CA3056439A1 - Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy - Google Patents

Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy Download PDF

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Publication number
CA3056439A1
CA3056439A1 CA3056439A CA3056439A CA3056439A1 CA 3056439 A1 CA3056439 A1 CA 3056439A1 CA 3056439 A CA3056439 A CA 3056439A CA 3056439 A CA3056439 A CA 3056439A CA 3056439 A1 CA3056439 A1 CA 3056439A1
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Prior art keywords
polynucleotide
seq
nkg2d
chimeric receptor
domain
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CA3056439A
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English (en)
French (fr)
Inventor
Jun Hao Leong
Noriko Shimasaki
See Voon Seow
Dario Campana
James Barnaby Trager
Alexandra Leida Liana LAZETIC
Chao GUO
Luxuan Guo Buren
Shyam Sashikant Masrani
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National University of Singapore
Nkarta Inc
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National University of Singapore
Nkarta Inc
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Publication of CA3056439A1 publication Critical patent/CA3056439A1/en
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3056439A 2017-03-27 2018-03-27 Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy Pending CA3056439A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762477335P 2017-03-27 2017-03-27
US62/477,335 2017-03-27
US201862628774P 2018-02-09 2018-02-09
US62/628,774 2018-02-09
PCT/US2018/024650 WO2018183385A1 (en) 2017-03-27 2018-03-27 Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy

Publications (1)

Publication Number Publication Date
CA3056439A1 true CA3056439A1 (en) 2018-10-04

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Family Applications (1)

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CA3056439A Pending CA3056439A1 (en) 2017-03-27 2018-03-27 Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy

Country Status (12)

Country Link
US (2) US11365236B2 (enExample)
EP (1) EP3600356A4 (enExample)
JP (3) JP7256749B2 (enExample)
KR (2) KR102660336B1 (enExample)
CN (3) CN117384929A (enExample)
AU (2) AU2018246235B2 (enExample)
BR (1) BR112019019917A2 (enExample)
CA (1) CA3056439A1 (enExample)
IL (1) IL269553B2 (enExample)
MX (3) MX2019011514A (enExample)
SG (1) SG11201908492PA (enExample)
WO (1) WO2018183385A1 (enExample)

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