RU2371176C2 - Самоэмульгирующаяся система доставки лекарственного средства бутилфталида, способ ее получения и применения - Google Patents
Самоэмульгирующаяся система доставки лекарственного средства бутилфталида, способ ее получения и применения Download PDFInfo
- Publication number
- RU2371176C2 RU2371176C2 RU2007111120/15A RU2007111120A RU2371176C2 RU 2371176 C2 RU2371176 C2 RU 2371176C2 RU 2007111120/15 A RU2007111120/15 A RU 2007111120/15A RU 2007111120 A RU2007111120 A RU 2007111120A RU 2371176 C2 RU2371176 C2 RU 2371176C2
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- RU
- Russia
- Prior art keywords
- butylphthalide
- emulsifying
- self
- oil
- dosage form
- Prior art date
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN200410075068.2 | 2004-08-27 | ||
| CNB2004100750682A CN100361656C (zh) | 2004-08-27 | 2004-08-27 | 丁苯酞自乳化释药体系及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
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| RU2007111120A RU2007111120A (ru) | 2008-10-20 |
| RU2371176C2 true RU2371176C2 (ru) | 2009-10-27 |
Family
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| RU2007111120/15A RU2371176C2 (ru) | 2004-08-27 | 2005-08-26 | Самоэмульгирующаяся система доставки лекарственного средства бутилфталида, способ ее получения и применения |
Country Status (15)
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| US (1) | US8728518B2 (https=) |
| EP (1) | EP1787638B1 (https=) |
| JP (1) | JP4653810B2 (https=) |
| KR (1) | KR100887034B1 (https=) |
| CN (1) | CN100361656C (https=) |
| AT (1) | ATE462410T1 (https=) |
| AU (1) | AU2005276811B8 (https=) |
| BR (1) | BRPI0515070B8 (https=) |
| CA (1) | CA2578130C (https=) |
| DE (1) | DE602005020317D1 (https=) |
| ES (1) | ES2341265T4 (https=) |
| MX (1) | MX2007002335A (https=) |
| NO (1) | NO336917B1 (https=) |
| RU (1) | RU2371176C2 (https=) |
| WO (1) | WO2006021160A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2837767C1 (ru) * | 2024-07-11 | 2025-04-04 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр оригинальных и перспективных биомедицинских и фармацевтических технологий" | Способ получения самоэмульгирующейся системы доставки лекарственного средства на основе плохорастворимой фармацевтической субстанции |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100367951C (zh) * | 2005-12-16 | 2008-02-13 | 石药集团恩必普药业有限公司 | 丁苯酞静脉乳剂及其应用 |
| CN101342152B (zh) * | 2007-07-10 | 2010-10-13 | 石药集团中奇制药技术（石家庄）有限公司 | 丁苯酞片及其制备方法 |
| CN101579323B (zh) * | 2008-05-16 | 2012-01-25 | 石药集团中奇制药技术（石家庄）有限公司 | 丁苯酞缓释片及其制备方法 |
| CN102178643B (zh) * | 2011-04-29 | 2014-05-14 | 石药集团恩必普药业有限公司 | 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法 |
| CN103784424B (zh) * | 2012-10-30 | 2018-04-27 | 石药集团中奇制药技术（石家庄）有限公司 | 一种丁苯酞经皮贴剂及其制备方法 |
| CN109394720A (zh) * | 2012-11-21 | 2019-03-01 | 石药集团中奇制药技术（石家庄）有限公司 | 一种3-正丁基苯酞衍生物的组合物及其制备方法 |
| WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| TWI547280B (zh) * | 2014-04-24 | 2016-09-01 | 長弘生物科技股份有限公司 | 穩定醫藥組合物 |
| CN105030760B (zh) | 2014-04-24 | 2018-10-02 | 长弘生物科技股份有限公司 | 稳定医药组合物 |
| CA2982162C (en) * | 2015-04-10 | 2023-10-10 | Bioresponse, L.L.C. | Self-emulsifying formulations of dim-related indoles |
| CN105267145B (zh) * | 2015-11-01 | 2019-06-21 | 袁旭东 | 双膦酸盐的自乳化配方和相关剂型 |
| CN105796486A (zh) * | 2016-03-17 | 2016-07-27 | 南京天翔医药科技有限公司 | 丁苯酞脂肪乳注射剂及其制备工艺 |
| CN107661287B (zh) * | 2017-11-28 | 2021-01-26 | 遵义医学院 | 地榆皂苷自乳化药物传递系统的制备 |
| CN110856712B (zh) * | 2018-08-06 | 2021-11-30 | 刘超 | 丁苯酞自微乳组合物及其制备方法和用途 |
| CN114073694B (zh) * | 2020-08-14 | 2024-03-12 | 北京科莱博医药开发有限责任公司 | 丁苯酞制剂及其制备方法 |
| CN114681389A (zh) * | 2020-12-29 | 2022-07-01 | 中国科学院上海药物研究所 | 一种经口腔黏膜递送的丁苯酞组合物及其用途 |
| JP2024505623A (ja) | 2020-12-31 | 2024-02-07 | ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント | 水難溶性極性溶質用の完全に希釈可能な自己マイクロ乳化デリバリーシステム（ｓｍｅｄｄｓ） |
| CN116407510B (zh) * | 2021-12-29 | 2025-11-21 | 河北赛谱睿思医药科技有限公司 | 一种丁苯酞舌下片及其制备方法 |
| KR102945311B1 (ko) | 2023-12-15 | 2026-04-01 | 한국 한의학 연구원 | 부틸프탈라이드 또는 이의 허용 가능한 염을 유효성분으로 포함하는 노화에 의한 난소 저반응군의 예방, 개선 또는 치료용 조성물 |
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| WO1999056727A2 (en) * | 1998-05-07 | 1999-11-11 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
| CN1257706A (zh) * | 1998-12-18 | 2000-06-28 | 中国医学科学院药物研究所 | 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2516477B2 (ja) * | 1990-12-17 | 1996-07-24 | 花王株式会社 | 皮膚の血行不良に起因する疾患の治療剤 |
| CN2123000U (zh) | 1992-04-24 | 1992-11-25 | 李广杰 | 塑料葡萄灯 |
| DE4313693A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2-Amino-4-chinolin-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung |
| CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| CN1048158C (zh) | 1993-09-09 | 2000-01-12 | 中国医学科学院药物研究所 | 芹菜甲素在制备预防和治疗哺乳动物或人类脑缺血引起的疾病的药中的应用 |
| US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| KR100661879B1 (ko) | 1998-04-01 | 2006-12-27 | 스키에파마 캐나다 인코포레이티드 | 항암 조성물 |
| MY120392A (en) * | 2000-06-08 | 2005-10-31 | Hovid Berhad | A novel drug delivery system : formulation for fat-soluble drugs |
| US6596306B1 (en) | 2000-07-07 | 2003-07-22 | David Ho Sue San Ho | Drug delivery system:formulation for fat-soluble drugs |
| SG97918A1 (en) * | 2000-06-08 | 2003-08-20 | Hovid Sdn Bhd | A novel drug delivery system: formulation for fat-soluble drugs |
| ATE290372T1 (de) * | 2000-07-24 | 2005-03-15 | Upjohn Co | Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln |
| CN1166693C (zh) * | 2001-06-18 | 2004-09-15 | 中奇制药技术（石家庄）有限公司 | 丁苯酞环糊精或环糊精衍生物包合物及其制备方法和用途 |
| CN1375288A (zh) * | 2002-05-13 | 2002-10-23 | 周桂荣 | 一种治疗脑血管疾病的药物组合物 |
| EP1535916B1 (en) * | 2002-08-21 | 2010-12-01 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Inclusion complexes of butylphthalide with cyclodextrin derivatives and processes for their preparation |
| JP4215633B2 (ja) | 2002-12-19 | 2009-01-28 | Ｊｆｅケミカル株式会社 | 複合黒鉛粒子の製造方法 |
| CN1233317C (zh) * | 2003-07-07 | 2005-12-28 | 西安利君制药有限责任公司 | 水飞蓟素自乳化微乳组合物及其制备工艺 |
-
2004
- 2004-08-27 CN CNB2004100750682A patent/CN100361656C/zh not_active Expired - Lifetime
-
2005
- 2005-08-26 DE DE602005020317T patent/DE602005020317D1/de not_active Expired - Lifetime
- 2005-08-26 KR KR1020077006741A patent/KR100887034B1/ko not_active Expired - Lifetime
- 2005-08-26 BR BRPI0515070A patent/BRPI0515070B8/pt active IP Right Grant
- 2005-08-26 AT AT05781769T patent/ATE462410T1/de not_active IP Right Cessation
- 2005-08-26 JP JP2007528562A patent/JP4653810B2/ja not_active Expired - Lifetime
- 2005-08-26 EP EP05781769A patent/EP1787638B1/en not_active Expired - Lifetime
- 2005-08-26 ES ES05781769T patent/ES2341265T4/es not_active Expired - Lifetime
- 2005-08-26 MX MX2007002335A patent/MX2007002335A/es active IP Right Grant
- 2005-08-26 CA CA2578130A patent/CA2578130C/en not_active Expired - Lifetime
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- 2005-08-26 WO PCT/CN2005/001332 patent/WO2006021160A1/zh not_active Ceased
- 2005-08-26 US US11/574,313 patent/US8728518B2/en active Active
- 2005-08-26 RU RU2007111120/15A patent/RU2371176C2/ru active
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2007
- 2007-03-12 NO NO20071354A patent/NO336917B1/no unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999056727A2 (en) * | 1998-05-07 | 1999-11-11 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
| CN1257706A (zh) * | 1998-12-18 | 2000-06-28 | 中国医学科学院药物研究所 | 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2837767C1 (ru) * | 2024-07-11 | 2025-04-04 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр оригинальных и перспективных биомедицинских и фармацевтических технологий" | Способ получения самоэмульгирующейся системы доставки лекарственного средства на основе плохорастворимой фармацевтической субстанции |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100887034B1 (ko) | 2009-03-04 |
| CN1726909A (zh) | 2006-02-01 |
| JP2008510737A (ja) | 2008-04-10 |
| EP1787638B1 (en) | 2010-03-31 |
| AU2005276811A1 (en) | 2006-03-02 |
| RU2007111120A (ru) | 2008-10-20 |
| AU2005276811B8 (en) | 2009-01-22 |
| NO20071354L (no) | 2007-05-29 |
| WO2006021160A1 (en) | 2006-03-02 |
| ES2341265T3 (es) | 2010-06-17 |
| EP1787638A1 (en) | 2007-05-23 |
| AU2005276811B2 (en) | 2008-11-13 |
| KR20070046948A (ko) | 2007-05-03 |
| BRPI0515070B1 (pt) | 2020-09-08 |
| WO2006021160A8 (fr) | 2006-04-13 |
| CN100361656C (zh) | 2008-01-16 |
| JP4653810B2 (ja) | 2011-03-16 |
| BRPI0515070A2 (pt) | 2009-08-04 |
| ES2341265T4 (es) | 2011-04-27 |
| US20080319056A1 (en) | 2008-12-25 |
| CA2578130C (en) | 2010-08-31 |
| EP1787638A4 (en) | 2008-12-03 |
| ATE462410T1 (de) | 2010-04-15 |
| US8728518B2 (en) | 2014-05-20 |
| CA2578130A1 (en) | 2006-03-02 |
| BRPI0515070B8 (pt) | 2021-05-25 |
| DE602005020317D1 (de) | 2010-05-12 |
| NO336917B1 (no) | 2015-11-23 |
| MX2007002335A (es) | 2007-10-10 |
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