ATE437946T1 - Ribozyme mit breiter trna-aminoacylierungswirkung - Google Patents
Ribozyme mit breiter trna-aminoacylierungswirkungInfo
- Publication number
- ATE437946T1 ATE437946T1 AT03709182T AT03709182T ATE437946T1 AT E437946 T1 ATE437946 T1 AT E437946T1 AT 03709182 T AT03709182 T AT 03709182T AT 03709182 T AT03709182 T AT 03709182T AT E437946 T1 ATE437946 T1 AT E437946T1
- Authority
- AT
- Austria
- Prior art keywords
- ribozymes
- broad
- action
- aminoacylation
- trna aminoacylation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35742402P | 2002-02-15 | 2002-02-15 | |
PCT/US2003/005007 WO2003070740A1 (en) | 2002-02-15 | 2003-02-18 | RIBOZYMES WITH BROAD tRNA AMINOACYLATION ACTIVITY |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE437946T1 true ATE437946T1 (de) | 2009-08-15 |
Family
ID=27757615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03709182T ATE437946T1 (de) | 2002-02-15 | 2003-02-18 | Ribozyme mit breiter trna-aminoacylierungswirkung |
Country Status (8)
Country | Link |
---|---|
US (1) | US7622248B2 (de) |
EP (1) | EP1483282B1 (de) |
JP (1) | JP4464684B2 (de) |
AT (1) | ATE437946T1 (de) |
AU (1) | AU2003213136A1 (de) |
CA (1) | CA2476425C (de) |
DE (1) | DE60328587D1 (de) |
WO (1) | WO2003070740A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005319099B2 (en) | 2004-02-02 | 2010-09-16 | Ambrx, Inc. | Modified human growth hormone |
EP1951890A4 (de) | 2005-11-16 | 2009-06-24 | Ambrx Inc | Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren |
JP5119444B2 (ja) * | 2005-12-06 | 2013-01-16 | 国立大学法人 東京大学 | 多目的アシル化触媒とその用途 |
EP2615108B1 (de) | 2006-09-08 | 2016-10-26 | Ambrx, Inc. | Modifiziertes humanes Plasmapolypeptid oder Fc-Gerüste und deren Verwendungen |
JP5200241B2 (ja) * | 2006-11-17 | 2013-06-05 | 国立大学法人 東京大学 | N末端に非天然骨格をもつポリペプチドの翻訳合成とその応用 |
US9090668B2 (en) * | 2007-03-26 | 2015-07-28 | The University Of Tokyo | Process for synthesizing cyclic peptide compound |
ATE554785T1 (de) | 2007-03-30 | 2012-05-15 | Ambrx Inc | Modifizierte fgf-21 polypeptide und ihre verwendung |
WO2008137471A2 (en) | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
EP2930182A1 (de) | 2007-11-20 | 2015-10-14 | Ambrx, Inc. | Modifizierte insulinpolypeptide und deren verwendungen |
US10138283B2 (en) | 2008-07-23 | 2018-11-27 | Ambrx, Inc. | Modified bovine G-CSF polypeptides and their uses |
MX2011003196A (es) | 2008-09-26 | 2011-04-27 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. |
EP2376647B1 (de) * | 2009-01-12 | 2014-03-05 | Sutro Biopharma, Inc. | Mono-ladesystem zur selektiven einführung von nichtnativen aminosäuren in proteine anhand eines in-vitro-proteinsynthesesystems |
BR112012015597A2 (pt) | 2009-12-21 | 2017-01-31 | Ambrx Inc | peptídeos de somatotropina suínos modificados e seus usos |
MX349301B (es) | 2009-12-21 | 2017-07-21 | Ambrx Inc | Polipéptidos de somatotropina bovina modificados y sus usos. |
HUE045845T2 (hu) | 2010-08-17 | 2021-12-28 | Ambrx Inc | Módosított relaxin polipeptidek és felhasználásuk |
JP5818237B2 (ja) * | 2010-09-09 | 2015-11-18 | 国立大学法人 東京大学 | N−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 |
AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
US10195578B2 (en) | 2010-12-03 | 2019-02-05 | The University Of Tokyo | Peptide library production method, peptide library, and screening method |
EA036697B1 (ru) | 2014-10-24 | 2020-12-09 | Бристол-Майерс Сквибб Компани | Модифицированные полипептиды fgf-21 и их применение |
FI3849614T3 (fi) | 2018-09-11 | 2024-02-08 | Ambrx Inc | Interleukiini-2-polypeptidikonjugaatteja ja niiden käyttöjä |
JP2022512746A (ja) | 2018-10-19 | 2022-02-07 | アンブルックス,インコーポレイテッド | インターロイキン-10ポリペプチド複合体、その二量体、およびそれらの使用 |
BR112021015832A2 (pt) | 2019-02-12 | 2022-01-18 | Ambrx Inc | Composições que contêm conjugados de anticorpo-agonista de tlr, métodos e usos dos mesmos |
AU2021233909A1 (en) | 2020-03-11 | 2022-09-29 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and methods of use thereof |
AU2021327396A1 (en) | 2020-08-20 | 2023-03-23 | Ambrx, Inc. | Antibody-TLR agonist conjugates, methods and uses thereof |
WO2022212899A1 (en) | 2021-04-03 | 2022-10-06 | Ambrx, Inc. | Anti-her2 antibody-drug conjugates and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2084987C (en) | 1990-06-11 | 2007-02-13 | Larry Gold | Nucleic acid ligands |
US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
US5998142A (en) | 1993-09-08 | 1999-12-07 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
US6063566A (en) | 1994-05-13 | 2000-05-16 | The Scripps Research Institute | Catalytic RNA molecules |
ES2127106B1 (es) | 1996-03-21 | 1999-11-16 | Menarini Lab | Derivados benzopiranicos con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de los mismos. |
US5871924A (en) * | 1997-01-27 | 1999-02-16 | Nexstar Pharmaceuticals, Inc. | Method for the production of ligands capable of facilitating aminoacyl-RNA synthesis |
US6280936B1 (en) * | 1997-06-09 | 2001-08-28 | Ribozyme Pharmaceuticals, Inc. | Method for screening nucleic acid catalysts |
DE19801153A1 (de) * | 1998-01-14 | 1999-07-15 | Jenne Andreas | Verfahren zur Selektion von Ribozymen, die Ribonucleinsäuren in trans an 2'-OH-Gruppen kovalent modifizieren können und durch dieses Verfahren erhältliche Ribozyme |
WO2001038582A1 (en) * | 1999-11-24 | 2001-05-31 | The Research Foundation Of State University Of New York | CATALYTIC RNAs WITH AMINOACYLATION ACTIVITY |
-
2003
- 2003-02-18 US US10/369,036 patent/US7622248B2/en not_active Expired - Lifetime
- 2003-02-18 WO PCT/US2003/005007 patent/WO2003070740A1/en active Application Filing
- 2003-02-18 CA CA2476425A patent/CA2476425C/en not_active Expired - Lifetime
- 2003-02-18 DE DE60328587T patent/DE60328587D1/de not_active Expired - Lifetime
- 2003-02-18 EP EP03709182A patent/EP1483282B1/de not_active Expired - Lifetime
- 2003-02-18 AT AT03709182T patent/ATE437946T1/de not_active IP Right Cessation
- 2003-02-18 JP JP2003569647A patent/JP4464684B2/ja not_active Expired - Lifetime
- 2003-02-18 AU AU2003213136A patent/AU2003213136A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030228593A1 (en) | 2003-12-11 |
EP1483282A4 (de) | 2007-06-06 |
US7622248B2 (en) | 2009-11-24 |
EP1483282A1 (de) | 2004-12-08 |
AU2003213136A1 (en) | 2003-09-09 |
JP4464684B2 (ja) | 2010-05-19 |
EP1483282B1 (de) | 2009-07-29 |
CA2476425C (en) | 2012-04-17 |
WO2003070740A1 (en) | 2003-08-28 |
DE60328587D1 (de) | 2009-09-10 |
CA2476425A1 (en) | 2003-08-28 |
JP2005528090A (ja) | 2005-09-22 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |