KR20070083471A - 시나칼셋 염산염 결정형 ｉ의 제조 방법 - Google Patents

시나칼셋 염산염 결정형 ｉ의 제조 방법 Download PDF

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Publication number
KR20070083471A
KR20070083471A KR1020077001966A KR20077001966A KR20070083471A KR 20070083471 A KR20070083471 A KR 20070083471A KR 1020077001966 A KR1020077001966 A KR 1020077001966A KR 20077001966 A KR20077001966 A KR 20077001966A KR 20070083471 A KR20070083471 A KR 20070083471A
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KR
South Korea
Prior art keywords
cinacalcet hydrochloride
hours
cinacalcet
crystalline form
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020077001966A
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English (en)
Korean (ko)
Inventor
레비탈 리프쉬츠-라이론
쉐론 아브하르-메이단
Original Assignee
테바 파마슈티컬 인더스트리즈 리미티드
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Publication of KR20070083471A publication Critical patent/KR20070083471A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/90—Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Catalysts (AREA)
KR1020077001966A 2005-05-23 2006-05-23 시나칼셋 염산염 결정형 ｉ의 제조 방법 Ceased KR20070083471A (ko)

Applications Claiming Priority (32)

Application Number Priority Date Filing Date Title
US68415205P 2005-05-23 2005-05-23
US60/684,152 2005-05-23
US69698105P 2005-07-05 2005-07-05
US60/696,981 2005-07-05
US69711105P 2005-07-06 2005-07-06
US60/697,111 2005-07-06
US69861305P 2005-07-11 2005-07-11
US60/698,613 2005-07-11
US70123205P 2005-07-20 2005-07-20
US60/701,232 2005-07-20
US70291805P 2005-07-26 2005-07-26
US60/702,918 2005-07-26
US70691005P 2005-08-09 2005-08-09
US60/706,910 2005-08-09
US73005005P 2005-10-24 2005-10-24
US60/730,050 2005-10-24
US73208305P 2005-10-31 2005-10-31
US60/732,083 2005-10-31
US73300805P 2005-11-02 2005-11-02
US60/733,008 2005-11-02
US73466905P 2005-11-07 2005-11-07
US60/734,669 2005-11-07
US73512605P 2005-11-08 2005-11-08
US60/735,126 2005-11-08
US73882705P 2005-11-21 2005-11-21
US60/738,827 2005-11-21
US74178705P 2005-12-01 2005-12-01
US60/741,787 2005-12-01
US75091005P 2005-12-15 2005-12-15
US60/750,910 2005-12-15
US79480406P 2006-04-24 2006-04-24
US60/794,804 2006-04-24

Publications (1)

Publication Number Publication Date
KR20070083471A true KR20070083471A (ko) 2007-08-24

Family

ID=37101358

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077001966A Ceased KR20070083471A (ko) 2005-05-23 2006-05-23 시나칼셋 염산염 결정형 ｉ의 제조 방법
KR1020077004036A Ceased KR20070088485A (ko) 2005-05-23 2006-05-23 시나칼세트의 정제법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020077004036A Ceased KR20070088485A (ko) 2005-05-23 2006-05-23 시나칼세트의 정제법

Country Status (12)

Country Link
US (2) US7247751B2 (https=)
EP (3) EP1883618B1 (https=)
JP (3) JP2008507565A (https=)
KR (2) KR20070083471A (https=)
CN (1) CN101180261A (https=)
AT (1) ATE445587T1 (https=)
CA (2) CA2605736A1 (https=)
ES (1) ES2334260T3 (https=)
IL (2) IL185108A0 (https=)
MX (1) MX2007000983A (https=)
TW (1) TW200716512A (https=)
WO (2) WO2006127933A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020040467A1 (ko) * 2018-08-23 2020-02-27 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6h)-온 염산염의 결정다형체 및 그 제조방법

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5309014B2 (ja) 2006-03-23 2013-10-09 アムジエン・インコーポレーテツド シナカルセットの多形体の製造および使用のための方法および組成物
WO2008000422A1 (en) * 2006-06-27 2008-01-03 Sandoz Ag Amorphous form of cinacalcet
US20090197970A1 (en) * 2006-06-27 2009-08-06 Sandoz Ag Crystalline form of cinacalcet
EP1913941A1 (en) * 2006-10-19 2008-04-23 Sandoz AG Polymorphic forms and solvates of Cinacalcet hydrochloride
CN101522173A (zh) * 2006-09-01 2009-09-02 特瓦制药工业有限公司 钙受体活性化合物的固体复合物
WO2008058236A2 (en) * 2006-11-08 2008-05-15 Dr. Reddy's Labortories, Ltd. Methods for preparing cinacalcet hydrochloride
WO2008063645A1 (en) * 2006-11-20 2008-05-29 Teva Pharmaceutical Industries Ltd. Process for preparing cinacalcet
ES2569483T3 (es) * 2007-06-21 2016-05-11 Amgen Inc. Métodos para sintetizar cinacalcet y sales del mismo
ITMI20071261A1 (it) 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
US20090093652A1 (en) * 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
CN101932549A (zh) * 2007-09-18 2010-12-29 麦迪凯姆股份公司 制备西那卡塞盐酸盐的改进方法
WO2009045410A1 (en) * 2007-10-01 2009-04-09 Ascenta Therapeutics, Inc. Process for preparing r-gossypol l-phenylalaninol dienamine
EP2300415A2 (en) * 2008-05-05 2011-03-30 Medichem, S.A. Process for controlling the particle size of a 3-(trifluoromethyl)phenyl¨-1-aminopropane derivative
US8614354B2 (en) * 2008-06-18 2013-12-24 Erregierre S.P.A. Process for the synthesis of cinacalcet hydrochloride
EP2328860A2 (en) * 2008-08-06 2011-06-08 Actavis Group PTC EHF Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride
EP2376424A1 (en) 2008-12-08 2011-10-19 Actavis Group PTC EHF Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
JP5503670B2 (ja) 2009-02-19 2014-05-28 ザック システム エス．ピー．エー． シナカルセト塩酸塩の製造方法
US8575393B2 (en) 2009-03-05 2013-11-05 Cipla Limited Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process
WO2010128388A2 (en) 2009-05-08 2010-11-11 Aurobindo Pharma Limited An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
WO2011029833A1 (en) 2009-09-10 2011-03-17 Zach System S.P.A. Process for preparing cinacalcet
US8722732B2 (en) 2009-09-29 2014-05-13 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
IT1396623B1 (it) 2009-11-26 2012-12-14 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet e suoi intermedi
CZ303627B6 (cs) * 2011-11-25 2013-01-16 Zentiva, K.S. Zpusob výroby Cinacalcetu
CN103450027B (zh) 2012-05-29 2015-07-29 上海京新生物医药有限公司 盐酸西那卡塞的制备方法
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
CN103739500B (zh) * 2012-12-27 2016-03-23 国药一心制药有限公司 一种盐酸西那卡塞的合成与精制方法
CN103193655B (zh) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 盐酸西那卡塞晶型ⅰ的制备方法
CN104512864B (zh) * 2013-09-30 2017-08-22 中国石油化工股份有限公司 一种低温脱除微量碳氧化物的方法
AR099354A1 (es) 2013-11-15 2016-07-20 Akebia Therapeutics Inc Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos
BR102015025502B1 (pt) * 2015-04-30 2022-06-21 Aegerion Pharmaceuticals, Inc Composição de lomitapida, tablete, produto de lomitapida, métodos para analisar uma composição de amostra de lomitapida e para determinar uma quantidade de uma impureza em uma amostra da composição
CN104892428A (zh) * 2015-06-05 2015-09-09 南京辰逸生物科技有限公司 一种盐酸西那卡塞的制备方法
CN106610404B (zh) * 2015-10-21 2019-01-15 华仁药业股份有限公司 采用hplc法检测盐酸西那卡塞同分异构体的方法
CN105439818B (zh) * 2015-12-31 2017-11-28 苏州汇和药业有限公司 一种西那卡塞中间体3‑(3‑三氟甲基苯基)丙醇的合成方法
CN107879939A (zh) * 2016-09-30 2018-04-06 上海天慈生物谷生物工程有限公司 一种制备 n‑((1r)‑1‑(1‑萘基)乙基)‑3‑(3‑(三氟甲基)苯基)丙‑1‑胺盐酸盐的方法
CN109096119B (zh) * 2018-10-29 2019-10-25 江苏永安制药有限公司 一种制备盐酸西那卡塞的方法
CN110041206B (zh) * 2019-04-29 2021-10-19 梯尔希（南京）药物研发有限公司 一种西那卡塞杂质的制备方法
CN111153832B (zh) * 2020-01-20 2022-02-25 广州九植医药科技有限公司 一种西那卡塞杂质的制备方法
CN121511241A (zh) * 2023-06-30 2026-02-10 株式会社 钟根堂 化合物的新制备方法及新结晶形式

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966988A (en) * 1989-02-17 1990-10-30 Chevron Research Company Process for preparing acetonitrile 3-trifluoromethyl benzene
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) * 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6211244B1 (en) * 1994-10-21 2001-04-03 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US5648541A (en) * 1995-09-28 1997-07-15 Nps Pharmaceuticals, Inc. Chiral reductions of imines leading to the syntheses of optically active amines
EP0907631B1 (en) * 1996-05-01 2003-06-18 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
ES2655435T3 (es) * 2003-09-12 2018-02-20 Amgen Inc. Formulación de disolución rápida de cinacalcet

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020040467A1 (ko) * 2018-08-23 2020-02-27 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6h)-온 염산염의 결정다형체 및 그 제조방법
US11731969B2 (en) 2018-08-23 2023-08-22 Oscotec Inc. Crystal polymorph of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride and method for preparing same

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Publication number Publication date
ES2334260T3 (es) 2010-03-08
EP1883618A1 (en) 2008-02-06
WO2006127933A1 (en) 2006-11-30
EP1883618B1 (en) 2009-10-14
EP1805135A2 (en) 2007-07-11
IL185494A0 (en) 2008-01-06
WO2006127932A3 (en) 2007-02-01
MX2007000983A (es) 2007-04-16
WO2006127933A8 (en) 2007-08-30
ATE445587T1 (de) 2009-10-15
US20070060645A1 (en) 2007-03-15
CA2605736A1 (en) 2006-11-30
US7294735B2 (en) 2007-11-13
CN101180261A (zh) 2008-05-14
JP2008507565A (ja) 2008-03-13
JP2008507566A (ja) 2008-03-13
EP1975150A1 (en) 2008-10-01
IL185108A0 (en) 2007-12-03
US20070099998A1 (en) 2007-05-03
JP4638491B2 (ja) 2011-02-23
JP2010280715A (ja) 2010-12-16
CA2606099A1 (en) 2006-11-30
WO2006127932A2 (en) 2006-11-30
US7247751B2 (en) 2007-07-24
KR20070088485A (ko) 2007-08-29
TW200716512A (en) 2007-05-01

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