DE122009000023I2 - Antikörper gegen menschlichen Interleukin-6-Rezeptor - Google Patents
Antikörper gegen menschlichen Interleukin-6-RezeptorInfo
- Publication number
- DE122009000023I2 DE122009000023I2 DE122009000023C DE122009000023C DE122009000023I2 DE 122009000023 I2 DE122009000023 I2 DE 122009000023I2 DE 122009000023 C DE122009000023 C DE 122009000023C DE 122009000023 C DE122009000023 C DE 122009000023C DE 122009000023 I2 DE122009000023 I2 DE 122009000023I2
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- receptor
- human interleukin
- competitive
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18601689 | 1989-07-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE122009000023I1 DE122009000023I1 (de) | 2009-08-06 |
DE122009000023I2 true DE122009000023I2 (de) | 2010-12-16 |
Family
ID=16180912
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122009000023C Active DE122009000023I2 (de) | 1989-07-20 | 1990-07-19 | Antikörper gegen menschlichen Interleukin-6-Rezeptor |
DE69029015T Expired - Lifetime DE69029015T2 (de) | 1989-07-20 | 1990-07-19 | Antikörper gegen menschlichen Interleukin-6-Rezeptor |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69029015T Expired - Lifetime DE69029015T2 (de) | 1989-07-20 | 1990-07-19 | Antikörper gegen menschlichen Interleukin-6-Rezeptor |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0409607B1 (de) |
JP (1) | JP2998976B2 (de) |
KR (1) | KR100214759B1 (de) |
AT (1) | ATE144713T1 (de) |
CA (1) | CA2021594C (de) |
DE (2) | DE122009000023I2 (de) |
ES (1) | ES2093017T3 (de) |
HK (1) | HK49497A (de) |
NL (1) | NL300387I1 (de) |
SG (1) | SG42954A1 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05236966A (ja) * | 1991-04-25 | 1993-09-17 | Chugai Pharmaceut Co Ltd | ヒトインターロイキン−6レセプターに対するマウスモノクローナル抗体の可変領域をコードするdna |
WO1992019759A1 (en) * | 1991-04-25 | 1992-11-12 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
FR2694767B1 (fr) * | 1992-08-13 | 1994-10-21 | Innotherapie Lab Sa | Anticorps monoclonaux anti-IL6R, et leurs applications. |
WO1996011020A1 (fr) * | 1994-10-07 | 1996-04-18 | Chugai Seiyaku Kabushiki Kaisha | Medicament contre la polyarthrite rhumatoide contenant un antagoniste d'interleukine 6 comme principe actif |
WO1995009873A1 (en) * | 1993-10-06 | 1995-04-13 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
US6451523B1 (en) | 1994-09-14 | 2002-09-17 | Interneuron Pharmaceuticals, Inc. | Detection of a leptin receptor variant and methods for regulating obesity |
US5763211A (en) * | 1994-09-14 | 1998-06-09 | Progenitor, Inc. | Isolated nucleic acid encoding Hu-B1.219, a novel human hematopoietin |
US5912123A (en) * | 1994-09-14 | 1999-06-15 | Progenitor, Inc. | Detection of the leptin receptor in reproductive organs and methods for regulating reproductive biology |
US5856098A (en) * | 1994-09-14 | 1999-01-05 | Progenitor, Inc. | Detection of a leptin receptor variant |
US6355237B1 (en) | 1994-09-14 | 2002-03-12 | Progenitor, Inc. | Methods for using the obese gene and its gene product to stimulate hematopoietic development |
US5643748A (en) * | 1994-09-14 | 1997-07-01 | Progenitor, Inc. | HU-B1.219, a novel human hematopoietin receptor |
WO1996012503A1 (fr) * | 1994-10-21 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Remede contre des maladies provoquees par la production d'il-6 |
JP3458512B2 (ja) | 1995-02-23 | 2003-10-20 | 東ソー株式会社 | 骨密度の変動推定方法又は骨そしょう症の診断方法及びこれに用いる試薬キット |
AU1833197A (en) * | 1996-01-18 | 1997-08-11 | Progenitor, Inc. | Detection of a leptin receptor variant and methods for regulating obesity |
PT923941E (pt) | 1996-06-27 | 2006-09-29 | Chugai Pharmaceutical Co Ltd | Medicamentos para mieloma a serem utilizados com agentes antitumorais de mostarda nitrogenada |
PT1314437E (pt) | 2000-08-11 | 2014-08-29 | Chugai Pharmaceutical Co Ltd | Preparações estabilizadas contendo anticorpo |
KR100824824B1 (ko) * | 2000-10-25 | 2008-04-23 | 추가이 세이야쿠 가부시키가이샤 | 아이엘-6 안타고니스트를 유효 성분으로서 함유하는건선의 예방 또는 치료제 |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
BRPI0415505A (pt) | 2003-10-17 | 2006-12-12 | Chugai Pharmaceutical Co Ltd | agente terapêutico para mesotelioma |
JP5191235B2 (ja) | 2005-10-21 | 2013-05-08 | 中外製薬株式会社 | 心疾患治療剤 |
AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
AR057941A1 (es) | 2005-11-25 | 2007-12-26 | Univ Keio | Agentes terapeuticos para el cancer de prostata |
AR059213A1 (es) | 2006-01-27 | 2008-03-19 | Univ Keio | Agentes terapeuticos para enfermedades que involucran neovascularizacion coroidal |
CN101495146B (zh) | 2006-04-07 | 2012-10-17 | 国立大学法人大阪大学 | 肌肉再生促进剂 |
US8080248B2 (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody |
RS52643B (en) | 2006-06-02 | 2013-06-28 | Regeneron Pharmaceuticals Inc. | HIGH AFINITY ANTIBODIES TO THE HUMAN IL-6 RECEPTOR |
CN101528778A (zh) * | 2006-08-18 | 2009-09-09 | 埃博灵克斯股份有限公司 | 用于治疗与il-6-介导的信号传导相关的疾病和病症的针对il-6r的氨基酸序列以及包括其的多肽 |
WO2008020079A1 (en) * | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
JP2010512734A (ja) * | 2006-12-13 | 2010-04-30 | アブリンクス エン.ヴェー. | Il−6/il−6受容体複合体等受容体介在性シグナル伝達に関与する複合体に特異的なポリペプチド |
WO2009014263A1 (ja) | 2007-07-26 | 2009-01-29 | Osaka University | インターロイキン6受容体阻害剤を有効成分とする眼炎症疾患治療剤 |
CA2701155C (en) | 2007-10-02 | 2016-11-22 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agents for graft-versus-host disease comprising interleukin 6 receptor inhibitor as active ingredient |
EP2297202B1 (de) | 2008-05-13 | 2016-01-13 | NovImmune SA | Anti-il-6/il-6r-antikörper und verfahren zu ihrer verwendung |
CN102256623A (zh) | 2008-06-05 | 2011-11-23 | 独立行政法人国立癌症研究中心 | 神经浸润抑制剂 |
US10618964B2 (en) | 2009-04-10 | 2020-04-14 | Ablynx N.V. | Nanobody against IL-6R |
US8748581B2 (en) | 2009-04-10 | 2014-06-10 | Ablynx N.V. | Anti-IL-6R polypeptides and pharmaceutical compositions thereof |
NZ598127A (en) | 2009-07-31 | 2014-03-28 | Shin Maeda | Cancer metastasis inhibitor |
BR112012009828B8 (pt) | 2009-10-26 | 2022-10-25 | Hoffmann La Roche | Método para a produção de uma imunoglobulina glicosilada e seu uso |
JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
DK2578231T3 (da) | 2010-05-28 | 2022-12-12 | Chugai Pharmaceutical Co Ltd | Antitumor-t-celle-reaktionsforstærker |
EP2747782B1 (de) | 2011-09-23 | 2018-01-17 | Ablynx NV | Verlängerte inhibition der interleukin-6-vermittelten signalisierung |
TWI589299B (zh) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
WO2014200018A1 (ja) | 2013-06-11 | 2014-12-18 | 独立行政法人 国立精神・神経医療研究センター | 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法 |
JP6563910B2 (ja) | 2013-07-04 | 2019-08-21 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ |
DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
AU2015334984A1 (en) | 2014-10-21 | 2017-04-13 | Ablynx Nv | Treatment of IL-6R related diseases |
US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
EP3747469A4 (de) | 2018-01-31 | 2022-03-23 | Motokazu Kato | Therapeutikum für asthma mit il-6-inhibitor |
JP2022519828A (ja) | 2019-01-31 | 2022-03-25 | サノフィ・バイオテクノロジー | 若年性特発性関節炎を治療するための抗il-6受容体抗体 |
EP4263602A1 (de) | 2020-12-18 | 2023-10-25 | Ablynx N.V. | Polypeptide mit variablen immunglobulin-einzeldomänen zum targeting von il-6 und tnf-alpha |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2598666B2 (ja) * | 1987-10-19 | 1997-04-09 | 忠三 岸本 | 抗ヒトbcdfモノクローナル抗体 |
CA1341152C (en) * | 1988-01-22 | 2000-12-12 | Tadamitsu Kishimoto | Receptor protein for human b cell stimulatory factor-2 |
-
1990
- 1990-07-19 DE DE122009000023C patent/DE122009000023I2/de active Active
- 1990-07-19 CA CA002021594A patent/CA2021594C/en not_active Expired - Lifetime
- 1990-07-19 ES ES90307879T patent/ES2093017T3/es not_active Expired - Lifetime
- 1990-07-19 JP JP18942090A patent/JP2998976B2/ja not_active Expired - Lifetime
- 1990-07-19 EP EP90307879A patent/EP0409607B1/de not_active Expired - Lifetime
- 1990-07-19 DE DE69029015T patent/DE69029015T2/de not_active Expired - Lifetime
- 1990-07-19 AT AT90307879T patent/ATE144713T1/de active
- 1990-07-19 SG SG1996001432A patent/SG42954A1/en unknown
- 1990-07-20 KR KR1019900011023A patent/KR100214759B1/ko not_active IP Right Cessation
-
1997
- 1997-04-17 HK HK49497A patent/HK49497A/xx not_active IP Right Cessation
-
2009
- 2009-04-27 NL NL300387C patent/NL300387I1/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0409607B1 (de) | 1996-10-30 |
CA2021594A1 (en) | 1991-01-21 |
NL300387I1 (nl) | 2009-07-01 |
EP0409607A2 (de) | 1991-01-23 |
EP0409607A3 (en) | 1991-06-12 |
CA2021594C (en) | 2002-01-08 |
HK49497A (en) | 1997-04-25 |
SG42954A1 (en) | 1997-10-17 |
DE122009000023I1 (de) | 2009-08-06 |
JP2998976B2 (ja) | 2000-01-17 |
JPH03139293A (ja) | 1991-06-13 |
ES2093017T3 (es) | 1996-12-16 |
DE69029015T2 (de) | 1998-01-22 |
KR100214759B1 (ko) | 1999-08-02 |
ATE144713T1 (de) | 1996-11-15 |
DE69029015D1 (de) | 1996-12-05 |
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