KR102660336B1 - 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 - Google Patents

절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 Download PDF

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KR102660336B1
KR102660336B1 KR1020197031584A KR20197031584A KR102660336B1 KR 102660336 B1 KR102660336 B1 KR 102660336B1 KR 1020197031584 A KR1020197031584 A KR 1020197031584A KR 20197031584 A KR20197031584 A KR 20197031584A KR 102660336 B1 KR102660336 B1 KR 102660336B1
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nkg2d
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KR20200006046A (ko
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준 하오 레옹
노리코 시마사키
쎄 분 세오우
다리오 캄파나
제임스 바르나비 트라저
알렉산드라 레이다 리아나 라제틱
차오 구오
루수안 구오 부렌
시얌 사시칸트 마스라니
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내셔널 유니버시티 오브 싱가포르
엔카르타, 인크.
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KR1020197031584A 2017-03-27 2018-03-27 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 Active KR102660336B1 (ko)

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KR1020247013105A KR20240057444A (ko) 2017-03-27 2018-03-27 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도

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US201762477335P 2017-03-27 2017-03-27
US62/477,335 2017-03-27
US201862628774P 2018-02-09 2018-02-09
US62/628,774 2018-02-09
PCT/US2018/024650 WO2018183385A1 (en) 2017-03-27 2018-03-27 Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy

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US12264335B2 (en) 2014-05-15 2025-04-01 National University Of Singapore Natural killer cells expressing membrane-bound interleukin 15 (mbIL15) and uses thereof
US12351617B2 (en) 2017-03-27 2025-07-08 National University Of Singapore Immune cells comprising truncated NKG2D chimeric receptors
US12398187B2 (en) 2019-03-05 2025-08-26 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
US12441787B2 (en) 2018-04-02 2025-10-14 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
US12486514B2 (en) 2018-08-29 2025-12-02 National University Of Singapore Method to specifically stimulate survival and expansion of genetically-modified immune cells

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
SG11201908337VA (en) 2017-03-27 2019-10-30 Nat Univ Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
WO2019127215A1 (en) * 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
CN110028589B (zh) * 2018-02-07 2023-07-21 阿思科力(苏州)生物科技有限公司 嵌合抗原受体、表达该嵌合抗原受体的nkg2d car-nk细胞及其制备方法和应用
SG11202007156QA (en) 2018-02-09 2020-08-28 Nat Univ Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
JP2021512614A (ja) * 2018-02-09 2021-05-20 ナショナル ユニヴァーシティー オブ シンガポール ナチュラルキラー細胞免疫療法における接着受容体構築物及びその使用
CN110343712B (zh) * 2018-04-04 2023-12-26 达仁生物科技有限公司 嵌合抗原受体和其治疗肺癌的方法
WO2020005837A1 (en) * 2018-06-25 2020-01-02 The Trustees Of The University Of Pennsylvania Compositions and methods of nkg2d chimeric antigen receptor t cells for controlling triple-negative breast cancer
EP3850004A4 (en) * 2018-09-13 2022-09-07 Nkarta, Inc. NATURAL KILLER CELL COMPOSITIONS AND IMMUNOTHERAPY METHODS FOR TREATMENT OF TUMORS
KR20210091220A (ko) * 2018-11-05 2021-07-21 사이포스 바이오사이언시스 인코포레이티드 부착된 세포에 직접 신호를 보내지 않는 비-천연 nkg2d 수용체
CN109777784B (zh) * 2019-02-22 2021-12-31 上海尚泰生物技术有限公司 一种增强向肿瘤部位迁移的嵌合抗原受体载体构建方法与应用
CA3140393A1 (en) * 2019-06-04 2020-12-10 Nkarta, Inc. Combinations of engineered natural killer cells and engineered t cells for immunotherapy
SG10201907378QA (en) * 2019-08-08 2021-03-30 Nat Univ Singapore Genetically modified nk cells and uses thereof
JP7692897B2 (ja) 2019-09-10 2025-06-16 オブシディアン セラピューティクス， インコーポレイテッド 調節可能な制御のためのｃａ２－ｉｌ１５融合タンパク質
GB201913697D0 (en) * 2019-09-23 2019-11-06 King S College London DAP10/DAP12 fusion polypeptides
WO2021068108A1 (zh) * 2019-10-08 2021-04-15 成都盛世君联生物技术有限公司 Nkg2d car-t细胞及其制备和应用
CN110981973B (zh) * 2019-12-25 2023-03-31 新乡医学院 靶向人膜结合型和可溶性nkg2d配体的嵌合受体、核酸分子、免疫效应细胞及其应用
IL294518A (en) * 2020-01-13 2022-09-01 Nkarta Inc Bcma-directed cellular immunotherapy compositions and methods
US20230293689A1 (en) * 2020-01-19 2023-09-21 Chineo Medical Technology Co., Ltd. Strengthened receptor for improving immune cell function
IL298510A (en) * 2020-06-12 2023-01-01 Nkarta Inc Genetically modified natural killer cells for cd70-directed cancer immunotherapy
EP4178678A1 (en) 2020-07-07 2023-05-17 Cancure, LLC Mic antibodies and binding agents and methods of using the same
CN117177760A (zh) * 2021-02-24 2023-12-05 小利兰·斯坦福大学董事会 用于受控和特异性car t细胞活性的嵌合抗原受体（car）信号传导分子
KR20240032732A (ko) * 2021-05-13 2024-03-12 엔카르타, 인크. 암 면역요법을 위한 투약 요법
CA3221231A1 (en) * 2021-05-24 2022-12-01 Kite Pharma, Inc. Chimeric antigen receptor
CN113621073A (zh) * 2021-07-14 2021-11-09 上海易慕峰生物科技有限公司 一种新型嵌合受体组合物、重组载体、细胞及其应用
JP2024541976A (ja) * 2021-10-27 2024-11-13 アディセット セラピューティクス， インク． キメラアダプターポリペプチド
CN120092090A (zh) * 2022-11-07 2025-06-03 上海先博生物科技有限公司 工程化嵌合抗原受体免疫细胞及其应用
WO2024158800A2 (en) * 2023-01-24 2024-08-02 Ginkgo Bioworks, Inc. Immune cell stimulatory sequences
CN117467022B (zh) * 2023-09-28 2024-10-22 上海恩凯细胞技术有限公司 嵌合抗原受体及其应用
CN117924518B (zh) * 2024-01-05 2025-08-22 苏州艾凯利元生物科技有限公司 用于nk细胞的嵌合抗原受体及工程化的nk细胞

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