CO6150187A2 - Vacunas para malaria - Google Patents
Vacunas para malariaInfo
- Publication number
- CO6150187A2 CO6150187A2 CO09004461A CO09004461A CO6150187A2 CO 6150187 A2 CO6150187 A2 CO 6150187A2 CO 09004461 A CO09004461 A CO 09004461A CO 09004461 A CO09004461 A CO 09004461A CO 6150187 A2 CO6150187 A2 CO 6150187A2
- Authority
- CO
- Colombia
- Prior art keywords
- protein
- vivax
- fragment
- protein according
- type
- Prior art date
Links
- 201000004792 malaria Diseases 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 10
- 102000004169 proteins and genes Human genes 0.000 abstract 10
- 240000009188 Phyllostachys vivax Species 0.000 abstract 5
- 239000012634 fragment Substances 0.000 abstract 3
- 101710117490 Circumsporozoite protein Proteins 0.000 abstract 2
- 210000004898 n-terminal fragment Anatomy 0.000 abstract 2
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 101000740205 Homo sapiens Sal-like protein 1 Proteins 0.000 abstract 1
- 102100037204 Sal-like protein 1 Human genes 0.000 abstract 1
- 101710137302 Surface antigen S Proteins 0.000 abstract 1
- 210000004900 c-terminal fragment Anatomy 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
1.- Una proteína de fusión híbrida inmunogénica que comprende: a. al menos una unidad de repetición derivada de la región de repetición de una proteína de circumsporozoito de tipo I de P. vivax, b. al menos una unidad de repetición derivada de la región de repetición de una proteína de circumsporozoito de tipo II de P. vivax., y c. antígeno S de superficie derivado del virus de Hepatitis B, o un fragmento del mismo. 2.- Una proteína de acuerdo con la reivindicación 1, en la que la proteína comprende además un fragmento N terminal de la proteína CS de P. vivax. 3.- Una proteína de acuerdo con la reivindicación 2, en la que el fragmento N terminal comprende el fragmento conocido como la región (I) tal como se muestra en la SEQ ID N° 1. 4.- Una proteína de acuerdo con cualquier reivindicación precedente en la que la proteína comprende además un fragmento C terminal de la proteína CS de P. vivax. 5.- Una proteína de acuerdo con la reivindicación 4, en la que el fragmento C terminal comprende la sección conocida como la región (II) tal como el motivo mostrado en la SEQ ID N° 2. 6.- Una proteína de acuerdo con cualquier reivindicación precedente en la que la unidad de repetición de tipo I se deriva de una o más de las siguientes cepas de P. vivax: de Latinoamérica (es decir Sal 1, Belem), de Corea, de China, de Tailandia, de Indonesia, de India y de Vietnam. 7.- Una proteína de acuerdo con cualquier reivindicación precedente en la que la unidad de repetición de tipo I se selecciona entre uno o más monómeros mostrados en la SEQ ID N° 3 a 9.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0614254.1A GB0614254D0 (en) | 2006-07-18 | 2006-07-18 | Vaccine |
| GB0614473A GB0614473D0 (en) | 2006-07-20 | 2006-07-20 | Vaccines |
| GB0614476A GB0614476D0 (en) | 2006-07-20 | 2006-07-20 | Vaccine |
| GB0615115A GB0615115D0 (en) | 2006-07-28 | 2006-07-28 | Vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6150187A2 true CO6150187A2 (es) | 2010-04-20 |
Family
ID=38957130
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09004461A CO6150187A2 (es) | 2006-07-18 | 2009-01-20 | Vacunas para malaria |
| CO09004463A CO6150189A2 (es) | 2006-07-18 | 2009-01-20 | Vacunas para malaria |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09004463A CO6150189A2 (es) | 2006-07-18 | 2009-01-20 | Vacunas para malaria |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9364525B2 (es) |
| EP (2) | EP2040743B1 (es) |
| JP (2) | JP5222289B2 (es) |
| KR (2) | KR20090092752A (es) |
| AR (1) | AR061894A1 (es) |
| AU (2) | AU2007276217B2 (es) |
| BR (2) | BRPI0714326A2 (es) |
| CA (2) | CA2657279A1 (es) |
| CO (2) | CO6150187A2 (es) |
| CR (2) | CR10555A (es) |
| EA (2) | EA200900033A1 (es) |
| ES (2) | ES2437082T3 (es) |
| IL (2) | IL196410A0 (es) |
| MA (2) | MA30670B1 (es) |
| MX (2) | MX2009000655A (es) |
| NO (2) | NO20090178L (es) |
| NZ (2) | NZ574238A (es) |
| PE (1) | PE20080428A1 (es) |
| SG (2) | SG173363A1 (es) |
| TW (1) | TW200819462A (es) |
| WO (2) | WO2008009650A2 (es) |
| ZA (1) | ZA200900386B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040136963A1 (en) * | 2001-06-22 | 2004-07-15 | The Trustees Of The University Of Pennsylvania | Simian adenovirus vectors and methods of use |
| SG165153A1 (en) | 2001-11-21 | 2010-10-28 | Univ Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
| AU2007276217B2 (en) * | 2006-07-18 | 2013-08-29 | Glaxosmithkline Biologicals S.A. | Vaccines for malaria |
| CA2707245A1 (en) * | 2007-12-06 | 2009-06-11 | Glaxosmithkline Biologicals S.A. | Vaccine |
| CN101951947A (zh) * | 2007-12-24 | 2011-01-19 | 葛兰素史密丝克莱恩生物有限公司 | 疟疾疫苗 |
| US8501926B2 (en) * | 2008-09-24 | 2013-08-06 | The Johns Hopkins University | Malaria vaccine |
| JP5770633B2 (ja) * | 2008-11-03 | 2015-08-26 | クルセル ホランド ベー ヴェー | アデノウイルスベクターの産生方法 |
| US8784832B2 (en) | 2011-08-19 | 2014-07-22 | University Of South Florida (A Florida Non-Profit Corporation) | Synthetic antigen based on the ligand domain of the Plasmodium vivax duffy binding protein |
| GB201116248D0 (en) * | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| WO2013123412A1 (en) * | 2012-02-17 | 2013-08-22 | Children's Medical Center Corporation | Conformation-stabilized trap antigens |
| US9821046B2 (en) | 2013-01-21 | 2017-11-21 | Oxford University Innovation Limited | Composition and uses thereof |
| EP3213638A1 (en) | 2016-03-01 | 2017-09-06 | Coöperatie Avebe U.A. | Vegan cheese analogue |
| GB201608821D0 (en) | 2016-05-19 | 2016-07-06 | Isis Innovation | Vaccines |
| CA3045952A1 (en) | 2016-12-07 | 2018-06-14 | Glaxosmithkline Biologicals Sa | Novel process |
| BR112019012843A2 (pt) * | 2016-12-23 | 2019-12-17 | The Walter And Eliza Hall Institute Of Medical Research | teste de diagnóstico, e, aparelho, sistema e método para o diagnóstico de p. vivax ou p. ovale. |
| JP7305057B2 (ja) | 2020-09-16 | 2023-07-07 | 三菱電機株式会社 | 前照灯装置 |
Family Cites Families (51)
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|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| AU590599B2 (en) * | 1985-07-12 | 1989-11-09 | New York University | Immunogenic peptide antigen corresponding to plasmodium vivax circumsporozoite protein |
| US4826957A (en) * | 1985-07-12 | 1989-05-02 | New York University | Immunogenic recombinant yeast expression product and method for purifying it |
| US5554372A (en) * | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
| JPH0222300A (ja) * | 1987-02-02 | 1990-01-25 | Swiss Serum & Vaccine Inst Bern | 免疫原性接合体およびその製法ならびに免疫を生ぜしめる方法 |
| US4997647A (en) | 1987-03-30 | 1991-03-05 | New York University | Vaccine against the sporozoite stage of malaria |
| WO1988009797A1 (en) | 1987-06-05 | 1988-12-15 | The United States Of America, As Represented By Th | Autocrine motility factors in cancer diagnosis and management |
| US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
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| UA40597C2 (uk) | 1992-06-25 | 2001-08-15 | Смітклайн Бічем Байолоджікалс С.А. | Вакцинна композиція,спосіб лікування ссавців, що страждають або сприйнятливі до інфекції, спосіб лікування ссавців, що страждають на рак, спосіб одержання вакцинної композиції, композиція ад'ювантів |
| ATE204762T1 (de) | 1993-03-23 | 2001-09-15 | Smithkline Beecham Biolog | 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen |
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| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
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| US6764840B2 (en) | 1997-05-08 | 2004-07-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
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| GB9711990D0 (en) | 1997-06-11 | 1997-08-06 | Smithkline Beecham Biolog | Vaccine |
| WO2000000462A1 (fr) | 1998-06-30 | 2000-01-06 | Om Pharma | Nouveaux pseudodipeptides acyles, leur mode de preparation et les compositions pharmaceutiques en renfermant |
| KR20000020497A (ko) | 1998-09-21 | 2000-04-15 | 임채승 | 말라리아의 검출방법 |
| WO2000062800A2 (en) | 1999-04-19 | 2000-10-26 | Smithkline Beecham Biologicals Sa | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
| US6558670B1 (en) | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
| AU1600401A (en) * | 1999-11-12 | 2001-06-06 | Chinese University Of Hong Kong, The | Malaria vaccine |
| WO2001046127A1 (fr) | 1999-12-22 | 2001-06-28 | Om Pharma | Pseudodipeptides acyles porteurs d'un bras auxiliaire fonctionnalise |
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| EP1201250A1 (en) * | 2000-10-25 | 2002-05-02 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Immunogenic compositions comprising liver stage malarial antigens |
| BR0210586A (pt) | 2001-06-22 | 2005-07-12 | Wistar Inst | Métodos para induzir uma reação imune citotóxica e composições de adenovìrus de sìmio recombinante úteis das mesmas |
| NZ539509A (en) | 2002-10-23 | 2008-05-30 | Glaxosmithkline Biolog Sa | Priming vaccine comprising a polynucleotide encoding at least one first malarial antigen and a boosting vaccine comprising at least one polypeptide comprising at least one second malarial antigen having at least one epitope in common with the first malarial antigen of the priming vaccine |
| EP2258850B1 (en) | 2002-12-17 | 2013-07-17 | Crucell Holland B.V. | Recominant viral-based malaria vaccins |
| JP4754480B2 (ja) | 2003-06-20 | 2011-08-24 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | キメラアデノウイルスの作成法およびそのようなキメラアデノウイルスの使用 |
| WO2004113369A1 (de) | 2003-06-20 | 2004-12-29 | Dade Behring Marburg Gmbh | NEUE OBERFLÄCHENPROTEIN- (HbsAg-) VARIANTE DES HEPATITIS B VIRUS |
| US20050233435A1 (en) * | 2003-09-04 | 2005-10-20 | Nyu Medical Center | Plasmodium axenic liver stages as a noninfectious whole organism malaria vaccine |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| US20060041248A1 (en) * | 2004-08-23 | 2006-02-23 | Patton David L | Pharmaceutical compositions delivery system and methods |
| GB0420634D0 (en) | 2004-09-16 | 2004-10-20 | Glaxosmithkline Biolog Sa | Vaccines |
| WO2006088597A2 (en) * | 2005-01-18 | 2006-08-24 | Walter Read Army Institute Of Research | A plasmodium vivax hybrid circumsporozoite protein and vaccine |
| GB0513421D0 (en) | 2005-06-30 | 2005-08-03 | Glaxosmithkline Biolog Sa | Vaccines |
| AU2007276217B2 (en) * | 2006-07-18 | 2013-08-29 | Glaxosmithkline Biologicals S.A. | Vaccines for malaria |
| CN101951947A (zh) * | 2007-12-24 | 2011-01-19 | 葛兰素史密丝克莱恩生物有限公司 | 疟疾疫苗 |
-
2007
- 2007-07-16 AU AU2007276217A patent/AU2007276217B2/en not_active Ceased
- 2007-07-16 ES ES07787569.8T patent/ES2437082T3/es active Active
- 2007-07-16 EA EA200900033A patent/EA200900033A1/ru unknown
- 2007-07-16 KR KR1020097003247A patent/KR20090092752A/ko not_active Application Discontinuation
- 2007-07-16 WO PCT/EP2007/057296 patent/WO2008009650A2/en active Application Filing
- 2007-07-16 CA CA002657279A patent/CA2657279A1/en not_active Abandoned
- 2007-07-16 EA EA200900032A patent/EA200900032A1/ru unknown
- 2007-07-16 JP JP2009519966A patent/JP5222289B2/ja not_active Expired - Fee Related
- 2007-07-16 PE PE2007000913A patent/PE20080428A1/es not_active Application Discontinuation
- 2007-07-16 NZ NZ574238A patent/NZ574238A/en not_active IP Right Cessation
- 2007-07-16 EP EP07787569.8A patent/EP2040743B1/en active Active
- 2007-07-16 TW TW096125902A patent/TW200819462A/zh unknown
- 2007-07-16 CA CA002657353A patent/CA2657353A1/en not_active Abandoned
- 2007-07-16 MX MX2009000655A patent/MX2009000655A/es active IP Right Grant
- 2007-07-16 SG SG2011050150A patent/SG173363A1/en unknown
- 2007-07-16 US US12/374,238 patent/US9364525B2/en not_active Expired - Fee Related
- 2007-07-16 NZ NZ574239A patent/NZ574239A/en not_active IP Right Cessation
- 2007-07-16 BR BRPI0714326-5A patent/BRPI0714326A2/pt not_active IP Right Cessation
- 2007-07-16 KR KR1020097003262A patent/KR20090094213A/ko not_active Application Discontinuation
- 2007-07-16 AU AU2007276219A patent/AU2007276219B2/en not_active Ceased
- 2007-07-16 US US12/374,214 patent/US9592282B2/en not_active Expired - Fee Related
- 2007-07-16 EP EP07787564.9A patent/EP2040742B1/en active Active
- 2007-07-16 JP JP2009519964A patent/JP5592110B2/ja not_active Expired - Fee Related
- 2007-07-16 SG SG201105140-6A patent/SG173377A1/en unknown
- 2007-07-16 WO PCT/EP2007/057301 patent/WO2008009652A2/en active Application Filing
- 2007-07-16 ES ES07787564.9T patent/ES2525732T3/es active Active
- 2007-07-16 BR BRPI0715581-6A patent/BRPI0715581A2/pt not_active IP Right Cessation
- 2007-07-16 MX MX2009000650A patent/MX2009000650A/es active IP Right Grant
- 2007-07-17 AR ARP070103168A patent/AR061894A1/es unknown
-
2009
- 2009-01-08 IL IL196410A patent/IL196410A0/en unknown
- 2009-01-13 NO NO20090178A patent/NO20090178L/no not_active Application Discontinuation
- 2009-01-13 IL IL196471A patent/IL196471A0/en unknown
- 2009-01-13 NO NO20090177A patent/NO20090177L/no not_active Application Discontinuation
- 2009-01-14 CR CR10555A patent/CR10555A/es not_active Application Discontinuation
- 2009-01-14 CR CR10561A patent/CR10561A/es not_active Application Discontinuation
- 2009-01-16 ZA ZA2009/00386A patent/ZA200900386B/en unknown
- 2009-01-20 CO CO09004461A patent/CO6150187A2/es unknown
- 2009-01-20 CO CO09004463A patent/CO6150189A2/es unknown
- 2009-02-27 MA MA31671A patent/MA30670B1/fr unknown
- 2009-02-27 MA MA31672A patent/MA30671B1/fr unknown
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