JP2008507565A - シナカルセトの精製 - Google Patents

シナカルセトの精製 Download PDF

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Publication number
JP2008507565A
JP2008507565A JP2007522851A JP2007522851A JP2008507565A JP 2008507565 A JP2008507565 A JP 2008507565A JP 2007522851 A JP2007522851 A JP 2007522851A JP 2007522851 A JP2007522851 A JP 2007522851A JP 2008507565 A JP2008507565 A JP 2008507565A
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JP
Japan
Prior art keywords
cinacalcet
carbamate
salt
area
hplc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007522851A
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English (en)
Japanese (ja)
Inventor
リフシッツリロン，レビタル
ライジ，ユーリー
ラマティー，レビタル
Original Assignee
テバ ファーマシューティカル インダストリーズ リミティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by テバ ファーマシューティカル インダストリーズ リミティド filed Critical テバ ファーマシューティカル インダストリーズ リミティド
Publication of JP2008507565A publication Critical patent/JP2008507565A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/90—Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Catalysts (AREA)
JP2007522851A 2005-05-23 2006-05-23 シナカルセトの精製 Pending JP2008507565A (ja)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US68415205P 2005-05-23 2005-05-23
US69698105P 2005-07-05 2005-07-05
US69711105P 2005-07-06 2005-07-06
US69861305P 2005-07-11 2005-07-11
US70123205P 2005-07-20 2005-07-20
US70291805P 2005-07-26 2005-07-26
US70691005P 2005-08-09 2005-08-09
US73005005P 2005-10-24 2005-10-24
US73208305P 2005-10-31 2005-10-31
US73300805P 2005-11-02 2005-11-02
US73466905P 2005-11-07 2005-11-07
US73512605P 2005-11-08 2005-11-08
US73882705P 2005-11-21 2005-11-21
US74178705P 2005-12-01 2005-12-01
US75091005P 2005-12-15 2005-12-15
US79480406P 2006-04-24 2006-04-24
PCT/US2006/020303 WO2006127932A2 (en) 2005-05-23 2006-05-23 Purification of cinacalcet

Publications (1)

Publication Number Publication Date
JP2008507565A true JP2008507565A (ja) 2008-03-13

Family

ID=37101358

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007522851A Pending JP2008507565A (ja) 2005-05-23 2006-05-23 シナカルセトの精製
JP2007522852A Expired - Fee Related JP4638491B2 (ja) 2005-05-23 2006-05-23 シナカルセト塩酸塩結晶フォームｉの調製方法
JP2010197123A Pending JP2010280715A (ja) 2005-05-23 2010-09-02 シナカルセト塩酸塩結晶フォームｉの調製方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2007522852A Expired - Fee Related JP4638491B2 (ja) 2005-05-23 2006-05-23 シナカルセト塩酸塩結晶フォームｉの調製方法
JP2010197123A Pending JP2010280715A (ja) 2005-05-23 2010-09-02 シナカルセト塩酸塩結晶フォームｉの調製方法

Country Status (12)

Country Link
US (2) US7247751B2 (https=)
EP (3) EP1883618B1 (https=)
JP (3) JP2008507565A (https=)
KR (2) KR20070083471A (https=)
CN (1) CN101180261A (https=)
AT (1) ATE445587T1 (https=)
CA (2) CA2605736A1 (https=)
ES (1) ES2334260T3 (https=)
IL (2) IL185108A0 (https=)
MX (1) MX2007000983A (https=)
TW (1) TW200716512A (https=)
WO (2) WO2006127933A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018517680A (ja) * 2015-04-30 2018-07-05 エージェリオン・ファーマシューティカルズ・インコーポレーテッド 化合物の不純物及びそれらの検出方法

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JP5309014B2 (ja) 2006-03-23 2013-10-09 アムジエン・インコーポレーテツド シナカルセットの多形体の製造および使用のための方法および組成物
WO2008000422A1 (en) * 2006-06-27 2008-01-03 Sandoz Ag Amorphous form of cinacalcet
US20090197970A1 (en) * 2006-06-27 2009-08-06 Sandoz Ag Crystalline form of cinacalcet
EP1913941A1 (en) * 2006-10-19 2008-04-23 Sandoz AG Polymorphic forms and solvates of Cinacalcet hydrochloride
CN101522173A (zh) * 2006-09-01 2009-09-02 特瓦制药工业有限公司 钙受体活性化合物的固体复合物
WO2008058236A2 (en) * 2006-11-08 2008-05-15 Dr. Reddy's Labortories, Ltd. Methods for preparing cinacalcet hydrochloride
WO2008063645A1 (en) * 2006-11-20 2008-05-29 Teva Pharmaceutical Industries Ltd. Process for preparing cinacalcet
ES2569483T3 (es) * 2007-06-21 2016-05-11 Amgen Inc. Métodos para sintetizar cinacalcet y sales del mismo
ITMI20071261A1 (it) 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
US20090093652A1 (en) * 2007-08-16 2009-04-09 Michal Rafilovich Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
CN101932549A (zh) * 2007-09-18 2010-12-29 麦迪凯姆股份公司 制备西那卡塞盐酸盐的改进方法
WO2009045410A1 (en) * 2007-10-01 2009-04-09 Ascenta Therapeutics, Inc. Process for preparing r-gossypol l-phenylalaninol dienamine
EP2300415A2 (en) * 2008-05-05 2011-03-30 Medichem, S.A. Process for controlling the particle size of a 3-(trifluoromethyl)phenyl¨-1-aminopropane derivative
US8614354B2 (en) * 2008-06-18 2013-12-24 Erregierre S.P.A. Process for the synthesis of cinacalcet hydrochloride
EP2328860A2 (en) * 2008-08-06 2011-06-08 Actavis Group PTC EHF Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride
EP2376424A1 (en) 2008-12-08 2011-10-19 Actavis Group PTC EHF Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
JP5503670B2 (ja) 2009-02-19 2014-05-28 ザック システム エス．ピー．エー． シナカルセト塩酸塩の製造方法
US8575393B2 (en) 2009-03-05 2013-11-05 Cipla Limited Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process
WO2010128388A2 (en) 2009-05-08 2010-11-11 Aurobindo Pharma Limited An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
WO2011029833A1 (en) 2009-09-10 2011-03-17 Zach System S.P.A. Process for preparing cinacalcet
US8722732B2 (en) 2009-09-29 2014-05-13 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
IT1396623B1 (it) 2009-11-26 2012-12-14 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet e suoi intermedi
CZ303627B6 (cs) * 2011-11-25 2013-01-16 Zentiva, K.S. Zpusob výroby Cinacalcetu
CN103450027B (zh) 2012-05-29 2015-07-29 上海京新生物医药有限公司 盐酸西那卡塞的制备方法
FR2995307A1 (fr) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables
CN103739500B (zh) * 2012-12-27 2016-03-23 国药一心制药有限公司 一种盐酸西那卡塞的合成与精制方法
CN103193655B (zh) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 盐酸西那卡塞晶型ⅰ的制备方法
CN104512864B (zh) * 2013-09-30 2017-08-22 中国石油化工股份有限公司 一种低温脱除微量碳氧化物的方法
AR099354A1 (es) 2013-11-15 2016-07-20 Akebia Therapeutics Inc Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos
CN104892428A (zh) * 2015-06-05 2015-09-09 南京辰逸生物科技有限公司 一种盐酸西那卡塞的制备方法
CN106610404B (zh) * 2015-10-21 2019-01-15 华仁药业股份有限公司 采用hplc法检测盐酸西那卡塞同分异构体的方法
CN105439818B (zh) * 2015-12-31 2017-11-28 苏州汇和药业有限公司 一种西那卡塞中间体3‑(3‑三氟甲基苯基)丙醇的合成方法
CN107879939A (zh) * 2016-09-30 2018-04-06 上海天慈生物谷生物工程有限公司 一种制备 n‑((1r)‑1‑(1‑萘基)乙基)‑3‑(3‑(三氟甲基)苯基)丙‑1‑胺盐酸盐的方法
KR20200022712A (ko) * 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
CN109096119B (zh) * 2018-10-29 2019-10-25 江苏永安制药有限公司 一种制备盐酸西那卡塞的方法
CN110041206B (zh) * 2019-04-29 2021-10-19 梯尔希（南京）药物研发有限公司 一种西那卡塞杂质的制备方法
CN111153832B (zh) * 2020-01-20 2022-02-25 广州九植医药科技有限公司 一种西那卡塞杂质的制备方法
CN121511241A (zh) * 2023-06-30 2026-02-10 株式会社 钟根堂 化合物的新制备方法及新结晶形式

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018517680A (ja) * 2015-04-30 2018-07-05 エージェリオン・ファーマシューティカルズ・インコーポレーテッド 化合物の不純物及びそれらの検出方法

Also Published As

Publication number Publication date
ES2334260T3 (es) 2010-03-08
EP1883618A1 (en) 2008-02-06
KR20070083471A (ko) 2007-08-24
WO2006127933A1 (en) 2006-11-30
EP1883618B1 (en) 2009-10-14
EP1805135A2 (en) 2007-07-11
IL185494A0 (en) 2008-01-06
WO2006127932A3 (en) 2007-02-01
MX2007000983A (es) 2007-04-16
WO2006127933A8 (en) 2007-08-30
ATE445587T1 (de) 2009-10-15
US20070060645A1 (en) 2007-03-15
CA2605736A1 (en) 2006-11-30
US7294735B2 (en) 2007-11-13
CN101180261A (zh) 2008-05-14
JP2008507566A (ja) 2008-03-13
EP1975150A1 (en) 2008-10-01
IL185108A0 (en) 2007-12-03
US20070099998A1 (en) 2007-05-03
JP4638491B2 (ja) 2011-02-23
JP2010280715A (ja) 2010-12-16
CA2606099A1 (en) 2006-11-30
WO2006127932A2 (en) 2006-11-30
US7247751B2 (en) 2007-07-24
KR20070088485A (ko) 2007-08-29
TW200716512A (en) 2007-05-01

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