KR102134088B1 - Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신 - Google Patents

Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신 Download PDF

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KR102134088B1
KR102134088B1 KR1020187037595A KR20187037595A KR102134088B1 KR 102134088 B1 KR102134088 B1 KR 102134088B1 KR 1020187037595 A KR1020187037595 A KR 1020187037595A KR 20187037595 A KR20187037595 A KR 20187037595A KR 102134088 B1 KR102134088 B1 KR 102134088B1
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ror1
antibody
seq
cells
chain variable
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KR20190000925A (ko
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토마스 제임스 킵스
지안 유
빙 쿠이
리구앙 첸
조지 위드호프
찰스 프루사크
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더 리젠츠 오브 더 유니버시티 오브 캘리포니아
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020187037595A 2012-08-24 2013-03-15 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신 Active KR102134088B1 (ko)

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Application Number Priority Date Filing Date Title
KR1020207018220A KR102312856B1 (ko) 2012-08-24 2013-03-15 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261693230P 2012-08-24 2012-08-24
US61/693,230 2012-08-24
US201261709055P 2012-10-02 2012-10-02
US61/709,055 2012-10-02
US201261709803P 2012-10-04 2012-10-04
US61/709,803 2012-10-04
PCT/US2013/032572 WO2014031174A1 (en) 2012-08-24 2013-03-15 Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis

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KR1020157006420A Division KR101935088B1 (ko) 2012-08-24 2013-03-15 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신

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KR1020207018220A Division KR102312856B1 (ko) 2012-08-24 2013-03-15 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신

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KR20190000925A KR20190000925A (ko) 2019-01-03
KR102134088B1 true KR102134088B1 (ko) 2020-07-14

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KR1020187037595A Active KR102134088B1 (ko) 2012-08-24 2013-03-15 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신
KR1020157006420A Active KR101935088B1 (ko) 2012-08-24 2013-03-15 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신
KR1020207018220A Active KR102312856B1 (ko) 2012-08-24 2013-03-15 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신

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KR1020207018220A Active KR102312856B1 (ko) 2012-08-24 2013-03-15 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신

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US (5) US9758591B2 (enExample)
EP (3) EP3838923B1 (enExample)
JP (4) JP6479660B2 (enExample)
KR (3) KR102134088B1 (enExample)
CN (2) CN104662044B (enExample)
AU (3) AU2013306390B2 (enExample)
BR (1) BR112015003757B1 (enExample)
CA (1) CA2881966C (enExample)
CL (1) CL2015000431A1 (enExample)
DK (3) DK3838923T3 (enExample)
ES (3) ES2845184T3 (enExample)
IL (2) IL236962B (enExample)
MX (1) MX362456B (enExample)
MY (1) MY181648A (enExample)
NI (1) NI201500024A (enExample)
PH (1) PH12015500390B1 (enExample)
PL (2) PL3489261T3 (enExample)
PT (1) PT2888283T (enExample)
SG (1) SG11201500730XA (enExample)
WO (1) WO2014031174A1 (enExample)

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