KR20070088485A - 시나칼세트의 정제법 - Google Patents

시나칼세트의 정제법 Download PDF

Info

Publication number
KR20070088485A
KR20070088485A KR1020077004036A KR20077004036A KR20070088485A KR 20070088485 A KR20070088485 A KR 20070088485A KR 1020077004036 A KR1020077004036 A KR 1020077004036A KR 20077004036 A KR20077004036 A KR 20077004036A KR 20070088485 A KR20070088485 A KR 20070088485A
Authority
KR
South Korea
Prior art keywords
cinacalcet
carbamate
area
salt
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020077004036A
Other languages
English (en)
Korean (ko)
Inventor
레비탈 리프시츠리론
유리이 라이지
레비탈 라마티
에스티 마롬
Original Assignee
테바 파마슈티컬 인더스트리즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 테바 파마슈티컬 인더스트리즈 리미티드 filed Critical 테바 파마슈티컬 인더스트리즈 리미티드
Publication of KR20070088485A publication Critical patent/KR20070088485A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/90—Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
KR1020077004036A 2005-05-23 2006-05-23 시나칼세트의 정제법 Ceased KR20070088485A (ko)

Applications Claiming Priority (32)

Application Number Priority Date Filing Date Title
US68415205P 2005-05-23 2005-05-23
US60/684,152 2005-05-23
US69698105P 2005-07-05 2005-07-05
US60/696,981 2005-07-05
US69711105P 2005-07-06 2005-07-06
US60/697,111 2005-07-06
US69861305P 2005-07-11 2005-07-11
US60/698,613 2005-07-11
US70123205P 2005-07-20 2005-07-20
US60/701,232 2005-07-20
US70291805P 2005-07-26 2005-07-26
US60/702,918 2005-07-26
US70691005P 2005-08-09 2005-08-09
US60/706,910 2005-08-09
US73005005P 2005-10-24 2005-10-24
US60/730,050 2005-10-24
US73208305P 2005-10-31 2005-10-31
US60/732,083 2005-10-31
US73300805P 2005-11-02 2005-11-02
US60/733,008 2005-11-02
US73466905P 2005-11-07 2005-11-07
US60/734,669 2005-11-07
US73512605P 2005-11-08 2005-11-08
US60/735,126 2005-11-08
US73882705P 2005-11-21 2005-11-21
US60/738,827 2005-11-21
US74178705P 2005-12-01 2005-12-01
US60/741,787 2005-12-01
US75091005P 2005-12-15 2005-12-15
US60/750,910 2005-12-15
US79480406P 2006-04-24 2006-04-24
US60/794,804 2006-04-24

Publications (1)

Publication Number Publication Date
KR20070088485A true KR20070088485A (ko) 2007-08-29

Family

ID=37101358

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077004036A Ceased KR20070088485A (ko) 2005-05-23 2006-05-23 시나칼세트의 정제법
KR1020077001966A Ceased KR20070083471A (ko) 2005-05-23 2006-05-23 시나칼셋 염산염 결정형 ｉ의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020077001966A Ceased KR20070083471A (ko) 2005-05-23 2006-05-23 시나칼셋 염산염 결정형 ｉ의 제조 방법

Country Status (12)

Country Link
US (2) US7294735B2 (enExample)
EP (3) EP1883618B1 (enExample)
JP (3) JP4638491B2 (enExample)
KR (2) KR20070088485A (enExample)
CN (1) CN101180261A (enExample)
AT (1) ATE445587T1 (enExample)
CA (2) CA2605736A1 (enExample)
ES (1) ES2334260T3 (enExample)
IL (2) IL185108A0 (enExample)
MX (1) MX2007000983A (enExample)
TW (1) TW200716512A (enExample)
WO (2) WO2006127932A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2645494C (en) * 2006-03-23 2016-01-12 Amgen Inc. Methods and compositions for making and using polymorphs of cinacalcet
EP1913941A1 (en) * 2006-10-19 2008-04-23 Sandoz AG Polymorphic forms and solvates of Cinacalcet hydrochloride
US20090258949A1 (en) * 2006-06-27 2009-10-15 Johannes Ludescher Amorphous form of cinacalcet
WO2008000423A1 (en) * 2006-06-27 2008-01-03 Sandoz Ag Crystalline form of cinacalcet
US20080181959A1 (en) * 2006-09-01 2008-07-31 Ilan Zalit Solid composites of a calcium receptor-active compound
WO2008058236A2 (en) * 2006-11-08 2008-05-15 Dr. Reddy's Labortories, Ltd. Methods for preparing cinacalcet hydrochloride
WO2008063645A1 (en) * 2006-11-20 2008-05-29 Teva Pharmaceutical Industries Ltd. Process for preparing cinacalcet
CA2691196C (en) * 2007-06-21 2016-05-24 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
ITMI20071261A1 (it) 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
US20090093652A1 (en) * 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
WO2009039241A2 (en) * 2007-09-18 2009-03-26 Medichem, S.A. Improved process for preparing cinacalcet hydrochloride
US7696372B2 (en) * 2007-10-01 2010-04-13 Ascenta Therapeutics, Inc. Process for preparing R-gossypol L-phenylalaninol dienamine
US20110189241A1 (en) * 2008-05-05 2011-08-04 Medichem, S.A. Process For Controlling The Particle Size of A [3-(Trifluoromethyl)Phenyl]-1-Aminopropane Derivative
EP2321256B1 (en) * 2008-06-18 2014-11-12 ERREGIERRE S.p.A. Process for the synthesis of cinacalcet hydrochloride
EP2328860A2 (en) * 2008-08-06 2011-06-08 Actavis Group PTC EHF Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride
US20110318417A1 (en) * 2008-12-08 2011-12-29 Actavis Group Ptc Ehf Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
EP2398763A2 (en) 2009-02-19 2011-12-28 ZaCh System S.p.A. Process for preparing cinacalcet hydrochloride
US8575393B2 (en) 2009-03-05 2013-11-05 Cipla Limited Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process
WO2010128388A2 (en) 2009-05-08 2010-11-11 Aurobindo Pharma Limited An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
CN102548955B (zh) 2009-09-10 2014-06-04 Zach系统股份公司 用于制备西那卡塞特的方法
US8722732B2 (en) 2009-09-29 2014-05-13 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
IT1396623B1 (it) 2009-11-26 2012-12-14 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet e suoi intermedi
CZ2011770A3 (cs) * 2011-11-25 2013-01-16 Zentiva, K.S. Zpusob výroby Cinacalcetu
CN103450027B (zh) 2012-05-29 2015-07-29 上海京新生物医药有限公司 盐酸西那卡塞的制备方法
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
CN103739500B (zh) * 2012-12-27 2016-03-23 国药一心制药有限公司 一种盐酸西那卡塞的合成与精制方法
CN103193655B (zh) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 盐酸西那卡塞晶型ⅰ的制备方法
CN104512864B (zh) * 2013-09-30 2017-08-22 中国石油化工股份有限公司 一种低温脱除微量碳氧化物的方法
AU2014348523B2 (en) 2013-11-15 2019-01-03 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
BR102015025502B1 (pt) * 2015-04-30 2022-06-21 Aegerion Pharmaceuticals, Inc Composição de lomitapida, tablete, produto de lomitapida, métodos para analisar uma composição de amostra de lomitapida e para determinar uma quantidade de uma impureza em uma amostra da composição
CN104892428A (zh) * 2015-06-05 2015-09-09 南京辰逸生物科技有限公司 一种盐酸西那卡塞的制备方法
CN106610404B (zh) * 2015-10-21 2019-01-15 华仁药业股份有限公司 采用hplc法检测盐酸西那卡塞同分异构体的方法
CN105439818B (zh) * 2015-12-31 2017-11-28 苏州汇和药业有限公司 一种西那卡塞中间体3‑(3‑三氟甲基苯基)丙醇的合成方法
CN107879939A (zh) * 2016-09-30 2018-04-06 上海天慈生物谷生物工程有限公司 一种制备 n‑((1r)‑1‑(1‑萘基)乙基)‑3‑(3‑(三氟甲基)苯基)丙‑1‑胺盐酸盐的方法
KR20200022712A (ko) 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
CN109096119B (zh) * 2018-10-29 2019-10-25 江苏永安制药有限公司 一种制备盐酸西那卡塞的方法
CN110041206B (zh) * 2019-04-29 2021-10-19 梯尔希（南京）药物研发有限公司 一种西那卡塞杂质的制备方法
CN111153832B (zh) * 2020-01-20 2022-02-25 广州九植医药科技有限公司 一种西那卡塞杂质的制备方法
KR20250003360A (ko) * 2023-06-30 2025-01-07 주식회사 종근당 화합물의 신규한 제조방법 및 신규한 결정형

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966988A (en) * 1989-02-17 1990-10-30 Chevron Research Company Process for preparing acetonitrile 3-trifluoromethyl benzene
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) * 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
HU228150B1 (en) * 1994-10-21 2012-12-28 Nps Pharma Inc Calcium receptor-active compounds, medicaments comprising them, and the use of said medicaments
US5648541A (en) * 1995-09-28 1997-07-15 Nps Pharmaceuticals, Inc. Chiral reductions of imines leading to the syntheses of optically active amines
EP0907631B1 (en) * 1996-05-01 2003-06-18 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
US7829595B2 (en) * 2003-09-12 2010-11-09 Amgen Inc. Rapid dissolution formulation of a calcium receptor-active compound

Also Published As

Publication number Publication date
JP2008507566A (ja) 2008-03-13
EP1805135A2 (en) 2007-07-11
US7294735B2 (en) 2007-11-13
CN101180261A (zh) 2008-05-14
ES2334260T3 (es) 2010-03-08
WO2006127933A1 (en) 2006-11-30
EP1883618B1 (en) 2009-10-14
US20070060645A1 (en) 2007-03-15
JP2010280715A (ja) 2010-12-16
IL185108A0 (en) 2007-12-03
MX2007000983A (es) 2007-04-16
ATE445587T1 (de) 2009-10-15
IL185494A0 (en) 2008-01-06
JP4638491B2 (ja) 2011-02-23
US20070099998A1 (en) 2007-05-03
US7247751B2 (en) 2007-07-24
CA2606099A1 (en) 2006-11-30
WO2006127932A2 (en) 2006-11-30
WO2006127932A3 (en) 2007-02-01
EP1975150A1 (en) 2008-10-01
JP2008507565A (ja) 2008-03-13
KR20070083471A (ko) 2007-08-24
CA2605736A1 (en) 2006-11-30
EP1883618A1 (en) 2008-02-06
WO2006127933A8 (en) 2007-08-30
TW200716512A (en) 2007-05-01

Similar Documents

Publication Publication Date Title
KR20070088485A (ko) 시나칼세트의 정제법
JP6800842B2 (ja) プリドピジンの類似体、それらの製造および使用
CA2618272A1 (en) Pure rocuronium bromide
US20100000302A1 (en) Process for preparing forms of atorvastatin calcium substantially free of impurities
CN106478637A (zh) 一种西格列汀的杂质及其制备、检测方法
US20170066748A1 (en) Radioactive fluorine labeling precursor compound and method for manufacturing radioactive fluorine labeled compound using the same
WO2011012659A2 (en) Diethyl 4-(4-fluorobenzylamino)-1,2-phenylenedicarbamate, and salts thereof
CN113004244A (zh) 一种曲格列汀杂质及其制备方法和用途
US20090298879A1 (en) Impurities of Donepezil
US20060252932A1 (en) Isolated bis-linezolid, preparation thereof, and its use as a reference standard
KR20070001250A (ko) 단리된 아토목세틴 불순물, 아토목세틴 불순물의 제조 방법및 이의 기준 표준물로서의 용도
US20180263972A1 (en) Analogs of deutetrabenazine, their preparation and use
KR100890595B1 (ko) 단리된 발라시클로버 불순물, 발라시클로버 불순물 제조방법 및 참조 표준 물질로서의 용도
CN106619636B (zh) 一种德拉沙星的杂质化合物及其制备方法
EP2189456A1 (en) New compounds prepared from omeprazole
WO2006121557A1 (en) Pregabalin free of lactam and a process for preparation thereof
US7488846B2 (en) Pregabalin free of lactam and a process for preparation thereof
CN112351969A (zh) 用于制备氨基二芳基醚和氨基二芳基醚盐酸盐的方法
JP2008510020A (ja) アナストロゾール中間体の不純物及びその使用
WO2007065869A1 (en) Labelled docetaxel
CN106478506B (zh) 半水绿卡色林盐酸盐的制备方法
MX2007000925A (en) Purification of cinacalcet
US20240059696A1 (en) Process for preparing high purity degree larotrectinib
US20090234020A1 (en) Processes for the preparation of odesmethylvenlafaxine, free from its dimer impurities
CN118994026A (zh) 一种替戈拉生杂质及其制备方法和应用

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R15-X000 Change to inventor requested

St.27 status event code: A-3-3-R10-R15-oth-X000

R16-X000 Change to inventor recorded

St.27 status event code: A-3-3-R10-R16-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000