CN100393702C - 用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法 - Google Patents

用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法 Download PDF

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Publication number
CN100393702C
CN100393702C CNB038176904A CN03817690A CN100393702C CN 100393702 C CN100393702 C CN 100393702C CN B038176904 A CNB038176904 A CN B038176904A CN 03817690 A CN03817690 A CN 03817690A CN 100393702 C CN100393702 C CN 100393702C
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China
Prior art keywords
formula
derivative
reaction
iii
organometallic compound
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Expired - Fee Related
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CNB038176904A
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English (en)
Chinese (zh)
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CN1671665A (zh
Inventor
小役丸健一
福永佳美
佐竹庸一
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Kuraray Co Ltd
Eisai R&D Management Co Ltd
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Sanitary Material R&d Management Co ltd
Kuraray Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB038176904A 2002-07-23 2003-07-23 用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法 Expired - Fee Related CN100393702C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002214098A JP4208512B2 (ja) 2002-07-23 2002-07-23 ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法
JP214098/2002 2002-07-23

Publications (2)

Publication Number Publication Date
CN1671665A CN1671665A (zh) 2005-09-21
CN100393702C true CN100393702C (zh) 2008-06-11

Family

ID=30767870

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038176904A Expired - Fee Related CN100393702C (zh) 2002-07-23 2003-07-23 用于制备5-(2′-吡啶基)-2-吡啶酮衍生物的方法

Country Status (13)

Country Link
US (1) US7524967B2 (enExample)
EP (1) EP1553086B1 (enExample)
JP (1) JP4208512B2 (enExample)
KR (1) KR101025528B1 (enExample)
CN (1) CN100393702C (enExample)
AT (1) ATE444952T1 (enExample)
AU (1) AU2003252241B2 (enExample)
CA (1) CA2493036C (enExample)
DE (1) DE60329615D1 (enExample)
HK (1) HK1077578B (enExample)
IL (1) IL166451A (enExample)
MX (1) MXPA05000944A (enExample)
WO (1) WO2004009553A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
ME01224B (me) * 2005-04-04 2013-06-20 Eisai R&D Man Co Ltd Jedinjenja dihidropiridina za liječenje neurodegenerativnih bolesti i demencije
AU2006285145A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-.receptor tyrosine kinases
WO2007027594A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
ATE528302T1 (de) 2005-08-29 2011-10-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind
JP4865337B2 (ja) * 2006-01-24 2012-02-01 富士フイルムファインケミカルズ株式会社 ２，３’−ビピリジル−６’−オンの製造方法
US20100016603A1 (en) * 2007-01-29 2010-01-21 Fujifilm Finechemicals Co., Ltd. Production process of 2,3'-bipyridyl-6'-one
JP2010520154A (ja) * 2007-03-05 2010-06-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 神経変性疾患のためのａｍｐａレセプターアンタゴニストおよびｎｍｄａレセプターアンタゴニスト
WO2008139984A1 (en) * 2007-04-26 2008-11-20 Eisai R & D Management Co., Ltd. Cinnamide compounds for dementia
US8742127B2 (en) 2007-12-21 2014-06-03 Kuraray Co., Ltd. Production method of 6-halogeno-3-arylpyridine derivative
ITMI20111952A1 (it) 2011-10-27 2013-04-28 Italiana Sint Spa Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel
EP2800747A4 (en) 2012-01-03 2015-12-09 Mapi Pharma Ltd POLYMORPHY OF PERAMPANEL
EP3024821B1 (en) 2013-07-25 2017-09-27 Teva Pharmaceuticals International GmbH Process for the preparation of perampanel
CN104725301A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种1,2-二氢吡啶-2-酮衍生物的制备方法
US10111867B2 (en) 2015-02-17 2018-10-30 Mapi Pharma Ltd. Process and intermediates for the preparation of perampanel
CA3109115A1 (en) 2018-08-06 2020-02-13 Olive Seed Industries, Llc Methods and systems for personalizing visitor experience at a venue
CN116930351A (zh) * 2023-06-08 2023-10-24 上海现代制药股份有限公司 一种hplc测定吡仑帕奈关键起始物料有关物质的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169184B1 (en) * 1996-09-12 2001-01-02 Basf Aktiengesellschaft Process for the production of substituted phenylpyridines
WO2001096308A1 (en) * 2000-06-12 2001-12-20 Eisai Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693611A (en) 1996-02-01 1997-12-02 Eli Lilly And Company Cyclic peptide antifungal agents
DE19633746A1 (de) 1996-08-22 1998-02-26 Basf Ag Substituierte 2-Phenylpyridine
JP4176201B2 (ja) 1998-09-02 2008-11-05 株式会社クラレ ５−ハロゲノ−２−置換ピリジンの製造方法
JP2003511452A (ja) 1999-10-11 2003-03-25 ファイザー・インク ホスホジエステラーゼ阻害剤としての５−（２−置換−５−ヘテロシクリルスルホニルピリド−３−イル）−ジヒドロピラゾロ［４，３−ｄ］ピリミジン−７−オン
US20020045613A1 (en) 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169184B1 (en) * 1996-09-12 2001-01-02 Basf Aktiengesellschaft Process for the production of substituted phenylpyridines
WO2001096308A1 (en) * 2000-06-12 2001-12-20 Eisai Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
synthesis of substitued pyridine quinolines and diazines viapallsdium catalized cross coupling of aryl grignard reagents. Bonnet,V.Tetrahedron,Vol.58 No.22. 2002 *

Also Published As

Publication number Publication date
MXPA05000944A (es) 2005-10-18
ATE444952T1 (de) 2009-10-15
HK1077578B (zh) 2009-03-27
IL166451A (en) 2011-07-31
CA2493036C (en) 2011-03-22
EP1553086A1 (en) 2005-07-13
US20060004205A1 (en) 2006-01-05
AU2003252241B2 (en) 2008-12-04
US7524967B2 (en) 2009-04-28
EP1553086B1 (en) 2009-10-07
WO2004009553A1 (ja) 2004-01-29
JP4208512B2 (ja) 2009-01-14
EP1553086A4 (en) 2007-04-25
DE60329615D1 (de) 2009-11-19
HK1077578A1 (en) 2006-02-17
KR101025528B1 (ko) 2011-04-04
CN1671665A (zh) 2005-09-21
IL166451A0 (en) 2006-01-15
JP2004051592A (ja) 2004-02-19
AU2003252241A1 (en) 2004-02-09
KR20050019919A (ko) 2005-03-03
CA2493036A1 (en) 2004-01-29

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