RS54761B1 - Pirazolo[1,5-a]pirimidini i-triazini kao antiviralni agensi - Google Patents
Pirazolo[1,5-a]pirimidini i-triazini kao antiviralni agensiInfo
- Publication number
- RS54761B1 RS54761B1 RS20160349A RSP20160349A RS54761B1 RS 54761 B1 RS54761 B1 RS 54761B1 RS 20160349 A RS20160349 A RS 20160349A RS P20160349 A RSP20160349 A RS P20160349A RS 54761 B1 RS54761 B1 RS 54761B1
- Authority
- RS
- Serbia
- Prior art keywords
- alkyl
- aryl
- optionally substituted
- heterocyclyl
- cycloalkyl
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 11
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 9
- -1 C2-C20 heterocyclyl Chemical group 0.000 abstract 8
- 125000006736 (C6-C20) aryl group Chemical group 0.000 abstract 7
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 5
- 125000005884 carbocyclylalkyl group Chemical group 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 229910017711 NHRa Inorganic materials 0.000 abstract 4
- 101150073096 NRAS gene Proteins 0.000 abstract 4
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- MPVDXIMFBOLMNW-UHFFFAOYSA-N chembl1615565 Chemical compound OC1=CC=C2C=C(S(O)(=O)=O)C=C(S(O)(=O)=O)C2=C1N=NC1=CC=CC=C1 MPVDXIMFBOLMNW-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Jedinjenje sa formulom I ili sa formulom II:ili farmaceustki prihvatljiva so ili estar tog jedinjenja,gde:A je -(C(R4)2)n- gde bilo koji C(R4)2 od pomenutog -(C(R4)2)n- može biti po izboru zamenjen sa -O-, -S-, -S(O)p-, NH ili NRa;n je 3, 4, 5 ili 6;svako p je 1 ili 2;Ar je C2-C20 heterociklil grupa ili C6-C20 aril grupa, gde C2-C20 heterociklil grupa ili C6-C20 aril grupa je po izboru supstituisana sa 1 do 5 R6,X je -C(R13)(R14)-, -N(CH2R14)- ili X je odsutno;Y jeNili CR7;svako R1, R2, R3, R4, R5, R6, R7 ili R8 je nezavisno H, okso, OR11, NR11R12,NR11C(O)R11, NR11C(O)OR11R11, NR11C(O)NR11R12, N3, CN, NO2, SR11, S(O)pRa, NR11S(O)pRa, -C(=O)R11, -C(=O)OR11 -C(=O)NR11R12, -C(=O)SR11, -S(O)p(OR11), -SO2NR11R12, -NR11S(O)p(OR11), -NR11SOpNR11R12, NR11C(=NR11)NR11R12, halogen, (C1-C8)alkil, (C2-C8)alkenil, (C2-C8)alkinil, aril(C1-C8)alkil, C6-C20 aril, C2-C20 heterociklil, (C3-C7)cikloalkil ili (C4-C8)karbociklilalkil;dva R4 na susednim atomima ugljenika, kada se uzmu zajedno, mogu formirati dvostruku vezu između dva ugljenika za koje su oni vezani ili mogu formirati (C3-C7)cikloalkil prsten gde jedan atom ugljenika od pomenutog (C3-C7)cikloalkil prstena može biti po izboru zamenjen sa -O-, - S-, -S(O)p-, -NH- ili -NRa-;četiri R4 na susednim atomima ugljenika, kada se uzmu zajedno mogu formirati po izboru supstituisani C6 aril prsten;dva R4 na istom atomu ugljenika, kada se uzmu zajedno mogu formirati (C3-C7)cikloalkil prsten gde jedan atom ugljenika pomenutog (C3-C7)cikloalkil prstena može bitipo izboru zamenjen sa -O-, -S-, -S(O)p-, -NH- ili-NRa-;dva R6 na susednim atomima ugljenika, kada se uzmu zajedno mogu formirati (C3-C7)cikloalkil prsten gde jedan atom ugljenika iz pomenutog (C3-C7)cikloalkil prstena može biti po izboru zamenjen sa -O-, -S-, -S(O)p-, -NH- ili -NRa-;bilo koje R6 susedno obavezno prisutnoj karbonilnoj grupi pomenute Ar, kada se uzme zajedno sa R3, može formirati vezu ili -(C(R5)2)m- grupu gde m je 1 ili 2;bilo koje R6 susedno obavezno prisutnoj karbonilnoj grupi pomenute Ar, kada se uzme zajedno sa R2, može formirati vezu;svako Ra je nezavisno (C1-C8)alkil, (C1-C8)haloalkil, (C2-C8)alkenil, (C2-C8)alkinil, aril(C1-C8)alkil, C6-C20 aril, C2-C20 heterociklil, (C3-C7)cikloalkil ili (C4-C8)karbociklilalkil gde je bilo koji (C1-C8)alkil, (C1-C8)haloalkil, (C2-C8)alkenil ili (C2-C8)alkinil od Ra po izboru supstituisan sa jednim ili više OH, NH2, CO2H, C2-C20 heterociklil, i gde bilo koji aril(C1-C8)alkil, C6-C20 aril, C2-C20 heterociklil, (C3-C7)cikloalkil ili (C4-C8)karbociklilalkil od Ra je po izboru supstituisan sa jednim ili više OH, NH2, CO2H, C2-C20 heterociklil ili (C1-C8)alkil;svako R11 ili R12 je nezavisno H, (C1-C8)alkil, (C2-C8)alkenil, (C2-C8)alkinil, aril(C1-C8)alkil, C6-C2o aril, C2-C20 heterociklil, (C3-C7)cikloalkil, (C4-C8)karbociklilalkil, -C(=O)Ra, -S(O)pRa, ili aril(C1-C8)alkil; ili R11 i R12 uzeti zajedno sa azotom za koji su oboje vezani formiraju heterociklični prsten sa 3 do 7 članova gde bilo koji atom ugljenika pomenutog heterocikličnog prstena može biti po izboru zamenjen sa - O-, -S-, -S(O)p-, -NH-, -NRa- ili -C(O)-;R13 je H ili (C1-C8)alkil;R14 je H, (C1-C8)alkil, NR11R12, NR11C(O)R11, NR11C(O)OR11, NR11C(O)NR11R12,NR11S(O)pRa, -NR11S(O)p(OR11) ili NR11SOpNR11R12; igde svaki (C1-C8)alkil, (C2-C8)alkenil, (C2-C8)alkinil, aril(C1-C8)alkil, C6-C20 aril, C2-C20 heterociklil, (C3-C7)cikloalkil ili (C4-C8)karbociklilalkil svakog od R1, R2, R3, R4, R5, R6, R7, R8, R11 ili R12 je, nezavisno, po izboru supstituisan sa jednom ili više okso, halogen, hidroksi, NH2, CN, N3, N(Ra)2, NHRa, SH, SRa, S(O)pRa, ORa, (C1-C8)alkil, (C1-C8)haloalkil, -C(O)Ra, -C(O)H, -C(=O)ORa, -C(=O)OH, -C(=O)N(Ra)2, -C(=O)NHRa , -C(=O)NH2, NHS(O)pRa, NRaS(O)PRa, NHC(O)Ra, NRaC(O)Ra, NHC(O)ORa, NRaC(O)ORa, NRaC(O)NHRa, NRaC(O)N(Ra)2, NRaC(O)NH2, NHC(O)NHRa, NHC(O)N(Ra)2,NHC(O)NH2, =NH, =NOH, =NORa, NRaS(O)pNHRa, NRaS(O)pN(Ra)2, NRaS(O)pNH2,NHS(O)pNHRa, NHS(O)pN(Ra)2, NHS(O)pNH2, -OC(=O)Ra, -OP(O)(OH)2 ili Ra.Prijava sadrži još 42 patentna zahteva.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35812210P | 2010-06-24 | 2010-06-24 | |
PCT/US2011/041688 WO2011163518A1 (en) | 2010-06-24 | 2011-06-23 | Pyrazolo [1, 5 -a] pyrimidines as antiviral agents |
EP11729018.9A EP2585467B1 (en) | 2010-06-24 | 2011-06-23 | Pyrazolo[1,5-a]pyrimidines and -triazines as antiviral agents |
Publications (1)
Publication Number | Publication Date |
---|---|
RS54761B1 true RS54761B1 (sr) | 2016-10-31 |
Family
ID=44509853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20160349A RS54761B1 (sr) | 2010-06-24 | 2011-06-23 | Pirazolo[1,5-a]pirimidini i-triazini kao antiviralni agensi |
Country Status (38)
Country | Link |
---|---|
US (7) | US8486938B2 (sr) |
EP (2) | EP2585467B1 (sr) |
JP (4) | JP5878171B2 (sr) |
KR (1) | KR101970837B1 (sr) |
CN (2) | CN102958933B (sr) |
AP (1) | AP3417A (sr) |
AR (1) | AR082275A1 (sr) |
AU (1) | AU2011270798B2 (sr) |
BR (1) | BR112012033117A2 (sr) |
CA (1) | CA2800834C (sr) |
CL (1) | CL2012003632A1 (sr) |
CO (1) | CO6640297A2 (sr) |
CR (1) | CR20130023A (sr) |
CY (1) | CY1118239T1 (sr) |
DK (1) | DK2585467T3 (sr) |
EA (2) | EA201591390A1 (sr) |
EC (2) | ECSP13012400A (sr) |
ES (2) | ES2700542T3 (sr) |
HK (3) | HK1223934A1 (sr) |
HR (1) | HRP20160431T1 (sr) |
HU (1) | HUE029174T2 (sr) |
IL (2) | IL223253B (sr) |
MA (1) | MA34392B1 (sr) |
ME (1) | ME02397B (sr) |
MX (1) | MX2012015292A (sr) |
NZ (1) | NZ604345A (sr) |
PE (1) | PE20130395A1 (sr) |
PL (1) | PL2585467T3 (sr) |
PT (1) | PT3012258T (sr) |
RS (1) | RS54761B1 (sr) |
SG (2) | SG10201505022WA (sr) |
SI (1) | SI2585467T1 (sr) |
SM (1) | SMT201600155B (sr) |
TW (3) | TWI626050B (sr) |
UA (1) | UA112292C2 (sr) |
UY (1) | UY33467A (sr) |
WO (1) | WO2011163518A1 (sr) |
ZA (1) | ZA201209549B (sr) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2540867T3 (es) * | 2010-02-26 | 2015-07-14 | Mitsubishi Tanabe Pharma Corporation | Compuestos de pirazolopirimidina y su uso como inhibidores de PDE10 |
BR112012033117A2 (pt) | 2010-06-24 | 2016-11-22 | Gilead Sciences Inc | pirazolo[1,5-a]pirimidinas como agentes antivirais |
MY165585A (en) | 2010-06-24 | 2018-04-05 | Takeda Pharmaceuticals Co | Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors |
MX355782B (es) | 2010-11-03 | 2018-04-30 | Dow Agrosciences Llc | Composiciones pesticidas y procesos relacionados a las mismas. |
JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
JP5531066B2 (ja) * | 2011-08-24 | 2014-06-25 | 田辺三菱製薬株式会社 | ピラゾロピリミジン化合物及びpde10阻害剤としてのその使用 |
MX355431B (es) | 2011-10-26 | 2018-04-18 | Dow Agrosciences Llc | Composiciones plaguicidas y procesos relacionados con dichas composiciones. |
PT2794611T (pt) * | 2011-12-22 | 2017-12-06 | Gilead Sciences Inc | Pirazolo[1,5-a]pirimidinas como agentes antivirais |
HUE045727T2 (hu) * | 2012-04-17 | 2021-12-28 | Gilead Sciences Inc | Vegyületek és eljárások vírusellenes kezeléshez |
US9708288B2 (en) | 2012-04-27 | 2017-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
BR112014026746A2 (pt) | 2012-04-27 | 2017-06-27 | Dow Agrosciences Llc | composições pesticidas e processos relacionados com as mesmas |
US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
AU2013344716B2 (en) | 2012-11-16 | 2018-03-01 | University Health Network | Pyrazolopyrimidine compounds |
LT3418281T (lt) | 2012-12-07 | 2021-01-11 | Vertex Pharmaceuticals Inc. | Pirazolo[1,5-a]pirimidinai, naudotini kaip atr kinazės inhibitoriai, skirti vėžinių ligų gydymui |
PT2968297T (pt) | 2013-03-15 | 2019-01-10 | Verseon Corp | Compostos aromáticos multissubstituídos como inibidores da serina protease |
WO2014143242A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
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RS53244B (sr) | 1`-supstituisani-karba-nukleozidni prolekovi za antivirusni tretman | |
EA201791584A1 (ru) | Агрохимическая композиция | |
RS54048B1 (sr) | Paraziticidna jedinjenja dihidroizoksazola | |
PH12014502211A1 (en) | Alkyl phenyl sulfide derivative and pest control agent | |
AR086539A1 (es) | COMPUESTOS PARA LA REDUCCION DE LA PRODUCCION DE b-AMILOIDE | |
RS54207B1 (sr) | Kondenzovani imidazolilimidazoli kao antiviralna jedinjenja | |
RS54263B1 (sr) | Jedinjenja pirolopirimidina kao inhibitori cdk4/6 | |
MX2012015023A (es) | Derivado novedoso de nicotinamida o sal del mismo. | |
RS53830B1 (sr) | Indazoli supstituisani oksazolom kao inhibitori pi3-kinaze | |
MX2014000452A (es) | Derivados de azabencimiazol que tiene actividad activadora de la proteina cinasa activada monofosfato de denosina (ampk). | |
IN2014CN03976A (sr) | ||
AR082414A1 (es) | Carboxamidas azaheterociclicas biciclicas utiles para tratar enfermedades hiperproliferativas e inflamatorias, composiciones farmaceuticas que las contienen y procedimiento para prepararlas | |
IN2014CN03130A (sr) | ||
CR20140294A (es) | Derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina | |
RS54526B1 (sr) | Upotreba derivata pirazolospiroketona kao inhibitora acetil-coa karboksilaze | |
AR085037A1 (es) | Acidos 6-amino-2-sustituido-5-vinilsililpirimidin-4-carboxilicos y esteres y acidos 4-amino-6-sustituido-3-vinilsililpiridin-picolinicos y esteres como herbicidas | |
RS54730B1 (sr) | Inhibitori beta sekretaze | |
IN2014DN07509A (sr) | ||
MA38583A1 (fr) | Dérivés de dolastatine 10 et d'auristatines | |
BR112014006559A2 (pt) | derivados do ácido betulínico com atividade antiviral | |
PH12015502429A1 (en) | Dicarboxylic acid compound | |
TR201902752T4 (tr) | Oftalmik formülasyon. | |
IN2012DN01251A (sr) | ||
MX2015002705A (es) | Compuestos de piridinona para usarse en terapia fotodinamica. |