KR100918223B1 - 배변 조성물 - Google Patents

배변 조성물 Download PDF

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Publication number
KR100918223B1
KR100918223B1 KR1020087021218A KR20087021218A KR100918223B1 KR 100918223 B1 KR100918223 B1 KR 100918223B1 KR 1020087021218 A KR1020087021218 A KR 1020087021218A KR 20087021218 A KR20087021218 A KR 20087021218A KR 100918223 B1 KR100918223 B1 KR 100918223B1
Authority
KR
South Korea
Prior art keywords
composition
bicyclic
formula
compound
triglyceride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020087021218A
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English (en)
Korean (ko)
Other versions
KR20080091278A (ko
Inventor
류지 우에노
Original Assignee
수캄포 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24630250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100918223(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 수캄포 아게 filed Critical 수캄포 아게
Publication of KR20080091278A publication Critical patent/KR20080091278A/ko
Application granted granted Critical
Publication of KR100918223B1 publication Critical patent/KR100918223B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
KR1020087021218A 2000-09-05 2001-09-04 배변 조성물 Expired - Lifetime KR100918223B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/655,760 2000-09-05
US09/655,760 US6414016B1 (en) 2000-09-05 2000-09-05 Anti-constipation composition

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020037003261A Division KR100901102B1 (ko) 2000-09-05 2001-09-04 배변 조성물

Publications (2)

Publication Number Publication Date
KR20080091278A KR20080091278A (ko) 2008-10-09
KR100918223B1 true KR100918223B1 (ko) 2009-09-21

Family

ID=24630250

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020087021218A Expired - Lifetime KR100918223B1 (ko) 2000-09-05 2001-09-04 배변 조성물
KR1020037003261A Expired - Lifetime KR100901102B1 (ko) 2000-09-05 2001-09-04 배변 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020037003261A Expired - Lifetime KR100901102B1 (ko) 2000-09-05 2001-09-04 배변 조성물

Country Status (25)

Country Link
US (7) US6414016B1 (https=)
EP (2) EP1857105B1 (https=)
JP (3) JP2004508327A (https=)
KR (2) KR100918223B1 (https=)
CN (1) CN100335049C (https=)
AR (2) AR030609A1 (https=)
AT (1) ATE476975T1 (https=)
AU (2) AU2001282615B2 (https=)
BR (1) BRPI0114042B8 (https=)
CA (1) CA2419741C (https=)
CZ (1) CZ304740B6 (https=)
DE (2) DE60142810D1 (https=)
DK (2) DK1857105T3 (https=)
ES (2) ES2296786T3 (https=)
HU (1) HU229319B1 (https=)
IL (2) IL154534A0 (https=)
MX (1) MXPA03001959A (https=)
NL (1) NL300757I1 (https=)
NO (1) NO332701B1 (https=)
NZ (1) NZ524401A (https=)
PT (2) PT1315485E (https=)
RU (1) RU2694361C3 (https=)
TW (1) TWI305147B (https=)
WO (1) WO2002020007A1 (https=)
ZA (1) ZA200301673B (https=)

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US6414016B1 (en) * 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
TWI302100B (en) * 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
AR037524A1 (es) 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
TWI263505B (en) * 2001-11-19 2006-10-11 Sucampo Ag Pharmaceutical composition comprising a C1C-2 channel opener
NZ539582A (en) * 2002-10-23 2007-07-27 Sucampo Ag Prostaglandin compounds for the treatment of obesity
EP1575596B1 (en) * 2002-12-27 2016-06-22 Sucampo AG Derivatives of prostaglandins for treating irritable bowel syndrome and/or functional dyspepsia
DE602004030245D1 (de) * 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
TWI495471B (zh) * 2003-08-12 2015-08-11 R Tech Ueno Ltd 促進毛髮生長之組成物及方法
RU2392941C2 (ru) * 2004-09-02 2010-06-27 Сукампо Аг Производные простагландинов для лечения желудочно-кишечного нарушения
TWI387454B (zh) * 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US8202909B2 (en) * 2005-01-27 2012-06-19 Sucampo Ag Method for treating central nervous system disorders
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ES2714198T3 (es) * 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
RU2468800C2 (ru) * 2005-04-12 2012-12-10 Сукампо Аг Комбинированное применение производного простагландина и ингибитора протонового насоса для лечения желудочно-кишечных заболеваний
JP5265369B2 (ja) 2006-01-24 2013-08-14 株式会社アールテック・ウエノ 二環式化合物を含む医薬組成物およびその二環式化合物の安定化方法
KR101437302B1 (ko) * 2006-02-07 2014-09-02 가부시키가이샤 아루떼꾸 우에노 프로스타글란딘 유도체의 제조 방법
US20090012165A1 (en) * 2007-07-03 2009-01-08 Sucampo Ag Pharmaceutical combination of nsaid and prostaglandin compound
US20090030072A1 (en) * 2007-07-03 2009-01-29 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
US20090082442A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched lubiprostone
CN101318948B (zh) * 2008-04-01 2011-04-27 上海天伟生物制药有限公司 鲁比前列酮晶体、其制备方法及用途
US8513441B2 (en) * 2008-08-29 2013-08-20 Alphora Research Inc. Prostaglandin synthesis and intermediates for use therein
PT2349250T (pt) * 2008-10-31 2017-07-25 Lipid Pharmaceuticals Ehf Ácidos gordos para uso como um medicamento
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
SI2384318T1 (en) 2008-12-31 2018-03-30 Ardelyx, Inc. MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT
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US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
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Also Published As

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US20120022152A1 (en) 2012-01-26
US8114890B1 (en) 2012-02-14
ES2296786T3 (es) 2008-05-01
US6414016B1 (en) 2002-07-02
NL300757I2 (https=) 2015-12-29
US20140235665A1 (en) 2014-08-21
EP1857105B1 (en) 2010-08-11
DE60142810D1 (de) 2010-09-23
IL154534A0 (en) 2003-09-17
DE60131547T2 (de) 2008-10-23
NO20030996L (no) 2003-05-02
AR100291A2 (es) 2016-09-28
HU229319B1 (en) 2013-10-28
ES2347697T3 (es) 2010-11-03
NO20030996D0 (no) 2003-03-04
RU2694361C3 (ru) 2020-07-20
EP1857105A3 (en) 2008-03-05
CZ304740B6 (cs) 2014-09-17
US8748454B2 (en) 2014-06-10
MXPA03001959A (es) 2003-06-24
NO332701B1 (no) 2012-12-10
BRPI0114042B8 (pt) 2021-05-25
TWI305147B (en) 2009-01-11
HUP0302422A2 (hu) 2003-10-28
EP1315485B1 (en) 2007-11-21
DE60131547D1 (de) 2008-01-03
ATE476975T1 (de) 2010-08-15
NL300757I1 (https=) 2015-12-29
AU2001282615B2 (en) 2006-06-22
PT1315485E (pt) 2008-01-23
EP1315485A1 (en) 2003-06-04
US20030040528A1 (en) 2003-02-27
CN1655776A (zh) 2005-08-17
DK1315485T3 (da) 2008-03-03
US8071613B2 (en) 2011-12-06
DK1857105T3 (da) 2010-09-20
JP2009286806A (ja) 2009-12-10
RU2694361C2 (ru) 2019-07-12
KR20030029919A (ko) 2003-04-16
US20030216465A1 (en) 2003-11-20
AR030609A1 (es) 2003-08-27
RU2694361C9 (ru) 2019-12-25
HUP0302422A3 (en) 2005-02-28
BRPI0114042B1 (pt) 2016-11-08
JP2004508327A (ja) 2004-03-18
CA2419741A1 (en) 2002-03-14
ZA200301673B (en) 2003-11-26
PT1857105E (pt) 2010-10-08
WO2002020007A1 (en) 2002-03-14
CN100335049C (zh) 2007-09-05
US20120237598A1 (en) 2012-09-20
KR20080091278A (ko) 2008-10-09
AU8261501A (en) 2002-03-22
JP2009114217A (ja) 2009-05-28
NZ524401A (en) 2004-08-27
CA2419741C (en) 2010-11-30
BR0114042A (pt) 2003-07-22
IL154534A (en) 2010-04-29
US20050222195A1 (en) 2005-10-06
US6610732B2 (en) 2003-08-26
EP1857105A2 (en) 2007-11-21
JP4684334B2 (ja) 2011-05-18
KR100901102B1 (ko) 2009-06-08

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