | 2020-03-19 | Technologies useful for oligonucleotide preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210149750A true KR20210149750A (ko) | 2021-12-09 |
Family
ID=72520512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217033895A Pending KR20210149750A (ko) | 2019-03-20 | 2020-03-19 | 올리고뉴클레오티드 제조에 유용한 기술 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12590115B2 (https=) |
| EP (1) | EP3941924A4 (https=) |
| JP (1) | JP2022525541A (https=) |
| KR (1) | KR20210149750A (https=) |
| CN (1) | CN113748116A (https=) |
| AU (2) | AU2020241559A1 (https=) |
| CA (1) | CA3134036A1 (https=) |
| IL (1) | IL286487A (https=) |
| MX (1) | MX2021011351A (https=) |
| SG (1) | SG11202110045PA (https=) |
| WO (1) | WO2020191252A1 (https=) |
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| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
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| CN108135921B (zh) | 2015-07-22 | 2023-10-17 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
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| EP3475424A1 (en) | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
| US10941402B2 (en) | 2016-09-01 | 2021-03-09 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded RNA-editing oligonucleotides |
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| TW201920672A (zh) | 2017-08-08 | 2019-06-01 | 新加坡商波濤生命科學有限公司 | 寡核苷酸組合物及其使用方法 |
| CN111108096A (zh) | 2017-09-18 | 2020-05-05 | 波涛生命科学有限公司 | 寡核苷酸制备技术 |
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| CN113748116A (zh) | 2019-03-20 | 2021-12-03 | 波涛生命科学有限公司 | 可用于寡核苷酸制备的技术 |
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| US20250154504A1 (en) | 2022-02-14 | 2025-05-15 | Proqr Therapeutics Ii B.V. | Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia |
| EP4555086A1 (en) | 2022-07-15 | 2025-05-21 | ProQR Therapeutics II B.V. | Oligonucleotides for adar-mediated rna editing and use thereof |
| WO2024013360A1 (en) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
| AR131145A1 (es) | 2022-11-24 | 2025-02-19 | Proqr Therapeutics Ii Bv | Oligonucleótidos antisentido para el tratamiento de hemocromatosis hfe hereditaria |
| GB202218090D0 (en) | 2022-12-01 | 2023-01-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency |
| CA3276262A1 (en) | 2022-12-09 | 2024-06-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of cardiovascular disease |
| GB202300865D0 (en) | 2023-01-20 | 2023-03-08 | Proqr Therapeutics Ii Bv | Delivery of oligonucleotides |
| EP4669753A1 (en) | 2023-02-20 | 2025-12-31 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease |
| WO2024206175A1 (en) | 2023-03-24 | 2024-10-03 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
| AU2024246572A1 (en) | 2023-03-27 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2024256620A1 (en) | 2023-06-16 | 2024-12-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurodegenerative disease |
| AU2024287308A1 (en) | 2023-07-13 | 2025-12-18 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| WO2025051946A1 (en) | 2023-09-07 | 2025-03-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| CN121909203A (zh) | 2023-10-31 | 2026-04-21 | 科罗生物公司 | 包含氨基磷酸酯核苷酸间键的寡核苷酸 |
| WO2025104239A1 (en) | 2023-11-16 | 2025-05-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of classic galactosemia |
| WO2025128799A1 (en) | 2023-12-12 | 2025-06-19 | Korro Bio, Inc. | Double-stranded rna-editing oligonucleotides and uses thereof |
| WO2025132708A1 (en) | 2023-12-20 | 2025-06-26 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of huntington's disease |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| WO2025224230A1 (en) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of fatty liver disease |
| GB202410081D0 (en) | 2024-07-11 | 2024-08-28 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of cardiovascular disease |
| WO2026022136A1 (en) | 2024-07-23 | 2026-01-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2026050243A1 (en) | 2024-08-26 | 2026-03-05 | Korro Bio, Inc. | Galnac conjugated oligonucleotides for rna editing |
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2020
- 2020-03-19 CN CN202080028682.0A patent/CN113748116A/zh active Pending
- 2020-03-19 JP JP2021556501A patent/JP2022525541A/ja active Pending
- 2020-03-19 EP EP20774109.1A patent/EP3941924A4/en active Pending
- 2020-03-19 SG SG11202110045PA patent/SG11202110045PA/en unknown
- 2020-03-19 US US17/439,755 patent/US12590115B2/en active Active
- 2020-03-19 WO PCT/US2020/023735 patent/WO2020191252A1/en not_active Ceased
- 2020-03-19 MX MX2021011351A patent/MX2021011351A/es unknown
- 2020-03-19 CA CA3134036A patent/CA3134036A1/en active Pending
- 2020-03-19 AU AU2020241559A patent/AU2020241559A1/en not_active Abandoned
- 2020-03-19 KR KR1020217033895A patent/KR20210149750A/ko active Pending
-
2021
- 2021-09-19 IL IL286487A patent/IL286487A/en unknown
-
2026
- 2026-03-23 AU AU2026202225A patent/AU2026202225A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020191252A1 (en) | 2020-09-24 |
| AU2026202225A1 (en) | 2026-04-09 |
| BR112021018492A2 (pt) | 2021-11-23 |
| JP2022525541A (ja) | 2022-05-17 |
| SG11202110045PA (en) | 2021-10-28 |
| CN113748116A (zh) | 2021-12-03 |
| IL286487A (en) | 2021-10-31 |
| CA3134036A1 (en) | 2020-09-24 |
| EP3941924A1 (en) | 2022-01-26 |
| EP3941924A4 (en) | 2022-12-28 |
| AU2020241559A1 (en) | 2021-11-11 |
| US20230089442A1 (en) | 2023-03-23 |
| MX2021011351A (es) | 2021-12-10 |
| US12590115B2 (en) | 2026-03-31 |
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