KR100842133B1 - 소아 만성 관절염 관련질환 치료제 - Google Patents
소아 만성 관절염 관련질환 치료제 Download PDFInfo
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- KR100842133B1 KR100842133B1 KR1020037012661A KR20037012661A KR100842133B1 KR 100842133 B1 KR100842133 B1 KR 100842133B1 KR 1020037012661 A KR1020037012661 A KR 1020037012661A KR 20037012661 A KR20037012661 A KR 20037012661A KR 100842133 B1 KR100842133 B1 KR 100842133B1
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- Prior art keywords
- antibody
- receptor
- pediatric
- chronic arthritis
- arthritis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Description
Claims (26)
- 삭제
- 삭제
- 인터루킨-6(IL-6) 수용체에 대한 항체를 유효성분으로 함유하는 소아 만성 관절염 치료제.
- 제 3항에 있어서, IL-6 수용체에 대한 항체가 IL-6 수용체에 대한 모노클로날 항체인 것을 특징으로 하는 소아 만성 관절염 치료제.
- 제 4항에 있어서, IL-6 수용체에 대한 항체가 인간 IL-6 수용체에 대한 모노클로날 항체인 것을 특징으로 하는 소아 만성 관절염 치료제.
- 제 4항에 있어서, IL-6 수용체에 대한 항체가 마우스 IL-6 수용체에 대한 모노클로날 항체인 것을 특징으로 하는 소아 만성 관절염 치료제.
- 제 3항 내지 6항 중 어느 하나의 항에 있어서, IL-6 수용체에 대한 항체가 재조합형 항체인 것을 특징으로 하는 소아 만성 관절염 치료제.
- 제 5항에 있어서, 인간 IL-6 수용체에 대한 모노클로날 항체가 PM-1 항체인 것을 특징으로 하는 소아 만성 관절염 치료제.
- 제 6항에 있어서, 마우스 IL-6 수용체에 대한 모노클로날 항체가 MR16-1 항체인 것을 특징으로 하는 소아 만성 관절염 치료제.
- 제 3항 내지 5항 중 어느 하나의 항에 있어서, IL-6 수용체에 대한 항체가 IL-6 수용체에 대한 키메라 항체, 인간형화 항체 또는 인간 항체인 것을 특징으로 하는 소아 만성 관절염 치료제.
- 제 10항에 있어서, IL-6 수용체에 대한 인간형화 항체가 인간형화 PM-1 항체인 것을 특징으로 하는 소아 만성 관절염 치료제.
- 제 3항 내지 제 6항, 제 8항, 제 9항, 또는 제 11항 중 어느 하나의 항에 있어서, 상기 소아 만성 관절염이 ARA(American Rheumatism Association) 분류에서는 전신형, 다관절형, 소관절형, EULAR(EUropean League Against Rheumatism) 분류에서는, 전신형, 다관절형, 소관절형, ILAR(International League of Associations for Rheumatology) 분류에서는 전신형, 다관절형(RF 양성형), 다관절형(RF 음성형), 소관절형, 진전형 소관절형, 본 발명자들의 분류에서는 소아 1차성 만성 관절염 (SPRASH 증후군(Spiking fever, Pericarditis, Rash, Arthritis, Splenomegaly, Hepatomegaly Syndrome), 소아 특발성 만성 관절염(a. 류마토이드 인자(RF) 양성형, b. 항핵항체(ANA) 양성형, c. RF/ANA 음성형))인 소아 만성 관절염 치료제.
- 제 3항 내지 제 6항, 제 8항, 제 9항 또는 제 11항 중 어느 하나의 항에 있어서, 상기 소아 만성 관절염이 ARA(American Rheumatism Association) 분류에서는 전신형, 다관절형, EULAR(EUropean League Against Rheumatism) 분류에서는 전신형, 다관절형, ILAR(International League of Associations for Rheumatology) 분류에서는 전신형, 다관절형(RF 양성형), 다관절형(RF 음성형), 진전형 소관절형, 본 발명자들의 분류에서는 소아 1차성 만성 관절염(SPRASH 증후군(Spiking fever, Pericarditis, Rash, Arthritis, Splenomegaly, Hepatomegaly Syndrome), 소아 특발성 만성 관절염(a. 류마토이드 인자(RF) 양성형, b. 항핵항체(ANA) 양성형))인 소아 만성 관절염 치료제.
- 제 3항 내지 제 6항, 제 8항, 제 9항, 또는 제 11항 중 어느 하나의 항에 있어서, 상기 소아 만성 관절염이 ARA(American Rheumatism Association) 분류로는 전신형, 다관절형, EULAR(EUropean League Against Rheumatism) 분류로는 전신형, 다관절형, ILAR(International League of Associations for Rheumatology) 분류로는 전신형, 다관절형(RF 양성형), 진전형 소관절형, 본 발명자들의 분류로는 소아 1차성 만성 관절염(SPRASH 증후군(Spiking fever, Pericarditis, Rash, Arthritis, Splenomegaly, Hepatomegaly Syndrome), 소아 특발성 만성 관절염(a. 류마토이드 인자 (RF) 양성형))인 소아 만성 관절염 치료제.
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001103627 | 2001-04-02 | ||
JPJP-P-2001-00103627 | 2001-04-02 | ||
JP2001109131 | 2001-04-06 | ||
JPJP-P-2001-00109131 | 2001-04-06 | ||
PCT/JP2002/003312 WO2002080969A1 (fr) | 2001-04-02 | 2002-04-02 | Remedes pour des maladies liees a l'arthrite chronique du nourrisson |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020087005693A Division KR100842132B1 (ko) | 2001-04-02 | 2002-04-02 | 소아 만성 관절염 관련질환 치료제 |
Publications (2)
Publication Number | Publication Date |
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KR20030087655A KR20030087655A (ko) | 2003-11-14 |
KR100842133B1 true KR100842133B1 (ko) | 2008-06-27 |
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KR1020037012661A KR100842133B1 (ko) | 2001-04-02 | 2002-04-02 | 소아 만성 관절염 관련질환 치료제 |
KR1020087005693A KR100842132B1 (ko) | 2001-04-02 | 2002-04-02 | 소아 만성 관절염 관련질환 치료제 |
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KR1020087005693A KR100842132B1 (ko) | 2001-04-02 | 2002-04-02 | 소아 만성 관절염 관련질환 치료제 |
Country Status (18)
Country | Link |
---|---|
US (5) | US20040115197A1 (ko) |
EP (4) | EP2298812A3 (ko) |
JP (5) | JP3702274B2 (ko) |
KR (2) | KR100842133B1 (ko) |
CN (1) | CN100562339C (ko) |
AU (1) | AU2002243032B2 (ko) |
BR (1) | BR0208636A (ko) |
CA (1) | CA2443294C (ko) |
HK (1) | HK1062408A1 (ko) |
HU (1) | HU230197B1 (ko) |
IL (3) | IL158079A0 (ko) |
MX (1) | MXPA03008955A (ko) |
NO (1) | NO20034388L (ko) |
NZ (1) | NZ528479A (ko) |
PL (1) | PL216534B1 (ko) |
RU (2) | RU2541165C2 (ko) |
UA (1) | UA80091C2 (ko) |
WO (1) | WO2002080969A1 (ko) |
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Cytokine, Vol. 10, No. 6, pp. 471-480 |
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