KR20190101406A - Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법 - Google Patents

Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법 Download PDF

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KR20190101406A
KR20190101406A KR1020197021538A KR20197021538A KR20190101406A KR 20190101406 A KR20190101406 A KR 20190101406A KR 1020197021538 A KR1020197021538 A KR 1020197021538A KR 20197021538 A KR20197021538 A KR 20197021538A KR 20190101406 A KR20190101406 A KR 20190101406A
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South Korea
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alkyl
optionally substituted
substituted
aryl
heteroaryl
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Korean (ko)
Inventor
앤드류 피. 크루
커트 짐머만
징 왕
미카엘 벨린
한칭 동
알렉세이 이셴코
이민 치안
크레이그 엠. 크루즈
사울 제이미-피게로아
조지 버슬렘
Original Assignee
아비나스 오퍼레이션스, 인코포레이티드
예일 유니버시티
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020197021538A 2016-12-23 2017-12-22 Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법 Ceased KR20190101406A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662438901P 2016-12-23 2016-12-23
US62/438,901 2016-12-23
US201762563494P 2017-09-26 2017-09-26
US62/563,494 2017-09-26
PCT/US2017/068308 WO2018119441A1 (en) 2016-12-23 2017-12-22 Egfr proteolysis targeting chimeric molecules and associated methods of use

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KR20190101406A true KR20190101406A (ko) 2019-08-30

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KR1020197021538A Ceased KR20190101406A (ko) 2016-12-23 2017-12-22 Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법

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US (3) US10994015B2 (enExample)
EP (1) EP3559002A4 (enExample)
JP (1) JP2020505327A (enExample)
KR (1) KR20190101406A (enExample)
CN (1) CN110753693A (enExample)
AU (1) AU2017382406A1 (enExample)
BR (1) BR112019012682A2 (enExample)
CA (1) CA3047586A1 (enExample)
CO (1) CO2019007892A2 (enExample)
IL (1) IL267398A (enExample)
MX (1) MX2019007646A (enExample)
RU (1) RU2019121527A (enExample)
WO (1) WO2018119441A1 (enExample)

Cited By (1)

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KR20250044979A (ko) 2023-09-25 2025-04-01 주식회사 메디아크 프로탁(Protac)이 탑재된 금속-유기 골격체(Metal-Organic Framework) 입자를 포함하는 약물 전달 시스템 및 이를 포함하는 약학 조성물

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WO2018053354A1 (en) 2016-09-15 2018-03-22 Arvinas, Inc. Indole derivatives as estrogen receptor degraders
JP2019537585A (ja) 2016-10-28 2019-12-26 アイカーン スクール オブ メディスン アット マウント シナイ Ｅｚｈ２媒介性がんを治療するための組成物および方法
KR20230127371A (ko) * 2016-11-01 2023-08-31 아비나스 오퍼레이션스, 인코포레이티드 타우(Tau)-단백질 표적화 프로탁(PROTAC) 및 관련 사용 방법
IL297717A (en) 2016-12-01 2022-12-01 Arvinas Operations Inc History of tetrahydronaphthalene and tetrahydroisoquinoline as estrogen receptor antagonists
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