KR20070034512A - 신규 항원-결합 폴리펩티드 및 이의 용도 - Google Patents

신규 항원-결합 폴리펩티드 및 이의 용도 Download PDF

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Publication number
KR20070034512A
KR20070034512A KR1020067027061A KR20067027061A KR20070034512A KR 20070034512 A KR20070034512 A KR 20070034512A KR 1020067027061 A KR1020067027061 A KR 1020067027061A KR 20067027061 A KR20067027061 A KR 20067027061A KR 20070034512 A KR20070034512 A KR 20070034512A
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South Korea
Prior art keywords
antigen
amino acid
abp
binding polypeptide
amino acids
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Ceased
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KR1020067027061A
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English (en)
Korean (ko)
Inventor
호 성 조
토마스 오. 다니엘
트로이 이. 윌슨
토마스 피. 큐젝
펭 티안
안나-마리아 헤이스
브루스 이. 킴멜
릴리안 호
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암브룩스, 인코포레이티드
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Publication of KR20070034512A publication Critical patent/KR20070034512A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020067027061A 2004-06-18 2005-06-17 신규 항원-결합 폴리펩티드 및 이의 용도 Ceased KR20070034512A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US58133404P 2004-06-18 2004-06-18
US60/581,334 2004-06-18
US64822205P 2005-01-28 2005-01-28
US60/648,222 2005-01-28
US65401805P 2005-02-17 2005-02-17
US60/654,018 2005-02-17
PCT/US2005/021579 WO2006009901A2 (en) 2004-06-18 2005-06-17 Novel antigen-binding polypeptides and their uses

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020147032081A Division KR101699142B1 (ko) 2004-06-18 2005-06-17 신규 항원-결합 폴리펩티드 및 이의 용도

Publications (1)

Publication Number Publication Date
KR20070034512A true KR20070034512A (ko) 2007-03-28

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ID=35785717

Family Applications (2)

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KR1020147032081A Expired - Fee Related KR101699142B1 (ko) 2004-06-18 2005-06-17 신규 항원-결합 폴리펩티드 및 이의 용도
KR1020067027061A Ceased KR20070034512A (ko) 2004-06-18 2005-06-17 신규 항원-결합 폴리펩티드 및 이의 용도

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KR1020147032081A Expired - Fee Related KR101699142B1 (ko) 2004-06-18 2005-06-17 신규 항원-결합 폴리펩티드 및 이의 용도

Country Status (13)

Country Link
US (4) US7632924B2 (enExample)
EP (1) EP1771205B1 (enExample)
JP (1) JP2008503217A (enExample)
KR (2) KR101699142B1 (enExample)
CN (2) CN102603895B (enExample)
AU (1) AU2005265163B2 (enExample)
BR (1) BRPI0512235A (enExample)
CA (1) CA2568952C (enExample)
GB (1) GB2430677A (enExample)
IL (1) IL179300B (enExample)
MX (1) MXPA06014684A (enExample)
NZ (2) NZ582684A (enExample)
WO (1) WO2006009901A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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WO2012169822A3 (ko) * 2011-06-10 2013-03-28 강원대학교산학협력단 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물
US9605043B2 (en) 2011-06-10 2017-03-28 Geneone Life Science, Inc. Fusion protein for suppressing cancer cell growth and suppressing vasculogenesis, and anticancer composition comprising same

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CN1909921B (zh) * 2003-11-10 2012-09-26 Uab研究基金会 减少细菌携带和中枢神经系统侵害的组合物及其使用方法
US9284375B2 (en) 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
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US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
US11254748B2 (en) 2005-04-15 2022-02-22 Macrogenics, Inc. Covalent diabodies and uses thereof
US7776535B2 (en) 2006-02-06 2010-08-17 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
US8946391B2 (en) * 2006-03-24 2015-02-03 The Regents Of The University Of California Construction of a multivalent scFv through alkyne-azide 1,3-dipolar cycloaddition
RU2424246C2 (ru) * 2006-05-26 2011-07-20 Ипсен Фарма С.А.С. Способы сайт-специфического пегилирования
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BRPI0507169A (pt) 2004-02-02 2007-06-26 Ambrx Inc polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos

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WO2012169822A3 (ko) * 2011-06-10 2013-03-28 강원대학교산학협력단 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물
US9605043B2 (en) 2011-06-10 2017-03-28 Geneone Life Science, Inc. Fusion protein for suppressing cancer cell growth and suppressing vasculogenesis, and anticancer composition comprising same

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US20060153860A1 (en) 2006-07-13
EP1771205A2 (en) 2007-04-11
WO2006009901A3 (en) 2006-10-05
MXPA06014684A (es) 2007-02-12
IL179300A0 (en) 2007-03-08
GB2430677A8 (en) 2007-06-12
IL179300B (en) 2018-01-31
CA2568952C (en) 2019-05-21
US9175083B2 (en) 2015-11-03
EP1771205A4 (en) 2008-10-01
NZ582684A (en) 2011-05-27
AU2005265163A1 (en) 2006-01-26
US20080081038A1 (en) 2008-04-03
KR20150005973A (ko) 2015-01-15
CN102532321A (zh) 2012-07-04
US20080085277A1 (en) 2008-04-10
KR101699142B1 (ko) 2017-01-23
US7632924B2 (en) 2009-12-15
GB0700909D0 (en) 2007-02-28
JP2008503217A (ja) 2008-02-07
EP1771205B1 (en) 2016-10-26
CN102603895A (zh) 2012-07-25
NZ551335A (en) 2010-03-26
CN102532321B (zh) 2018-10-12
US20080050374A1 (en) 2008-02-28
WO2006009901A2 (en) 2006-01-26
CN102603895B (zh) 2016-09-28
BRPI0512235A (pt) 2008-02-19
GB2430677A (en) 2007-04-04
CA2568952A1 (en) 2006-01-26
AU2005265163B2 (en) 2009-10-01

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