KR102492532B1 - 항-ctla-4 항체 및 이의 사용 방법 - Google Patents

항-ctla-4 항체 및 이의 사용 방법 Download PDF

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KR102492532B1
KR102492532B1 KR1020177037545A KR20177037545A KR102492532B1 KR 102492532 B1 KR102492532 B1 KR 102492532B1 KR 1020177037545 A KR1020177037545 A KR 1020177037545A KR 20177037545 A KR20177037545 A KR 20177037545A KR 102492532 B1 KR102492532 B1 KR 102492532B1
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antibody
delete delete
ctla
certain embodiments
amino acid
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KR20180037924A (ko
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마크 반 다이크
코르넬리아 앤 문트
게르드 리터
데이비드 쉬아
제드 데이비드 월초크
타하 멀고브
데이비드 아담 사비츠키
마크 아서 핀데이스
니콜라스 스튜어트 윌슨
Original Assignee
아게누스 인코포레이티드
루드비히 인스티튜트 포 캔서 리서치 리미티드
메모리얼 슬로안 케터링 캔서 센터
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Priority to KR1020237002568A priority Critical patent/KR20230028478A/ko
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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KR1020177037545A 2015-05-29 2016-05-27 항-ctla-4 항체 및 이의 사용 방법 Active KR102492532B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237002568A KR20230028478A (ko) 2015-05-29 2016-05-27 항-ctla-4 항체 및 이의 사용 방법

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Application Number Priority Date Filing Date Title
US201562168391P 2015-05-29 2015-05-29
US62/168,391 2015-05-29
US201562182363P 2015-06-19 2015-06-19
US62/182,363 2015-06-19
US201562190653P 2015-07-09 2015-07-09
US62/190,653 2015-07-09
US201562257202P 2015-11-18 2015-11-18
US62/257,202 2015-11-18
US201662280263P 2016-01-19 2016-01-19
US62/280,263 2016-01-19
US201662292500P 2016-02-08 2016-02-08
US62/292,500 2016-02-08
US201662294558P 2016-02-12 2016-02-12
US62/294,558 2016-02-12
US201662323226P 2016-04-15 2016-04-15
US62/323,226 2016-04-15
PCT/US2016/034508 WO2016196237A1 (en) 2015-05-29 2016-05-27 Anti-ctla-4 antibodies and methods of use thereof

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KR102492532B1 true KR102492532B1 (ko) 2023-01-30

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