JP4638491B2 - シナカルセト塩酸塩結晶フォームｉの調製方法 - Google Patents

シナカルセト塩酸塩結晶フォームｉの調製方法 Download PDF

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Publication number
JP4638491B2
JP4638491B2 JP2007522852A JP2007522852A JP4638491B2 JP 4638491 B2 JP4638491 B2 JP 4638491B2 JP 2007522852 A JP2007522852 A JP 2007522852A JP 2007522852 A JP2007522852 A JP 2007522852A JP 4638491 B2 JP4638491 B2 JP 4638491B2
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cinacalcet hydrochloride
hours
crystalline form
room temperature
cinacalcet
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Japanese (ja)
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JP2008507566A (ja
JP2008507566A6 (ja
JP2008507566A5 (enExample
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リフシツリロン，レビタル
アブハル−マイダン，シャロン
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テバ ファーマシューティカル インダストリーズ リミティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/90—Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Catalysts (AREA)
JP2007522852A 2005-05-23 2006-05-23 シナカルセト塩酸塩結晶フォームｉの調製方法 Expired - Fee Related JP4638491B2 (ja)

Applications Claiming Priority (33)

Application Number Priority Date Filing Date Title
US68415205P 2005-05-23 2005-05-23
US60/684,152 2005-05-23
US69698105P 2005-07-05 2005-07-05
US60/696,981 2005-07-05
US69711105P 2005-07-06 2005-07-06
US60/697,111 2005-07-06
US69861305P 2005-07-11 2005-07-11
US60/698,613 2005-07-11
US70123205P 2005-07-20 2005-07-20
US60/701,232 2005-07-20
US70291805P 2005-07-26 2005-07-26
US60/702,918 2005-07-26
US70691005P 2005-08-09 2005-08-09
US60/706,910 2005-08-09
US73005005P 2005-10-24 2005-10-24
US60/730,050 2005-10-24
US73208305P 2005-10-31 2005-10-31
US60/732,083 2005-10-31
US73300805P 2005-11-02 2005-11-02
US60/733,008 2005-11-02
US73466905P 2005-11-07 2005-11-07
US60/734,669 2005-11-07
US73512605P 2005-11-08 2005-11-08
US60/735,126 2005-11-08
US73882705P 2005-11-21 2005-11-21
US60/738,827 2005-11-21
US74178705P 2005-12-01 2005-12-01
US60/741,787 2005-12-01
US75091005P 2005-12-15 2005-12-15
US60/750,910 2005-12-15
US79480406P 2006-04-24 2006-04-24
US60/794,804 2006-04-24
PCT/US2006/020304 WO2006127933A1 (en) 2005-05-23 2006-05-23 Processes for preparing cinacalcet hydrochloride crystal form i

Related Child Applications (1)

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JP2010197123A Division JP2010280715A (ja) 2005-05-23 2010-09-02 シナカルセト塩酸塩結晶フォームｉの調製方法

Publications (4)

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JP2008507566A JP2008507566A (ja) 2008-03-13
JP2008507566A6 JP2008507566A6 (ja) 2008-07-03
JP2008507566A5 JP2008507566A5 (enExample) 2010-03-04
JP4638491B2 true JP4638491B2 (ja) 2011-02-23

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JP2007522852A Expired - Fee Related JP4638491B2 (ja) 2005-05-23 2006-05-23 シナカルセト塩酸塩結晶フォームｉの調製方法
JP2007522851A Pending JP2008507565A (ja) 2005-05-23 2006-05-23 シナカルセトの精製
JP2010197123A Pending JP2010280715A (ja) 2005-05-23 2010-09-02 シナカルセト塩酸塩結晶フォームｉの調製方法

Family Applications After (2)

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JP2007522851A Pending JP2008507565A (ja) 2005-05-23 2006-05-23 シナカルセトの精製
JP2010197123A Pending JP2010280715A (ja) 2005-05-23 2010-09-02 シナカルセト塩酸塩結晶フォームｉの調製方法

Country Status (12)

Country Link
US (2) US7294735B2 (enExample)
EP (3) EP1883618B1 (enExample)
JP (3) JP4638491B2 (enExample)
KR (2) KR20070088485A (enExample)
CN (1) CN101180261A (enExample)
AT (1) ATE445587T1 (enExample)
CA (2) CA2605736A1 (enExample)
ES (1) ES2334260T3 (enExample)
IL (2) IL185108A0 (enExample)
MX (1) MX2007000983A (enExample)
TW (1) TW200716512A (enExample)
WO (2) WO2006127932A2 (enExample)

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CA2645494C (en) * 2006-03-23 2016-01-12 Amgen Inc. Methods and compositions for making and using polymorphs of cinacalcet
EP1913941A1 (en) * 2006-10-19 2008-04-23 Sandoz AG Polymorphic forms and solvates of Cinacalcet hydrochloride
US20090258949A1 (en) * 2006-06-27 2009-10-15 Johannes Ludescher Amorphous form of cinacalcet
WO2008000423A1 (en) * 2006-06-27 2008-01-03 Sandoz Ag Crystalline form of cinacalcet
US20080181959A1 (en) * 2006-09-01 2008-07-31 Ilan Zalit Solid composites of a calcium receptor-active compound
WO2008058236A2 (en) * 2006-11-08 2008-05-15 Dr. Reddy's Labortories, Ltd. Methods for preparing cinacalcet hydrochloride
WO2008063645A1 (en) * 2006-11-20 2008-05-29 Teva Pharmaceutical Industries Ltd. Process for preparing cinacalcet
CA2691196C (en) * 2007-06-21 2016-05-24 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
ITMI20071261A1 (it) 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
US20090093652A1 (en) * 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
WO2009039241A2 (en) * 2007-09-18 2009-03-26 Medichem, S.A. Improved process for preparing cinacalcet hydrochloride
US7696372B2 (en) * 2007-10-01 2010-04-13 Ascenta Therapeutics, Inc. Process for preparing R-gossypol L-phenylalaninol dienamine
US20110189241A1 (en) * 2008-05-05 2011-08-04 Medichem, S.A. Process For Controlling The Particle Size of A [3-(Trifluoromethyl)Phenyl]-1-Aminopropane Derivative
EP2321256B1 (en) * 2008-06-18 2014-11-12 ERREGIERRE S.p.A. Process for the synthesis of cinacalcet hydrochloride
EP2328860A2 (en) * 2008-08-06 2011-06-08 Actavis Group PTC EHF Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride
US20110318417A1 (en) * 2008-12-08 2011-12-29 Actavis Group Ptc Ehf Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
EP2398763A2 (en) 2009-02-19 2011-12-28 ZaCh System S.p.A. Process for preparing cinacalcet hydrochloride
US8575393B2 (en) 2009-03-05 2013-11-05 Cipla Limited Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process
WO2010128388A2 (en) 2009-05-08 2010-11-11 Aurobindo Pharma Limited An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
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IT1396623B1 (it) 2009-11-26 2012-12-14 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet e suoi intermedi
CZ2011770A3 (cs) * 2011-11-25 2013-01-16 Zentiva, K.S. Zpusob výroby Cinacalcetu
CN103450027B (zh) 2012-05-29 2015-07-29 上海京新生物医药有限公司 盐酸西那卡塞的制备方法
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
CN103739500B (zh) * 2012-12-27 2016-03-23 国药一心制药有限公司 一种盐酸西那卡塞的合成与精制方法
CN103193655B (zh) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 盐酸西那卡塞晶型ⅰ的制备方法
CN104512864B (zh) * 2013-09-30 2017-08-22 中国石油化工股份有限公司 一种低温脱除微量碳氧化物的方法
AU2014348523B2 (en) 2013-11-15 2019-01-03 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
BR102015025502B1 (pt) * 2015-04-30 2022-06-21 Aegerion Pharmaceuticals, Inc Composição de lomitapida, tablete, produto de lomitapida, métodos para analisar uma composição de amostra de lomitapida e para determinar uma quantidade de uma impureza em uma amostra da composição
CN104892428A (zh) * 2015-06-05 2015-09-09 南京辰逸生物科技有限公司 一种盐酸西那卡塞的制备方法
CN106610404B (zh) * 2015-10-21 2019-01-15 华仁药业股份有限公司 采用hplc法检测盐酸西那卡塞同分异构体的方法
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KR20200022712A (ko) 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
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KR20250003360A (ko) * 2023-06-30 2025-01-07 주식회사 종근당 화합물의 신규한 제조방법 및 신규한 결정형

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Publication number Publication date
JP2008507566A (ja) 2008-03-13
EP1805135A2 (en) 2007-07-11
US7294735B2 (en) 2007-11-13
CN101180261A (zh) 2008-05-14
ES2334260T3 (es) 2010-03-08
WO2006127933A1 (en) 2006-11-30
EP1883618B1 (en) 2009-10-14
US20070060645A1 (en) 2007-03-15
JP2010280715A (ja) 2010-12-16
KR20070088485A (ko) 2007-08-29
IL185108A0 (en) 2007-12-03
MX2007000983A (es) 2007-04-16
ATE445587T1 (de) 2009-10-15
IL185494A0 (en) 2008-01-06
US20070099998A1 (en) 2007-05-03
US7247751B2 (en) 2007-07-24
CA2606099A1 (en) 2006-11-30
WO2006127932A2 (en) 2006-11-30
WO2006127932A3 (en) 2007-02-01
EP1975150A1 (en) 2008-10-01
JP2008507565A (ja) 2008-03-13
KR20070083471A (ko) 2007-08-24
CA2605736A1 (en) 2006-11-30
EP1883618A1 (en) 2008-02-06
WO2006127933A8 (en) 2007-08-30
TW200716512A (en) 2007-05-01

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