BR112021018492A2 - Método para preparar um oligonucleotídeo, oligonucleotídeo, composição, fosforamidita e composto - Google Patents

Método para preparar um oligonucleotídeo, oligonucleotídeo, composição, fosforamidita e composto

Info

Publication number
BR112021018492A2
BR112021018492A2 BR112021018492A BR112021018492A BR112021018492A2 BR 112021018492 A2 BR112021018492 A2 BR 112021018492A2 BR 112021018492 A BR112021018492 A BR 112021018492A BR 112021018492 A BR112021018492 A BR 112021018492A BR 112021018492 A2 BR112021018492 A2 BR 112021018492A2
Authority
BR
Brazil
Prior art keywords
oligonucleotide
phosphoramidite
preparing
compound
composition
Prior art date
Application number
BR112021018492A
Other languages
English (en)
Inventor
Tilak Bhattarai Bijay
Chandra Vargeese
Charles Donnell Butler David
Reddy Bommineni Gopal
Jayakanthan Kumarasamy
Andrew Bowman Keith
Mamoru Shimizu
Rowshon Alam Mohammed
Pachamuthu Kandasamy
Sethumadhavan Divakaramenon
Michelle Standley Stephany
Original Assignee
Wave Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wave Life Sciences Ltd filed Critical Wave Life Sciences Ltd
Publication of BR112021018492A2 publication Critical patent/BR112021018492A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

método para preparar um oligonucleotídeo, oligonucleotídeo, composição, fosforamidita e composto. trata-se, dentre outras coisas, de tecnologias para preparação de oligonucleotídeo, particularmente preparação de oligonucleotídeo quiralmente controlada, tais tecnologias fornecem rendimento e pureza brutos grandemente melhorados e reduzem significativamente os custos de fabricação.
BR112021018492A 2019-03-20 2020-03-19 Método para preparar um oligonucleotídeo, oligonucleotídeo, composição, fosforamidita e composto BR112021018492A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962821423P 2019-03-20 2019-03-20
PCT/US2020/023735 WO2020191252A1 (en) 2019-03-20 2020-03-19 Technologies useful for oligonucleotide preparation

Publications (1)

Publication Number Publication Date
BR112021018492A2 true BR112021018492A2 (pt) 2021-11-23

Family

ID=72520512

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021018492A BR112021018492A2 (pt) 2019-03-20 2020-03-19 Método para preparar um oligonucleotídeo, oligonucleotídeo, composição, fosforamidita e composto

Country Status (12)

Country Link
US (1) US20230089442A1 (pt)
EP (1) EP3941924A4 (pt)
JP (1) JP2022525541A (pt)
KR (1) KR20210149750A (pt)
CN (1) CN113748116A (pt)
AU (1) AU2020241559A1 (pt)
BR (1) BR112021018492A2 (pt)
CA (1) CA3134036A1 (pt)
IL (1) IL286487A (pt)
MX (1) MX2021011351A (pt)
SG (1) SG11202110045PA (pt)
WO (1) WO2020191252A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
RU2708237C2 (ru) 2014-08-22 2019-12-05 Общество с ограниченной ответственностью "НооГен" Модифицированные олигонуклеотиды и способ их получения
MA43072A (fr) 2015-07-22 2018-05-30 Wave Life Sciences Ltd Compositions d'oligonucléotides et procédés associés
AU2017234150B2 (en) 2016-03-13 2021-09-16 Wave Life Sciences Ltd. Compositions and methods for phosphoramidite and oligonucleotide synthesis
CN110088113A (zh) 2016-11-23 2019-08-02 波涛生命科学有限公司 用于亚磷酰胺和寡核苷酸合成的组合物和方法
US11597927B2 (en) 2017-06-02 2023-03-07 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
US11603532B2 (en) 2017-06-02 2023-03-14 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
EP3642182A4 (en) 2017-06-21 2020-12-09 Wave Life Sciences Ltd. COMPOUNDS, COMPOSITIONS AND SYNTHESIS METHODS
AU2018316159A1 (en) 2017-08-08 2020-02-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
CN111108096A (zh) 2017-09-18 2020-05-05 波涛生命科学有限公司 寡核苷酸制备技术
JP2020537518A (ja) 2017-10-12 2020-12-24 ウェーブ ライフ サイエンシーズ リミテッド オリゴヌクレオチド組成物及びその方法
MX2022000113A (es) * 2019-07-09 2022-02-10 Hoffmann La Roche Proceso para la desproteccion de oligonucleotidos.
WO2023152371A1 (en) 2022-02-14 2023-08-17 Proqr Therapeutics Ii B.V. Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia
WO2024013361A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Oligonucleotides for adar-mediated rna editing and use thereof
WO2024013360A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Chemically modified oligonucleotides for adar-mediated rna editing
GB202215614D0 (en) 2022-10-21 2022-12-07 Proqr Therapeutics Ii Bv Heteroduplex rna editing oligonucleotide complexes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2498111A1 (en) * 2002-09-11 2004-03-25 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
US10428019B2 (en) * 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
JP6268157B2 (ja) * 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
SG10201912895PA (en) * 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
MA43072A (fr) * 2015-07-22 2018-05-30 Wave Life Sciences Ltd Compositions d'oligonucléotides et procédés associés
JP7164540B2 (ja) * 2017-03-29 2022-11-01 ロシュ イノベーション センター コペンハーゲン エーエス 立体的に規定されたホスホロチオエートオリゴヌクレオチドの調製のための直交保護基
JP2021521140A (ja) * 2018-04-12 2021-08-26 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法
CN112218664A (zh) * 2018-05-11 2021-01-12 波涛生命科学有限公司 寡核苷酸组合物及其使用方法
AU2019392928A1 (en) * 2018-12-06 2021-06-17 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
CA3154768A1 (en) * 2019-10-06 2021-04-15 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof

Also Published As

Publication number Publication date
MX2021011351A (es) 2021-12-10
KR20210149750A (ko) 2021-12-09
US20230089442A1 (en) 2023-03-23
CN113748116A (zh) 2021-12-03
EP3941924A4 (en) 2022-12-28
IL286487A (en) 2021-10-31
WO2020191252A1 (en) 2020-09-24
CA3134036A1 (en) 2020-09-24
SG11202110045PA (en) 2021-10-28
AU2020241559A1 (en) 2021-11-11
JP2022525541A (ja) 2022-05-17
EP3941924A1 (en) 2022-01-26

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