KR20170048410A - 세린 프로테아제 저해제로서의 피라졸릴-치환된 피리돈 화합물 - Google Patents
세린 프로테아제 저해제로서의 피라졸릴-치환된 피리돈 화합물 Download PDFInfo
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- KR20170048410A KR20170048410A KR1020177007352A KR20177007352A KR20170048410A KR 20170048410 A KR20170048410 A KR 20170048410A KR 1020177007352 A KR1020177007352 A KR 1020177007352A KR 20177007352 A KR20177007352 A KR 20177007352A KR 20170048410 A KR20170048410 A KR 20170048410A
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Psychiatry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051511P | 2014-09-17 | 2014-09-17 | |
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| BR112014030954A2 (pt) | 2012-06-14 | 2017-06-27 | Daiichi Sankyo Co Ltd | composto , composição farmacêutica , ativador de lecitina-colesterol aciltransferase , agente antiaterosclerótico , agente profilático ou terapêutico para aterosclerose , agente para diminuir a concentração de colesterol ldl no sangue e para elevar a concentração de colesterol hdl no sangue , uso de um composto , e , métodos para ativar lecitina-colesterol aciltransferase , e para o tratamento ou profilaxia de uma doença. |
| BR112015016395A2 (pt) | 2013-01-18 | 2017-07-11 | Hoffmann La Roche | pirazóis 3-substituídos e uso como inibidores de dlk |
| MX373964B (es) * | 2013-03-15 | 2020-07-13 | Verseon Corp | Compuestos aromaticos multisustituidos como inhibidores de serina proteasa. |
| WO2015087995A1 (ja) | 2013-12-13 | 2015-06-18 | 第一三共株式会社 | シクロアルキル又はヘテロシクリルピラゾロピリジン誘導体 |
| EP4413985A3 (en) | 2014-02-06 | 2024-10-23 | Nxera Pharma UK Limited | Pharmaceutical compounds |
| US10189810B2 (en) * | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
-
2015
- 2015-09-17 US US15/512,037 patent/US10189810B2/en active Active
- 2015-09-17 BR BR112017004704A patent/BR112017004704A2/pt not_active Application Discontinuation
- 2015-09-17 MX MX2017003624A patent/MX2017003624A/es unknown
- 2015-09-17 CA CA2960790A patent/CA2960790A1/en not_active Abandoned
- 2015-09-17 AU AU2015317522A patent/AU2015317522A1/en not_active Abandoned
- 2015-09-17 JP JP2017514899A patent/JP2017528486A/ja active Pending
- 2015-09-17 EP EP15841577.8A patent/EP3194369A4/en not_active Withdrawn
- 2015-09-17 WO PCT/US2015/050809 patent/WO2016044662A1/en not_active Ceased
- 2015-09-17 SG SG11201701940UA patent/SG11201701940UA/en unknown
- 2015-09-17 RU RU2017112739A patent/RU2017112739A/ru not_active Application Discontinuation
- 2015-09-17 KR KR1020177007352A patent/KR20170048410A/ko not_active Withdrawn
- 2015-09-17 CN CN201580050088.0A patent/CN106687445A/zh active Pending
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2017
- 2017-03-06 IL IL250965A patent/IL250965A0/en unknown
- 2017-03-13 ZA ZA2017/01799A patent/ZA201701799B/en unknown
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2018
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2020
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- 2020-05-19 JP JP2020087253A patent/JP2020143112A/ja active Pending
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| US20170267656A1 (en) | 2017-09-21 |
| AU2015317522A1 (en) | 2017-03-23 |
| WO2016044662A1 (en) | 2016-03-24 |
| US10189810B2 (en) | 2019-01-29 |
| CA2960790A1 (en) | 2016-03-24 |
| EP3194369A1 (en) | 2017-07-26 |
| ZA201701799B (en) | 2019-06-26 |
| SG11201701940UA (en) | 2017-04-27 |
| US20190359586A1 (en) | 2019-11-28 |
| MX2017003624A (es) | 2017-07-13 |
| AU2020202167A1 (en) | 2020-04-30 |
| RU2017112739A3 (enExample) | 2019-04-01 |
| CN106687445A (zh) | 2017-05-17 |
| RU2017112739A (ru) | 2018-10-17 |
| JP2017528486A (ja) | 2017-09-28 |
| BR112017004704A2 (pt) | 2018-01-23 |
| JP2020143112A (ja) | 2020-09-10 |
| IL250965A0 (en) | 2017-04-30 |
| EP3194369A4 (en) | 2018-02-28 |
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