DE602005020317D1 - Selbstemulgierendes butylbenzolphthalein-arzneimittelabgabesystem, sein herstellungsverfahren und seine anwendung - Google Patents

Selbstemulgierendes butylbenzolphthalein-arzneimittelabgabesystem, sein herstellungsverfahren und seine anwendung

Info

Publication number
DE602005020317D1
DE602005020317D1 DE602005020317T DE602005020317T DE602005020317D1 DE 602005020317 D1 DE602005020317 D1 DE 602005020317D1 DE 602005020317 T DE602005020317 T DE 602005020317T DE 602005020317 T DE602005020317 T DE 602005020317T DE 602005020317 D1 DE602005020317 D1 DE 602005020317D1
Authority
DE
Germany
Prior art keywords
emulsifying
self
butylphthalide
butylbenzolphthalene
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005020317T
Other languages
English (en)
Inventor
Zhentao Liu
Liying Yang
Hanyu Yang
Yuqing Gao
Dongmin Shen
Wenmin Guo
Xiaolong Feng
Jia Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Co Ltd
Original Assignee
Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Co Ltd filed Critical Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Co Ltd
Publication of DE602005020317D1 publication Critical patent/DE602005020317D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602005020317T 2004-08-27 2005-08-26 Selbstemulgierendes butylbenzolphthalein-arzneimittelabgabesystem, sein herstellungsverfahren und seine anwendung Active DE602005020317D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB2004100750682A CN100361656C (zh) 2004-08-27 2004-08-27 丁苯酞自乳化释药体系及其制备方法和应用
PCT/CN2005/001332 WO2006021160A1 (fr) 2004-08-27 2005-08-26 Système de relargage de médicament auto-émulsifiant à base de butylbenzènephtaléine, méthode de préparation et applications d’un tel système

Publications (1)

Publication Number Publication Date
DE602005020317D1 true DE602005020317D1 (de) 2010-05-12

Family

ID=35926548

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005020317T Active DE602005020317D1 (de) 2004-08-27 2005-08-26 Selbstemulgierendes butylbenzolphthalein-arzneimittelabgabesystem, sein herstellungsverfahren und seine anwendung

Country Status (15)

Country Link
US (1) US8728518B2 (de)
EP (1) EP1787638B1 (de)
JP (1) JP4653810B2 (de)
KR (1) KR100887034B1 (de)
CN (1) CN100361656C (de)
AT (1) ATE462410T1 (de)
AU (1) AU2005276811B8 (de)
BR (1) BRPI0515070B8 (de)
CA (1) CA2578130C (de)
DE (1) DE602005020317D1 (de)
ES (1) ES2341265T4 (de)
MX (1) MX2007002335A (de)
NO (1) NO336917B1 (de)
RU (1) RU2371176C2 (de)
WO (1) WO2006021160A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100367951C (zh) 2005-12-16 2008-02-13 石药集团恩必普药业有限公司 丁苯酞静脉乳剂及其应用
CN101342152B (zh) * 2007-07-10 2010-10-13 石药集团中奇制药技术（石家庄）有限公司 丁苯酞片及其制备方法
CN101579323B (zh) * 2008-05-16 2012-01-25 石药集团中奇制药技术（石家庄）有限公司 丁苯酞缓释片及其制备方法
CN102178643B (zh) * 2011-04-29 2014-05-14 石药集团恩必普药业有限公司 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法
CN103784424B (zh) * 2012-10-30 2018-04-27 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞经皮贴剂及其制备方法
CN103830200A (zh) * 2012-11-21 2014-06-04 石药集团中奇制药技术（石家庄）有限公司 一种3-正丁基苯酞衍生物的组合物及其制备方法
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
CN105030760B (zh) 2014-04-24 2018-10-02 长弘生物科技股份有限公司 稳定医药组合物
TWI547280B (zh) * 2014-04-24 2016-09-01 長弘生物科技股份有限公司 穩定醫藥組合物
CA2982162C (en) 2015-04-10 2023-10-10 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
CN105267145B (zh) * 2015-11-01 2019-06-21 袁旭东 双膦酸盐的自乳化配方和相关剂型
CN105796486A (zh) * 2016-03-17 2016-07-27 南京天翔医药科技有限公司 丁苯酞脂肪乳注射剂及其制备工艺
CN107661287B (zh) * 2017-11-28 2021-01-26 遵义医学院 地榆皂苷自乳化药物传递系统的制备
CN110856712B (zh) * 2018-08-06 2021-11-30 刘超 丁苯酞自微乳组合物及其制备方法和用途
CN114073694B (zh) * 2020-08-14 2024-03-12 北京科莱博医药开发有限责任公司 丁苯酞制剂及其制备方法
CN114681389A (zh) * 2020-12-29 2022-07-01 中国科学院上海药物研究所 一种经口腔黏膜递送的丁苯酞组合物及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2516477B2 (ja) * 1990-12-17 1996-07-24 花王株式会社 皮膚の血行不良に起因する疾患の治療剤
CN2123000U (zh) 1992-04-24 1992-11-25 李广杰 塑料葡萄灯
DE4313693A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 2-Amino-4-chinolin-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
CN1048158C (zh) * 1993-09-09 2000-01-12 中国医学科学院药物研究所 芹菜甲素在制备预防和治疗哺乳动物或人类脑缺血引起的疾病的药中的应用
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
WO1999049848A1 (en) 1998-04-01 1999-10-07 Rtp Pharma Inc. Anticancer compositions
AU3843999A (en) 1998-05-07 1999-11-23 Elan Corporation, Plc Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
CN1086942C (zh) 1998-12-18 2002-07-03 中国医学科学院药物研究所 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用
SG97918A1 (en) * 2000-06-08 2003-08-20 Hovid Sdn Bhd A novel drug delivery system: formulation for fat-soluble drugs
MY120392A (en) * 2000-06-08 2005-10-31 Hovid Berhad A novel drug delivery system : formulation for fat-soluble drugs
US6596306B1 (en) 2000-07-07 2003-07-22 David Ho Sue San Ho Drug delivery system:formulation for fat-soluble drugs
ATE290372T1 (de) * 2000-07-24 2005-03-15 Upjohn Co Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln
CN1166693C (zh) * 2001-06-18 2004-09-15 中奇制药技术（石家庄）有限公司 丁苯酞环糊精或环糊精衍生物包合物及其制备方法和用途
CN1375288A (zh) * 2002-05-13 2002-10-23 周桂荣 一种治疗脑血管疾病的药物组合物
CA2494157C (en) * 2002-08-21 2010-10-12 Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof
JP4215633B2 (ja) 2002-12-19 2009-01-28 Ｊｆｅケミカル株式会社 複合黒鉛粒子の製造方法
CN1233317C (zh) * 2003-07-07 2005-12-28 西安利君制药有限责任公司 水飞蓟素自乳化微乳组合物及其制备工艺

Also Published As

Publication number Publication date
ES2341265T3 (es) 2010-06-17
EP1787638B1 (de) 2010-03-31
US8728518B2 (en) 2014-05-20
MX2007002335A (es) 2007-10-10
KR100887034B1 (ko) 2009-03-04
AU2005276811B2 (en) 2008-11-13
WO2006021160A8 (en) 2006-04-13
JP2008510737A (ja) 2008-04-10
CA2578130A1 (en) 2006-03-02
CA2578130C (en) 2010-08-31
RU2007111120A (ru) 2008-10-20
ES2341265T4 (es) 2011-04-27
AU2005276811A1 (en) 2006-03-02
JP4653810B2 (ja) 2011-03-16
CN1726909A (zh) 2006-02-01
NO336917B1 (no) 2015-11-23
EP1787638A1 (de) 2007-05-23
EP1787638A4 (de) 2008-12-03
WO2006021160A1 (fr) 2006-03-02
ATE462410T1 (de) 2010-04-15
RU2371176C2 (ru) 2009-10-27
AU2005276811B8 (en) 2009-01-22
BRPI0515070B8 (pt) 2021-05-25
NO20071354L (no) 2007-05-29
BRPI0515070B1 (pt) 2020-09-08
CN100361656C (zh) 2008-01-16
US20080319056A1 (en) 2008-12-25
BRPI0515070A2 (pt) 2009-08-04
KR20070046948A (ko) 2007-05-03

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