EA200900032A1 - Вакцины против малярии - Google Patents

Вакцины против малярии

Info

Publication number
EA200900032A1
EA200900032A1 EA200900032A EA200900032A EA200900032A1 EA 200900032 A1 EA200900032 A1 EA 200900032A1 EA 200900032 A EA200900032 A EA 200900032A EA 200900032 A EA200900032 A EA 200900032A EA 200900032 A1 EA200900032 A1 EA 200900032A1
Authority
EA
Eurasian Patent Office
Prior art keywords
protein
particle
hepatitis
virus
antigen
Prior art date
Application number
EA200900032A
Other languages
English (en)
Inventor
Джозеф Д. Коэн
Мартин Маршан
Кристиан Ф. Окенхаус
Анджали Ядава
Original Assignee
Глаксосмитклайн Байолоджикалс С.А.
Де Юнайтед Стейтс Оф Америка, Эз Репрезентид Бай Де Секретари Оф Де Арми
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0614254.1A external-priority patent/GB0614254D0/en
Priority claimed from GB0614473A external-priority patent/GB0614473D0/en
Priority claimed from GB0614476A external-priority patent/GB0614476D0/en
Priority claimed from GB0615115A external-priority patent/GB0615115D0/en
Application filed by Глаксосмитклайн Байолоджикалс С.А., Де Юнайтед Стейтс Оф Америка, Эз Репрезентид Бай Де Секретари Оф Де Арми filed Critical Глаксосмитклайн Байолоджикалс С.А.
Publication of EA200900032A1 publication Critical patent/EA200900032A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к липопротеиновой частице, способам ее получения и очистки, ее применению в медицине, в частности в предотвращении малярийных инфекций, композициям/вакцинам, содержащим указанную частицу или антитела против белковой частицы, такие как моноклональные или поликлональные антитела, и их применению, в частности в терапии. В частности, оно относится к иммуногенной белковой частице, содержащей следующие мономеры: (а) слитый белок, содержащий последовательности, имеющие происхождение из белка CS P. vivax и антигена S вируса гепатита В (CSV-S), и (б) слитый белок, содержащий последовательности, имеющие происхождение из белка CS P. falciparum и антигена S вируса гепатита В (RTS), и (в) возможно, антиген S, имеющий происхождение из вируса гепатита В.
EA200900032A 2006-07-18 2007-07-16 Вакцины против малярии EA200900032A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0614254.1A GB0614254D0 (en) 2006-07-18 2006-07-18 Vaccine
GB0614473A GB0614473D0 (en) 2006-07-20 2006-07-20 Vaccines
GB0614476A GB0614476D0 (en) 2006-07-20 2006-07-20 Vaccine
GB0615115A GB0615115D0 (en) 2006-07-28 2006-07-28 Vaccines
PCT/EP2007/057296 WO2008009650A2 (en) 2006-07-18 2007-07-16 Vaccines for malaria

Publications (1)

Publication Number Publication Date
EA200900032A1 true EA200900032A1 (ru) 2011-02-28

Family

ID=38957130

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200900033A EA200900033A1 (ru) 2006-07-18 2007-07-16 Вакцины против малярии
EA200900032A EA200900032A1 (ru) 2006-07-18 2007-07-16 Вакцины против малярии

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200900033A EA200900033A1 (ru) 2006-07-18 2007-07-16 Вакцины против малярии

Country Status (22)

Country Link
US (2) US9364525B2 (ru)
EP (2) EP2040742B1 (ru)
JP (2) JP5222289B2 (ru)
KR (2) KR20090094213A (ru)
AR (1) AR061894A1 (ru)
AU (2) AU2007276219B2 (ru)
BR (2) BRPI0714326A2 (ru)
CA (2) CA2657353A1 (ru)
CO (2) CO6150189A2 (ru)
CR (2) CR10561A (ru)
EA (2) EA200900033A1 (ru)
ES (2) ES2437082T3 (ru)
IL (2) IL196410A0 (ru)
MA (2) MA30671B1 (ru)
MX (2) MX2009000650A (ru)
NO (2) NO20090177L (ru)
NZ (2) NZ574239A (ru)
PE (1) PE20080428A1 (ru)
SG (2) SG173377A1 (ru)
TW (1) TW200819462A (ru)
WO (2) WO2008009652A2 (ru)
ZA (1) ZA200900386B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040136963A1 (en) * 2001-06-22 2004-07-15 The Trustees Of The University Of Pennsylvania Simian adenovirus vectors and methods of use
BR0214350A (pt) 2001-11-21 2005-05-10 Univ Pennsylvania Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso
KR20090094213A (ko) * 2006-07-18 2009-09-04 글락소스미스클라인 바이오로지칼즈 에스.에이. 말라리아 백신
WO2009071613A2 (en) * 2007-12-06 2009-06-11 Glaxosmithkline Biologicals S.A. Vaccine
AP2010005294A0 (en) * 2007-12-24 2010-06-30 Glaxosmithkline Biolog Sa Vaccines for malaria
AU2009297127A1 (en) * 2008-09-24 2010-04-01 The Government Of The United States, As Represented By The Secretary Of The Army Malaria vaccine
JP5770633B2 (ja) * 2008-11-03 2015-08-26 クルセル ホランド ベー ヴェー アデノウイルスベクターの産生方法
US8784832B2 (en) 2011-08-19 2014-07-22 University Of South Florida (A Florida Non-Profit Corporation) Synthetic antigen based on the ligand domain of the Plasmodium vivax duffy binding protein
GB201116248D0 (en) 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
WO2013123412A1 (en) * 2012-02-17 2013-08-22 Children's Medical Center Corporation Conformation-stabilized trap antigens
US9821046B2 (en) 2013-01-21 2017-11-21 Oxford University Innovation Limited Composition and uses thereof
EP3213638A1 (en) 2016-03-01 2017-09-06 Coöperatie Avebe U.A. Vegan cheese analogue
GB201608821D0 (en) 2016-05-19 2016-07-06 Isis Innovation Vaccines
CN110035770B (zh) 2016-12-07 2023-06-16 葛兰素史密丝克莱恩生物有限公司 新方法
BR112019012843A2 (pt) * 2016-12-23 2019-12-17 The Walter And Eliza Hall Institute Of Medical Research teste de diagnóstico, e, aparelho, sistema e método para o diagnóstico de p. vivax ou p. ovale.
DE112020007612T5 (de) 2020-09-16 2023-06-29 Mitsubishi Electric Corporation Scheinwerfereinrichtung

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
ATE118784T1 (de) * 1985-07-12 1995-03-15 Univ New York Mit dem plasmodium-vivax-circumsporozoit-protein übereinstimmendes immunogenes peptidantigen.
US4826957A (en) * 1985-07-12 1989-05-02 New York University Immunogenic recombinant yeast expression product and method for purifying it
US5554372A (en) 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
JPH0222300A (ja) * 1987-02-02 1990-01-25 Swiss Serum & Vaccine Inst Bern 免疫原性接合体およびその製法ならびに免疫を生ぜしめる方法
US4997647A (en) * 1987-03-30 1991-03-05 New York University Vaccine against the sporozoite stage of malaria
AU614755B2 (en) 1987-06-05 1991-09-12 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Autocrine motility factors in cancer diagnosis and management
US5278302A (en) 1988-05-26 1994-01-11 University Patents, Inc. Polynucleotide phosphorodithioates
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US4977647A (en) * 1989-10-27 1990-12-18 D.B. Industries, Inc. Double locking snap hook
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
ES2129461T3 (es) * 1991-11-16 1999-06-16 Smithkline Beecham Biolog Proteina hibrida entre cs de plasmodium y hbsag.
JP3755890B2 (ja) 1992-06-25 2006-03-15 スミスクライン・ビーチャム・バイオロジカルス（ソシエテ・アノニム） アジュバント含有ワクチン組成物
CN1087176C (zh) 1993-03-23 2002-07-10 史密斯克莱·比奇曼生物公司 含有3－o脱酰基单磷酰脂a的疫苗制剂
CN1134173A (zh) * 1993-09-10 1996-10-23 美国国有健康与人类服务部 间日疟原虫和镰状疟原虫红细胞结合蛋白的结合区
WO1995014026A1 (en) 1993-11-17 1995-05-26 Laboratoires Om S.A. Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
WO1995026204A1 (en) 1994-03-25 1995-10-05 Isis Pharmaceuticals, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
GB9620795D0 (en) 1996-10-05 1996-11-20 Smithkline Beecham Plc Vaccines
UA56132C2 (ru) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиция вакцины (варианты), способ стабилизации qs21 по отношению к гидролизу (варианты), способ приготовления вакцины
US5666153A (en) 1995-10-03 1997-09-09 Virtual Shopping, Inc. Retractable teleconferencing apparatus
GB9616351D0 (en) 1996-08-02 1996-09-11 Smithkline Beecham Biolog Vaccine composition
US20030133944A1 (en) 2001-04-05 2003-07-17 Smithkline Beecham Biologicals S.A. Vaccine composition against malaria
US6083716A (en) 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
US6764840B2 (en) 1997-05-08 2004-07-20 Corixa Corporation Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
US6303347B1 (en) 1997-05-08 2001-10-16 Corixa Corporation Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
GB9711990D0 (en) 1997-06-11 1997-08-06 Smithkline Beecham Biolog Vaccine
HUP0102475A3 (en) 1998-06-30 2001-12-28 Om Pharma Novel acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same
KR20000020497A (ko) 1998-09-21 2000-04-15 임채승 말라리아의 검출방법
US6558670B1 (en) 1999-04-19 2003-05-06 Smithkline Beechman Biologicals S.A. Vaccine adjuvants
KR100922031B1 (ko) 1999-04-19 2009-10-19 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
WO2001034188A1 (en) * 1999-11-12 2001-05-17 University Of Hawaii Malaria vaccine
AU1581400A (en) 1999-12-22 2001-07-03 Om Pharma Acyl pseudopeptides bearing a functionalised auxiliary spacer
GB0027088D0 (en) 2000-11-06 2000-12-20 Glaxo Group Ltd DNA expression vectors
US6942866B2 (en) * 2000-08-16 2005-09-13 Apovia, Inc. Malaria immunogen and vaccine
EP1201250A1 (en) * 2000-10-25 2002-05-02 SMITHKLINE BEECHAM BIOLOGICALS s.a. Immunogenic compositions comprising liver stage malarial antigens
PT1409012E (pt) 2001-06-22 2009-05-11 Wistar Inst Métodos de indução de uma resposta imunitária citotóxica e composições de adenovírus recombinantes de símio úteis para esse efeito
NZ539509A (en) 2002-10-23 2008-05-30 Glaxosmithkline Biolog Sa Priming vaccine comprising a polynucleotide encoding at least one first malarial antigen and a boosting vaccine comprising at least one polypeptide comprising at least one second malarial antigen having at least one epitope in common with the first malarial antigen of the priming vaccine
SG156535A1 (en) 2002-12-17 2009-11-26 Crucell Holland Bv Recombinant viral-based malaria vaccines
WO2004113369A1 (de) 2003-06-20 2004-12-29 Dade Behring Marburg Gmbh NEUE OBERFLÄCHENPROTEIN- (HbsAg-) VARIANTE DES HEPATITIS B VIRUS
ES2478625T3 (es) 2003-06-20 2014-07-22 The Trustees Of The University Of Pennsylvania Método de generación de adenovirus quiméricos y usos de tales adenovirus quiméricos
US20050233435A1 (en) * 2003-09-04 2005-10-20 Nyu Medical Center Plasmodium axenic liver stages as a noninfectious whole organism malaria vaccine
GB0321615D0 (en) 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
US20060041248A1 (en) * 2004-08-23 2006-02-23 Patton David L Pharmaceutical compositions delivery system and methods
GB0420634D0 (en) 2004-09-16 2004-10-20 Glaxosmithkline Biolog Sa Vaccines
WO2006088597A2 (en) * 2005-01-18 2006-08-24 Walter Read Army Institute Of Research A plasmodium vivax hybrid circumsporozoite protein and vaccine
GB0513421D0 (en) * 2005-06-30 2005-08-03 Glaxosmithkline Biolog Sa Vaccines
KR20090094213A (ko) * 2006-07-18 2009-09-04 글락소스미스클라인 바이오로지칼즈 에스.에이. 말라리아 백신
AP2010005294A0 (en) * 2007-12-24 2010-06-30 Glaxosmithkline Biolog Sa Vaccines for malaria

Also Published As

Publication number Publication date
MX2009000655A (es) 2009-07-02
BRPI0714326A2 (pt) 2013-05-07
CR10561A (es) 2009-04-29
ES2525732T3 (es) 2014-12-29
MA30670B1 (fr) 2009-08-03
NO20090177L (no) 2009-02-16
US20100150998A1 (en) 2010-06-17
MA30671B1 (fr) 2009-08-03
WO2008009652A2 (en) 2008-01-24
CO6150187A2 (es) 2010-04-20
BRPI0715581A2 (pt) 2013-04-24
JP5592110B2 (ja) 2014-09-17
PE20080428A1 (es) 2008-05-15
EA200900033A1 (ru) 2009-12-30
AR061894A1 (es) 2008-10-01
EP2040742B1 (en) 2014-10-29
JP2009543569A (ja) 2009-12-10
CA2657353A1 (en) 2008-01-24
SG173377A1 (en) 2011-08-29
AU2007276217B2 (en) 2013-08-29
IL196471A0 (en) 2011-08-01
IL196410A0 (en) 2011-08-01
MX2009000650A (es) 2009-07-02
EP2040743A2 (en) 2009-04-01
AU2007276217A8 (en) 2009-02-26
US20100062028A1 (en) 2010-03-11
US9592282B2 (en) 2017-03-14
NZ574239A (en) 2011-12-22
AU2007276219A1 (en) 2008-01-24
WO2008009650A3 (en) 2008-04-10
CO6150189A2 (es) 2010-04-20
US9364525B2 (en) 2016-06-14
EP2040743B1 (en) 2013-10-02
AU2007276219B2 (en) 2013-10-03
JP5222289B2 (ja) 2013-06-26
EP2040742A2 (en) 2009-04-01
NZ574238A (en) 2012-02-24
WO2008009652A3 (en) 2008-05-08
JP2009543846A (ja) 2009-12-10
CA2657279A1 (en) 2008-01-24
WO2008009650A2 (en) 2008-01-24
AU2007276217A1 (en) 2008-01-24
ES2437082T3 (es) 2014-01-08
KR20090092752A (ko) 2009-09-01
CR10555A (es) 2009-04-29
NO20090178L (no) 2009-02-09
KR20090094213A (ko) 2009-09-04
ZA200900386B (en) 2014-03-26
SG173363A1 (en) 2011-08-29
TW200819462A (en) 2008-05-01

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