KR101025528B1 - 5-(2'-피리딜)-2-피리돈 유도체의 제조 방법 - Google Patents

5-(2'-피리딜)-2-피리돈 유도체의 제조 방법 Download PDF

Info

Publication number
KR101025528B1
KR101025528B1 KR1020057001229A KR20057001229A KR101025528B1 KR 101025528 B1 KR101025528 B1 KR 101025528B1 KR 1020057001229 A KR1020057001229 A KR 1020057001229A KR 20057001229 A KR20057001229 A KR 20057001229A KR 101025528 B1 KR101025528 B1 KR 101025528B1
Authority
KR
South Korea
Prior art keywords
group
formula
substituent
atom
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020057001229A
Other languages
English (en)
Korean (ko)
Other versions
KR20050019919A (ko
Inventor
겐이치 고야쿠마루
요시미 후쿠나가
요우이치 사타케
Original Assignee
에자이 알앤드디 매니지먼트 가부시키가이샤
가부시키가이샤 구라레
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에자이 알앤드디 매니지먼트 가부시키가이샤, 가부시키가이샤 구라레 filed Critical 에자이 알앤드디 매니지먼트 가부시키가이샤
Publication of KR20050019919A publication Critical patent/KR20050019919A/ko
Application granted granted Critical
Publication of KR101025528B1 publication Critical patent/KR101025528B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020057001229A 2002-07-23 2003-07-23 5-(2'-피리딜)-2-피리돈 유도체의 제조 방법 Expired - Fee Related KR101025528B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002214098A JP4208512B2 (ja) 2002-07-23 2002-07-23 ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法
JPJP-P-2002-00214098 2002-07-23

Publications (2)

Publication Number Publication Date
KR20050019919A KR20050019919A (ko) 2005-03-03
KR101025528B1 true KR101025528B1 (ko) 2011-04-04

Family

ID=30767870

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057001229A Expired - Fee Related KR101025528B1 (ko) 2002-07-23 2003-07-23 5-(2'-피리딜)-2-피리돈 유도체의 제조 방법

Country Status (13)

Country Link
US (1) US7524967B2 (enExample)
EP (1) EP1553086B1 (enExample)
JP (1) JP4208512B2 (enExample)
KR (1) KR101025528B1 (enExample)
CN (1) CN100393702C (enExample)
AT (1) ATE444952T1 (enExample)
AU (1) AU2003252241B2 (enExample)
CA (1) CA2493036C (enExample)
DE (1) DE60329615D1 (enExample)
HK (1) HK1077578B (enExample)
IL (1) IL166451A (enExample)
MX (1) MXPA05000944A (enExample)
WO (1) WO2004009553A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
EP1871368B1 (en) * 2005-04-04 2011-06-08 Eisai R&D Management Co., Ltd. Dihydropyridine compounds for neurodegenerative diseases and dementia
JP5112317B2 (ja) 2005-08-29 2013-01-09 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
EP1919906B1 (en) 2005-08-29 2011-10-12 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
JP2009507792A (ja) * 2005-08-29 2009-02-26 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
JP4865337B2 (ja) * 2006-01-24 2012-02-01 富士フイルムファインケミカルズ株式会社 ２，３’−ビピリジル−６’−オンの製造方法
US20100016603A1 (en) * 2007-01-29 2010-01-21 Fujifilm Finechemicals Co., Ltd. Production process of 2,3'-bipyridyl-6'-one
US20100099714A1 (en) * 2007-03-05 2010-04-22 Eisai R&D Management Co., Ltd. AMPA and NMDA Receptor Antagonists for Neurodegenerative Diseases
JP2010524844A (ja) * 2007-04-26 2010-07-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 認知症のためのシンナミド化合物
JP5536458B2 (ja) * 2007-12-21 2014-07-02 株式会社クラレ ６−ハロゲノ−３−アリールピリジン誘導体の製造方法
ITMI20111952A1 (it) * 2011-10-27 2013-04-28 Italiana Sint Spa Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel
US9096574B2 (en) 2012-01-03 2015-08-04 Mapi Pharma Ltd. Polymorphs of perampanel
EP3024821B1 (en) 2013-07-25 2017-09-27 Teva Pharmaceuticals International GmbH Process for the preparation of perampanel
CN104725301A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种1,2-二氢吡啶-2-酮衍生物的制备方法
US10111867B2 (en) 2015-02-17 2018-10-30 Mapi Pharma Ltd. Process and intermediates for the preparation of perampanel
EP3834167A4 (en) 2018-08-06 2022-05-04 Olive Seed Industries, LLC PROCESSES AND SYSTEMS FOR PERSONALIZING VISITOR EXPERIENCES AT A VENUE
CN116930351A (zh) * 2023-06-08 2023-10-24 上海现代制药股份有限公司 一种hplc测定吡仑帕奈关键起始物料有关物质的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027112A1 (en) * 1999-10-11 2001-04-19 Pfizer Limited 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693611A (en) * 1996-02-01 1997-12-02 Eli Lilly And Company Cyclic peptide antifungal agents
DE19633746A1 (de) * 1996-08-22 1998-02-26 Basf Ag Substituierte 2-Phenylpyridine
DE19636995A1 (de) * 1996-09-12 1998-03-19 Basf Ag Verfahren zur Herstellung substituierter Phenylpyridine
JP4176201B2 (ja) * 1998-09-02 2008-11-05 株式会社クラレ ５−ハロゲノ−２−置換ピリジンの製造方法
US20020045613A1 (en) 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
KR100904011B1 (ko) * 2000-06-12 2009-06-22 에자이 알앤드디 매니지먼트 가부시키가이샤 1,2-디하이드로피리딘 화합물 및 그의 제조 방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027112A1 (en) * 1999-10-11 2001-04-19 Pfizer Limited 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors

Also Published As

Publication number Publication date
JP4208512B2 (ja) 2009-01-14
HK1077578A1 (en) 2006-02-17
AU2003252241B2 (en) 2008-12-04
DE60329615D1 (de) 2009-11-19
MXPA05000944A (es) 2005-10-18
KR20050019919A (ko) 2005-03-03
HK1077578B (zh) 2009-03-27
IL166451A (en) 2011-07-31
US20060004205A1 (en) 2006-01-05
US7524967B2 (en) 2009-04-28
IL166451A0 (en) 2006-01-15
EP1553086B1 (en) 2009-10-07
CN1671665A (zh) 2005-09-21
EP1553086A1 (en) 2005-07-13
EP1553086A4 (en) 2007-04-25
AU2003252241A1 (en) 2004-02-09
ATE444952T1 (de) 2009-10-15
WO2004009553A1 (ja) 2004-01-29
JP2004051592A (ja) 2004-02-19
CA2493036C (en) 2011-03-22
CA2493036A1 (en) 2004-01-29
CN100393702C (zh) 2008-06-11

Similar Documents

Publication Publication Date Title
KR101025528B1 (ko) 5-(2'-피리딜)-2-피리돈 유도체의 제조 방법
KR100381484B1 (ko) 4-트리플루오로메틸니코틴산의제조방법
JP2012255014A (ja) 安息香酸類の製造方法
KR101653025B1 (ko) 2-아미노-4-트리플루오로메틸피리딘류의 제조 방법
US10329311B1 (en) Process for the preparation of crisaborole
US8742118B2 (en) Methods for preparing intermediates of perampanel
IL277812B1 (en) Process for the production of 6,2-dialkylphenyl acetic acids
JP2583062B2 (ja) 複素環化合物の製造法
HK1077579A (en) Process for producing 5-(2'-pyridyl)-2-pyridone derivative
JP5536458B2 (ja) ６−ハロゲノ−３−アリールピリジン誘導体の製造方法
JP3890535B2 (ja) ２−クロロピリジン誘導体及びその製造方法
JP4570057B2 (ja) アリールピリジン誘導体の製造法
EA005857B1 (ru) Промежуточные соединения для использования при получении витамина e
KR100359256B1 (ko) 란소프라졸의 개선된 제조방법
US6096894A (en) Production method of 2-(p-alkylphenyl)pyridine compound
JP3907721B2 (ja) ２−アラルキルオキシピリジン類の製造法
JP4209137B2 (ja) ベンゾチオフェン類の製造方法
JP4287083B2 (ja) ２−または４−モノ置換ピリジンの製造方法並びに４−モノ置換ピリジンまたはその塩の選択的製造方法および分離方法
JP2583061B2 (ja) ピリジン誘導体の新規製造法
JP4230172B2 (ja) ベンゾチオフェン類の製造方法
JPH11171849A (ja) 臭化ベンジル誘導体の製造法
JP2002003483A (ja) ５−置換−２（５ｈ）−フラノンの製造方法
JPH0442394B2 (enExample)
JPH1192452A (ja) ４’−（２−ピリジル）アセトフェノンの製造方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R15-X000 Change to inventor requested

St.27 status event code: A-3-3-R10-R15-oth-X000

R16-X000 Change to inventor recorded

St.27 status event code: A-3-3-R10-R16-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PE0801 Dismissal of amendment

St.27 status event code: A-2-2-P10-P12-nap-PE0801

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20140228

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

R17-X000 Change to representative recorded

St.27 status event code: A-5-5-R10-R17-oth-X000

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20150323

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20150323

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000