ATE290372T1 - Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln - Google Patents

Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln

Info

Publication number
ATE290372T1
ATE290372T1 AT01954879T AT01954879T ATE290372T1 AT E290372 T1 ATE290372 T1 AT E290372T1 AT 01954879 T AT01954879 T AT 01954879T AT 01954879 T AT01954879 T AT 01954879T AT E290372 T1 ATE290372 T1 AT E290372T1
Authority
AT
Austria
Prior art keywords
insoluble
delivery
self
water
medicinal products
Prior art date
Application number
AT01954879T
Other languages
English (en)
Inventor
Ping Gao
Walter Morozowich
Narmada Shenoy
Original Assignee
Upjohn Co
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Sugen Inc filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE290372T1 publication Critical patent/ATE290372T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01954879T 2000-07-24 2001-07-20 Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln ATE290372T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22037600P 2000-07-24 2000-07-24
PCT/US2001/023140 WO2002007712A2 (en) 2000-07-24 2001-07-20 Self-emulsifying drug delivery systems for extremely water-insoluble, lipophilic drugs

Publications (1)

Publication Number Publication Date
ATE290372T1 true ATE290372T1 (de) 2005-03-15

Family

ID=22823309

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01954879T ATE290372T1 (de) 2000-07-24 2001-07-20 Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln

Country Status (14)

Country Link
US (1) US20020119198A1 (de)
EP (1) EP1303261B1 (de)
JP (1) JP2004504342A (de)
AR (1) AR030253A1 (de)
AT (1) ATE290372T1 (de)
AU (2) AU2001277099B2 (de)
CA (1) CA2410683A1 (de)
DE (1) DE60109295T2 (de)
DK (1) DK1303261T3 (de)
ES (1) ES2238050T3 (de)
MX (1) MXPA03000720A (de)
PE (1) PE20020261A1 (de)
PT (1) PT1303261E (de)
WO (1) WO2002007712A2 (de)

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ITRM20030074A1 (it) * 2003-02-21 2004-08-22 Pharmacia Italia Spa Formulazioni semisolide a rilascio immediato intese
AU2004308712A1 (en) * 2003-12-23 2005-07-14 Tibotec Pharmaceuticals Ltd. Self-microemulsifying drug delivery systems of a HIV protease inhibitor
JP2007516297A (ja) * 2003-12-23 2007-06-21 アルザ・コーポレーシヨン 制御送達用薬剤組成物の溶解度を高くする方法および投薬形態物
US7659310B2 (en) 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
US7345093B2 (en) 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
EP1748759B1 (de) * 2004-04-27 2013-03-27 Javeri, Indu Verfahren zur verbesserung der wasserlöslichkeit von hydrophoben verbindungen durch mizellendispersionen
CN100361656C (zh) * 2004-08-27 2008-01-16 石药集团中奇制药技术（石家庄）有限公司 丁苯酞自乳化释药体系及其制备方法和应用
CN101137395B (zh) * 2005-03-14 2012-10-31 株式会社大塚制药工场 含有水难溶性药物的医药组合物
US20140357708A1 (en) * 2005-11-07 2014-12-04 Murty Pharmaceuticals, Inc. Oral dosage form of tetrahydrocannabinol and a method of avoiding and/or suppressing hepatic first pass metabolism via targeted chylomicron/lipoprotein delivery
US20160184258A1 (en) * 2005-11-07 2016-06-30 Murty Pharmaceuticals, Inc. Oral gastrointestinal dosage form delivery system of cannabinoids and/or standardized marijuana extracts
MY153288A (en) * 2006-06-28 2015-01-29 Hovid Berhad An effective pharmaceutical carrier for poorly bioavailable drugs
EP2178893A4 (de) * 2007-07-16 2012-09-19 Poniard Pharmaceuticals Inc Orale formulierungen für picoplatin
EP2200613B1 (de) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazin-derivate und ihre verwendungen
US20130045238A1 (en) * 2009-04-22 2013-02-21 Agency For Science, Technology And Research Emulsions for transdermal delivery
CA2781529C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes comprising docetaxel
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
EP2488022B1 (de) 2009-10-16 2018-01-10 Mochida Pharmaceutical Co., Ltd. Zusammensetzungen
US9468638B2 (en) 2010-09-24 2016-10-18 Texas Southern University Itraconazole formulations
US20120302954A1 (en) * 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
CN102415995B (zh) * 2011-12-09 2013-11-13 广东众生药业股份有限公司 一种黄体酮过饱和自微乳组合物及其制备方法
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
AU2015237243A1 (en) * 2014-03-28 2016-09-29 Therapeuticsmd, Inc. Progesterone formulations
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
RU2016141135A (ru) 2014-07-29 2018-08-28 Терапьютиксмд, Инк. Трансдермальный крем
US20160346221A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
TW201718598A (zh) * 2015-08-27 2017-06-01 美國禮來大藥廠 Ｅｚｈ２抑制劑
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
JP6871542B2 (ja) * 2017-02-28 2021-05-12 国立大学法人横浜国立大学 無機物成形体およびその製造方法
US20200206139A1 (en) * 2017-09-11 2020-07-02 Board Of Regents, The University Of Texas System Compositions for the improved delivery of drugs
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
WO2025153584A1 (en) * 2024-01-17 2025-07-24 Basf Se Solid self-emulsifying dosage form
CN118593433A (zh) * 2024-06-18 2024-09-06 浙江大学 一种黄体酮自乳化制剂及其制备方法和应用

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US4816247A (en) * 1985-09-11 1989-03-28 American Cyanamid Company Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
JP4713698B2 (ja) * 1997-03-05 2011-06-29 スージェン， インク． 疎水性薬剤の処方
KR100661879B1 (ko) * 1998-04-01 2006-12-27 스키에파마 캐나다 인코포레이티드 항암 조성물
US6221391B1 (en) * 1998-11-23 2001-04-24 Accucaps Industries Limited Self-emulsifying ibuprofen solution and soft gelatin capsule for use therewith
US20020102301A1 (en) * 2000-01-13 2002-08-01 Joseph Schwarz Pharmaceutical solid self-emulsifying composition for sustained delivery of biologically active compounds and the process for preparation thereof
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung

Also Published As

Publication number Publication date
AU7709901A (en) 2002-02-05
MXPA03000720A (es) 2004-11-01
US20020119198A1 (en) 2002-08-29
DE60109295T2 (de) 2006-04-13
DK1303261T3 (da) 2005-05-23
WO2002007712A3 (en) 2002-06-13
PE20020261A1 (es) 2002-04-18
CA2410683A1 (en) 2002-01-31
AR030253A1 (es) 2003-08-13
PT1303261E (pt) 2005-06-30
AU2001277099B2 (en) 2006-08-31
EP1303261B1 (de) 2005-03-09
DE60109295D1 (de) 2005-04-14
EP1303261A2 (de) 2003-04-23
WO2002007712A2 (en) 2002-01-31
ES2238050T3 (es) 2005-08-16
JP2004504342A (ja) 2004-02-12

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