IL185108A0 - Processes for preparing cinacalcet hydrochloride crystal form i - Google Patents

Processes for preparing cinacalcet hydrochloride crystal form i

Info

Publication number
IL185108A0
IL185108A0 IL185108A IL18510807A IL185108A0 IL 185108 A0 IL185108 A0 IL 185108A0 IL 185108 A IL185108 A IL 185108A IL 18510807 A IL18510807 A IL 18510807A IL 185108 A0 IL185108 A0 IL 185108A0
Authority
IL
Israel
Prior art keywords
processes
crystal form
cinacalcet hydrochloride
hydrochloride crystal
preparing cinacalcet
Prior art date
Application number
IL185108A
Other languages
English (en)
Original Assignee
Teva Pharma
Lifshitz Revital
Avhar Maydan Sharon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Lifshitz Revital, Avhar Maydan Sharon filed Critical Teva Pharma
Publication of IL185108A0 publication Critical patent/IL185108A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/90—Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Catalysts (AREA)
IL185108A 2005-05-23 2007-08-07 Processes for preparing cinacalcet hydrochloride crystal form i IL185108A0 (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US68415205P 2005-05-23 2005-05-23
US69698105P 2005-07-05 2005-07-05
US69711105P 2005-07-06 2005-07-06
US69861305P 2005-07-11 2005-07-11
US70123205P 2005-07-20 2005-07-20
US70291805P 2005-07-26 2005-07-26
US70691005P 2005-08-09 2005-08-09
US73005005P 2005-10-24 2005-10-24
US73208305P 2005-10-31 2005-10-31
US73300805P 2005-11-02 2005-11-02
US73466905P 2005-11-07 2005-11-07
US73512605P 2005-11-08 2005-11-08
US73882705P 2005-11-21 2005-11-21
US74178705P 2005-12-01 2005-12-01
US75091005P 2005-12-15 2005-12-15
US79480406P 2006-04-24 2006-04-24
PCT/US2006/020304 WO2006127933A1 (en) 2005-05-23 2006-05-23 Processes for preparing cinacalcet hydrochloride crystal form i

Publications (1)

Publication Number Publication Date
IL185108A0 true IL185108A0 (en) 2007-12-03

Family

ID=37101358

Family Applications (2)

Application Number Title Priority Date Filing Date
IL185108A IL185108A0 (en) 2005-05-23 2007-08-07 Processes for preparing cinacalcet hydrochloride crystal form i
IL185494A IL185494A0 (en) 2005-05-23 2007-08-23 Purification of cinacalcet

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL185494A IL185494A0 (en) 2005-05-23 2007-08-23 Purification of cinacalcet

Country Status (12)

Country Link
US (2) US7294735B2 (enExample)
EP (3) EP1975150A1 (enExample)
JP (3) JP2008507565A (enExample)
KR (2) KR20070088485A (enExample)
CN (1) CN101180261A (enExample)
AT (1) ATE445587T1 (enExample)
CA (2) CA2606099A1 (enExample)
ES (1) ES2334260T3 (enExample)
IL (2) IL185108A0 (enExample)
MX (1) MX2007000983A (enExample)
TW (1) TW200716512A (enExample)
WO (2) WO2006127932A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5309014B2 (ja) * 2006-03-23 2013-10-09 アムジエン・インコーポレーテツド シナカルセットの多形体の製造および使用のための方法および組成物
WO2008000422A1 (en) * 2006-06-27 2008-01-03 Sandoz Ag Amorphous form of cinacalcet
WO2008000423A1 (en) * 2006-06-27 2008-01-03 Sandoz Ag Crystalline form of cinacalcet
EP1913941A1 (en) * 2006-10-19 2008-04-23 Sandoz AG Polymorphic forms and solvates of Cinacalcet hydrochloride
EP1945184A2 (en) * 2006-09-01 2008-07-23 Teva Pharmaceutical Industries Ltd. Solid composites of a calicum receptor-active compound
WO2008058236A2 (en) * 2006-11-08 2008-05-15 Dr. Reddy's Labortories, Ltd. Methods for preparing cinacalcet hydrochloride
WO2008063645A1 (en) * 2006-11-20 2008-05-29 Teva Pharmaceutical Industries Ltd. Process for preparing cinacalcet
WO2009002427A2 (en) * 2007-06-21 2008-12-31 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
ITMI20071261A1 (it) 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
US20090093652A1 (en) * 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
CN101932549A (zh) * 2007-09-18 2010-12-29 麦迪凯姆股份公司 制备西那卡塞盐酸盐的改进方法
US7696372B2 (en) * 2007-10-01 2010-04-13 Ascenta Therapeutics, Inc. Process for preparing R-gossypol L-phenylalaninol dienamine
US20090275780A1 (en) * 2008-05-05 2009-11-05 Medichem, S.A. Process for controlling the particle size of a 3-(trifluoromethyl)phenyl]-1-aminopropane derivative
WO2009153814A1 (en) * 2008-06-18 2009-12-23 Erregierre S.P.A. A process for the synthesis of cinacalcet hydrochloride
EP2328860A2 (en) * 2008-08-06 2011-06-08 Actavis Group PTC EHF Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride
WO2010067204A1 (en) 2008-12-08 2010-06-17 Actavis Group Ptc Ehf Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
WO2010094674A2 (en) 2009-02-19 2010-08-26 Zach System S.P.A. Process for preparing cinacalcet hydrochloride
JP2012519677A (ja) 2009-03-05 2012-08-30 シプラ・リミテッド シナカルセト及びその塩の製造方法、並びに該方法に使用する中間体
WO2010128388A2 (en) 2009-05-08 2010-11-11 Aurobindo Pharma Limited An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
JP5685594B2 (ja) 2009-09-10 2015-03-18 ザック システム エス．ピー．エー．ＺａＣｈ Ｓｙｓｔｅｍ Ｓ．ｐ．Ａ． シナカルセトの製造方法
US8722732B2 (en) 2009-09-29 2014-05-13 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
IT1396623B1 (it) 2009-11-26 2012-12-14 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet e suoi intermedi
CZ303627B6 (cs) * 2011-11-25 2013-01-16 Zentiva, K.S. Zpusob výroby Cinacalcetu
CN103450027B (zh) 2012-05-29 2015-07-29 上海京新生物医药有限公司 盐酸西那卡塞的制备方法
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
CN103739500B (zh) * 2012-12-27 2016-03-23 国药一心制药有限公司 一种盐酸西那卡塞的合成与精制方法
CN103193655B (zh) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 盐酸西那卡塞晶型ⅰ的制备方法
CN104512864B (zh) * 2013-09-30 2017-08-22 中国石油化工股份有限公司 一种低温脱除微量碳氧化物的方法
EP3068394A4 (en) 2013-11-15 2017-04-26 Akebia Therapeutics Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
BR102015025502B1 (pt) * 2015-04-30 2022-06-21 Aegerion Pharmaceuticals, Inc Composição de lomitapida, tablete, produto de lomitapida, métodos para analisar uma composição de amostra de lomitapida e para determinar uma quantidade de uma impureza em uma amostra da composição
CN104892428A (zh) * 2015-06-05 2015-09-09 南京辰逸生物科技有限公司 一种盐酸西那卡塞的制备方法
CN106610404B (zh) * 2015-10-21 2019-01-15 华仁药业股份有限公司 采用hplc法检测盐酸西那卡塞同分异构体的方法
CN105439818B (zh) * 2015-12-31 2017-11-28 苏州汇和药业有限公司 一种西那卡塞中间体3‑(3‑三氟甲基苯基)丙醇的合成方法
CN107879939A (zh) * 2016-09-30 2018-04-06 上海天慈生物谷生物工程有限公司 一种制备 n‑((1r)‑1‑(1‑萘基)乙基)‑3‑(3‑(三氟甲基)苯基)丙‑1‑胺盐酸盐的方法
KR20200022712A (ko) * 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
CN109096119B (zh) * 2018-10-29 2019-10-25 江苏永安制药有限公司 一种制备盐酸西那卡塞的方法
CN110041206B (zh) * 2019-04-29 2021-10-19 梯尔希（南京）药物研发有限公司 一种西那卡塞杂质的制备方法
CN111153832B (zh) * 2020-01-20 2022-02-25 广州九植医药科技有限公司 一种西那卡塞杂质的制备方法
TW202517274A (zh) * 2023-06-30 2025-05-01 韓商鐘根堂股份有限公司 化合物之新穎製備方法及新結晶形式

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US4966988A (en) 1989-02-17 1990-10-30 Chevron Research Company Process for preparing acetonitrile 3-trifluoromethyl benzene
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) * 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
CN1312116C (zh) * 1994-10-21 2007-04-25 Nps药物有限公司 钙受体活性化合物
US5648541A (en) * 1995-09-28 1997-07-15 Nps Pharmaceuticals, Inc. Chiral reductions of imines leading to the syntheses of optically active amines
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GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
DK3395338T3 (da) * 2003-09-12 2019-07-22 Amgen Inc Hurtigt opløsende formulering af cinacalcet-hcl

Also Published As

Publication number Publication date
WO2006127932A3 (en) 2007-02-01
CA2605736A1 (en) 2006-11-30
EP1883618B1 (en) 2009-10-14
MX2007000983A (es) 2007-04-16
EP1883618A1 (en) 2008-02-06
JP2008507566A (ja) 2008-03-13
US7247751B2 (en) 2007-07-24
KR20070088485A (ko) 2007-08-29
US7294735B2 (en) 2007-11-13
JP2010280715A (ja) 2010-12-16
EP1975150A1 (en) 2008-10-01
JP4638491B2 (ja) 2011-02-23
JP2008507565A (ja) 2008-03-13
IL185494A0 (en) 2008-01-06
KR20070083471A (ko) 2007-08-24
WO2006127933A8 (en) 2007-08-30
US20070099998A1 (en) 2007-05-03
CA2606099A1 (en) 2006-11-30
CN101180261A (zh) 2008-05-14
ATE445587T1 (de) 2009-10-15
WO2006127933A1 (en) 2006-11-30
WO2006127932A2 (en) 2006-11-30
US20070060645A1 (en) 2007-03-15
EP1805135A2 (en) 2007-07-11
ES2334260T3 (es) 2010-03-08
TW200716512A (en) 2007-05-01

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