KR100842132B1 - 소아 만성 관절염 관련질환 치료제 - Google Patents
소아 만성 관절염 관련질환 치료제 Download PDFInfo
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- KR100842132B1 KR100842132B1 KR1020087005693A KR20087005693A KR100842132B1 KR 100842132 B1 KR100842132 B1 KR 100842132B1 KR 1020087005693 A KR1020087005693 A KR 1020087005693A KR 20087005693 A KR20087005693 A KR 20087005693A KR 100842132 B1 KR100842132 B1 KR 100842132B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (11)
- 인터루킨-6(IL-6) 수용체에 대한 항체를 유효성분으로 함유하는 스틸병 치료제.
- 제 1항에 있어서, IL-6 수용체에 대한 항체가 IL-6 수용체에 대한 모노클로날 항체인 것을 특징으로 하는 스틸병 치료제.
- 제 2항에 있어서, IL-6 수용체에 대한 항체가 인간 IL-6 수용체에 대한 모노클로날 항체인 것을 특징으로 하는 스틸병 치료제.
- 제 2항에 있어서, IL-6 수용체에 대한 항체가 마우스 IL-6 수용체에 대한 모노클로날 항체인 것을 특징으로 하는 스틸병 치료제.
- 제 1항 내지 제 4항 중 어느 하나의 항에 있어서, IL-6 수용체에 대한 항체가 재조합형 항체인 것을 특징으로 하는 스틸병 치료제.
- 제 3항에 있어서, 인간 IL-6 수용체에 대한 모노클로날 항체가 PM-1 항체인 것을 특징으로 하는 스틸병 치료제.
- 제 4항에 있어서, 마우스 IL-6 수용체에 대한 모노클로날 항체가 MR16-1 항체인 것을 특징으로 하는 스틸병 치료제.
- 제 1항 내지 제 3항 중 어느 하나의 항에 있어서, IL-6 수용체에 대한 항체가 IL-6 수용체에 대한 키메라 항체, 인간화 항체, 또는 인간 항체인 것을 특징으로 하는 스틸병 치료제.
- 제 8항에 있어서, IL-6 수용체에 대한 인간화 항체가 인간화 PM-1 항체인 것을 특징으로 하는 스틸병 치료제.
- 제 1항 내지 제 4항, 제 6항, 또는 제 7항 중 어느 하나의 항에 있어서, 스틸병이 성인 스틸병인 것을 특징으로 하는 스틸병 치료제.
- 제 1항 내지 제 4항, 제 6항, 또는 제 7항 중 어느 하나의 항에 있어서, 스틸병이 소아 스틸병인 것을 특징으로 하는 스틸병 치료제.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2001-00103627 | 2001-04-02 | ||
JP2001103627 | 2001-04-02 | ||
JP2001109131 | 2001-04-06 | ||
JPJP-P-2001-00109131 | 2001-04-06 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020037012661A Division KR100842133B1 (ko) | 2001-04-02 | 2002-04-02 | 소아 만성 관절염 관련질환 치료제 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20080027401A KR20080027401A (ko) | 2008-03-26 |
KR100842132B1 true KR100842132B1 (ko) | 2008-06-27 |
Family
ID=26612973
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020037012661A KR100842133B1 (ko) | 2001-04-02 | 2002-04-02 | 소아 만성 관절염 관련질환 치료제 |
KR1020087005693A KR100842132B1 (ko) | 2001-04-02 | 2002-04-02 | 소아 만성 관절염 관련질환 치료제 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020037012661A KR100842133B1 (ko) | 2001-04-02 | 2002-04-02 | 소아 만성 관절염 관련질환 치료제 |
Country Status (18)
Country | Link |
---|---|
US (5) | US20040115197A1 (ko) |
EP (4) | EP1972638A1 (ko) |
JP (5) | JP3702274B2 (ko) |
KR (2) | KR100842133B1 (ko) |
CN (1) | CN100562339C (ko) |
AU (1) | AU2002243032B2 (ko) |
BR (1) | BR0208636A (ko) |
CA (1) | CA2443294C (ko) |
HK (1) | HK1062408A1 (ko) |
HU (1) | HU230197B1 (ko) |
IL (3) | IL158079A0 (ko) |
MX (1) | MXPA03008955A (ko) |
NO (1) | NO20034388L (ko) |
NZ (1) | NZ528479A (ko) |
PL (1) | PL216534B1 (ko) |
RU (2) | RU2361613C2 (ko) |
UA (1) | UA80091C2 (ko) |
WO (1) | WO2002080969A1 (ko) |
Families Citing this family (84)
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