ATE444952T1 - Verfahren zur herstellung eines 5-(2'-pyridyl)-2- pyridonderivats - Google Patents
Verfahren zur herstellung eines 5-(2'-pyridyl)-2- pyridonderivatsInfo
- Publication number
- ATE444952T1 ATE444952T1 AT03765356T AT03765356T ATE444952T1 AT E444952 T1 ATE444952 T1 AT E444952T1 AT 03765356 T AT03765356 T AT 03765356T AT 03765356 T AT03765356 T AT 03765356T AT E444952 T1 ATE444952 T1 AT E444952T1
- Authority
- AT
- Austria
- Prior art keywords
- derivative
- formula
- pyridyl
- give
- reacting
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- NYPYPOZNGOXYSU-UHFFFAOYSA-N 3-bromopyridine Chemical class BrC1=CC=CN=C1 NYPYPOZNGOXYSU-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000002902 organometallic compounds Chemical class 0.000 abstract 2
- RWNISPVLLBWJBU-UHFFFAOYSA-N 2-sulfonyl-1h-pyridine Chemical class O=S(=O)=C1C=CC=CN1 RWNISPVLLBWJBU-UHFFFAOYSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002214098A JP4208512B2 (ja) | 2002-07-23 | 2002-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
| PCT/JP2003/009316 WO2004009553A1 (ja) | 2002-07-23 | 2003-07-23 | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE444952T1 true ATE444952T1 (de) | 2009-10-15 |
Family
ID=30767870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03765356T ATE444952T1 (de) | 2002-07-23 | 2003-07-23 | Verfahren zur herstellung eines 5-(2'-pyridyl)-2- pyridonderivats |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7524967B2 (enExample) |
| EP (1) | EP1553086B1 (enExample) |
| JP (1) | JP4208512B2 (enExample) |
| KR (1) | KR101025528B1 (enExample) |
| CN (1) | CN100393702C (enExample) |
| AT (1) | ATE444952T1 (enExample) |
| AU (1) | AU2003252241B2 (enExample) |
| CA (1) | CA2493036C (enExample) |
| DE (1) | DE60329615D1 (enExample) |
| HK (1) | HK1077578B (enExample) |
| IL (1) | IL166451A (enExample) |
| MX (1) | MXPA05000944A (enExample) |
| WO (1) | WO2004009553A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| HRP20110524T1 (hr) * | 2005-04-04 | 2011-08-31 | Eisai R&D Management Co. | Spojevi dihidropiridina za neurodegenerativne bolesti i demenciju |
| WO2007027729A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| ATE548363T1 (de) * | 2005-08-29 | 2012-03-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen |
| ES2361338T3 (es) | 2005-08-29 | 2011-06-16 | Vertex Pharmaceuticals Incorporated | Pirid-2-onas 3,5-disustituidas útiles como inhibidores de la familia tec de tirosina quinasas no ligadas a receptor. |
| JP4865337B2 (ja) * | 2006-01-24 | 2012-02-01 | 富士フイルムファインケミカルズ株式会社 | ２，３’−ビピリジル−６’−オンの製造方法 |
| WO2008093392A1 (ja) * | 2007-01-29 | 2008-08-07 | Fujifilm Finechemicals Co., Ltd. | ２，３'－ビピリジル－６'－オンの製造方法 |
| JP2010520154A (ja) * | 2007-03-05 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患のためのａｍｐａレセプターアンタゴニストおよびｎｍｄａレセプターアンタゴニスト |
| US20100130537A1 (en) * | 2007-04-26 | 2010-05-27 | Eisai R&D Management Co., Ltd | Cinnamide compounds for dementia |
| JP5536458B2 (ja) * | 2007-12-21 | 2014-07-02 | 株式会社クラレ | ６−ハロゲノ−３−アリールピリジン誘導体の製造方法 |
| ITMI20111952A1 (it) | 2011-10-27 | 2013-04-28 | Italiana Sint Spa | Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel |
| EP2800747A4 (en) | 2012-01-03 | 2015-12-09 | Mapi Pharma Ltd | POLYMORPHY OF PERAMPANEL |
| EA031384B1 (ru) | 2013-07-25 | 2018-12-28 | Тева Фармасьютикалз Интернэшнл Гмбх | Улучшенные способы получения перампанеля |
| CN104725301A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种1,2-二氢吡啶-2-酮衍生物的制备方法 |
| US10111867B2 (en) | 2015-02-17 | 2018-10-30 | Mapi Pharma Ltd. | Process and intermediates for the preparation of perampanel |
| EP3834167A4 (en) | 2018-08-06 | 2022-05-04 | Olive Seed Industries, LLC | PROCESSES AND SYSTEMS FOR PERSONALIZING VISITOR EXPERIENCES AT A VENUE |
| CN116930351A (zh) * | 2023-06-08 | 2023-10-24 | 上海现代制药股份有限公司 | 一种hplc测定吡仑帕奈关键起始物料有关物质的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693611A (en) | 1996-02-01 | 1997-12-02 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| DE19633746A1 (de) * | 1996-08-22 | 1998-02-26 | Basf Ag | Substituierte 2-Phenylpyridine |
| DE19636995A1 (de) * | 1996-09-12 | 1998-03-19 | Basf Ag | Verfahren zur Herstellung substituierter Phenylpyridine |
| JP4176201B2 (ja) * | 1998-09-02 | 2008-11-05 | 株式会社クラレ | ５−ハロゲノ−２−置換ピリジンの製造方法 |
| SK4562002A3 (en) | 1999-10-11 | 2003-04-01 | Pfizer | 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)- dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors |
| US20020045613A1 (en) | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
| ES2320973T3 (es) * | 2000-06-12 | 2009-06-01 | EISAI R&D MANAGEMENT CO., LTD. | Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos. |
-
2002
- 2002-07-23 JP JP2002214098A patent/JP4208512B2/ja not_active Expired - Fee Related
-
2003
- 2003-07-23 CN CNB038176904A patent/CN100393702C/zh not_active Expired - Fee Related
- 2003-07-23 MX MXPA05000944A patent/MXPA05000944A/es active IP Right Grant
- 2003-07-23 EP EP03765356A patent/EP1553086B1/en not_active Expired - Lifetime
- 2003-07-23 WO PCT/JP2003/009316 patent/WO2004009553A1/ja not_active Ceased
- 2003-07-23 DE DE60329615T patent/DE60329615D1/de not_active Expired - Lifetime
- 2003-07-23 AT AT03765356T patent/ATE444952T1/de not_active IP Right Cessation
- 2003-07-23 AU AU2003252241A patent/AU2003252241B2/en not_active Ceased
- 2003-07-23 CA CA2493036A patent/CA2493036C/en not_active Expired - Fee Related
- 2003-07-23 HK HK05112103.4A patent/HK1077578B/zh not_active IP Right Cessation
- 2003-07-23 KR KR1020057001229A patent/KR101025528B1/ko not_active Expired - Fee Related
- 2003-07-23 US US10/521,800 patent/US7524967B2/en not_active Expired - Fee Related
-
2005
- 2005-01-23 IL IL166451A patent/IL166451A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05000944A (es) | 2005-10-18 |
| HK1077578B (zh) | 2009-03-27 |
| CA2493036C (en) | 2011-03-22 |
| HK1077578A1 (en) | 2006-02-17 |
| EP1553086A1 (en) | 2005-07-13 |
| US7524967B2 (en) | 2009-04-28 |
| US20060004205A1 (en) | 2006-01-05 |
| JP4208512B2 (ja) | 2009-01-14 |
| EP1553086A4 (en) | 2007-04-25 |
| JP2004051592A (ja) | 2004-02-19 |
| DE60329615D1 (de) | 2009-11-19 |
| EP1553086B1 (en) | 2009-10-07 |
| CN1671665A (zh) | 2005-09-21 |
| KR20050019919A (ko) | 2005-03-03 |
| AU2003252241A1 (en) | 2004-02-09 |
| CA2493036A1 (en) | 2004-01-29 |
| AU2003252241B2 (en) | 2008-12-04 |
| IL166451A (en) | 2011-07-31 |
| WO2004009553A1 (ja) | 2004-01-29 |
| CN100393702C (zh) | 2008-06-11 |
| IL166451A0 (en) | 2006-01-15 |
| KR101025528B1 (ko) | 2011-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE444952T1 (de) | Verfahren zur herstellung eines 5-(2'-pyridyl)-2- pyridonderivats | |
| WO2006004100A8 (ja) | １，２－ジヒドロピリジン－２－オン化合物の製造方法 | |
| DE60311599D1 (de) | Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten | |
| EP1275727A3 (en) | Polyhydroxyalkanoate with (methylsulfanyl) phenoxy structure in side chain | |
| DE602004019329D1 (de) | Verfahren zur herstellung substituierter nikotinsäureester | |
| CA2289409A1 (en) | Sulfoxide compounds and acetone complexes, and a process for producing the same | |
| ATE444747T1 (de) | Verfahren zur herstellung von expoxybutanol- zwischenprodukten | |
| CY1111277T1 (el) | Μεθοδος παραγωγης κιλοσταζολης | |
| EP1535914A4 (en) | METHOD FOR THE PRODUCTION OF EPOXYTRIAZOL DERIVATIVE AND INTERMEDIATE PRODUCTS THEREFOR | |
| EP1247791A4 (en) | PROCESS FOR PRODUCING PERFLUOROALCADIENES | |
| ATE506352T1 (de) | Verfahren zur herstellung von optional 2- substituierten 1,6-dihydro-6-oxo-4- pyrimidincarboxylsäuren | |
| EP1880987A4 (en) | PROCESS FOR PREPARING A CYCLOPROPYLPHENOL DERIVATIVE | |
| DE60227595D1 (de) | Verfahren zur Herstellung von Cytosin-Nukleosidverbindungen | |
| ATE546432T1 (de) | Verfahren zur herstellung von 2- aminomethylpyridin-derivate | |
| ATE378312T1 (de) | Verfahren zur herstellung von adapalene | |
| EP1666440A4 (en) | METHOD FOR PRODUCING AN AROMATICALLY UNSATURATED COMPOUND | |
| ATE459617T1 (de) | Verfahren zur herstellung von pyridinmethylsulphinylverbindungen | |
| ATE419230T1 (de) | Verfahren zur herstellung von 2,6-dihalo-para- trifluoromethylanilin | |
| EP1627875A4 (en) | PROCESS FOR PRODUCING CYCLIC DIAMINE DERIVATIVE OR SALT THEREOF | |
| DE60336739D1 (de) | Verfahren zur herstellung eines 2-substituierten pyridinderivats | |
| BR0317781A (pt) | Processo para produção de derivado de benzilamina | |
| EP1211239A4 (en) | PROCESSES FOR THE PREPARATION OF 2,3-DIHYDROAZEPINE COMPOUNDS | |
| ATE425972T1 (de) | Verfahren zur herstellung substituierter imidazolderivate und in dem verfahren verwendete zwischenprodukte | |
| WO2003099198A3 (en) | A process for the preparation of oxindole derivatives | |
| EP1484311A4 (en) | PROCESS FOR PRODUCING A CHAIN OLIGOLACTIC ACID ESTER |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |