MA30671B1 - Vaccins contre le paludisme - Google Patents
Vaccins contre le paludismeInfo
- Publication number
- MA30671B1 MA30671B1 MA31672A MA31672A MA30671B1 MA 30671 B1 MA30671 B1 MA 30671B1 MA 31672 A MA31672 A MA 31672A MA 31672 A MA31672 A MA 31672A MA 30671 B1 MA30671 B1 MA 30671B1
- Authority
- MA
- Morocco
- Prior art keywords
- protein
- particle
- hepatitis
- antigen
- vaccines against
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 201000004792 malaria Diseases 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 208000002672 hepatitis B Diseases 0.000 abstract 3
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 240000009188 Phyllostachys vivax Species 0.000 abstract 1
- 241000223960 Plasmodium falciparum Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne une particule lipoprotéique innovante, des procédés de préparation et de purification de celle-ci, son utilisation en médecine, en particulier pour la prévention des infections paludéennes, des compositions/vaccins contenant la particule ou des anticorps contre la particule protéique tels que des anticorps monoclonaux ou polyclonaux et leur utilisation, en particulier dans des buts thérapeutiques. L'invention concerne en particulier une particule protéique immunogène qui comprend les monomères suivants: (a) une protéine de fusion comprenant des séquences dérivées d'une protéine CS de P. vivax et de l'antigène S de l'hépatite B (CSV-S), et (b) une protéine de fusion comprenant des séquences dérivées d'une protéine CS de P. falciparum et de l'antigène S de l'hépatite B (RTS), et (c) facultativement l'antigène S dérivé de l'hépatite B.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0614254.1A GB0614254D0 (en) | 2006-07-18 | 2006-07-18 | Vaccine |
GB0614473A GB0614473D0 (en) | 2006-07-20 | 2006-07-20 | Vaccines |
GB0614476A GB0614476D0 (en) | 2006-07-20 | 2006-07-20 | Vaccine |
GB0615115A GB0615115D0 (en) | 2006-07-28 | 2006-07-28 | Vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30671B1 true MA30671B1 (fr) | 2009-08-03 |
Family
ID=38957130
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31672A MA30671B1 (fr) | 2006-07-18 | 2009-02-27 | Vaccins contre le paludisme |
MA31671A MA30670B1 (fr) | 2006-07-18 | 2009-02-27 | Vaccins contre le paludisme |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31671A MA30670B1 (fr) | 2006-07-18 | 2009-02-27 | Vaccins contre le paludisme |
Country Status (22)
Country | Link |
---|---|
US (2) | US9364525B2 (fr) |
EP (2) | EP2040742B1 (fr) |
JP (2) | JP5222289B2 (fr) |
KR (2) | KR20090094213A (fr) |
AR (1) | AR061894A1 (fr) |
AU (2) | AU2007276219B2 (fr) |
BR (2) | BRPI0714326A2 (fr) |
CA (2) | CA2657353A1 (fr) |
CO (2) | CO6150189A2 (fr) |
CR (2) | CR10561A (fr) |
EA (2) | EA200900033A1 (fr) |
ES (2) | ES2437082T3 (fr) |
IL (2) | IL196410A0 (fr) |
MA (2) | MA30671B1 (fr) |
MX (2) | MX2009000650A (fr) |
NO (2) | NO20090177L (fr) |
NZ (2) | NZ574239A (fr) |
PE (1) | PE20080428A1 (fr) |
SG (2) | SG173377A1 (fr) |
TW (1) | TW200819462A (fr) |
WO (2) | WO2008009652A2 (fr) |
ZA (1) | ZA200900386B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040136963A1 (en) * | 2001-06-22 | 2004-07-15 | The Trustees Of The University Of Pennsylvania | Simian adenovirus vectors and methods of use |
BR0214350A (pt) | 2001-11-21 | 2005-05-10 | Univ Pennsylvania | Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso |
KR20090094213A (ko) * | 2006-07-18 | 2009-09-04 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 말라리아 백신 |
WO2009071613A2 (fr) * | 2007-12-06 | 2009-06-11 | Glaxosmithkline Biologicals S.A. | Vaccin |
AP2010005294A0 (en) * | 2007-12-24 | 2010-06-30 | Glaxosmithkline Biolog Sa | Vaccines for malaria |
AU2009297127A1 (en) * | 2008-09-24 | 2010-04-01 | The Government Of The United States, As Represented By The Secretary Of The Army | Malaria vaccine |
JP5770633B2 (ja) * | 2008-11-03 | 2015-08-26 | クルセル ホランド ベー ヴェー | アデノウイルスベクターの産生方法 |
US8784832B2 (en) | 2011-08-19 | 2014-07-22 | University Of South Florida (A Florida Non-Profit Corporation) | Synthetic antigen based on the ligand domain of the Plasmodium vivax duffy binding protein |
GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
WO2013123412A1 (fr) * | 2012-02-17 | 2013-08-22 | Children's Medical Center Corporation | Antigènes trap à conformation stabilisée |
US9821046B2 (en) | 2013-01-21 | 2017-11-21 | Oxford University Innovation Limited | Composition and uses thereof |
EP3213638A1 (fr) | 2016-03-01 | 2017-09-06 | Coöperatie Avebe U.A. | Analogue de fromage vegan |
GB201608821D0 (en) | 2016-05-19 | 2016-07-06 | Isis Innovation | Vaccines |
CN110035770B (zh) | 2016-12-07 | 2023-06-16 | 葛兰素史密丝克莱恩生物有限公司 | 新方法 |
BR112019012843A2 (pt) * | 2016-12-23 | 2019-12-17 | The Walter And Eliza Hall Institute Of Medical Research | teste de diagnóstico, e, aparelho, sistema e método para o diagnóstico de p. vivax ou p. ovale. |
DE112020007612T5 (de) | 2020-09-16 | 2023-06-29 | Mitsubishi Electric Corporation | Scheinwerfereinrichtung |
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SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
ATE118784T1 (de) * | 1985-07-12 | 1995-03-15 | Univ New York | Mit dem plasmodium-vivax-circumsporozoit-protein übereinstimmendes immunogenes peptidantigen. |
US4826957A (en) * | 1985-07-12 | 1989-05-02 | New York University | Immunogenic recombinant yeast expression product and method for purifying it |
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US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
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HUP0102475A3 (en) | 1998-06-30 | 2001-12-28 | Om Pharma | Novel acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same |
KR20000020497A (ko) | 1998-09-21 | 2000-04-15 | 임채승 | 말라리아의 검출방법 |
US6558670B1 (en) | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
KR100922031B1 (ko) | 1999-04-19 | 2009-10-19 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
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US6942866B2 (en) * | 2000-08-16 | 2005-09-13 | Apovia, Inc. | Malaria immunogen and vaccine |
EP1201250A1 (fr) * | 2000-10-25 | 2002-05-02 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Composition immunogène contenant des antigènes de plasmodium spécifiques des stades hépatiques |
PT1409012E (pt) | 2001-06-22 | 2009-05-11 | Wistar Inst | Métodos de indução de uma resposta imunitária citotóxica e composições de adenovírus recombinantes de símio úteis para esse efeito |
NZ539509A (en) | 2002-10-23 | 2008-05-30 | Glaxosmithkline Biolog Sa | Priming vaccine comprising a polynucleotide encoding at least one first malarial antigen and a boosting vaccine comprising at least one polypeptide comprising at least one second malarial antigen having at least one epitope in common with the first malarial antigen of the priming vaccine |
SG156535A1 (en) | 2002-12-17 | 2009-11-26 | Crucell Holland Bv | Recombinant viral-based malaria vaccines |
WO2004113369A1 (fr) | 2003-06-20 | 2004-12-29 | Dade Behring Marburg Gmbh | Nouvelle variante de la proteine de surface (hbsag-) du virus de l'hepatite b |
ES2478625T3 (es) | 2003-06-20 | 2014-07-22 | The Trustees Of The University Of Pennsylvania | Método de generación de adenovirus quiméricos y usos de tales adenovirus quiméricos |
US20050233435A1 (en) * | 2003-09-04 | 2005-10-20 | Nyu Medical Center | Plasmodium axenic liver stages as a noninfectious whole organism malaria vaccine |
GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
US20060041248A1 (en) * | 2004-08-23 | 2006-02-23 | Patton David L | Pharmaceutical compositions delivery system and methods |
GB0420634D0 (en) | 2004-09-16 | 2004-10-20 | Glaxosmithkline Biolog Sa | Vaccines |
WO2006088597A2 (fr) * | 2005-01-18 | 2006-08-24 | Walter Read Army Institute Of Research | Proteine circumsporozoite hybride de plasmodium vivax et son vaccin |
GB0513421D0 (en) * | 2005-06-30 | 2005-08-03 | Glaxosmithkline Biolog Sa | Vaccines |
KR20090094213A (ko) * | 2006-07-18 | 2009-09-04 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 말라리아 백신 |
AP2010005294A0 (en) * | 2007-12-24 | 2010-06-30 | Glaxosmithkline Biolog Sa | Vaccines for malaria |
-
2007
- 2007-07-16 KR KR1020097003262A patent/KR20090094213A/ko not_active Application Discontinuation
- 2007-07-16 PE PE2007000913A patent/PE20080428A1/es not_active Application Discontinuation
- 2007-07-16 NZ NZ574239A patent/NZ574239A/en not_active IP Right Cessation
- 2007-07-16 WO PCT/EP2007/057301 patent/WO2008009652A2/fr active Application Filing
- 2007-07-16 EA EA200900033A patent/EA200900033A1/ru unknown
- 2007-07-16 AU AU2007276219A patent/AU2007276219B2/en not_active Ceased
- 2007-07-16 AU AU2007276217A patent/AU2007276217B2/en not_active Ceased
- 2007-07-16 JP JP2009519966A patent/JP5222289B2/ja not_active Expired - Fee Related
- 2007-07-16 US US12/374,238 patent/US9364525B2/en not_active Expired - Fee Related
- 2007-07-16 EP EP07787564.9A patent/EP2040742B1/fr active Active
- 2007-07-16 MX MX2009000650A patent/MX2009000650A/es active IP Right Grant
- 2007-07-16 CA CA002657353A patent/CA2657353A1/fr not_active Abandoned
- 2007-07-16 KR KR1020097003247A patent/KR20090092752A/ko not_active Application Discontinuation
- 2007-07-16 BR BRPI0714326-5A patent/BRPI0714326A2/pt not_active IP Right Cessation
- 2007-07-16 ES ES07787569.8T patent/ES2437082T3/es active Active
- 2007-07-16 MX MX2009000655A patent/MX2009000655A/es active IP Right Grant
- 2007-07-16 EA EA200900032A patent/EA200900032A1/ru unknown
- 2007-07-16 JP JP2009519964A patent/JP5592110B2/ja not_active Expired - Fee Related
- 2007-07-16 WO PCT/EP2007/057296 patent/WO2008009650A2/fr active Application Filing
- 2007-07-16 EP EP07787569.8A patent/EP2040743B1/fr active Active
- 2007-07-16 ES ES07787564.9T patent/ES2525732T3/es active Active
- 2007-07-16 CA CA002657279A patent/CA2657279A1/fr not_active Abandoned
- 2007-07-16 NZ NZ574238A patent/NZ574238A/en not_active IP Right Cessation
- 2007-07-16 SG SG201105140-6A patent/SG173377A1/en unknown
- 2007-07-16 US US12/374,214 patent/US9592282B2/en not_active Expired - Fee Related
- 2007-07-16 TW TW096125902A patent/TW200819462A/zh unknown
- 2007-07-16 BR BRPI0715581-6A patent/BRPI0715581A2/pt not_active IP Right Cessation
- 2007-07-16 SG SG2011050150A patent/SG173363A1/en unknown
- 2007-07-17 AR ARP070103168A patent/AR061894A1/es unknown
-
2009
- 2009-01-08 IL IL196410A patent/IL196410A0/en unknown
- 2009-01-13 IL IL196471A patent/IL196471A0/en unknown
- 2009-01-13 NO NO20090177A patent/NO20090177L/no not_active Application Discontinuation
- 2009-01-13 NO NO20090178A patent/NO20090178L/no not_active Application Discontinuation
- 2009-01-14 CR CR10561A patent/CR10561A/es not_active Application Discontinuation
- 2009-01-14 CR CR10555A patent/CR10555A/es not_active Application Discontinuation
- 2009-01-16 ZA ZA2009/00386A patent/ZA200900386B/en unknown
- 2009-01-20 CO CO09004463A patent/CO6150189A2/es unknown
- 2009-01-20 CO CO09004461A patent/CO6150187A2/es unknown
- 2009-02-27 MA MA31672A patent/MA30671B1/fr unknown
- 2009-02-27 MA MA31671A patent/MA30670B1/fr unknown
Also Published As
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Publication | Publication Date | Title |
---|---|---|
MA30671B1 (fr) | Vaccins contre le paludisme | |
Wright et al. | Plasmodium falciparum erythrocyte invasion: combining function with immune evasion | |
TNSN07066A1 (fr) | Inhibiteurs de l'arn-polymerase, dependant d'arn, du virus de l'hepatite c, et compositions et traitements les utilisant | |
MA27699A1 (fr) | Vaccin contre vhc | |
Healer et al. | Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum | |
MA30359B1 (fr) | Composition pharmaceutique a liberation prolongee sur la base d'un systeme de liberation comprenant un polymere soluble dans l'acide et un polymere dependant du ph | |
MA32030B1 (fr) | Vaccins anti-malaria | |
Taechalertpaisarn et al. | Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41 | |
MA33285B1 (fr) | Anticorps anti-cxcr4 pour le traitement du vih | |
MA30345B1 (fr) | Formulation d'anticorps monoclonal humain anti-igf-1r | |
IL178474A0 (en) | Monoclonal antibodies to hepatocyte growth factor and pharmaceutical compositions containing the same | |
Jelínková et al. | An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein | |
EA200970586A1 (ru) | Антитела к цитомегаловирусу человека (hcmv) | |
MA34175B1 (fr) | Anticorps anti-cxcr4 humanisés pour le traitement de cancer | |
Radocha et al. | Monoclonal antibodies and antibody drug conjugates in multiple myeloma | |
Kengne-Ouafo et al. | Immune responses to the sexual stages of Plasmodium falciparum parasites | |
MA32821B1 (fr) | Vaccin combine notamment contre la coqueluche (vaccin cellulaire entier) | |
Suau et al. | RTS, S/AS01E malaria vaccine induces IgA responses against CSP and vaccine-unrelated antigens in African children in the phase 3 trial | |
Ord et al. | Malaria invasion ligand RH5 and its prime candidacy in blood-stage malaria vaccine design | |
Ouédraogo et al. | Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: A phase 1b randomised, controlled, double-blinded, age de-escalation trial | |
Mehrizi et al. | Th1 immune response to Plasmodium falciparum recombinant thrombospondin‐related adhesive protein (TRAP) antigen is enhanced by TLR3‐specific adjuvant, poly (I: C) in BALB/c mice | |
MA30691B1 (fr) | Compositions pharmaceutiques contenant un anticorps monoclonal anti-idiotypique anti-ca-125 et de l'aluminium. | |
Atcheson et al. | A VLP for validation of the Plasmodium falciparum circumsporozoite protein junctional epitope for vaccine development | |
MA27474A1 (fr) | Vaccin | |
Vigdorovich et al. | Coimmunization with preerythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection |