KR102327888B1 - 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 - Google Patents

치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 Download PDF

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KR102327888B1
KR102327888B1 KR1020207029698A KR20207029698A KR102327888B1 KR 102327888 B1 KR102327888 B1 KR 102327888B1 KR 1020207029698 A KR1020207029698 A KR 1020207029698A KR 20207029698 A KR20207029698 A KR 20207029698A KR 102327888 B1 KR102327888 B1 KR 102327888B1
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compound
optionally substituted
alkyl
pharmaceutically acceptable
mmol
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KR20200120776A (ko
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레오니드 베이겔만
광이 왕
데이빗 버나드 스미스
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얀센 바이오파마, 인코퍼레이트.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • A—HUMAN NECESSITIES
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

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KR1020207029698A 2012-12-21 2013-12-19 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 Active KR102327888B1 (ko)

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US201261745466P 2012-12-21 2012-12-21
US61/745,466 2012-12-21
US201361890125P 2013-10-11 2013-10-11
US61/890,125 2013-10-11
PCT/US2013/076740 WO2014100505A1 (en) 2012-12-21 2013-12-19 Substituted nucleosides, nucleotides and analogs thereof
KR1020157019672A KR102168621B1 (ko) 2012-12-21 2013-12-19 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체

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KR1020237015721A Active KR102788773B1 (ko) 2012-12-21 2013-12-19 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
KR1020157019672A Active KR102168621B1 (ko) 2012-12-21 2013-12-19 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
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KR1020157019672A Active KR102168621B1 (ko) 2012-12-21 2013-12-19 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
KR1020217037049A Active KR102532198B1 (ko) 2012-12-21 2013-12-19 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체

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