HRP20161606T1 - Novi postupak i pripravci - Google Patents

Novi postupak i pripravci Download PDF

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Publication number
HRP20161606T1
HRP20161606T1 HRP20161606TT HRP20161606T HRP20161606T1 HR P20161606 T1 HRP20161606 T1 HR P20161606T1 HR P20161606T T HRP20161606T T HR P20161606TT HR P20161606 T HRP20161606 T HR P20161606T HR P20161606 T1 HRP20161606 T1 HR P20161606T1
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HR
Croatia
Prior art keywords
vaccine preparation
immunogenic
preparation according
immunogenic polypeptides
nef
Prior art date
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HRP20161606TT
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English (en)
Inventor
Gerald Hermann Voss
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Glaxosmithkline Biologicals Sa
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39415279&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20161606(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of HRP20161606T1 publication Critical patent/HRP20161606T1/hr

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Claims (16)

1. Cjepivni pripravak, naznačen time što sadrži (i) jedan ili više prvih imunogenih polipeptida, naznačen time što sadrži jedan ili više HIV antigensa, koje se bira između Env, Nef, Gag i/ili Pol, ili imunogenog fragmenta; (ii) jedan ili više adenovirusnih vektora, koji sadrže jedan ili više heterolognih polinukleotida koji kodiraju jedan ili više drugih imunogenih polipeptida, koji sadrže jedan ili više HIV antigena, koji se biraju između Env, Nef, Gag i/ili Pol, ili imunogenog fragmenta; i (iii) adjuvans, koji sadrži 3D-MPL i QS21.
2. Cjepivni pripravak u skladu s patentnim zahtjevom 1, naznačen time što je jedan ili više od navedenih jednog ili više prvih imunogenih polipeptida uglavnom isti, ili sadrži najmanje jedan antigen koji je uglavnom isti kao antigen sadržan u jednom ili više od navedenih jednog ili više drugih imunogenih polipeptida.
3. Cjepivni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što jedan ili više prvih imunogenih polipeptida sadrži najmanje jedan T-stanični epitop i/ili najmanje jedan B-stanični epitop.
4. Cjepivni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što jedan ili više od navedenih jednog ili više prvih imunogenih polipeptida i jedan ili više od navedenih jednog ili više drugih imunogenih polipeptida dijele jednu ili više istovjetnih B-staničnih i/ili T-staničnih epitopa.
5. Cjepivni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što niti jedan od jednog ili više od navedenih jednog ili više prvih imunogenih polipeptida nije uglavnom isti kao ili ne sadrži niti jedan antigen zajednički jednom ili više od navedenih jednog ili više drugih imunogenih polipeptida.
6. Cjepivni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je jedan ili više adenovirusnih vektora izveden iz ljudskog adenovirusa ili neljudskog primatskog adenovirusa.
7. Cjepivni pripravak u skladu s patentnim zahtjevom 6, naznačen time što se serotip ljudskog adenovirusa bira između Ad1, Ad2, Ad4, Ad5, Ad6, Ad11, Ad 24, Ad34 i Ad35, a serotip neljudskog primatskog adenovirusa se bira između serotipova adenovirusa Pan5, Pan6, Pan7 i Pan9 čimpanze.
8. Cjepivni pripravak u skladu s patentnim zahtjevom 1, naznačen time što je prvi imunogeni polipeptid p24-RT-Nef-p17 i/ili drugi imunogeni polipeptid je Gag-RT-Nef.
9. Cjepivni pripravak prema patentnom zahtjevu 8, naznačen time što jedan ili više prvih imunogenih polipeptida i/ili jedan ili više drugih imunogenih polipeptida sadrže Env.
10. Cjepivni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što adjuvans dodatno sadrži CpG.
11. Cjepivni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što adjuvans sadrži emulziju ulja u vodi, ili što adjuvans sadrži liposome.
12. Cjepivni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je namijenjen upotrebi u poticanju imunosnog odgovora protiv HIV-a ili upotrebi u stimuliranju proizvodnje CD4+ i/ili CD8+ T-stanica i/ili protutijela specifičnih za HIV kod sisavaca.
13. Upotreba cjepivnog pripravka u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što je cjepivni pripravak namijenjen proizvodnji medikamenta za poticanje imunosnog odgovora protiv HIV-a ili za stimuliranje proizvodnje CD4+ i/ili CD8+ T-stanica i/ili protutijela specifičnih za HIV kod sisavaca.
14. Komplet, naznačen time što sadrži (i) jedan ili više prvih imunogenih polipeptida, koje se bira između HIV Env, Nef, Gag i/ili Pol, ili imunogenog fragmenta; (ii) jedan ili više adenovirusnih vektora, koji sadrže jedan ili više heterolognih polinukleotida, koji kodiraju jedan ili više drugih imunogenih polipeptida, koji se biraju između HIV Env, Nef, Gag i/ili Pol, ili imunogenog fragmenta; i (iii) adjuvans, koji sadrži 3D- MPL i QS21.
15. Cjepivni pripravak, ili upotreba, ili komplet u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačeni time što prvi imunogeni polipeptid sadrži p24-RT-Nef-p17, gdje adjuvans sadrži 3D-MPL i QS21 u liposomskoj formulaciji, a adenovirusni vektor sadrži serotip adenovirusa Pan7 čimpanze kao vektor, koji sadrži polinukleotid koji kodira imunogeni polipeptid Gag-RT-Nef, koji može biti kodonski optimiran.
16. Cjepivni pripravak, ili upotreba, ili komplet u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačeni time što se jedan, ili dva, ili svi od polipeptida, adenovirusni vektor i adjuvantne komponente kombiniraju s farmaceutski prihvatljivom pomoćnom tvari.
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Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040136963A1 (en) * 2001-06-22 2004-07-15 The Trustees Of The University Of Pennsylvania Simian adenovirus vectors and methods of use
EP3108899A1 (en) 2001-11-21 2016-12-28 The Trustees of the University of Pennsylvania Simian adenovirus adsv1 nucleic acid and amino acid sequences, vectors containing same, and methods of use
US20090110695A1 (en) * 2006-03-27 2009-04-30 Menzo Jans Emko Havenga Compositions Comprising a Recombinant Adenovirus and an Adjuvant
US9717788B2 (en) 2007-03-02 2017-08-01 Glaxosmithkline Biologicals Sa Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant
MX2009009342A (es) * 2007-03-02 2009-09-11 Glaxosmithkline Biolog Sa Metodo novedoso y composiciones.
US8400408B2 (en) * 2007-06-13 2013-03-19 Apple Inc. Touch screens with transparent conductive material resistors
GB2452958A (en) * 2007-09-20 2009-03-25 Glaxosmithkline Biolog Sa HIV vaccine compositions
JP2011505796A (ja) * 2007-12-06 2011-03-03 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
KR20110060891A (ko) * 2008-07-25 2011-06-08 글락소스미스클라인 바이오로지칼즈 에스.에이. 신규한 조성물 및 방법
HUE039159T2 (hu) 2008-07-25 2018-12-28 Glaxosmithkline Biologicals Sa Tuberkulózis Rv2386c protein, ezt tartalmazó készítmények és ezek alkalmazása
GB0815872D0 (en) * 2008-09-01 2008-10-08 Pasteur Institut Novel method and compositions
CA2742474C (en) * 2008-11-03 2016-05-31 Crucell Holland B.V. Method for the production of adenoviral vectors
KR20120129927A (ko) * 2010-01-27 2012-11-28 글락소 그룹 리미티드 변형된 투베르쿨로시스 항원
CN103221065A (zh) * 2010-03-26 2013-07-24 葛兰素史密斯克莱生物公司 Hiv疫苗
ITRM20100411A1 (it) * 2010-07-23 2012-01-24 Massimo Amicosante Uso di sequenze amminoacidiche da mycobacterium tuberculosis o dei loro corrispondenti acidi nucleici per la diagnosi e la prevenzione di infezione tubercolare, relativo kit diagnostico e vaccino.
AU2011310643A1 (en) * 2010-09-27 2013-04-11 Glaxosmithkline Biologicals S.A. Vaccine
CN102260712B (zh) * 2011-05-31 2013-10-02 北京锤特生物科技有限公司 溶肿瘤能力增强的B型人腺病毒Ad11突变体的构建和应用
WO2015092710A1 (en) 2013-12-19 2015-06-25 Glaxosmithkline Biologicals, S.A. Contralateral co-administration of vaccines
WO2015136479A1 (en) * 2014-03-12 2015-09-17 Glaxosmithkline Biologicals S.A. Liposomal compositions for mucosal delivery
WO2015136480A1 (en) * 2014-03-12 2015-09-17 Glaxosmithkline Biologicals S.A. Immunogenic liposomal formulation
GB201405921D0 (en) * 2014-04-02 2014-05-14 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
US11571472B2 (en) 2014-06-13 2023-02-07 Glaxosmithkline Biologicals Sa Immunogenic combinations
KR102159626B1 (ko) 2014-09-26 2020-09-25 베쓰 이스라엘 디코니스 메디칼 센터 인크 인간 면역 결핍 바이러스 감염에 대한 방어 면역을 유도하기 위한 방법 및 조성물
AU2016275619B2 (en) 2015-06-12 2019-09-19 Glaxosmithkline Biologicals Sa Adenovirus polynucleotides and polypeptides
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
DK3390430T3 (da) 2015-12-15 2019-11-18 Janssen Vaccines & Prevention Bv Human immundefektvirus-antigener, vektorer, sammensætninger og fremgangsmåder til anvendelse deraf
WO2017189448A1 (en) 2016-04-25 2017-11-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bivalent immunogenic conjugate for malaria and typhoid
AU2017286375B2 (en) 2016-06-16 2019-04-18 Janssen Vaccines & Prevention B.V. HIV vaccine formulation
CN106248934B (zh) * 2016-08-25 2018-04-06 中国疾病预防控制中心传染病预防控制所 结核分枝杆菌抗原蛋白Rv0446c及其T细胞表位肽的应用
CN106248935B (zh) * 2016-08-31 2018-04-06 中国疾病预防控制中心传染病预防控制所 结核分枝杆菌抗原蛋白Rv1798及其T细胞表位肽的应用
AU2017318689A1 (en) 2016-09-02 2019-04-11 Beth Israel Deaconess Medical Center, Inc. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
IL265186B (en) 2016-09-15 2022-09-01 Janssen Vaccines Prevention B V HIV envelope proteins with trimer-stabilizing mutations
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
GB201701239D0 (en) 2017-01-25 2017-03-08 Glaxosmithkline Biologicals Sa Novel formulation
JP7291633B2 (ja) 2017-05-30 2023-06-15 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム アジュバントを製造する方法
CN110958887B (zh) 2017-06-15 2023-10-31 扬森疫苗与预防公司 编码hiv抗原的痘病毒载体及其使用方法
CN110891601A (zh) 2017-07-19 2020-03-17 扬森疫苗与预防公司 三聚体稳定性hiv包膜蛋白突变
CA3083078A1 (en) 2017-12-01 2019-06-06 Glaxosmithkline Biologicals Sa Saponin purification
US20200397892A1 (en) * 2018-02-22 2020-12-24 Turnstone Limited Partnership Oncolytic viruses as adjuvants
EP3856238A1 (en) * 2018-09-25 2021-08-04 Janssen Vaccines & Prevention B.V. Method of inducing an immune response against human immunodeficiency virus by co-localized administration of vaccine components
US20220211835A1 (en) * 2019-04-17 2022-07-07 The Wistar Institute Replication Deficient Adenoviral Vectors for HIV Vaccine Applications
US20220235095A1 (en) 2019-06-05 2022-07-28 Glaxosmithkline Biologicals Sa Saponin purification
CN110327314B (zh) * 2019-07-23 2021-10-22 中国人民解放军军事科学院军事医学研究院 一种可气溶胶化的A型肉毒毒素AHc亚单位疫苗干粉吸入剂
CN112220921B (zh) * 2020-08-25 2022-08-16 北京交通大学 一种针对呼吸道合胞病毒感染的组合疫苗
RU2752967C1 (ru) * 2021-02-10 2021-08-11 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) Способ индукции антигенассоциированного иммунного ответа
WO2023242155A1 (en) * 2022-06-14 2023-12-21 Janssen Vaccines & Prevention B.V. Compositions and methods for the diagnosis of hiv infection

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB8819209D0 (en) 1988-08-12 1988-09-14 Research Corp Ltd Polypeptide & dna encoding same
AU626961B2 (en) 1988-12-16 1992-08-13 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur Pneumolysin mutants and pneumococcal vaccines made therefrom
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
US7476389B1 (en) 1991-07-19 2009-01-13 The University Of Queensland Papillomavirus vaccines
DE69228698T2 (de) 1991-11-16 1999-09-16 Smithkline Beecham Biologicals S.A., Rixensart HYBRIDES PROTEIN ZWISCHEN CS AUS PLASMODIUM UND HBsAG
DE122007000095I1 (de) 1992-06-25 2008-03-27 Papillomavirus vakzine
ES2143716T3 (es) 1992-06-25 2000-05-16 Smithkline Beecham Biolog Composicion de vacuna que contiene adyuvantes.
US5437951A (en) 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
DE122007000014I1 (de) 1993-03-09 2007-05-24 Univ Rochester Herstellung von menschlichem Papillomavirus Hüllprotein und virus-ähnlichen Teilchen
SG48309A1 (en) 1993-03-23 1998-04-17 Smithkline Beecham Biolog Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
PT729473E (pt) 1993-11-17 2001-02-28 Deutsche Om Arzneimittel Gmbh Dissacaridos de glucosamina metodo para a sua preparacao composicao farmaceutica contendo os mesmos e sua utilizacao
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
EP1167377B2 (en) 1994-07-15 2012-08-08 University of Iowa Research Foundation Immunomodulatory oligonucleotides
EP1728800A1 (de) 1994-10-07 2006-12-06 Loyola University Of Chicago Papillomavirusähnliche Partikel, Fusionsproteine sowie Verfahren zu deren Herstellung
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
WO1996026277A1 (en) 1995-02-24 1996-08-29 Cantab Pharmaceuticals Research Limited Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
GB9620795D0 (en) 1996-10-05 1996-11-20 Smithkline Beecham Plc Vaccines
US5843464A (en) 1995-06-02 1998-12-01 The Ohio State University Synthetic chimeric fimbrin peptides
WO1998010087A1 (en) 1996-09-06 1998-03-12 Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
ES2241042T3 (es) 1996-10-11 2005-10-16 The Regents Of The University Of California Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora.
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6303347B1 (en) 1997-05-08 2001-10-16 Corixa Corporation Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
US6764840B2 (en) 1997-05-08 2004-07-20 Corixa Corporation Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
GB9711990D0 (en) 1997-06-11 1997-08-06 Smithkline Beecham Biolog Vaccine
AU740956B2 (en) 1997-07-21 2001-11-15 Baxter Healthcare Sa Modified immunogenic pneumolysin compositions as vaccines
ES2500490T3 (es) 1997-08-29 2014-09-30 Antigenics Inc. Composiciones que comprenden el adyuvante QS-21 y polisorbato o ciclodextrina como excipiente
DE69815692T2 (de) 1997-09-05 2004-04-29 Glaxosmithkline Biologicals S.A. Öl in wasser emulsionen mit saponinen
GB9718901D0 (en) 1997-09-05 1997-11-12 Smithkline Beecham Biolog Vaccine
CN1163602C (zh) 1998-04-07 2004-08-25 科里克萨公司 结核杆菌抗原融合蛋白及其应用
HUP0102332A3 (en) 1998-06-08 2002-11-28 Sca Emballage France Fast flattening packaging
ATE355266T1 (de) 1998-06-30 2006-03-15 Om Pharma Neue acylierte pseudodipeptide, verfahren zu ihrer herstellung, und diese enthaltende pharmazeutische zusammensetzungen
WO2001046127A1 (fr) 1999-12-22 2001-06-28 Om Pharma Pseudodipeptides acyles porteurs d'un bras auxiliaire fonctionnalise
NZ520327A (en) * 2000-01-31 2004-06-25 Smithkline Beecham Biolog S Use of human immunodeficiency virus proteins in vaccines
GB0027088D0 (en) 2000-11-06 2000-12-20 Glaxo Group Ltd DNA expression vectors
GB0019375D0 (en) 2000-08-07 2000-09-27 Int Centre Genetic Eng & Bio Method of polypeptide renaturation
JP2004508064A (ja) * 2000-09-15 2004-03-18 メルク　エンド　カムパニー　インコーポレーテッド コドン最適化ｈｉｖ１−ｇａｇ、ｐｏｌ、ｎｅｆおよび修飾体を発現する増強された第１世代アデノウイルスワクチン
KR20040043129A (ko) 2001-06-22 2004-05-22 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 세포독성 면역 반응을 유도하는 방법과 그에 유용한재조합체 원숭이 아데노바이러스 조성물
GB0118367D0 (en) * 2001-07-27 2001-09-19 Glaxosmithkline Biolog Sa Novel use
EP1427826B1 (en) 2001-09-20 2011-04-20 Glaxo Group Limited HIV- RT-nef-Gag codon optimised DNA vaccines
EP3108899A1 (en) 2001-11-21 2016-12-28 The Trustees of the University of Pennsylvania Simian adenovirus adsv1 nucleic acid and amino acid sequences, vectors containing same, and methods of use
CN100333791C (zh) * 2002-10-23 2007-08-29 葛兰素史密丝克莱恩生物有限公司 抗疟疾的疫苗接种方法
GB0225788D0 (en) * 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
WO2004110482A1 (en) * 2003-06-13 2004-12-23 Isis Innovation Limited Improved vaccines
WO2005001103A2 (en) 2003-06-20 2005-01-06 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
GB0321615D0 (en) 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
GB0417494D0 (en) * 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
GB0420634D0 (en) * 2004-09-16 2004-10-20 Glaxosmithkline Biolog Sa Vaccines
EA201001322A1 (ru) 2005-03-31 2011-02-28 Глаксосмитклайн Байолоджикалс С.А. Вакцины против хламидиоза
ATE543832T1 (de) 2005-04-29 2012-02-15 Glaxosmithkline Biolog Sa Verfahren zur vorbeugung oder behandlung einer m.-tuberculosis-infektion
JP5175178B2 (ja) * 2005-05-12 2013-04-03 グラクソ グループ リミテッド ワクチン組成物
GB0513421D0 (en) * 2005-06-30 2005-08-03 Glaxosmithkline Biolog Sa Vaccines
AT502275B8 (de) 2005-08-08 2007-08-15 Greenhills Biotechnology Res D Immunantwort-induzierende zusammensetzungen
US20100209451A1 (en) * 2006-06-16 2010-08-19 Introgen Therapeutics, Inc. Compositions and Methods Related to Adenovirus Based Delivery of Antigens
MX2009009342A (es) * 2007-03-02 2009-09-11 Glaxosmithkline Biolog Sa Metodo novedoso y composiciones.
GB0706914D0 (en) * 2007-04-10 2007-05-16 Isis Innovation Novel adenovirus vectors
GB2452958A (en) * 2007-09-20 2009-03-25 Glaxosmithkline Biolog Sa HIV vaccine compositions
GB0815872D0 (en) * 2008-09-01 2008-10-08 Pasteur Institut Novel method and compositions
WO2010037027A2 (en) * 2008-09-26 2010-04-01 Auburn University Immunization of avians by mucosal administration of non-replicating vectored vaccines

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US20100055166A1 (en) 2010-03-04
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