KR100911069B1 - 치환된 알킬아미노피리다지논 유도체, 이의 제조 방법 및이를 함유하는 약제학적 조성물 - Google Patents

치환된 알킬아미노피리다지논 유도체, 이의 제조 방법 및이를 함유하는 약제학적 조성물 Download PDF

Info

Publication number
KR100911069B1
KR100911069B1 KR1020047004607A KR20047004607A KR100911069B1 KR 100911069 B1 KR100911069 B1 KR 100911069B1 KR 1020047004607 A KR1020047004607 A KR 1020047004607A KR 20047004607 A KR20047004607 A KR 20047004607A KR 100911069 B1 KR100911069 B1 KR 100911069B1
Authority
KR
South Korea
Prior art keywords
formula
compound
acid addition
pharmaceutically acceptable
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020047004607A
Other languages
English (en)
Korean (ko)
Other versions
KR20040039446A (ko
Inventor
조세프 바르코치
기율라 시미그
페터 코타이나기
기요르기 레베이
이스트반 가크살리
베르나데트 마르토네마르코
에바 쉬미트
안드라스 에기에드
하날카 콤파그네
씨실라 레벨레키
아니코 미클로스네코바크스
가보르 스제나시
자노스 웰맨
라스즐로 가보르 하르싱
Original Assignee
에지스 지오기스제르기아르 니일바노산 무코도 레스즈베니타르사사그
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에지스 지오기스제르기아르 니일바노산 무코도 레스즈베니타르사사그 filed Critical 에지스 지오기스제르기아르 니일바노산 무코도 레스즈베니타르사사그
Publication of KR20040039446A publication Critical patent/KR20040039446A/ko
Application granted granted Critical
Publication of KR100911069B1 publication Critical patent/KR100911069B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020047004607A 2001-09-27 2002-09-26 치환된 알킬아미노피리다지논 유도체, 이의 제조 방법 및이를 함유하는 약제학적 조성물 Expired - Fee Related KR100911069B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
HUP0103912 2001-09-27
PCT/HU2002/000097 WO2003027078A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Publications (2)

Publication Number Publication Date
KR20040039446A KR20040039446A (ko) 2004-05-10
KR100911069B1 true KR100911069B1 (ko) 2009-08-06

Family

ID=89979721

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020047004606A Expired - Fee Related KR100890667B1 (ko) 2001-09-27 2002-09-26 치환된 알킬아미노피리다지논 유도체, 이의 제조 방법 및이를 함유하는 약제학적 조성물
KR1020047004607A Expired - Fee Related KR100911069B1 (ko) 2001-09-27 2002-09-26 치환된 알킬아미노피리다지논 유도체, 이의 제조 방법 및이를 함유하는 약제학적 조성물

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020047004606A Expired - Fee Related KR100890667B1 (ko) 2001-09-27 2002-09-26 치환된 알킬아미노피리다지논 유도체, 이의 제조 방법 및이를 함유하는 약제학적 조성물

Country Status (25)

Country Link
US (2) US6930110B2 (OSRAM)
EP (2) EP1430047B1 (OSRAM)
JP (2) JP2005508914A (OSRAM)
KR (2) KR100890667B1 (OSRAM)
CN (3) CN101099740B (OSRAM)
AT (2) ATE288910T1 (OSRAM)
AU (2) AU2002328166B2 (OSRAM)
BR (2) BR0212839A (OSRAM)
CA (2) CA2461510C (OSRAM)
CZ (2) CZ2004528A3 (OSRAM)
DE (2) DE60202970T2 (OSRAM)
DK (2) DK1430047T3 (OSRAM)
EA (2) EA006942B1 (OSRAM)
ES (2) ES2237690T3 (OSRAM)
HU (1) HU227237B1 (OSRAM)
MA (2) MA27068A1 (OSRAM)
MX (2) MXPA04002838A (OSRAM)
NO (2) NO326370B1 (OSRAM)
NZ (2) NZ532103A (OSRAM)
PL (2) PL369256A1 (OSRAM)
PT (2) PT1430034E (OSRAM)
SI (2) SI1430047T1 (OSRAM)
SK (2) SK1902004A3 (OSRAM)
WO (2) WO2003027078A1 (OSRAM)
ZA (2) ZA200402544B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
AU2008227100B2 (en) * 2007-03-15 2014-01-09 Albany Molecular Research, Inc. Pyridazinone derivatives useful as glucan synthase inhibitors
TWI877697B (zh) * 2018-04-30 2025-03-21 美商律幫治療股份有限公司 作為parp7抑制劑的嗒酮
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
US12371421B2 (en) 2019-04-29 2025-07-29 Ribon Therapeutics, Inc. Solid forms of a PARP7 inhibitor
CN117425648A (zh) * 2021-03-12 2024-01-19 杭州英创医药科技有限公司 作为parp7抑制剂的化合物
CN115490671B (zh) * 2022-10-21 2024-05-14 水木未来(北京)科技有限公司 Parp7抑制剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0372305A1 (de) * 1988-12-06 1990-06-13 Hafslund Nycomed Pharma Aktiengesellschaft Neue Piperazinylalkyl-3(2H)-pyridazinone, Verfahren zu ihrer Herstellung und ihre Verwendung als blutdrucksenkende Mittel
WO1992012137A1 (en) * 1990-12-27 1992-07-23 Richter Gedeon Vegyészeti Gyár Rt. Novel 3(2h)-pyridazinones, pharmaceutical compositions containing them and process for preparing same
US5395934A (en) 1991-12-20 1995-03-07 Egis Gyogyszergyar 3(2H)-pyridazinone derivatives and process for the preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
PL164079B1 (pl) * 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU224067B1 (hu) * 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
US6800758B1 (en) * 1998-06-05 2004-10-05 Egis Gyogyszergyar Rt. Process for the preparation of a 3(2H)-pyridazinone-4- substituted amino 5-chloro derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0372305A1 (de) * 1988-12-06 1990-06-13 Hafslund Nycomed Pharma Aktiengesellschaft Neue Piperazinylalkyl-3(2H)-pyridazinone, Verfahren zu ihrer Herstellung und ihre Verwendung als blutdrucksenkende Mittel
WO1992012137A1 (en) * 1990-12-27 1992-07-23 Richter Gedeon Vegyészeti Gyár Rt. Novel 3(2h)-pyridazinones, pharmaceutical compositions containing them and process for preparing same
US5395934A (en) 1991-12-20 1995-03-07 Egis Gyogyszergyar 3(2H)-pyridazinone derivatives and process for the preparation thereof

Also Published As

Publication number Publication date
AU2002330656A2 (en) 2003-04-07
NO326370B1 (no) 2008-11-17
CA2461510C (en) 2009-07-07
SI1430034T1 (en) 2005-08-31
ZA200402544B (en) 2005-04-26
EA006392B1 (ru) 2005-12-29
EP1430047A1 (en) 2004-06-23
HUP0103912A2 (hu) 2003-07-28
CZ2004532A3 (cs) 2004-08-18
HK1115728A1 (en) 2008-12-05
KR20040039445A (ko) 2004-05-10
CA2461467A1 (en) 2003-04-03
NO20041551L (no) 2004-06-10
PL369107A1 (en) 2005-04-18
CN101099740B (zh) 2010-09-08
WO2003027078A1 (en) 2003-04-03
AU2002328166B2 (en) 2008-04-17
AU2002330656B9 (en) 2009-09-03
DE60202969D1 (de) 2005-03-17
US6930110B2 (en) 2005-08-16
EP1430034B1 (en) 2005-02-09
DE60202969T2 (de) 2006-01-19
JP2005503437A (ja) 2005-02-03
ES2237696T3 (es) 2005-08-01
US20050043314A1 (en) 2005-02-24
CN101099740A (zh) 2008-01-09
AU2002330656B2 (en) 2009-04-09
MXPA04002836A (es) 2004-07-05
HU227237B1 (en) 2010-12-28
DK1430047T3 (da) 2005-06-06
SK1892004A3 (en) 2004-10-05
MXPA04002838A (es) 2004-07-05
CN100368404C (zh) 2008-02-13
PT1430047E (pt) 2005-06-30
EA200400470A1 (ru) 2004-08-26
HUP0103912A3 (en) 2004-03-01
JP4472337B2 (ja) 2010-06-02
SI1430047T1 (en) 2005-08-31
ZA200402545B (en) 2005-04-26
NZ532104A (en) 2005-10-28
MA27137A1 (fr) 2005-01-03
US20040242873A1 (en) 2004-12-02
HU0103912D0 (en) 2001-12-28
EA200400469A1 (ru) 2004-08-26
DE60202970T2 (de) 2006-02-16
KR100890667B1 (ko) 2009-03-26
CA2461510A1 (en) 2003-04-03
CN1571783A (zh) 2005-01-26
HK1069816A1 (en) 2005-06-03
BR0212932A (pt) 2004-10-13
ES2237690T3 (es) 2005-08-01
DE60202970D1 (de) 2005-03-17
ATE288910T1 (de) 2005-02-15
ATE288899T1 (de) 2005-02-15
PL369256A1 (en) 2005-04-18
BR0212839A (pt) 2004-10-13
CZ2004528A3 (cs) 2004-08-18
HK1069817A1 (en) 2005-06-03
NO20041704L (no) 2004-04-26
CN1325489C (zh) 2007-07-11
NZ532103A (en) 2005-08-26
EP1430047B1 (en) 2005-02-09
DK1430034T3 (da) 2005-05-30
JP2005508914A (ja) 2005-04-07
NO325080B1 (no) 2008-01-28
MA27068A1 (fr) 2004-12-20
AU2002328166A2 (en) 2003-04-07
CN1558904A (zh) 2004-12-29
KR20040039446A (ko) 2004-05-10
SK1902004A3 (en) 2004-10-05
PT1430034E (pt) 2005-06-30
EA006942B1 (ru) 2006-06-30
WO2003027097A1 (en) 2003-04-03
EP1430034A1 (en) 2004-06-23

Similar Documents

Publication Publication Date Title
KR100911069B1 (ko) 치환된 알킬아미노피리다지논 유도체, 이의 제조 방법 및이를 함유하는 약제학적 조성물
JP2005508914A5 (OSRAM)
AU2002330656A1 (en) Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
AU2002328166A1 (en) Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
KR20040104608A (ko) 피페리디닐-알킬아미노-피리다지논 유도체, 이의 제조방법, 및 이 화합물을 함유하는 약제 조성물
HK1115728B (en) Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
HK1069816B (en) Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
US20060211703A1 (en) Substituted alkyl-pyridazinones for the treatment of memory and learning malfunctions
HK1069817B (en) Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
HU227294B1 (en) Substituted alkylpyridazone derivatives, process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20120731

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20120731

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301