CN1726909A - 丁苯酞自乳化释药体系及其制备方法和应用 - Google Patents
丁苯酞自乳化释药体系及其制备方法和应用 Download PDFInfo
- Publication number
- CN1726909A CN1726909A CNA2004100750682A CN200410075068A CN1726909A CN 1726909 A CN1726909 A CN 1726909A CN A2004100750682 A CNA2004100750682 A CN A2004100750682A CN 200410075068 A CN200410075068 A CN 200410075068A CN 1726909 A CN1726909 A CN 1726909A
- Authority
- CN
- China
- Prior art keywords
- emulsifying
- butyphthalide
- self emulsifying
- releasing medicine
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
031201 | 031202 | 031203 | 备注 | ||
粒径μm | >51~5<1 | 2.784.6492.68 | 3.055.6491.31 | 2.545.0192.45 | 每批次计数总量为300个 |
结论1 | 三批样品均为自微乳化释药体系 | ||||
溶出度(%) | 自乳化(45min)普通软胶囊(60min) | 100.0195.4 | 99.696.8 | 98.992.5 | 遇水自成均一乳剂崩解时油滴贴于杯壁不能分散,溶出介质中需加入乳化剂方可测定 |
结论2 | 自乳化释药体系溶出度明显优于普通软胶囊 |
考察条件 | 外观 | 含量(%) | 降解物(%) | 自乳化时间(秒) | 体外释放度(%) | 崩解时限 | |
时间(月) | |||||||
初始 | 0 | 黄色透明软胶囊 | 100.3 | 0.61 | 2.33 | 99.3 | 5’50? |
加速试验 | 1 | 黄色透明软胶囊 | 101.1 | 0.66 | 2.67 | 100.2 | 6’45? |
2 | 黄色透明软胶囊 | 99.3 | 0.63 | 3.33 | 99.6 | 14’10? | |
3 | 黄色透明软胶囊 | 98.4 | 0.62 | 3.5 | 100.2 | 28’30? | |
6 | 黄色透明软胶囊 | 99.0 | 0.58 | 3.33 | 98.5 | 49’52? | |
室温留样 | 1 | 黄色透明软胶囊 | 100.1 | 0.63 | 2.50 | 100.5 | 6’15? |
3 | 黄色透明软胶囊 | 101.0 | 0.67 | 2.50 | 98.9 | 8’35? | |
6 | 黄色透明软胶囊 | 99.4 | 0.66 | 2.67 | 100.1 | 9’45? | |
12 | 黄色透明软胶囊 | 99.1 | 0.62 | 2.83 | 99.7 | 17’50? |
取样点(hr) | 血药浓度(μg/ml) | |
普通软胶囊 | 自乳化软胶囊 | |
0.080.170.50.812357912 | 5.326.798.067.0210.154.224.314.049.55.162.5 | 13.6216.1712.259.39.326.617.434.362.541.921.36 |
Claims (12)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100750682A CN100361656C (zh) | 2004-08-27 | 2004-08-27 | 丁苯酞自乳化释药体系及其制备方法和应用 |
PCT/CN2005/001332 WO2006021160A1 (fr) | 2004-08-27 | 2005-08-26 | Système de relargage de médicament auto-émulsifiant à base de butylbenzènephtaléine, méthode de préparation et applications d’un tel système |
BRPI0515070A BRPI0515070B8 (pt) | 2004-08-27 | 2005-08-26 | sistema de entrega de medicamentos auto-emulsificante de butilftalida e processo para a preparação do sistema de entrega de medicamentos auto-emulsificante de butilftalida |
DE602005020317T DE602005020317D1 (de) | 2004-08-27 | 2005-08-26 | Selbstemulgierendes butylbenzolphthalein-arzneimittelabgabesystem, sein herstellungsverfahren und seine anwendung |
JP2007528562A JP4653810B2 (ja) | 2004-08-27 | 2005-08-26 | ブチルフタリド自己乳化薬物送達システム、その調製方法および用途 |
CA2578130A CA2578130C (en) | 2004-08-27 | 2005-08-26 | Butylbenzene phthalein self-emulsifying drug delivery system, its preparation method and application |
ES05781769T ES2341265T4 (es) | 2004-08-27 | 2005-08-26 | Sistema de administración de fármaco autoemulsionante de butilbenceno ftaleína su procedimiento de preparación y aplicación. |
KR1020077006741A KR100887034B1 (ko) | 2004-08-27 | 2005-08-26 | 부틸프탈라이드 자가 에멀젼화 약물 전달 시스템, 그 제조방법 및 응용 |
MX2007002335A MX2007002335A (es) | 2004-08-27 | 2005-08-26 | Sistema de liberacion de farmaco de auto-emulsificacion de butilftalato, metodo para su preparacion y aplicacion. |
US11/574,313 US8728518B2 (en) | 2004-08-27 | 2005-08-26 | Butylphthalide self-emulsifying drug delivery system, its preparation and method and application |
AU2005276811A AU2005276811B8 (en) | 2004-08-27 | 2005-08-26 | Butylphthalide self-emulsifying drug delivery system, its preparation method and application |
AT05781769T ATE462410T1 (de) | 2004-08-27 | 2005-08-26 | Selbstemulgierendes butylbenzolphthalein- arzneimittelabgabesystem, sein herstellungsverfahren und seine anwendung |
RU2007111120/15A RU2371176C2 (ru) | 2004-08-27 | 2005-08-26 | Самоэмульгирующаяся система доставки лекарственного средства бутилфталида, способ ее получения и применения |
EP05781769A EP1787638B1 (en) | 2004-08-27 | 2005-08-26 | Butylbenzene phthalein self-emulsifying drug delivery system, its preparation method and application |
NO20071354A NO336917B1 (no) | 2004-08-27 | 2007-03-12 | Butylftalid selvemulgerende medikamentavgivelsessystem, samt fremgangsmåter for fremstilling og anvendelse av samme |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100750682A CN100361656C (zh) | 2004-08-27 | 2004-08-27 | 丁苯酞自乳化释药体系及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1726909A true CN1726909A (zh) | 2006-02-01 |
CN100361656C CN100361656C (zh) | 2008-01-16 |
Family
ID=35926548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100750682A Active CN100361656C (zh) | 2004-08-27 | 2004-08-27 | 丁苯酞自乳化释药体系及其制备方法和应用 |
Country Status (15)
Country | Link |
---|---|
US (1) | US8728518B2 (zh) |
EP (1) | EP1787638B1 (zh) |
JP (1) | JP4653810B2 (zh) |
KR (1) | KR100887034B1 (zh) |
CN (1) | CN100361656C (zh) |
AT (1) | ATE462410T1 (zh) |
AU (1) | AU2005276811B8 (zh) |
BR (1) | BRPI0515070B8 (zh) |
CA (1) | CA2578130C (zh) |
DE (1) | DE602005020317D1 (zh) |
ES (1) | ES2341265T4 (zh) |
MX (1) | MX2007002335A (zh) |
NO (1) | NO336917B1 (zh) |
RU (1) | RU2371176C2 (zh) |
WO (1) | WO2006021160A1 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101342152B (zh) * | 2007-07-10 | 2010-10-13 | 石药集团中奇制药技术(石家庄)有限公司 | 丁苯酞片及其制备方法 |
CN102178643A (zh) * | 2011-04-29 | 2011-09-14 | 石药集团恩必普药业有限公司 | 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法 |
CN101579323B (zh) * | 2008-05-16 | 2012-01-25 | 石药集团中奇制药技术(石家庄)有限公司 | 丁苯酞缓释片及其制备方法 |
CN103784424A (zh) * | 2012-10-30 | 2014-05-14 | 石药集团中奇制药技术(石家庄)有限公司 | 一种丁苯酞经皮贴剂及其制备方法 |
CN105796486A (zh) * | 2016-03-17 | 2016-07-27 | 南京天翔医药科技有限公司 | 丁苯酞脂肪乳注射剂及其制备工艺 |
CN110856712A (zh) * | 2018-08-06 | 2020-03-03 | 刘超 | 丁苯酞自微乳组合物及其制备方法和用途 |
CN114073694A (zh) * | 2020-08-14 | 2022-02-22 | 北京科莱博医药开发有限责任公司 | 丁苯酞制剂及其制备方法 |
WO2022143631A1 (zh) * | 2020-12-29 | 2022-07-07 | 中国科学院上海药物研究所 | 经口腔黏膜递送的丁苯酞组合物及其用途 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100367951C (zh) | 2005-12-16 | 2008-02-13 | 石药集团恩必普药业有限公司 | 丁苯酞静脉乳剂及其应用 |
CN103830200A (zh) * | 2012-11-21 | 2014-06-04 | 石药集团中奇制药技术(石家庄)有限公司 | 一种3-正丁基苯酞衍生物的组合物及其制备方法 |
WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
CN105030760B (zh) | 2014-04-24 | 2018-10-02 | 长弘生物科技股份有限公司 | 稳定医药组合物 |
TWI547280B (zh) * | 2014-04-24 | 2016-09-01 | 長弘生物科技股份有限公司 | 穩定醫藥組合物 |
CA2982162C (en) | 2015-04-10 | 2023-10-10 | Bioresponse, L.L.C. | Self-emulsifying formulations of dim-related indoles |
CN105267145B (zh) * | 2015-11-01 | 2019-06-21 | 袁旭东 | 双膦酸盐的自乳化配方和相关剂型 |
CN107661287B (zh) * | 2017-11-28 | 2021-01-26 | 遵义医学院 | 地榆皂苷自乳化药物传递系统的制备 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2516477B2 (ja) * | 1990-12-17 | 1996-07-24 | 花王株式会社 | 皮膚の血行不良に起因する疾患の治療剤 |
CN2123000U (zh) | 1992-04-24 | 1992-11-25 | 李广杰 | 塑料葡萄灯 |
DE4313693A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2-Amino-4-chinolin-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
CN1048158C (zh) * | 1993-09-09 | 2000-01-12 | 中国医学科学院药物研究所 | 芹菜甲素在制备预防和治疗哺乳动物或人类脑缺血引起的疾病的药中的应用 |
US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
WO1999049848A1 (en) | 1998-04-01 | 1999-10-07 | Rtp Pharma Inc. | Anticancer compositions |
AU3843999A (en) | 1998-05-07 | 1999-11-23 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
CN1086942C (zh) | 1998-12-18 | 2002-07-03 | 中国医学科学院药物研究所 | 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用 |
SG97918A1 (en) * | 2000-06-08 | 2003-08-20 | Hovid Sdn Bhd | A novel drug delivery system: formulation for fat-soluble drugs |
MY120392A (en) * | 2000-06-08 | 2005-10-31 | Hovid Berhad | A novel drug delivery system : formulation for fat-soluble drugs |
US6596306B1 (en) | 2000-07-07 | 2003-07-22 | David Ho Sue San Ho | Drug delivery system:formulation for fat-soluble drugs |
ATE290372T1 (de) * | 2000-07-24 | 2005-03-15 | Upjohn Co | Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln |
CN1166693C (zh) * | 2001-06-18 | 2004-09-15 | 中奇制药技术(石家庄)有限公司 | 丁苯酞环糊精或环糊精衍生物包合物及其制备方法和用途 |
CN1375288A (zh) * | 2002-05-13 | 2002-10-23 | 周桂荣 | 一种治疗脑血管疾病的药物组合物 |
CA2494157C (en) * | 2002-08-21 | 2010-10-12 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof |
JP4215633B2 (ja) | 2002-12-19 | 2009-01-28 | Jfeケミカル株式会社 | 複合黒鉛粒子の製造方法 |
CN1233317C (zh) * | 2003-07-07 | 2005-12-28 | 西安利君制药有限责任公司 | 水飞蓟素自乳化微乳组合物及其制备工艺 |
-
2004
- 2004-08-27 CN CNB2004100750682A patent/CN100361656C/zh active Active
-
2005
- 2005-08-26 JP JP2007528562A patent/JP4653810B2/ja active Active
- 2005-08-26 DE DE602005020317T patent/DE602005020317D1/de active Active
- 2005-08-26 AU AU2005276811A patent/AU2005276811B8/en active Active
- 2005-08-26 WO PCT/CN2005/001332 patent/WO2006021160A1/zh active Application Filing
- 2005-08-26 AT AT05781769T patent/ATE462410T1/de not_active IP Right Cessation
- 2005-08-26 MX MX2007002335A patent/MX2007002335A/es active IP Right Grant
- 2005-08-26 US US11/574,313 patent/US8728518B2/en active Active
- 2005-08-26 RU RU2007111120/15A patent/RU2371176C2/ru active
- 2005-08-26 KR KR1020077006741A patent/KR100887034B1/ko active IP Right Grant
- 2005-08-26 BR BRPI0515070A patent/BRPI0515070B8/pt active IP Right Grant
- 2005-08-26 ES ES05781769T patent/ES2341265T4/es active Active
- 2005-08-26 CA CA2578130A patent/CA2578130C/en active Active
- 2005-08-26 EP EP05781769A patent/EP1787638B1/en active Active
-
2007
- 2007-03-12 NO NO20071354A patent/NO336917B1/no unknown
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101342152B (zh) * | 2007-07-10 | 2010-10-13 | 石药集团中奇制药技术(石家庄)有限公司 | 丁苯酞片及其制备方法 |
CN101579323B (zh) * | 2008-05-16 | 2012-01-25 | 石药集团中奇制药技术(石家庄)有限公司 | 丁苯酞缓释片及其制备方法 |
CN102178643A (zh) * | 2011-04-29 | 2011-09-14 | 石药集团恩必普药业有限公司 | 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法 |
CN102178643B (zh) * | 2011-04-29 | 2014-05-14 | 石药集团恩必普药业有限公司 | 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法 |
CN103784424A (zh) * | 2012-10-30 | 2014-05-14 | 石药集团中奇制药技术(石家庄)有限公司 | 一种丁苯酞经皮贴剂及其制备方法 |
CN103784424B (zh) * | 2012-10-30 | 2018-04-27 | 石药集团中奇制药技术(石家庄)有限公司 | 一种丁苯酞经皮贴剂及其制备方法 |
CN105796486A (zh) * | 2016-03-17 | 2016-07-27 | 南京天翔医药科技有限公司 | 丁苯酞脂肪乳注射剂及其制备工艺 |
CN110856712A (zh) * | 2018-08-06 | 2020-03-03 | 刘超 | 丁苯酞自微乳组合物及其制备方法和用途 |
CN110856712B (zh) * | 2018-08-06 | 2021-11-30 | 刘超 | 丁苯酞自微乳组合物及其制备方法和用途 |
CN114073694A (zh) * | 2020-08-14 | 2022-02-22 | 北京科莱博医药开发有限责任公司 | 丁苯酞制剂及其制备方法 |
CN114073694B (zh) * | 2020-08-14 | 2024-03-12 | 北京科莱博医药开发有限责任公司 | 丁苯酞制剂及其制备方法 |
WO2022143631A1 (zh) * | 2020-12-29 | 2022-07-07 | 中国科学院上海药物研究所 | 经口腔黏膜递送的丁苯酞组合物及其用途 |
Also Published As
Publication number | Publication date |
---|---|
ES2341265T3 (es) | 2010-06-17 |
EP1787638B1 (en) | 2010-03-31 |
US8728518B2 (en) | 2014-05-20 |
MX2007002335A (es) | 2007-10-10 |
KR100887034B1 (ko) | 2009-03-04 |
AU2005276811B2 (en) | 2008-11-13 |
WO2006021160A8 (en) | 2006-04-13 |
JP2008510737A (ja) | 2008-04-10 |
CA2578130A1 (en) | 2006-03-02 |
CA2578130C (en) | 2010-08-31 |
RU2007111120A (ru) | 2008-10-20 |
ES2341265T4 (es) | 2011-04-27 |
AU2005276811A1 (en) | 2006-03-02 |
JP4653810B2 (ja) | 2011-03-16 |
NO336917B1 (no) | 2015-11-23 |
EP1787638A1 (en) | 2007-05-23 |
EP1787638A4 (en) | 2008-12-03 |
WO2006021160A1 (fr) | 2006-03-02 |
DE602005020317D1 (de) | 2010-05-12 |
ATE462410T1 (de) | 2010-04-15 |
RU2371176C2 (ru) | 2009-10-27 |
AU2005276811B8 (en) | 2009-01-22 |
BRPI0515070B8 (pt) | 2021-05-25 |
NO20071354L (no) | 2007-05-29 |
BRPI0515070B1 (pt) | 2020-09-08 |
CN100361656C (zh) | 2008-01-16 |
US20080319056A1 (en) | 2008-12-25 |
BRPI0515070A2 (pt) | 2009-08-04 |
KR20070046948A (ko) | 2007-05-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6596308B2 (en) | Controlled release pharmaceutical composition | |
CN100361656C (zh) | 丁苯酞自乳化释药体系及其制备方法和应用 | |
JP4815053B2 (ja) | 経口投与の固形投与形態物としてのマイクロエマルション | |
US20090060993A1 (en) | Solid pharmaceutical composition for enhanced delivery of coenzyme q-10 and ubiquinones | |
JP2002522473A5 (zh) | ||
CN1335126A (zh) | 保证生物活性化合物质持续递送的药物固体自乳化组合物及其制备方法 | |
JP2008510737A5 (zh) | ||
WO2002011701A1 (en) | A controlled release pharmaceutical composition | |
AU2021107168A4 (en) | Vitamin d pediatric dosage forms, methods of making and using | |
JP2019163327A (ja) | 三種混合製剤 | |
CN107921017A (zh) | 使用卡多曲组合物进行治疗的方法 | |
US20220151941A1 (en) | Pulsed release caffeine formulations and a process for preparation thereof | |
CN100479822C (zh) | 包封氯氮平的固体脂质微颗粒及其制备方法 | |
Renthlei et al. | Floating Drug Delivery System: An Outlook | |
WO2016166767A1 (en) | Pharmaceutical formulation comprising low melting, highly lipophilic drugs | |
CN102309476A (zh) | 非诺贝特组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: ENBIPU PHARMACY CO., LTD., SHIYAO GROUP. Effective date: 20130319 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 050051 SHIJIAZHUANG, HEBEI PROVINCE TO: 050035 SHIJIAZHUANG, HEBEI PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130319 Address after: 050035 No. 226 the Yellow River Avenue, Shijiazhuang hi tech Development Zone, Hebei Patentee after: Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. of CSPC Group Patentee after: Enbipu Pharmacy Co., Ltd., Shiyao Group. Address before: 050051 No. 276 West Zhongshan Road, Hebei, Shijiazhuang Patentee before: Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. of CSPC Group |