KR101963460B1 - 변형된 릴랙신 폴리펩타이드 및 그것의 용도 - Google Patents

변형된 릴랙신 폴리펩타이드 및 그것의 용도 Download PDF

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KR101963460B1
KR101963460B1 KR1020137006654A KR20137006654A KR101963460B1 KR 101963460 B1 KR101963460 B1 KR 101963460B1 KR 1020137006654 A KR1020137006654 A KR 1020137006654A KR 20137006654 A KR20137006654 A KR 20137006654A KR 101963460 B1 KR101963460 B1 KR 101963460B1
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polypeptide
amino acid
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KR20130136450A (ko
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바딤 크레이노브
닉 크누드센
암하 헤웨트
크리스틴 데 디오스
제이슨 핑크스태프
로레인 설리반
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암브룩스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
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KR1020137006654A 2010-08-17 2011-08-17 변형된 릴랙신 폴리펩타이드 및 그것의 용도 Expired - Fee Related KR101963460B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37458210P 2010-08-17 2010-08-17
US61/374,582 2010-08-17
PCT/US2011/048157 WO2012024452A2 (en) 2010-08-17 2011-08-17 Modified relaxin polypeptides and their uses

Publications (2)

Publication Number Publication Date
KR20130136450A KR20130136450A (ko) 2013-12-12
KR101963460B1 true KR101963460B1 (ko) 2019-03-28

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Country Status (33)

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US (6) US8735539B2 (https=)
EP (3) EP2605789B1 (https=)
JP (1) JP6054294B2 (https=)
KR (1) KR101963460B1 (https=)
CN (2) CN103201285A (https=)
AU (1) AU2011291943B2 (https=)
BR (1) BR112013003522B1 (https=)
CA (1) CA2808596C (https=)
CL (2) CL2013000475A1 (https=)
CO (1) CO6680644A2 (https=)
CY (1) CY1122101T1 (https=)
DK (2) DK2605789T3 (https=)
EA (1) EA030886B1 (https=)
ES (2) ES2972902T3 (https=)
FI (1) FI3572091T3 (https=)
HK (1) HK1258140A1 (https=)
HR (2) HRP20191564T1 (https=)
HU (2) HUE045845T2 (https=)
IL (1) IL224748A (https=)
LT (2) LT2605789T (https=)
MA (1) MA34521B1 (https=)
MX (1) MX346786B (https=)
MY (1) MY162837A (https=)
NZ (1) NZ607069A (https=)
PE (1) PE20140160A1 (https=)
PH (1) PH12013500241A1 (https=)
PL (2) PL2605789T3 (https=)
PT (2) PT3572091T (https=)
RS (2) RS65223B1 (https=)
SG (3) SG10201913122WA (https=)
SI (2) SI3572091T1 (https=)
SM (2) SMT201900495T1 (https=)
WO (1) WO2012024452A2 (https=)

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US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
RU2014103288A (ru) * 2011-07-01 2015-08-10 Байер Интеллектчуал Проперти Гмбх Слитые полипептиды релаксина и их применение
WO2013033324A2 (en) * 2011-08-31 2013-03-07 University Of Florida Research Foundation, Inc. Materials and methods for modulating activity of bone marrow derived cells
US9393288B2 (en) * 2012-05-29 2016-07-19 The University Of Vermont And State Agricultural College Methods of treating diseases associated with PPARγ
AR094147A1 (es) * 2012-12-27 2015-07-15 Bayer Pharma Aktiengellschaft Polipeptidos de fusion con actividad de relaxina y sus usos
JP6822839B2 (ja) * 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
KR102455171B1 (ko) 2013-12-18 2022-10-14 더 스크립스 리서치 인스티튜트 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물
MA41794A (fr) * 2015-03-18 2018-01-23 The California Institute For Biomedical Res Agents thérapeutiques modifiés et compositions associées
LT3388075T (lt) 2015-03-27 2023-11-10 Immatics Biotechnologies Gmbh Nauji peptidai ir peptidų deriniai, skirti naudoti imunoterapijai prieš įvairius navikus (seq id 25 - mrax5-003)
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
IL263079B2 (en) 2016-05-18 2024-05-01 Modernatx Inc Polynucleotides encoding relaxin
WO2018068047A1 (en) * 2016-10-07 2018-04-12 Beth Israel Deaconess Medical Center, Inc. Compositions comprising relaxin and methods of use thereof
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP3574004A1 (en) * 2017-01-25 2019-12-04 Medimmune, LLC Relaxin fusion polypeptides and uses thereof
PE20191716A1 (es) 2017-02-08 2019-12-05 Bristol Myers Squibb Co Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos
AU2018260628A1 (en) 2017-04-25 2019-12-12 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
MX2022006861A (es) 2019-12-04 2022-07-11 Scripps Research Inst Agonistas del receptor glp2 y metodos de uso.
JP7516061B2 (ja) * 2020-02-18 2024-07-16 ポーラ化成工業株式会社 血管収縮抑制剤
CN114075276A (zh) * 2020-08-17 2022-02-22 成都奥达生物科技有限公司 一种长效松弛素2类似物
KR20240032010A (ko) 2021-06-09 2024-03-08 더 스크립스 리서치 인스티튜트 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법
CN118510536A (zh) 2021-11-11 2024-08-16 泰克托尼治疗股份有限公司 松弛素-2融合蛋白类似物及其使用方法
AU2024270919A1 (en) * 2023-05-18 2026-01-15 Tectonic Operating Company, Inc. Relaxin-2 fusion protein analogs and methods of using same

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WO2008077079A1 (en) 2006-12-18 2008-06-26 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
WO2009055854A1 (en) 2007-10-30 2009-05-07 Howard Florey Institute Of Experimental Physiology And Medicine Chimeric relaxin polypeptides comprising an a and b chain derived from different relaxin family peptides

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