KR100904582B1 - 건성 지혈 조성물 및 그 제조 방법 - Google Patents

건성 지혈 조성물 및 그 제조 방법 Download PDF

Info

Publication number
KR100904582B1
KR100904582B1 KR1020047000565A KR20047000565A KR100904582B1 KR 100904582 B1 KR100904582 B1 KR 100904582B1 KR 1020047000565 A KR1020047000565 A KR 1020047000565A KR 20047000565 A KR20047000565 A KR 20047000565A KR 100904582 B1 KR100904582 B1 KR 100904582B1
Authority
KR
South Korea
Prior art keywords
hydration
powder
gelatin
crosslinked
aid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020047000565A
Other languages
English (en)
Korean (ko)
Other versions
KR20040025698A (ko
Inventor
젠 키안
에드워드 에이. 오사와
카리 제이. 레이취
Original Assignee
백스터 인터내셔널 인코포레이티드
박스터 헬쓰케어 에스.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 백스터 인터내셔널 인코포레이티드, 박스터 헬쓰케어 에스.에이. filed Critical 백스터 인터내셔널 인코포레이티드
Publication of KR20040025698A publication Critical patent/KR20040025698A/ko
Application granted granted Critical
Publication of KR100904582B1 publication Critical patent/KR100904582B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/104—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020047000565A 2001-07-17 2002-06-21 건성 지혈 조성물 및 그 제조 방법 Expired - Lifetime KR100904582B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/908,464 2001-07-17
US09/908,464 US7435425B2 (en) 2001-07-17 2001-07-17 Dry hemostatic compositions and methods for their preparation
PCT/US2002/020022 WO2003007845A1 (en) 2001-07-17 2002-06-21 Dry hemostatic compositions and methods for their preparation

Publications (2)

Publication Number Publication Date
KR20040025698A KR20040025698A (ko) 2004-03-24
KR100904582B1 true KR100904582B1 (ko) 2009-06-25

Family

ID=25425842

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047000565A Expired - Lifetime KR100904582B1 (ko) 2001-07-17 2002-06-21 건성 지혈 조성물 및 그 제조 방법

Country Status (15)

Country Link
US (4) US7435425B2 (OSRAM)
EP (2) EP1803417B1 (OSRAM)
JP (1) JP4316374B2 (OSRAM)
KR (1) KR100904582B1 (OSRAM)
CN (2) CN101284146B (OSRAM)
AT (2) ATE358455T1 (OSRAM)
AU (1) AU2002345846B2 (OSRAM)
BR (1) BRPI0211258B8 (OSRAM)
CA (1) CA2453592C (OSRAM)
DE (2) DE60219319T2 (OSRAM)
DK (2) DK1414370T3 (OSRAM)
ES (2) ES2284883T3 (OSRAM)
MX (1) MXPA04000514A (OSRAM)
PT (2) PT1803417E (OSRAM)
WO (1) WO2003007845A1 (OSRAM)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7923431B2 (en) * 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
BR0317237A (pt) 2002-12-11 2005-11-01 Ferrosan As Dispositivo para amostragem ou coleta, kit, usos de um dispositivo e de um kit, e, métodos para diminuir a quantidade de um marcador em uma área de amostra, para amostrar de modo qualitativo ou quantitativo uma área quanto ao teor de um marcador e para cultivar microorganismos ou células de mamìferos coletados
US8834864B2 (en) 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US8440225B2 (en) * 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20060019868A1 (en) * 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US7109163B2 (en) * 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
ATE475434T1 (de) 2004-01-30 2010-08-15 Ferrosan As Hämostatische sprays und zusammensetzungen
US8119160B2 (en) * 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
RU2369408C2 (ru) 2004-07-09 2009-10-10 Ферросан А/С Гемостатическая композиция, включающая гиалуроновую кислоту
FR2881651A1 (fr) * 2005-02-09 2006-08-11 Urodelia Sa Nouveau produit pharmaceutique et procede de fabrication de ce produit pharmaceutique
CA2616865C (en) * 2005-07-28 2014-07-08 Carnegie Mellon University Biocompatible polymers and methods of use
WO2007075447A2 (en) * 2005-12-16 2007-07-05 Oxthera, Inc. Compositions and methods for oxalate reduction
BRPI0712088B8 (pt) 2006-05-31 2021-06-22 Baxter Healthcare Sa uso de uma biomatriz de lâmina de colágeno de múltiplas camadas microscópicas não porosa e hermética a fluido
TWI436793B (zh) 2006-08-02 2014-05-11 巴克斯特國際公司 快速作用之乾密封膠及其使用和製造方法
US8133484B2 (en) 2006-12-15 2012-03-13 Lifebond Ltd Hemostatic materials and dressing
MX2009006369A (es) 2006-12-15 2010-02-24 Lifebond Ltd Apositos y selladores hemostaticos de gelatina-transglutaminasa.
US20100143447A1 (en) * 2006-12-19 2010-06-10 Ferrosan A/S Wound or tissue dressing comprising lactic acid bacteria
DE102007038125A1 (de) 2007-08-03 2009-02-05 Aesculap Ag Kombination zum Verkleben von biologischen Geweben
AR069109A1 (es) 2007-10-30 2009-12-30 Baxter Int Uso de una biomatriz de colageno biofuncional regenerativa para tratar defectos viscerales o parietales
EP2222159B1 (en) * 2007-11-20 2018-02-21 Pioneer Surgical Orthobiologics, Inc. Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles
WO2009109194A2 (en) 2008-02-29 2009-09-11 Ferrosan A/S Device for promotion of hemostasis and/or wound healing
WO2009123903A1 (en) * 2008-04-03 2009-10-08 Zymogenetics, Inc. Hemostatic microspheres
CN104031393B (zh) 2008-06-18 2017-08-01 生命连结有限公司 改进的交联组合物
US8110208B1 (en) 2009-03-30 2012-02-07 Biolife, L.L.C. Hemostatic compositions for arresting blood flow from an open wound or surgical site
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
DK2442835T3 (en) 2009-06-16 2015-03-16 Baxter Int Styptic sponge
US20110081398A1 (en) * 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
US8968785B2 (en) * 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
US20110081701A1 (en) * 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
BR112012014773A2 (pt) 2009-12-16 2015-11-03 Baxter Healthcare Sa esponja de compósito hemostática, método para fabricar uma esponja de compósito hemostática, e, uso da referida esponja
JP5796860B2 (ja) 2009-12-22 2015-10-21 ライフボンド リミテッドＬｉｆｅｂｏｎｄ Ｌｔｄ 架橋マトリックスの特性を調節するための酵素的架橋剤の改変
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
MX352875B (es) 2010-06-01 2017-12-13 Baxter Healthcare Sa Proceso para elaborar composiciones hemostaticas secas y estables.
AU2011260258B2 (en) 2010-06-01 2015-07-09 Baxter Healthcare S.A. Process for making dry and stable hemostatic compositions
CA2801118C (en) * 2010-06-01 2016-01-05 Baxter International Inc. Process for making dry and stable hemostatic compositions
EP2600910B1 (en) 2010-08-05 2016-01-20 Lifebond Ltd Dry composition wound dressings and adhesives
JP2014511694A (ja) 2011-04-03 2014-05-19 ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル 修飾型ｒｎａ（ｍｏｄ−ｒｎａ）を使用する効率的なインビボタンパク質発現
US9149511B2 (en) * 2011-06-30 2015-10-06 Ethicon, Inc. Procoagulant peptides and their derivatives and uses therefor
HK1201212A1 (en) 2011-10-11 2015-08-28 Baxter International Inc Hemostatic compositions
AU2012318259A1 (en) 2011-10-11 2013-05-02 Baxter Healthcare S.A. Hemostatic compositions
CA2851321C (en) 2011-10-11 2020-07-07 Baxter International Inc. Hemostatic compositions
MX355924B (es) * 2011-10-11 2018-05-04 Baxter Int Composicion hemostatica.
ES2553702T3 (es) * 2011-10-27 2015-12-11 Baxter International Inc Composiciones hemostáticas
UY34415A (es) 2011-10-27 2013-05-31 Baxter Int Composiciones hemostáticas
MX352601B (es) 2011-12-23 2017-11-30 Pioneer Surgical Tech Matriz continua con particulas osteoconductoras dispersadas en ella, método para formarla y método para regenerar hueso con ella.
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス 止血ペーストを収容する加圧容器
CN104349797B (zh) 2012-06-12 2017-10-27 弗罗桑医疗设备公司 干止血组合物
EP3010419B1 (en) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
EP3079731B1 (en) * 2013-12-11 2018-08-08 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US10814032B2 (en) 2014-08-08 2020-10-27 The Brigham And Women's Hospital, Inc. Elastic biopolymer and use as a tissue adhesive
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス 止血および創傷治癒に使用するための乾燥組成物
RU2705905C2 (ru) 2014-12-24 2019-11-12 Ферросан Медикал Дивайсиз А/С Шприц для удерживания и смешивания первого и второго веществ
WO2016149615A1 (en) 2015-03-19 2016-09-22 The Brigham And Women's Hospital, Inc. Polypeptide compositions and methods of using the same
AU2016290433B2 (en) 2015-07-03 2018-05-24 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
CA2996853A1 (en) 2015-09-01 2017-03-09 Baxter International Inc. Hemostatic material
ES3027197T3 (en) 2016-02-08 2025-06-13 Brigham & Womens Hospital Inc Bioadhesive for corneal repair
CN105879109A (zh) * 2016-03-31 2016-08-24 武汉华同信生物科技有限公司 一种医用胶粘剂及其制备方法
KR20180027126A (ko) * 2016-09-06 2018-03-14 (주)한국비엠아이 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물
US11679177B2 (en) 2017-08-08 2023-06-20 Baxter International Inc. Polymeric compositions, delivery devices, and methods
KR102662531B1 (ko) 2017-11-03 2024-05-03 백스터 인터내셔널 인코포레이티드 중합체 조성물, 전달 장치 및 방법
KR20200093600A (ko) * 2017-11-28 2020-08-05 백스터 인터내셔널 인코포레이티드 상처-치료용 흡수제
KR20200105680A (ko) 2017-12-29 2020-09-08 백스터 인터내셔널 인코포레이티드 분무-건조된 트롬빈, 및 분무-건조된 트롬빈의 사용 및 제조 방법
CN112368028A (zh) 2018-05-09 2021-02-12 弗罗桑医疗设备公司 用于制备止血组合物的方法
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
CA3111444A1 (en) 2018-09-04 2020-03-12 Massachusetts Eye And Ear Infirmary Light activated adhesive scaffold
EP4218839B1 (en) 2019-07-12 2024-09-11 Cilag GmbH Haemostatic sheet
JP7555981B2 (ja) 2019-07-12 2024-09-25 ガット テクノロジーズ ビー．ブイ． 組織接着性シートを調製するための方法
EP3996757B1 (en) 2019-07-12 2023-04-19 GATT Technologies B.V. Biocompatible, flexible, haemostatic sheet
WO2021261080A1 (ja) * 2020-06-26 2021-12-30 国立研究開発法人物質・材料研究機構 多孔体、封止材、穿刺部封止装置、止血シート、及び、多孔体の製造方法
KR20230130049A (ko) 2021-01-08 2023-09-11 시락 게엠베하 인터내셔날 생체흡수성 밀봉 분말
CN113144277B (zh) * 2021-04-13 2022-06-14 武汉理工大学 一种可注射流体明胶及其制备方法和应用
CN113209357B (zh) * 2021-05-14 2023-02-17 南方科技大学 复合止血粉
JP2024534444A (ja) * 2021-09-16 2024-09-20 エシコン・インコーポレイテッド 組織経路封止用組成物のためのキット
KR20240110866A (ko) 2021-11-29 2024-07-16 백스터 인터내셔널 인코포레이티드 개선된 지혈제 재구성 방법 및 디바이스
CN117298327B (zh) * 2023-11-15 2024-10-01 北京帝康医药投资管理有限公司 一种止血微球颗粒及其制备方法和应用
CN117503988A (zh) * 2023-12-01 2024-02-06 上海瀚滏生物科技有限责任公司 一种流体明胶止血材料的制备方法及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543332A (en) * 1982-03-29 1985-09-24 Miles Laboratories, Inc. Method for the preparation of spherical microorganism cell aggregates

Family Cites Families (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507244A (en) 1947-04-14 1950-05-09 Upjohn Co Surgical gelatin dusting powder and process for preparing same
CH264752A (de) 1947-06-03 1949-10-31 Hoffmann La Roche Verfahren zur Herstellung von Trägern für Arzneimittel.
US3089315A (en) 1961-09-25 1963-05-14 Gen Electric Convertible self-contained cooling unit for air conditioning
SE420565B (sv) 1974-06-06 1981-10-19 Pharmacia Ab Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel
US4013078A (en) * 1974-11-25 1977-03-22 Feild James Rodney Intervertebral protector means
US4006220A (en) 1975-06-04 1977-02-01 Gottlieb Sheldon K Compositions and methods useful for repairing depressed cutaneous scars
US4164559A (en) * 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
US4265233A (en) * 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4179400A (en) 1978-05-09 1979-12-18 W. R. Grace & Co. Process for preparing catalytic solutions of sulfonium salts
AT359652B (de) 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
AT359653B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
DE3036033A1 (de) 1980-09-24 1982-05-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung
US4300494A (en) 1979-09-26 1981-11-17 Shell Oil Company Thermal insulated intake ports
US4292972A (en) 1980-07-09 1981-10-06 E. R. Squibb & Sons, Inc. Lyophilized hydrocolloio foam
US4443332A (en) * 1980-07-14 1984-04-17 Oros Company Cross flow solid-to-solid heat transfer apparatus
DE3105624A1 (de) * 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München Material zum abdichten und heilen von wunden
US4424208A (en) * 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
EP0086627B1 (en) * 1982-02-12 1985-08-28 Unitika Ltd. Anti-cancer device
US4482386A (en) 1982-03-26 1984-11-13 Warner-Lambert Company Method of conditioning a water swellable hydrocolloid
US4540410A (en) 1982-11-16 1985-09-10 Serono Pharmaceutical Partners Lyophilized compositions, preparation and use thereof
DE3466702D1 (en) 1983-07-14 1987-11-12 Hitachi Chemical Co Ltd Gelatin spherical gels and production thereof
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4515637A (en) * 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
AT389815B (de) * 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4600574A (en) * 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
JPS6144825A (ja) * 1984-08-09 1986-03-04 Unitika Ltd 止血剤
GB8422950D0 (en) * 1984-09-11 1984-10-17 Warne K J Hydrogel
JPS61122222A (ja) * 1984-11-19 1986-06-10 Koken:Kk コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤
US5165938A (en) 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5178883A (en) * 1984-11-29 1993-01-12 Regents Of The University Of Minnesota Method for promoting hair growth
US4600533A (en) 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US5007916A (en) * 1985-08-22 1991-04-16 Johnson & Johnson Medical, Inc. Method and material for prevention of surgical adhesions
IE59361B1 (en) * 1986-01-24 1994-02-09 Akzo Nv Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5300494A (en) * 1986-06-06 1994-04-05 Union Carbide Chemicals & Plastics Technology Corporation Delivery systems for quaternary and related compounds
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US4832686A (en) * 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US4885161A (en) 1987-03-11 1989-12-05 Medi-Tech International Corporation Wound dressings in gelled paste form
CA1305069C (en) 1987-03-11 1992-07-14 John Cornell Wound dressings in sheet or gelled paste form
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5350573A (en) * 1988-05-31 1994-09-27 University Of Florida Research Foundation, Inc. Method and composition for preventing surgical adhesions
US5140016A (en) * 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5447966A (en) * 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US5041292A (en) * 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US4925677A (en) * 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5614587A (en) * 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
DE3903672C1 (OSRAM) * 1989-02-08 1990-02-01 Lohmann Gmbh & Co Kg
WO1991001711A1 (en) 1989-08-10 1991-02-21 W.L. Gore & Associates, Inc. A medical dispensing system for tissue adhesive components
US5196185A (en) * 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
US5061274A (en) 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5134229A (en) * 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5306501A (en) * 1990-05-01 1994-04-26 Mediventures, Inc. Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers
US5595735A (en) * 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
US5292362A (en) * 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5209776A (en) * 1990-07-27 1993-05-11 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
ZA918168B (en) * 1990-10-16 1993-04-14 Takeda Chemical Industries Ltd Prolonged release preparation and polymers thereof.
US5129882A (en) * 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US5690675A (en) 1991-02-13 1997-11-25 Fusion Medical Technologies, Inc. Methods for sealing of staples and other fasteners in tissue
JPH06500802A (ja) * 1991-06-14 1994-01-27 アムジエン・インコーポレーテツド コラーゲンフィルムによるタンパクのドラッグ・デリバリー
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
DK0632820T3 (da) * 1992-02-28 2000-10-02 Collagen Corp Højkoncentrerede, homogeniserede collagensammensætninger
ATE269371T1 (de) 1992-02-28 2004-07-15 Cohesion Tech Inc Injektierbare, keramische verbindungen sowie verfahren zu deren herstellung und anwendung
US5384333A (en) * 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
JPH07506991A (ja) * 1992-04-23 1995-08-03 シメッド　ライフ　システムズ　インコーポレイテッド 血管穿刺を密封するための装置及び方法
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
AU4406793A (en) * 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5385606A (en) * 1992-07-06 1995-01-31 Kowanko; Nicholas Adhesive composition and method
US5413571A (en) * 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
US5428022A (en) * 1992-07-29 1995-06-27 Collagen Corporation Composition of low type III content human placental collagen
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
DE4227681C2 (de) 1992-08-21 1995-05-18 Becker & Co Naturinwerk Wundabdeckungsmaterial auf der Basis von Kollagenfasern und Verfahren zu seiner Herstellung
DE69330909T2 (de) * 1992-11-12 2002-06-20 Neville Alleyne Einrichtung zum schutz des herzens
US5667839A (en) * 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
ATE203913T1 (de) 1993-05-31 2001-08-15 Kaken Pharma Co Ltd Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält
FR2715309B1 (fr) * 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
US5674275A (en) 1994-04-06 1997-10-07 Graphic Controls Corporation Polyacrylate and polymethacrylate ester based hydrogel adhesives
US5531759A (en) * 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
WO1995031223A1 (en) * 1994-05-13 1995-11-23 Kuraray Co., Ltd. Medical polymer gel
GB9415739D0 (en) 1994-07-30 1994-09-21 Scimat Ltd Gel wound dressing
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US5698213A (en) 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5580923A (en) 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
PT876165E (pt) 1995-12-18 2006-10-31 Angiotech Biomaterials Corp Composicoes de polimeros reticulados e processos para a sua utilizacao
US5748318A (en) * 1996-01-23 1998-05-05 Brown University Research Foundation Optical stress generator and detector
ATE247494T1 (de) 1996-04-04 2003-09-15 Baxter Ag Blutstillender schwamm auf kollagenbasis
US5902832A (en) * 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6706690B2 (en) * 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7320962B2 (en) * 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7871637B2 (en) * 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
CN1157355A (zh) * 1996-10-21 1997-08-20 山西省化学纤维研究所 止血纤维组成及其气体牵伸法纺丝工艺
EP0986408B1 (en) * 1997-06-03 2005-05-11 Innogenetics N.V. New medicaments based on polymers composed of methacrylamide-modified gelatin
US5908054A (en) 1997-06-16 1999-06-01 Fusion Medical Technologies, Inc. Fluid dispersion and delivery assembly and method
US5997895A (en) 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix
CA2303317C (en) 1997-09-16 2011-11-15 Integra Lifesciences Corporation Product for promoting dural or meningeal tissue growth comprising collagen
US6179872B1 (en) * 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
US6227394B1 (en) * 1998-06-09 2001-05-08 Asahi Glass Company Ltd. Glass bulb for a cathode ray tube and a method for producing a cathode ray tube
US6110484A (en) * 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US6328229B1 (en) 1998-12-18 2001-12-11 Cohesion Technologies, Inc. Low volume mixing spray head for mixing and dispensing of two reactive fluid components
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6221109B1 (en) 1999-09-15 2001-04-24 Ed. Geistlich Söhne AG fur Chemische Industrie Method of protecting spinal area
US6312474B1 (en) 1999-09-15 2001-11-06 Bio-Vascular, Inc. Resorbable implant materials
CN1114728C (zh) * 2000-04-21 2003-07-16 中国石油化工集团公司 止血纤维及其制造方法
AU9109201A (en) 2000-09-18 2002-03-26 Organogenesis Inc Methods for treating a patient using a bioengineered flat sheet graft prostheses
AR032517A1 (es) 2001-01-25 2003-11-12 Nycomed Pharma As Un metodo para preparar una esponja de colageno, un dispositivo para extraer una parte de una espuma de colageno, y una esponja de colageno alargada
AU2002300450B2 (en) 2001-08-10 2007-04-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen Carrier of Therapeutic Genetic Material, and Method
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
GB2403409B (en) 2003-06-05 2005-11-23 Baxter Int Methods for repairing and regenerating human dura mater
AU2004291062A1 (en) * 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
US20080091277A1 (en) * 2004-08-13 2008-04-17 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
ES2367583T3 (es) 2005-05-04 2011-11-10 Suprapolix B.V. Hidrogeles con enlaces de hidrógeno.
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
BRPI0712088B8 (pt) * 2006-05-31 2021-06-22 Baxter Healthcare Sa uso de uma biomatriz de lâmina de colágeno de múltiplas camadas microscópicas não porosa e hermética a fluido
TWI436793B (zh) 2006-08-02 2014-05-11 巴克斯特國際公司 快速作用之乾密封膠及其使用和製造方法
AR069109A1 (es) * 2007-10-30 2009-12-30 Baxter Int Uso de una biomatriz de colageno biofuncional regenerativa para tratar defectos viscerales o parietales
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
DK2442835T3 (en) 2009-06-16 2015-03-16 Baxter Int Styptic sponge

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543332A (en) * 1982-03-29 1985-09-24 Miles Laboratories, Inc. Method for the preparation of spherical microorganism cell aggregates

Also Published As

Publication number Publication date
US7547446B2 (en) 2009-06-16
BRPI0211258B8 (pt) 2021-07-27
EP1414370A1 (en) 2004-05-06
US20080286376A1 (en) 2008-11-20
EP1803417A1 (en) 2007-07-04
CA2453592C (en) 2009-10-06
DE60219319D1 (de) 2007-05-16
ES2317600T3 (es) 2009-04-16
EP1414370A4 (en) 2005-11-09
MXPA04000514A (es) 2005-03-07
CN101284146A (zh) 2008-10-15
DE60230079D1 (de) 2009-01-08
ES2284883T3 (es) 2007-11-16
DE60219319T2 (de) 2008-01-03
WO2003007845A9 (en) 2004-04-01
HK1060277A1 (en) 2004-08-06
HK1103342A1 (en) 2007-12-21
EP1803417B1 (en) 2008-11-26
CA2453592A1 (en) 2003-01-30
JP2005500102A (ja) 2005-01-06
US20090227779A1 (en) 2009-09-10
CN100402096C (zh) 2008-07-16
CN1555249A (zh) 2004-12-15
BR0211258A (pt) 2004-07-27
EP1414370B1 (en) 2007-04-04
ATE358455T1 (de) 2007-04-15
JP4316374B2 (ja) 2009-08-19
US7435425B2 (en) 2008-10-14
US8383141B2 (en) 2013-02-26
PT1803417E (pt) 2008-12-31
DK1803417T3 (da) 2009-03-16
PT1414370E (pt) 2007-05-31
US20030064109A1 (en) 2003-04-03
ATE415136T1 (de) 2008-12-15
WO2003007845A1 (en) 2003-01-30
US20070248685A1 (en) 2007-10-25
BRPI0211258B1 (pt) 2015-06-02
KR20040025698A (ko) 2004-03-24
DK1414370T3 (da) 2007-04-30
AU2002345846B2 (en) 2007-08-23
CN101284146B (zh) 2013-05-08
US8092820B2 (en) 2012-01-10

Similar Documents

Publication Publication Date Title
JP4316374B2 (ja) 乾燥止血組成物およびそれらの調製のための方法
US7871637B2 (en) Dry hemostatic compositions and methods for their preparation
AU2002345846A1 (en) Dry hemostatic compositions and methods for their preparation
KR102135484B1 (ko) 지혈 조성물
KR102102002B1 (ko) 지혈 조성물
KR101814841B1 (ko) 건조 및 안정한 지혈 조성물의 제조 방법
KR102143252B1 (ko) 지혈 조성물
KR20180027126A (ko) 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물
HK1103342B (en) Dry hemostatic compositions and methods for their preparation
HK1060277B (en) Dry hemostatic compositions and methods for their preparation
KR20210053275A (ko) 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20040114

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20070503

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20080314

Patent event code: PE09021S01D

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

Comment text: Final Notice of Reason for Refusal

Patent event date: 20081111

Patent event code: PE09021S02D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20090430

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20090617

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20090617

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20120605

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20130610

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20130610

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20140610

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20140610

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20150605

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20150605

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20160607

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20160607

Start annual number: 8

End annual number: 8

FPAY Annual fee payment

Payment date: 20170609

Year of fee payment: 9

PR1001 Payment of annual fee

Payment date: 20170609

Start annual number: 9

End annual number: 9

FPAY Annual fee payment

Payment date: 20190422

Year of fee payment: 11

PR1001 Payment of annual fee

Payment date: 20190422

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20200420

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20210506

Start annual number: 13

End annual number: 13

PC1801 Expiration of term

Termination date: 20221221

Termination category: Expiration of duration