KR101504392B1 - 아데노바이러스 벡터의 제조방법 - Google Patents
아데노바이러스 벡터의 제조방법 Download PDFInfo
- Publication number
- KR101504392B1 KR101504392B1 KR1020117010793A KR20117010793A KR101504392B1 KR 101504392 B1 KR101504392 B1 KR 101504392B1 KR 1020117010793 A KR1020117010793 A KR 1020117010793A KR 20117010793 A KR20117010793 A KR 20117010793A KR 101504392 B1 KR101504392 B1 KR 101504392B1
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- South Korea
- Prior art keywords
- cells
- cell
- bioreactor
- rad35
- infection
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- Expired - Fee Related
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19812208P | 2008-11-03 | 2008-11-03 | |
| EP08168181.9 | 2008-11-03 | ||
| US61/198,122 | 2008-11-03 | ||
| EP08168181 | 2008-11-03 | ||
| PCT/EP2009/064265 WO2010060719A1 (en) | 2008-11-03 | 2009-10-29 | Method for the production of adenoviral vectors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110093793A KR20110093793A (ko) | 2011-08-18 |
| KR101504392B1 true KR101504392B1 (ko) | 2015-03-19 |
Family
ID=40344776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117010793A Expired - Fee Related KR101504392B1 (ko) | 2008-11-03 | 2009-10-29 | 아데노바이러스 벡터의 제조방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10041049B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2350268B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5770633B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101504392B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102203242B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009319254B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0921651A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2742474C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2350268T3 (cg-RX-API-DMAC7.html) |
| EA (1) | EA019928B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2532015T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011004292A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ593235A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2350268T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010060719A1 (cg-RX-API-DMAC7.html) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11608486B2 (en) | 2015-07-02 | 2023-03-21 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2532015T3 (es) | 2008-11-03 | 2015-03-23 | Crucell Holland B.V. | Método para la producción de vectores adenovíricos |
| CA2777116C (en) | 2009-10-15 | 2020-09-01 | Crucell Holland B.V. | Process for adenovirus purification from high cell density cultures |
| MX2012004222A (es) | 2009-10-15 | 2012-06-08 | Crucell Holland Bv | Metodo para purificacion de particulas de adenovirus. |
| AU2011214262B2 (en) * | 2010-02-15 | 2015-05-21 | Crucell Holland B.V. | Method for the production of Ad26 adenoviral vectors |
| WO2012038367A1 (en) | 2010-09-20 | 2012-03-29 | Crucell Holland B.V. | Therapeutic vaccination against active tuberculosis |
| BR112013004582A2 (pt) | 2010-09-27 | 2016-09-06 | Crucell Holland Bv | método para induzir uma resposta imune em um sujeito contra um antígeno de um parasita que causa a malária |
| SG192611A1 (en) | 2011-02-10 | 2013-09-30 | Crucell Holland Bv | Pneumatic alternating pressure membrane cell separation system |
| US20130122038A1 (en) | 2011-11-14 | 2013-05-16 | The United States Of America As Represented By The Secretary Of The Department | Heterologous prime-boost immunization using measles virus-based vaccines |
| CN104379733B (zh) | 2012-03-12 | 2016-01-20 | 克鲁塞尔荷兰公司 | 具改变末端的重组腺病毒群 |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| BR112014023196B1 (pt) | 2012-03-22 | 2021-09-08 | Janssen Vaccines & Prevention B.V. | Vacinas contra o vírus sincicial respiratório (rsv), seu método de produção, e ácido nucleico recombinante isolado |
| US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
| HUE041659T2 (hu) | 2013-04-25 | 2019-05-28 | Janssen Vaccines & Prevention Bv | Stabilizált oldható pre-fúziós RSV F polipeptidek |
| MX362792B (es) | 2013-06-17 | 2019-02-13 | Janssen Vaccines & Prevention Bv | Polipeptidos f de prefusion del virus sincicial respiratorio (rsv) solubles y estabilizados. |
| CA2920934C (en) * | 2013-08-30 | 2022-12-06 | Glaxosmithkline Biologicals S.A. | Large scale production of viruses in cell culture |
| AU2015341926B2 (en) | 2014-11-04 | 2018-09-27 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV16 vaccines |
| PL3319633T3 (pl) | 2015-07-07 | 2021-04-19 | Janssen Vaccines & Prevention B.V. | Szczepionka przeciwko rsv |
| CN107847581B (zh) | 2015-07-07 | 2022-03-22 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| US9663766B2 (en) | 2015-07-24 | 2017-05-30 | Bio-Rad Laboratories, Inc. | Methods for purifying adenovirus vectors |
| HK1252967A1 (zh) | 2015-08-20 | 2019-06-06 | Janssen Vaccines & Prevention B.V. | 治疗性hpv18疫苗 |
| SG11201807913XA (en) | 2016-04-05 | 2018-10-30 | Janssen Vaccines & Prevention Bv | Stabilized soluble pre-fusion rsv f proteins |
| BR112018070323A2 (pt) | 2016-04-05 | 2019-01-29 | Janssen Vaccines & Prevention Bv | vacina contra rsv |
| AU2017249402A1 (en) * | 2016-04-12 | 2018-10-04 | Artemis Biosystems, Inc. | Perfusion filtration systems |
| EP3452087A1 (en) | 2016-05-02 | 2019-03-13 | Janssen Vaccines & Prevention B.V. | Therapeutic hpv vaccine combinations |
| BR112018074483A2 (pt) | 2016-05-30 | 2019-03-19 | Janssen Vaccines & Prevention B.V. | proteínas f do rsv pré-fusão estabilizadas |
| WO2018011196A1 (en) | 2016-07-14 | 2018-01-18 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
| CA3061278A1 (en) | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
| KR20200053518A (ko) | 2017-09-15 | 2020-05-18 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 면역의 안전한 유도를 위한 방법 |
| MA50502A (fr) | 2017-10-31 | 2020-09-09 | Janssen Vaccines & Prevention Bv | Adénovirus et utilisations associées |
| SG11202003398SA (en) | 2017-10-31 | 2020-05-28 | Janssen Vaccines & Prevention Bv | Adenovirus vectors and uses thereof |
| MX2020004492A (es) | 2017-10-31 | 2020-11-24 | Janssen Vaccines & Prevention Bv | Adenovirus y usos de los mismos. |
| KR20200077559A (ko) | 2017-10-31 | 2020-06-30 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
| CN111315780A (zh) * | 2017-12-11 | 2020-06-19 | 安进公司 | 双特异性抗体产品的连续制造工艺 |
| CN110317832B (zh) | 2018-03-28 | 2022-07-05 | 西比曼生物科技(香港)有限公司 | Gmp级规模化制备重组慢病毒载体的纯化制剂的方法 |
| CN110317791A (zh) | 2018-03-29 | 2019-10-11 | 西比曼生物科技(香港)有限公司 | Gmp级无血清悬浮细胞大规模生产慢病毒的方法 |
| WO2019209632A1 (en) | 2018-04-24 | 2019-10-31 | Merck Sharp & Dohme Corp. | Scalable chromatography process for purification of human cytomegalovirus |
| CR20210306A (es) | 2018-11-13 | 2021-07-22 | Janssen Vaccines & Prevention Bv | Proteínas f de prefusión del vrs estabilizadas |
| MX2022000002A (es) * | 2019-07-01 | 2022-03-17 | Ology Bioservices Inc | Método para cultivo de células adherentes en un biorreactor multiparalelo. |
| TW202204380A (zh) | 2020-01-31 | 2022-02-01 | 美商詹森藥物公司 | 用於預防及治療冠狀病毒感染之組合物及方法-sars-cov-2疫苗 |
| GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
| JP2023545731A (ja) | 2020-10-07 | 2023-10-31 | アスクレピオス バイオファーマシューティカル, インコーポレイテッド | 肢帯型2i(lgmd2i)を含むジストログリカノパチー障害を処置するためのフクチン関連タンパク質(fkrp)の治療的アデノ随伴ウイルス送達 |
| CN118234739A (zh) | 2021-04-01 | 2024-06-21 | 扬森疫苗与预防公司 | 稳定的融合前piv3 f蛋白 |
| WO2023020939A1 (en) | 2021-08-17 | 2023-02-23 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
| WO2023111725A1 (en) | 2021-12-14 | 2023-06-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
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| EP4590690A1 (en) | 2022-09-23 | 2025-07-30 | Janssen Vaccines & Prevention B.V. | Pre-fusion human piv1 f proteins |
| CN120344553A (zh) | 2022-10-06 | 2025-07-18 | Msd国际商务股份有限公司 | 稳定的融合前piv3 f蛋白 |
Citations (2)
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| WO2005080556A2 (en) * | 2004-02-23 | 2005-09-01 | Crucell Holland B.V. | Virus purification methods |
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| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| US11795432B2 (en) | 2014-03-25 | 2023-10-24 | Terumo Bct, Inc. | Passive replacement of media |
| US11608486B2 (en) | 2015-07-02 | 2023-03-21 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11634677B2 (en) | 2016-06-07 | 2023-04-25 | Terumo Bct, Inc. | Coating a bioreactor in a cell expansion system |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US11702634B2 (en) | 2017-03-31 | 2023-07-18 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2742474A1 (en) | 2010-06-03 |
| AU2009319254A1 (en) | 2010-06-03 |
| ES2532015T3 (es) | 2015-03-23 |
| KR20110093793A (ko) | 2011-08-18 |
| CA2742474C (en) | 2016-05-31 |
| EA019928B1 (ru) | 2014-07-30 |
| JP2012507270A (ja) | 2012-03-29 |
| MX2011004292A (es) | 2011-05-31 |
| DK2350268T3 (en) | 2015-03-23 |
| EP2350268A1 (en) | 2011-08-03 |
| JP5770633B2 (ja) | 2015-08-26 |
| US10041049B2 (en) | 2018-08-07 |
| CN102203242B (zh) | 2013-06-12 |
| CN102203242A (zh) | 2011-09-28 |
| AU2009319254B2 (en) | 2015-04-30 |
| NZ593235A (en) | 2013-02-22 |
| EA201170638A1 (ru) | 2011-12-30 |
| WO2010060719A1 (en) | 2010-06-03 |
| BRPI0921651A2 (pt) | 2015-08-18 |
| US20110207202A1 (en) | 2011-08-25 |
| HK1160664A1 (en) | 2012-08-10 |
| EP2350268B1 (en) | 2014-12-24 |
| PL2350268T3 (pl) | 2015-05-29 |
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