KR100887034B1 - 부틸프탈라이드 자가 에멀젼화 약물 전달 시스템, 그 제조방법 및 응용 - Google Patents

부틸프탈라이드 자가 에멀젼화 약물 전달 시스템, 그 제조방법 및 응용 Download PDF

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KR100887034B1
KR100887034B1 KR1020077006741A KR20077006741A KR100887034B1 KR 100887034 B1 KR100887034 B1 KR 100887034B1 KR 1020077006741 A KR1020077006741 A KR 1020077006741A KR 20077006741 A KR20077006741 A KR 20077006741A KR 100887034 B1 KR100887034 B1 KR 100887034B1
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butylphthalide
self
drug delivery
dosage form
emulsifying drug
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KR20070046948A (ko
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젠타오 리우
리잉 양
한유 양
유킹 가오
동민 센
웬민 구오
샤올롱 펭
지아 쳉
Original Assignee
스자좡 파마 그룹 중치 파마슈티컬 테크놀로지 (스자좡) 컴퍼니 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077006741A 2004-08-27 2005-08-26 부틸프탈라이드 자가 에멀젼화 약물 전달 시스템, 그 제조방법 및 응용 Expired - Lifetime KR100887034B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200410075068.2 2004-08-27
CNB2004100750682A CN100361656C (zh) 2004-08-27 2004-08-27 丁苯酞自乳化释药体系及其制备方法和应用
PCT/CN2005/001332 WO2006021160A1 (en) 2004-08-27 2005-08-26 Butylbenzene phthalein self-emulsifying drug delivery system, its preparation method and application

Publications (2)

Publication Number Publication Date
KR20070046948A KR20070046948A (ko) 2007-05-03
KR100887034B1 true KR100887034B1 (ko) 2009-03-04

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KR1020077006741A Expired - Lifetime KR100887034B1 (ko) 2004-08-27 2005-08-26 부틸프탈라이드 자가 에멀젼화 약물 전달 시스템, 그 제조방법 및 응용

Country Status (15)

Country Link
US (1) US8728518B2 (https=)
EP (1) EP1787638B1 (https=)
JP (1) JP4653810B2 (https=)
KR (1) KR100887034B1 (https=)
CN (1) CN100361656C (https=)
AT (1) ATE462410T1 (https=)
AU (1) AU2005276811B8 (https=)
BR (1) BRPI0515070B8 (https=)
CA (1) CA2578130C (https=)
DE (1) DE602005020317D1 (https=)
ES (1) ES2341265T4 (https=)
MX (1) MX2007002335A (https=)
NO (1) NO336917B1 (https=)
RU (1) RU2371176C2 (https=)
WO (1) WO2006021160A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107661287A (zh) * 2017-11-28 2018-02-06 遵义医学院 地榆皂苷自乳化药物传递系统的制备
WO2025127804A1 (ko) * 2023-12-15 2025-06-19 한국 한의학 연구원 부틸프탈라이드 또는 이의 허용 가능한 염을 유효성분으로 포함하는 노화에 의한 난소 저반응군의 예방, 개선 또는 치료용 조성물

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CN100367951C (zh) * 2005-12-16 2008-02-13 石药集团恩必普药业有限公司 丁苯酞静脉乳剂及其应用
CN101342152B (zh) * 2007-07-10 2010-10-13 石药集团中奇制药技术（石家庄）有限公司 丁苯酞片及其制备方法
CN101579323B (zh) * 2008-05-16 2012-01-25 石药集团中奇制药技术（石家庄）有限公司 丁苯酞缓释片及其制备方法
CN102178643B (zh) * 2011-04-29 2014-05-14 石药集团恩必普药业有限公司 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法
CN103784424B (zh) * 2012-10-30 2018-04-27 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞经皮贴剂及其制备方法
CN109394720A (zh) * 2012-11-21 2019-03-01 石药集团中奇制药技术（石家庄）有限公司 一种3-正丁基苯酞衍生物的组合物及其制备方法
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
TWI547280B (zh) * 2014-04-24 2016-09-01 長弘生物科技股份有限公司 穩定醫藥組合物
CN105030760B (zh) 2014-04-24 2018-10-02 长弘生物科技股份有限公司 稳定医药组合物
CA2982162C (en) * 2015-04-10 2023-10-10 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
CN105267145B (zh) * 2015-11-01 2019-06-21 袁旭东 双膦酸盐的自乳化配方和相关剂型
CN105796486A (zh) * 2016-03-17 2016-07-27 南京天翔医药科技有限公司 丁苯酞脂肪乳注射剂及其制备工艺
CN110856712B (zh) * 2018-08-06 2021-11-30 刘超 丁苯酞自微乳组合物及其制备方法和用途
CN114073694B (zh) * 2020-08-14 2024-03-12 北京科莱博医药开发有限责任公司 丁苯酞制剂及其制备方法
CN114681389A (zh) * 2020-12-29 2022-07-01 中国科学院上海药物研究所 一种经口腔黏膜递送的丁苯酞组合物及其用途
JP2024505623A (ja) 2020-12-31 2024-02-07 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント 水難溶性極性溶質用の完全に希釈可能な自己マイクロ乳化デリバリーシステム（ｓｍｅｄｄｓ）
CN116407510B (zh) * 2021-12-29 2025-11-21 河北赛谱睿思医药科技有限公司 一种丁苯酞舌下片及其制备方法

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CN1257706A (zh) * 1998-12-18 2000-06-28 中国医学科学院药物研究所 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用
EP1170003A1 (en) 2000-07-07 2002-01-09 Hovid SDN BHD Self-emulsifying drug delivery system for fat-soluble drugs

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JPH04210634A (ja) * 1990-12-17 1992-07-31 Kao Corp 皮膚の血行不良に起因する疾患の治療剤
CN1257706A (zh) * 1998-12-18 2000-06-28 中国医学科学院药物研究所 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用
EP1170003A1 (en) 2000-07-07 2002-01-09 Hovid SDN BHD Self-emulsifying drug delivery system for fat-soluble drugs

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107661287A (zh) * 2017-11-28 2018-02-06 遵义医学院 地榆皂苷自乳化药物传递系统的制备
WO2025127804A1 (ko) * 2023-12-15 2025-06-19 한국 한의학 연구원 부틸프탈라이드 또는 이의 허용 가능한 염을 유효성분으로 포함하는 노화에 의한 난소 저반응군의 예방, 개선 또는 치료용 조성물
KR102945311B1 (ko) 2023-12-15 2026-04-01 한국 한의학 연구원 부틸프탈라이드 또는 이의 허용 가능한 염을 유효성분으로 포함하는 노화에 의한 난소 저반응군의 예방, 개선 또는 치료용 조성물

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Publication number Publication date
CN1726909A (zh) 2006-02-01
JP2008510737A (ja) 2008-04-10
EP1787638B1 (en) 2010-03-31
AU2005276811A1 (en) 2006-03-02
RU2007111120A (ru) 2008-10-20
AU2005276811B8 (en) 2009-01-22
RU2371176C2 (ru) 2009-10-27
NO20071354L (no) 2007-05-29
WO2006021160A1 (en) 2006-03-02
ES2341265T3 (es) 2010-06-17
EP1787638A1 (en) 2007-05-23
AU2005276811B2 (en) 2008-11-13
KR20070046948A (ko) 2007-05-03
BRPI0515070B1 (pt) 2020-09-08
WO2006021160A8 (fr) 2006-04-13
CN100361656C (zh) 2008-01-16
JP4653810B2 (ja) 2011-03-16
BRPI0515070A2 (pt) 2009-08-04
ES2341265T4 (es) 2011-04-27
US20080319056A1 (en) 2008-12-25
CA2578130C (en) 2010-08-31
EP1787638A4 (en) 2008-12-03
ATE462410T1 (de) 2010-04-15
US8728518B2 (en) 2014-05-20
CA2578130A1 (en) 2006-03-02
BRPI0515070B8 (pt) 2021-05-25
DE602005020317D1 (de) 2010-05-12
NO336917B1 (no) 2015-11-23
MX2007002335A (es) 2007-10-10

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