CN100393702C - 用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法 - Google Patents

用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法 Download PDF

Info

Publication number
CN100393702C
CN100393702C CNB038176904A CN03817690A CN100393702C CN 100393702 C CN100393702 C CN 100393702C CN B038176904 A CNB038176904 A CN B038176904A CN 03817690 A CN03817690 A CN 03817690A CN 100393702 C CN100393702 C CN 100393702C
Authority
CN
China
Prior art keywords
formula
derivative
reaction
iii
organometallic compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038176904A
Other languages
English (en)
Chinese (zh)
Other versions
CN1671665A (zh
Inventor
小役丸健一
福永佳美
佐竹庸一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Eisai R&D Management Co Ltd
Original Assignee
Sanitary Material R&d Management Co ltd
Eisai Co Ltd
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanitary Material R&d Management Co ltd, Eisai Co Ltd, Kuraray Co Ltd filed Critical Sanitary Material R&d Management Co ltd
Publication of CN1671665A publication Critical patent/CN1671665A/zh
Application granted granted Critical
Publication of CN100393702C publication Critical patent/CN100393702C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB038176904A 2002-07-23 2003-07-23 用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法 Expired - Fee Related CN100393702C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002214098A JP4208512B2 (ja) 2002-07-23 2002-07-23 ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法
JP214098/2002 2002-07-23

Publications (2)

Publication Number Publication Date
CN1671665A CN1671665A (zh) 2005-09-21
CN100393702C true CN100393702C (zh) 2008-06-11

Family

ID=30767870

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038176904A Expired - Fee Related CN100393702C (zh) 2002-07-23 2003-07-23 用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法

Country Status (13)

Country Link
US (1) US7524967B2 (enExample)
EP (1) EP1553086B1 (enExample)
JP (1) JP4208512B2 (enExample)
KR (1) KR101025528B1 (enExample)
CN (1) CN100393702C (enExample)
AT (1) ATE444952T1 (enExample)
AU (1) AU2003252241B2 (enExample)
CA (1) CA2493036C (enExample)
DE (1) DE60329615D1 (enExample)
HK (1) HK1077578B (enExample)
IL (1) IL166451A (enExample)
MX (1) MXPA05000944A (enExample)
WO (1) WO2004009553A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
JP5180816B2 (ja) * 2005-04-04 2013-04-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 神経変性疾患および認知症のためのジヒドロピリジン化合物
JP5112317B2 (ja) 2005-08-29 2013-01-09 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
WO2007027729A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
AU2006285038A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
JP4865337B2 (ja) * 2006-01-24 2012-02-01 富士フイルムファインケミカルズ株式会社 ２，３’−ビピリジル−６’−オンの製造方法
US20100016603A1 (en) * 2007-01-29 2010-01-21 Fujifilm Finechemicals Co., Ltd. Production process of 2,3'-bipyridyl-6'-one
US20100099714A1 (en) * 2007-03-05 2010-04-22 Eisai R&D Management Co., Ltd. AMPA and NMDA Receptor Antagonists for Neurodegenerative Diseases
WO2008139984A1 (en) * 2007-04-26 2008-11-20 Eisai R & D Management Co., Ltd. Cinnamide compounds for dementia
WO2009081872A1 (ja) * 2007-12-21 2009-07-02 Kuraray Co., Ltd. ６－ハロゲノ－３－アリールピリジン誘導体の製造方法
ITMI20111952A1 (it) 2011-10-27 2013-04-28 Italiana Sint Spa Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel
US9096574B2 (en) 2012-01-03 2015-08-04 Mapi Pharma Ltd. Polymorphs of perampanel
EA031384B1 (ru) 2013-07-25 2018-12-28 Тева Фармасьютикалз Интернэшнл Гмбх Улучшенные способы получения перампанеля
CN104725301A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种1,2-二氢吡啶-2-酮衍生物的制备方法
US10111867B2 (en) 2015-02-17 2018-10-30 Mapi Pharma Ltd. Process and intermediates for the preparation of perampanel
AU2019317366A1 (en) 2018-08-06 2021-03-04 Olive Seed Industries, Llc Methods and systems for personalizing visitor experience at a venue
US20240247019A1 (en) * 2021-05-24 2024-07-25 Sumitomo Chemical Company, Limited Method for producing bipyridine derivative, method for producing macrocyclic compound, method for producing metal complex containing macrocyclic compound as ligand, metal complex, electrode for air battery, and air battery
CN116930351A (zh) * 2023-06-08 2023-10-24 上海现代制药股份有限公司 一种hplc测定吡仑帕奈关键起始物料有关物质的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169184B1 (en) * 1996-09-12 2001-01-02 Basf Aktiengesellschaft Process for the production of substituted phenylpyridines
WO2001096308A1 (en) * 2000-06-12 2001-12-20 Eisai Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693611A (en) 1996-02-01 1997-12-02 Eli Lilly And Company Cyclic peptide antifungal agents
DE19633746A1 (de) 1996-08-22 1998-02-26 Basf Ag Substituierte 2-Phenylpyridine
JP4176201B2 (ja) 1998-09-02 2008-11-05 株式会社クラレ ５−ハロゲノ−２−置換ピリジンの製造方法
HK1049834A1 (zh) 1999-10-11 2003-05-30 辉瑞大药厂 用作磷酸二酯酶抑制剂的5-(2-取代的-5-杂环基磺酰基吡啶-3-基)-二氢吡唑并[4，3-d]嘧啶-7-酮类化合物
US20020045613A1 (en) 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169184B1 (en) * 1996-09-12 2001-01-02 Basf Aktiengesellschaft Process for the production of substituted phenylpyridines
WO2001096308A1 (en) * 2000-06-12 2001-12-20 Eisai Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
synthesis of substitued pyridine quinolines and diazines viapallsdium catalized cross coupling of aryl grignard reagents. Bonnet,V.Tetrahedron,Vol.58 No.22. 2002 *

Also Published As

Publication number Publication date
KR101025528B1 (ko) 2011-04-04
HK1077578A1 (en) 2006-02-17
JP2004051592A (ja) 2004-02-19
WO2004009553A1 (ja) 2004-01-29
ATE444952T1 (de) 2009-10-15
EP1553086A1 (en) 2005-07-13
US20060004205A1 (en) 2006-01-05
US7524967B2 (en) 2009-04-28
JP4208512B2 (ja) 2009-01-14
CA2493036C (en) 2011-03-22
AU2003252241A1 (en) 2004-02-09
IL166451A0 (en) 2006-01-15
CA2493036A1 (en) 2004-01-29
IL166451A (en) 2011-07-31
DE60329615D1 (de) 2009-11-19
MXPA05000944A (es) 2005-10-18
CN1671665A (zh) 2005-09-21
KR20050019919A (ko) 2005-03-03
EP1553086B1 (en) 2009-10-07
HK1077578B (zh) 2009-03-27
AU2003252241B2 (en) 2008-12-04
EP1553086A4 (en) 2007-04-25

Similar Documents

Publication Publication Date Title
CA2493036C (en) Process for producing 5-(2'-pyridyl)-2-pyridone derivative
KR100423627B1 (ko) 캄프토테신유도체(씨피티-11)및관련화합물의제조를위한신규중간체및제조방법
CN117343004A (zh) 一种2-氨基吡啶类化合物的制备方法
CN113135869A (zh) 一种制备α-芳基羰基化合物的方法及产品
JP5536458B2 (ja) ６−ハロゲノ−３−アリールピリジン誘導体の製造方法
CN117164497A (zh) 一种吡咯-2-酮类化合物的合成方法
HK1077579A (en) Process for producing 5-(2'-pyridyl)-2-pyridone derivative
CN116396328A (zh) 一种二芳基膦酰基-4-氟-1,3-丁二烯磷酸酯化合物及其制备方法
US5677458A (en) Method of preparing azatetralones
JP2583062B2 (ja) 複素環化合物の製造法
CN109053780B (zh) 一种抗肿瘤药物Acalabrutinib关键中间体的制备方法
Ko et al. Synthesis of difluorinated pyridinecarboxaldehyde via electrophilic fluorination
JPH0959254A (ja) ２−ヒドロキシピリジン類および／または２（１ｈ）−ピリドン類の製造法
US6096894A (en) Production method of 2-(p-alkylphenyl)pyridine compound
JP3875740B2 (ja) ２−クロロピリジン類およびその製造原料の製造法
JP3569877B2 (ja) ｍ−置換−α−ヒドロキシメチルスチレン誘導体の製造法および３−クロロ−α−ブロモスチレン
JP4602686B2 (ja) ２，６−ジハロゲノ−４−アリールピリジン類の製造法
CN121895144A (zh) 一种苏泽曲林关键中间体的合成方法
JP2001081074A (ja) アリールピリジン誘導体の製造法
JPH10130178A (ja) ｇｅｍ−ジフルオロオレフィン類の製造方法、同製造方法に用いるジルコノセン、及びその製造方法
CN119350210A (zh) 一种具有含氮杂环的萘衍生物的制备方法
JPH078857B2 (ja) アジド化合物
JPH08311060A (ja) 臭素化剤
JPH09132565A (ja) ３−（置換アミノメチル）−６−クロロピリジン及びその製造方法
CN113087669A (zh) 一种4-氰基-5-溴嘧啶的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1077578

Country of ref document: HK

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20070330

Address after: Okayama County, Japan

Applicant after: Kuraray Co., Ltd.

Co-applicant after: Eisai R. & D. Man Co., Ltd.

Address before: Okayama County, Japan

Applicant before: Kuraray Co., Ltd.

Co-applicant before: Eisai co., Ltd.

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1077578

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080611

Termination date: 20150723

EXPY Termination of patent right or utility model