DE69927388D1 - Gerät zur verabreichung von medikamenten und genen in gewebe - Google Patents
Gerät zur verabreichung von medikamenten und genen in gewebeInfo
- Publication number
- DE69927388D1 DE69927388D1 DE69927388T DE69927388T DE69927388D1 DE 69927388 D1 DE69927388 D1 DE 69927388D1 DE 69927388 T DE69927388 T DE 69927388T DE 69927388 T DE69927388 T DE 69927388T DE 69927388 D1 DE69927388 D1 DE 69927388D1
- Authority
- DE
- Germany
- Prior art keywords
- medicaments
- genes
- administration
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
- A61N1/0424—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
- A61N1/042—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US134245 | 1987-12-17 | ||
US09/134,245 US6192270B1 (en) | 1998-08-14 | 1998-08-14 | Apparatus and method for the delivery of drugs and genes into tissue |
PCT/US1999/010664 WO2000009205A1 (en) | 1998-08-14 | 1999-05-14 | Apparatus and method for the delivery of drugs and genes into tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69927388D1 true DE69927388D1 (de) | 2005-10-27 |
DE69927388T2 DE69927388T2 (de) | 2006-07-13 |
Family
ID=22462442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69927388T Expired - Fee Related DE69927388T2 (de) | 1998-08-14 | 1999-05-14 | Gerät zur verabreichung von medikamenten und genen in gewebe |
Country Status (9)
Country | Link |
---|---|
US (3) | US6192270B1 (de) |
EP (1) | EP1104326B1 (de) |
JP (1) | JP2002522180A (de) |
CN (1) | CN1141989C (de) |
AU (1) | AU769758C (de) |
CA (1) | CA2340075A1 (de) |
DE (1) | DE69927388T2 (de) |
RU (1) | RU2222358C2 (de) |
WO (1) | WO2000009205A1 (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6775569B2 (en) * | 1997-11-05 | 2004-08-10 | Hisamitsu Pharmaceutical Co., Inc. | Electroporation device for in vivo delivery of therapeutic agents |
US6757560B1 (en) * | 1999-04-09 | 2004-06-29 | Novosis Pharma Ag | Transdermal delivery system (TDS) with electrode network |
AU761522B2 (en) | 1998-07-13 | 2003-06-05 | Genetronics, Inc. | Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications |
US7922709B2 (en) * | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
US6192270B1 (en) * | 1998-08-14 | 2001-02-20 | Genetronics, Inc. | Apparatus and method for the delivery of drugs and genes into tissue |
US7171264B1 (en) * | 1999-05-10 | 2007-01-30 | Genetronics, Inc. | Intradermal delivery of active agents by needle-free injection and electroporation |
US7245963B2 (en) * | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
US8209006B2 (en) * | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
US8016810B2 (en) * | 2003-06-23 | 2011-09-13 | Transpharma Medical Ltd. | Transdermal delivery system for cosmetic agents |
AU2005289828A1 (en) | 2004-09-24 | 2006-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for the non-thermal, electrically-induced closure of blood vessels |
ES2278499B1 (es) * | 2005-06-10 | 2008-07-16 | Narciso Barbero Castro | Dispositivo para generar electroosmosis. |
AU2006335194B2 (en) * | 2006-01-03 | 2011-10-27 | Alcon Inc. | System for dissociation and removal of proteinaceous tissue |
US20070185431A1 (en) * | 2006-02-03 | 2007-08-09 | Kern Dale G | Galvanic Current Skin Treatment |
CN101370553B (zh) * | 2006-02-11 | 2013-04-10 | 基因特伦尼克斯公司 | 用于单针体内电穿孔的装置和方法 |
HUP0600444A2 (en) * | 2006-05-29 | 2007-11-28 | Istvan Magyar | Microcurrent therapy device |
US7996077B2 (en) * | 2006-09-06 | 2011-08-09 | Encore Medical Asset Corporation | Iontophoresis apparatus and method |
PL2409727T3 (pl) | 2006-10-17 | 2019-03-29 | Inovio Pharmaceuticals, Inc. | Urządzenia elektroporacyjne do elektroporacji komórek u ssaków |
US20080188791A1 (en) * | 2007-02-02 | 2008-08-07 | Difiore Attilio E | Active iontophoresis delivery system |
US8197844B2 (en) * | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
US8718778B2 (en) * | 2008-04-15 | 2014-05-06 | Research Foundation Of The City University Of New York | Apparatus and method for neurocranial electrostimulation |
US20110118729A1 (en) * | 2009-11-13 | 2011-05-19 | Alcon Research, Ltd | High-intensity pulsed electric field vitrectomy apparatus with load detection |
US20110118734A1 (en) * | 2009-11-16 | 2011-05-19 | Alcon Research, Ltd. | Capsularhexis device using pulsed electric fields |
US20110135626A1 (en) * | 2009-12-08 | 2011-06-09 | Alcon Research, Ltd. | Localized Chemical Lysis of Ocular Tissue |
US20110144562A1 (en) * | 2009-12-14 | 2011-06-16 | Alcon Research, Ltd. | Localized Pharmacological Treatment of Ocular Tissue Using High-Intensity Pulsed Electrical Fields |
WO2011081897A1 (en) * | 2009-12-15 | 2011-07-07 | Alcon Research, Ltd. | High-intensity pulsed electric field vitrectomy apparatus |
DE102010024558B4 (de) * | 2010-06-22 | 2016-04-21 | Amw Gmbh | Transdermales therapeutisches System mit Elektroden |
US8546979B2 (en) | 2010-08-11 | 2013-10-01 | Alcon Research, Ltd. | Self-matching pulse generator with adjustable pulse width and pulse frequency |
CN103200959A (zh) | 2010-09-27 | 2013-07-10 | 中国农业大学 | 预防和治疗自身免疫性疾病的联合抗原和dna疫苗 |
US8428709B1 (en) * | 2012-06-11 | 2013-04-23 | Incline Therapeutics, Inc. | Current control for electrotransport drug delivery |
US8428708B1 (en) | 2012-05-21 | 2013-04-23 | Incline Therapeutics, Inc. | Self-test for analgesic product |
USD733899S1 (en) | 2011-09-30 | 2015-07-07 | Nse Products, Inc. | Skin treatment device |
CN103239734B (zh) | 2012-02-10 | 2016-02-24 | 北京艾棣维欣生物技术有限公司 | 用于预防和/或治疗呼吸道合胞病毒感染的疫苗 |
JP6523174B2 (ja) | 2012-12-13 | 2019-05-29 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Wt1ワクチン |
US10364451B2 (en) | 2013-05-30 | 2019-07-30 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
US9592303B2 (en) | 2013-05-30 | 2017-03-14 | Duke University | Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates |
US10392611B2 (en) | 2013-05-30 | 2019-08-27 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
EP3054972B1 (de) | 2013-10-07 | 2019-02-27 | The Trustees Of The University Of Pennsylvania | Impfstoffe mit interleukin-33 als adjuvans |
WO2015070027A1 (en) | 2013-11-07 | 2015-05-14 | University Of Southern California | Use of ikk epsilon inhibitors to activate nfat and t cell response |
EP3964231A1 (de) | 2013-11-14 | 2022-03-09 | Inovio Pharmaceuticals, Inc. | Hiv-1-env-dna-impfstoff plus proteinboost |
IL305392A (en) | 2013-11-29 | 2023-10-01 | Inovio Pharmaceuticals Inc | MERS-COV vaccine |
KR20220062143A (ko) | 2014-01-06 | 2022-05-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용 |
US10772473B2 (en) | 2014-08-13 | 2020-09-15 | Nse Products, Inc. | Device and method for cleansing and treating skin |
SG11201700989XA (en) | 2014-08-13 | 2017-03-30 | Nse Products Inc | Device and method for cleansing and treating skin |
US10166288B2 (en) | 2014-10-01 | 2019-01-01 | The Trustees Of The University Of Pennsylvania | Vaccines having an antigen and interleukin-21 as an adjuvant |
CA2974956A1 (en) | 2015-01-29 | 2016-08-04 | The Trustees Of The University Of Pennsylvania | Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy |
WO2016154530A1 (en) | 2015-03-26 | 2016-09-29 | Duke University | Targeted therapeutic agents comprising multivalent protein-biopolymer fusions |
WO2017024182A1 (en) | 2015-08-04 | 2017-02-09 | Duke University | Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same |
USD782197S1 (en) * | 2015-08-13 | 2017-03-28 | Nse Products, Inc. | Treatment brush head |
USD829445S1 (en) * | 2015-08-13 | 2018-10-02 | Nse Products, Inc. | Treatment brush head |
USD778066S1 (en) * | 2015-08-13 | 2017-02-07 | Nse Products, Inc. | Treatment brush head |
EP3393500B1 (de) | 2015-12-21 | 2021-10-13 | Duke University | Polymerkonjugate mit verringerter antigenizität |
US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
WO2017173398A1 (en) | 2016-04-01 | 2017-10-05 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
US20190284263A1 (en) | 2016-04-29 | 2019-09-19 | Inovio Pharmaceuticals, Inc. | In vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent |
WO2017210476A1 (en) | 2016-06-01 | 2017-12-07 | Duke University | Nonfouling biosensors |
US10233419B2 (en) | 2016-06-30 | 2019-03-19 | Zymergen Inc. | Apparatuses and methods for electroporation |
WO2018053201A1 (en) | 2016-09-14 | 2018-03-22 | Duke University | Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs |
KR20190064600A (ko) | 2016-09-23 | 2019-06-10 | 듀크 유니버시티 | Lcst 거동을 갖는 비구조화된 비-반복적 폴리펩티드 |
US10376495B2 (en) | 2016-11-23 | 2019-08-13 | University Of South Florida | Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF) |
WO2018132732A1 (en) | 2017-01-12 | 2018-07-19 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
US10813935B2 (en) | 2017-02-23 | 2020-10-27 | Transgenex Nanobiotech, Inc. | Methods and compositions for treating drug resistance in cancer |
US10272052B2 (en) | 2017-02-24 | 2019-04-30 | University Of South Florida | Compositions and methods for the treatment of tauopathies |
US11318155B2 (en) | 2017-02-24 | 2022-05-03 | University Of South Florida | Hsp90 activator Aha1 drives production of pathological tau aggregates |
WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
JP2020521528A (ja) | 2017-05-25 | 2020-07-27 | エヌエスイー プロダクツ インコーポレイテッド | 皮膚を洗浄し処理する装置用tensアタッチメント |
WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
RU2705104C2 (ru) * | 2017-10-17 | 2019-11-05 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Дагестанский Государственный Технический Университет" (Дгту) | Термоэлектрическое устройство для проведения электрофоретических лечебных процедур |
JP6964235B2 (ja) * | 2018-01-17 | 2021-11-10 | パナソニックIpマネジメント株式会社 | 薬剤浸透装置 |
US11649275B2 (en) | 2018-08-02 | 2023-05-16 | Duke University | Dual agonist fusion proteins |
RU2709159C1 (ru) * | 2018-10-26 | 2019-12-16 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Владимирский Государственный Университет имени Александра Григорьевича и Николая Григорьевича Столетовых" (ВлГУ) | Устройство для лечения грибковых инфекций ногтей |
US11786707B2 (en) | 2019-04-08 | 2023-10-17 | Astikay Medical LLC | Inflatable balloon over catheter with bypass passageway |
US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
TW202128775A (zh) | 2019-10-16 | 2021-08-01 | 英商阿法克塔生命科學有限公司 | PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分 |
PE20230171A1 (es) | 2020-02-25 | 2023-02-01 | Inovio Pharmaceuticals Inc | Vacunas contra el coronavirus y metodos de uso |
USD933840S1 (en) | 2020-04-21 | 2021-10-19 | Nse Products, Inc. | Microcurrent skin treatment device |
MX2022014248A (es) | 2020-05-14 | 2022-12-02 | Inovio Pharmaceuticals Inc | Vacunas para la papilomatosis respiratoria recurrente y metodos para usar estas. |
GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
JP2023533174A (ja) | 2020-06-12 | 2023-08-02 | ユニバーシティ オブ ロチェスター | ACE-tRNAのコード化及び発現 |
WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
WO2022238789A1 (en) * | 2021-05-12 | 2022-11-17 | Cochlear Limited | Electroporation gene therapy for tissue barriers |
WO2023057567A1 (en) | 2021-10-07 | 2023-04-13 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
WO2023057946A1 (en) | 2021-10-07 | 2023-04-13 | Avacta Life Sciences Limited | Serum half-life extended pd-l1 binding polypeptides |
WO2023150753A1 (en) | 2022-02-07 | 2023-08-10 | University Of Rochester | Optimized sequences for enhanced trna expression or/and nonsense mutation suppression |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135477A (en) * | 1984-10-29 | 1992-08-04 | Medtronic, Inc. | Iontophoretic drug delivery |
IL86076A (en) | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
US4950229A (en) * | 1989-09-25 | 1990-08-21 | Becton, Dickinson And Company | Apparatus for an electrode used for iontophoresis |
IE920763A1 (en) | 1991-03-11 | 1992-09-23 | Alza Corp | Iontophoretic delivery device and method of making same |
CA2084734C (en) * | 1991-12-17 | 1998-12-01 | John L. Haynes | Iontophoresis system having features for reducing skin irritation |
US5318514A (en) | 1992-08-17 | 1994-06-07 | Btx, Inc. | Applicator for the electroporation of drugs and genes into surface cells |
US5464386A (en) | 1992-08-17 | 1995-11-07 | Genetronics, Inc. | Transdermal drug delivery by electroincorporation of vesicles |
US6009345A (en) * | 1992-08-17 | 1999-12-28 | Genetronics, Inc. | Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes |
US5462520A (en) | 1992-08-17 | 1995-10-31 | Genetronics, Inc. | Transsurface drug delivery by electrofusion of microbubbles to the tissue surface |
JPH0670987A (ja) * | 1992-08-28 | 1994-03-15 | Katsuro Tachibana | 薬物投与・体液採取ユニット及び装置 |
US5380272A (en) * | 1993-01-28 | 1995-01-10 | Scientific Innovations Ltd. | Transcutaneous drug delivery applicator |
US5667487A (en) * | 1993-04-07 | 1997-09-16 | Henley; Julian L. | Ionosonic drug delivery apparatus |
AU2947795A (en) | 1994-06-24 | 1996-01-19 | Cygnus, Inc. | Pulsatile delivery systems of biologically active agents using electro voltage pulsing for controlling membrane permeability |
EP0781150B1 (de) | 1995-07-25 | 2002-11-06 | Massachusetts Institute Of Technology | Verbesserter transdermaler transport unter verwendung von ultraschall |
US5944685A (en) * | 1996-02-09 | 1999-08-31 | Polytronics, Ltd. | Skin-contact type medical treatment apparatus |
US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
US5704908A (en) | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
US6192270B1 (en) * | 1998-08-14 | 2001-02-20 | Genetronics, Inc. | Apparatus and method for the delivery of drugs and genes into tissue |
-
1998
- 1998-08-14 US US09/134,245 patent/US6192270B1/en not_active Expired - Fee Related
-
1999
- 1999-05-14 EP EP99923054A patent/EP1104326B1/de not_active Expired - Lifetime
- 1999-05-14 DE DE69927388T patent/DE69927388T2/de not_active Expired - Fee Related
- 1999-05-14 CN CNB998096458A patent/CN1141989C/zh not_active Expired - Fee Related
- 1999-05-14 AU AU39912/99A patent/AU769758C/en not_active Ceased
- 1999-05-14 RU RU2001106989/14A patent/RU2222358C2/ru not_active IP Right Cessation
- 1999-05-14 CA CA002340075A patent/CA2340075A1/en not_active Abandoned
- 1999-05-14 JP JP2000564706A patent/JP2002522180A/ja not_active Withdrawn
- 1999-05-14 WO PCT/US1999/010664 patent/WO2000009205A1/en active IP Right Grant
-
2001
- 2001-05-02 US US09/847,468 patent/US6748265B2/en not_active Expired - Fee Related
-
2004
- 2004-02-20 US US10/783,164 patent/US7395110B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2000009205A1 (en) | 2000-02-24 |
CN1141989C (zh) | 2004-03-17 |
CN1312731A (zh) | 2001-09-12 |
CA2340075A1 (en) | 2000-02-24 |
AU769758C (en) | 2007-09-06 |
US6192270B1 (en) | 2001-02-20 |
EP1104326B1 (de) | 2005-09-21 |
RU2222358C2 (ru) | 2004-01-27 |
US6748265B2 (en) | 2004-06-08 |
JP2002522180A (ja) | 2002-07-23 |
AU3991299A (en) | 2000-03-06 |
US20040176716A1 (en) | 2004-09-09 |
EP1104326A1 (de) | 2001-06-06 |
US7395110B2 (en) | 2008-07-01 |
US20020165481A1 (en) | 2002-11-07 |
DE69927388T2 (de) | 2006-07-13 |
AU769758B2 (en) | 2004-02-05 |
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Inventor name: HOFFMAN, GUENTER A., SAN DIEGO, CALIF., US Inventor name: RABUSSAY, DIETMAR, SOLANA BEACH, US Inventor name: TONNESSEN, ARNT, SAN DIEGO, CALIF., US Inventor name: ZHANG, LEI, SAN DIEGO, CALIF., US |
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