TW200716512A - Processes for preparing cinacalcet hydrochloride crystal form I - Google Patents

Processes for preparing cinacalcet hydrochloride crystal form I

Info

Publication number
TW200716512A
TW200716512A TW095118275A TW95118275A TW200716512A TW 200716512 A TW200716512 A TW 200716512A TW 095118275 A TW095118275 A TW 095118275A TW 95118275 A TW95118275 A TW 95118275A TW 200716512 A TW200716512 A TW 200716512A
Authority
TW
Taiwan
Prior art keywords
processes
crystal form
cinacalcet hydrochloride
hydrochloride crystal
preparing cinacalcet
Prior art date
Application number
TW095118275A
Other languages
English (en)
Inventor
Revital Lifshitz-Liron
Sharon Avhar-Maydan
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of TW200716512A publication Critical patent/TW200716512A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/90—Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
TW095118275A 2005-05-23 2006-05-23 Processes for preparing cinacalcet hydrochloride crystal form I TW200716512A (en)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US68415205P 2005-05-23 2005-05-23
US69698105P 2005-07-05 2005-07-05
US69711105P 2005-07-06 2005-07-06
US69861305P 2005-07-11 2005-07-11
US70123205P 2005-07-20 2005-07-20
US70291805P 2005-07-26 2005-07-26
US70691005P 2005-08-09 2005-08-09
US73005005P 2005-10-24 2005-10-24
US73208305P 2005-10-31 2005-10-31
US73300805P 2005-11-02 2005-11-02
US73466905P 2005-11-07 2005-11-07
US73512605P 2005-11-08 2005-11-08
US73882705P 2005-11-21 2005-11-21
US74178705P 2005-12-01 2005-12-01
US75091005P 2005-12-15 2005-12-15
US79480406P 2006-04-24 2006-04-24

Publications (1)

Publication Number Publication Date
TW200716512A true TW200716512A (en) 2007-05-01

Family

ID=37101358

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095118275A TW200716512A (en) 2005-05-23 2006-05-23 Processes for preparing cinacalcet hydrochloride crystal form I

Country Status (12)

Country Link
US (2) US7294735B2 (zh)
EP (3) EP1883618B1 (zh)
JP (3) JP4638491B2 (zh)
KR (2) KR20070083471A (zh)
CN (1) CN101180261A (zh)
AT (1) ATE445587T1 (zh)
CA (2) CA2606099A1 (zh)
ES (1) ES2334260T3 (zh)
IL (2) IL185108A0 (zh)
MX (1) MX2007000983A (zh)
TW (1) TW200716512A (zh)
WO (2) WO2006127932A2 (zh)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5309014B2 (ja) 2006-03-23 2013-10-09 アムジエン・インコーポレーテツド シナカルセットの多形体の製造および使用のための方法および組成物
EP1913941A1 (en) * 2006-10-19 2008-04-23 Sandoz AG Polymorphic forms and solvates of Cinacalcet hydrochloride
WO2008000422A1 (en) * 2006-06-27 2008-01-03 Sandoz Ag Amorphous form of cinacalcet
EP2064173A1 (en) * 2006-06-27 2009-06-03 Sandoz AG Crystalline form of cinacalcet
CA2662315A1 (en) * 2006-09-01 2008-03-06 Teva Pharmaceutical Industries Ltd. Solid composites of a calcium receptor-active compound
WO2008058236A2 (en) * 2006-11-08 2008-05-15 Dr. Reddy's Labortories, Ltd. Methods for preparing cinacalcet hydrochloride
US20080146845A1 (en) * 2006-11-20 2008-06-19 Boaz Gome Process for preparing Cinacalcet
EP2170805B1 (en) * 2007-06-21 2016-03-16 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
ITMI20071261A1 (it) 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
US20090093652A1 (en) * 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
WO2009039241A2 (en) * 2007-09-18 2009-03-26 Medichem, S.A. Improved process for preparing cinacalcet hydrochloride
CN101883486B (zh) * 2007-10-01 2014-09-17 阿森达治疗学股份有限公司 制备r-棉酚l-苯丙氨醇二烯胺的方法
WO2010071689A2 (en) * 2008-05-05 2010-06-24 Medichem, S.A. Process for controlling the particle size of a 3-(trifluoromethyl)phenyl]-1-aminopropane derivative
US8614354B2 (en) * 2008-06-18 2013-12-24 Erregierre S.P.A. Process for the synthesis of cinacalcet hydrochloride
US20110178326A1 (en) * 2008-08-06 2011-07-21 Actavis Group Ptc Ehf Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride
EP2376424A1 (en) * 2008-12-08 2011-10-19 Actavis Group PTC EHF Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
JP5503670B2 (ja) 2009-02-19 2014-05-28 ザック システム エス．ピー．エー． シナカルセト塩酸塩の製造方法
CA2754209A1 (en) 2009-03-05 2010-09-10 Cipla Limited Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process
WO2010128388A2 (en) 2009-05-08 2010-11-11 Aurobindo Pharma Limited An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
AU2010294283B2 (en) 2009-09-10 2016-09-29 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for preparing Cinacalcet
US8722732B2 (en) 2009-09-29 2014-05-13 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
IT1396623B1 (it) 2009-11-26 2012-12-14 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet e suoi intermedi
CZ2011770A3 (cs) * 2011-11-25 2013-01-16 Zentiva, K.S. Zpusob výroby Cinacalcetu
CN103450027B (zh) 2012-05-29 2015-07-29 上海京新生物医药有限公司 盐酸西那卡塞的制备方法
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
CN103739500B (zh) * 2012-12-27 2016-03-23 国药一心制药有限公司 一种盐酸西那卡塞的合成与精制方法
CN103193655B (zh) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 盐酸西那卡塞晶型ⅰ的制备方法
CN104512864B (zh) * 2013-09-30 2017-08-22 中国石油化工股份有限公司 一种低温脱除微量碳氧化物的方法
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途
BR102015025502B1 (pt) * 2015-04-30 2022-06-21 Aegerion Pharmaceuticals, Inc Composição de lomitapida, tablete, produto de lomitapida, métodos para analisar uma composição de amostra de lomitapida e para determinar uma quantidade de uma impureza em uma amostra da composição
CN104892428A (zh) * 2015-06-05 2015-09-09 南京辰逸生物科技有限公司 一种盐酸西那卡塞的制备方法
CN106610404B (zh) * 2015-10-21 2019-01-15 华仁药业股份有限公司 采用hplc法检测盐酸西那卡塞同分异构体的方法
CN105439818B (zh) * 2015-12-31 2017-11-28 苏州汇和药业有限公司 一种西那卡塞中间体3‑(3‑三氟甲基苯基)丙醇的合成方法
CN107879939A (zh) * 2016-09-30 2018-04-06 上海天慈生物谷生物工程有限公司 一种制备 n‑((1r)‑1‑(1‑萘基)乙基)‑3‑(3‑(三氟甲基)苯基)丙‑1‑胺盐酸盐的方法
KR20200022712A (ko) 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
CN109096119B (zh) * 2018-10-29 2019-10-25 江苏永安制药有限公司 一种制备盐酸西那卡塞的方法
CN110041206B (zh) * 2019-04-29 2021-10-19 梯尔希（南京）药物研发有限公司 一种西那卡塞杂质的制备方法
CN111153832B (zh) * 2020-01-20 2022-02-25 广州九植医药科技有限公司 一种西那卡塞杂质的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966988A (en) 1989-02-17 1990-10-30 Chevron Research Company Process for preparing acetonitrile 3-trifluoromethyl benzene
US6313146B1 (en) * 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
BRPI9509411B8 (pt) * 1994-10-21 2021-07-06 Nps Pharma Inc composto modulador de receptor de íon inorgânico e composição farmacêutica
US5648541A (en) * 1995-09-28 1997-07-15 Nps Pharmaceuticals, Inc. Chiral reductions of imines leading to the syntheses of optically active amines
ES2201300T3 (es) * 1996-05-01 2004-03-16 Nps Pharmaceuticals, Inc. Compuestos activos frente a receptores de iones inorganicos.
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
NZ545498A (en) * 2003-09-12 2010-04-30 Amgen Inc Rapid dissolution formulation of a calcium receptor-active compound

Also Published As

Publication number Publication date
EP1883618A1 (en) 2008-02-06
WO2006127932A2 (en) 2006-11-30
US7247751B2 (en) 2007-07-24
ATE445587T1 (de) 2009-10-15
JP2008507565A (ja) 2008-03-13
EP1805135A2 (en) 2007-07-11
CA2606099A1 (en) 2006-11-30
ES2334260T3 (es) 2010-03-08
JP2010280715A (ja) 2010-12-16
EP1883618B1 (en) 2009-10-14
US20070060645A1 (en) 2007-03-15
KR20070088485A (ko) 2007-08-29
CN101180261A (zh) 2008-05-14
IL185108A0 (en) 2007-12-03
WO2006127932A3 (en) 2007-02-01
JP4638491B2 (ja) 2011-02-23
EP1975150A1 (en) 2008-10-01
US20070099998A1 (en) 2007-05-03
MX2007000983A (es) 2007-04-16
KR20070083471A (ko) 2007-08-24
WO2006127933A8 (en) 2007-08-30
CA2605736A1 (en) 2006-11-30
JP2008507566A (ja) 2008-03-13
WO2006127933A1 (en) 2006-11-30
IL185494A0 (en) 2008-01-06
US7294735B2 (en) 2007-11-13

Similar Documents

Publication Publication Date Title
TW200716512A (en) Processes for preparing cinacalcet hydrochloride crystal form I
MX2010002081A (es) Procesos para la preparacion de formas a, b cristalinas y de la forma a cristalina pura de erlotinib hc1.
IL185107A0 (en) Process for preparing cinacalcet hydrochloride
PL1743882T3 (pl) Sposób do produkcji izocyjanianów
HK1129277A1 (en) Tannate salt of rasagiline
MX2009012561A (es) Formas polimorficas y amorfas de esteviosida, metodos para su formulacion, y usos.
UA97502C2 (ru) Кристаллическая твердая основа разагилина
MX2007005221A (es) Formas cristalinas de ascomicina y preparacion de ellas.
IL183237A0 (en) Polymorphs of memantine hydrochloride
MX2011006334A (es) Polimorfos de (s)-3-amino-metil-7-(3-hidroxi-propoxi)-3h-benzo-[c] [1,2]-oxaborol-1-ol.
UA93531C2 (en) Novel hydrogen sulfate salt
IL194718A0 (en) Process for the preparation of cinacalcet base
WO2008066935A3 (en) Crystalline forms of tigecycline and processes for preparation thereof
WO2008068625A3 (en) Processes for preparing cinacalcet hydrochloride and polymorphic forms thereof
WO2007141593A3 (en) Process for the preparation of metoprolol and its salts
IL195757A0 (en) Processes for preparing intermediate compounds useful for the preparation of cinacalcet
EG25547A (en) Process for the preparation of amines
IL183379A0 (en) Processes for the preparation of linezolid intermediate
TW200637832A (en) Process for preparing amorphous valsartan
TW200833649A (en) Method for the preparation of hydroxyadamantanamine
TW200730521A (en) Triazine compounds having amino-and carboxyl-containing substituents
TW200613308A (en) Cyclobutanetetracarboxylate compound and preparation method thereof
TW200638932A (en) CCI-779 polymorph and use thereof
TW200637804A (en) Substantially pure tolterodine tartrate and process for preparing thereof
EP1939170A4 (en) PROCESS FOR PREPARING GABAPENTINE HYDROCHLORIDE