KR100705519B1 - P38 map 키나제의 조절제로서의 치환된 피리디논 - Google Patents
P38 map 키나제의 조절제로서의 치환된 피리디논 Download PDFInfo
- Publication number
- KR100705519B1 KR100705519B1 KR1020047012622A KR20047012622A KR100705519B1 KR 100705519 B1 KR100705519 B1 KR 100705519B1 KR 1020047012622 A KR1020047012622 A KR 1020047012622A KR 20047012622 A KR20047012622 A KR 20047012622A KR 100705519 B1 KR100705519 B1 KR 100705519B1
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- oxy
- methyl
- difluorobenzyl
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc1cnc(*)nc1* Chemical compound Cc1cnc(*)nc1* 0.000 description 16
- NOEPXEBJSKGVOF-AATRIKPKSA-N CC(/C=C/C(C=C(C)N(Cc1cccnc1)C1=O)=C1Br)c(cc1)ccc1F Chemical compound CC(/C=C/C(C=C(C)N(Cc1cccnc1)C1=O)=C1Br)c(cc1)ccc1F NOEPXEBJSKGVOF-AATRIKPKSA-N 0.000 description 1
- NPUCBSZMHXZMJX-UHFFFAOYSA-N CC(C(C(N(C(C)=C1)c(c(Cl)ccc2)c2Cl)=O)=C1O)=O Chemical compound CC(C(C(N(C(C)=C1)c(c(Cl)ccc2)c2Cl)=O)=C1O)=O NPUCBSZMHXZMJX-UHFFFAOYSA-N 0.000 description 1
- GPKIOSQMGXUSBW-UHFFFAOYSA-N CC(C)(CC(NCc(cc1F)cc(F)c1N(C=CC(OCc(c(F)c1)ccc1F)=C1Cl)C1=O)=O)O Chemical compound CC(C)(CC(NCc(cc1F)cc(F)c1N(C=CC(OCc(c(F)c1)ccc1F)=C1Cl)C1=O)=O)O GPKIOSQMGXUSBW-UHFFFAOYSA-N 0.000 description 1
- FOAYXMZGFOZSFX-UHFFFAOYSA-N CC(C)(CNC(NCc1ccc(CN(C(C)=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)cc1)=O)O Chemical compound CC(C)(CNC(NCc1ccc(CN(C(C)=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)cc1)=O)O FOAYXMZGFOZSFX-UHFFFAOYSA-N 0.000 description 1
- LABNLGUMFPYBDL-UHFFFAOYSA-N CC(C)(CNC(c1cccc(CN(C(C)=CC(OCc(c(F)c2)ccc2F)=C2Cl)C2=O)c1)=O)O Chemical compound CC(C)(CNC(c1cccc(CN(C(C)=CC(OCc(c(F)c2)ccc2F)=C2Cl)C2=O)c1)=O)O LABNLGUMFPYBDL-UHFFFAOYSA-N 0.000 description 1
- QDESANPQNZNGCN-UHFFFAOYSA-N CC(C)(CNC(c1ncc(CN(C(C)=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)nc1)=O)O Chemical compound CC(C)(CNC(c1ncc(CN(C(C)=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)nc1)=O)O QDESANPQNZNGCN-UHFFFAOYSA-N 0.000 description 1
- KEXUEYNFGDBUMD-UHFFFAOYSA-N CC(C)(CNS(c1ccc(CN(C(C)=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)cc1)(=O)=O)O Chemical compound CC(C)(CNS(c1ccc(CN(C(C)=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)cc1)(=O)=O)O KEXUEYNFGDBUMD-UHFFFAOYSA-N 0.000 description 1
- AQNWZYKLBZEUQH-UHFFFAOYSA-N CC(N(Cc(cc1)cc(CC2)c1N2C(N(C)C)=O)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(N(Cc(cc1)cc(CC2)c1N2C(N(C)C)=O)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl AQNWZYKLBZEUQH-UHFFFAOYSA-N 0.000 description 1
- DLOVTNDVNZIJEP-UHFFFAOYSA-N CC(N(Cc(nc1)cnc1C(NCCO)=O)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br Chemical compound CC(N(Cc(nc1)cnc1C(NCCO)=O)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br DLOVTNDVNZIJEP-UHFFFAOYSA-N 0.000 description 1
- YBBFVAWQIFBBKY-UHFFFAOYSA-N CC(N(Cc1c(N)nc(C)nc1)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Cl Chemical compound CC(N(Cc1c(N)nc(C)nc1)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Cl YBBFVAWQIFBBKY-UHFFFAOYSA-N 0.000 description 1
- XFMDXAFBKLYOJD-UHFFFAOYSA-N CC(N(Cc1c(N)nc(C)nc1)C1=O)=CC(OCc(c(F)cc(F)c2)c2F)=C1Br Chemical compound CC(N(Cc1c(N)nc(C)nc1)C1=O)=CC(OCc(c(F)cc(F)c2)c2F)=C1Br XFMDXAFBKLYOJD-UHFFFAOYSA-N 0.000 description 1
- URJYEWISMPOIJU-UHFFFAOYSA-N CC(N(Cc1c(NC(CO)=O)nc(C)nc1)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(N(Cc1c(NC(CO)=O)nc(C)nc1)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl URJYEWISMPOIJU-UHFFFAOYSA-N 0.000 description 1
- QTNDSGYMKFLNBE-UHFFFAOYSA-N CC(N(Cc1cc(C#N)ccc1)C1=O)=CC(NCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(N(Cc1cc(C#N)ccc1)C1=O)=CC(NCc(ccc(F)c2)c2F)=C1Cl QTNDSGYMKFLNBE-UHFFFAOYSA-N 0.000 description 1
- YOJUVPNDCZWFID-UHFFFAOYSA-N CC(N(Cc1cc(N)ccc1)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br Chemical compound CC(N(Cc1cc(N)ccc1)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br YOJUVPNDCZWFID-UHFFFAOYSA-N 0.000 description 1
- ISMWDMYHRRSDOQ-UHFFFAOYSA-N CC(N(Cc1ccc(CN)cc1)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(N(Cc1ccc(CN)cc1)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl ISMWDMYHRRSDOQ-UHFFFAOYSA-N 0.000 description 1
- HIAKFPKSNDCJIG-UHFFFAOYSA-N CC(N(Cc1cccc(F)c1)C1=O)=CC(CCc2ccccc2)=C1Br Chemical compound CC(N(Cc1cccc(F)c1)C1=O)=CC(CCc2ccccc2)=C1Br HIAKFPKSNDCJIG-UHFFFAOYSA-N 0.000 description 1
- GBUQLUJFRRTCJR-UHFFFAOYSA-N CC(N(Cc1cccnc1)C1=O)=CC(O)=C1Cl Chemical compound CC(N(Cc1cccnc1)C1=O)=CC(O)=C1Cl GBUQLUJFRRTCJR-UHFFFAOYSA-N 0.000 description 1
- UQPCFSNIBYRSRB-UHFFFAOYSA-N CC(N(Cc1nc(O)ncc1)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(N(Cc1nc(O)ncc1)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br UQPCFSNIBYRSRB-UHFFFAOYSA-N 0.000 description 1
- QAHVHNJXNUXSMD-UHFFFAOYSA-N CC(N(Cc1nc(OC)ncc1)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(N(Cc1nc(OC)ncc1)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br QAHVHNJXNUXSMD-UHFFFAOYSA-N 0.000 description 1
- YMGLBCYIVNKZCZ-UHFFFAOYSA-N CC(N(Cc1ncc(C(N2CCOCC2)=O)nc1)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br Chemical compound CC(N(Cc1ncc(C(N2CCOCC2)=O)nc1)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br YMGLBCYIVNKZCZ-UHFFFAOYSA-N 0.000 description 1
- VAFPWSDXIBPWPS-UHFFFAOYSA-N CC(N(c(c(Cl)c1)ccc1C(OC)=O)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(N(c(c(Cl)c1)ccc1C(OC)=O)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br VAFPWSDXIBPWPS-UHFFFAOYSA-N 0.000 description 1
- NNLBOXYORLIKMU-UHFFFAOYSA-N CC(N(c(c(F)cc(F)c1)c1N(C)C)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(N(c(c(F)cc(F)c1)c1N(C)C)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br NNLBOXYORLIKMU-UHFFFAOYSA-N 0.000 description 1
- GQNDLBHAIXJGDR-UHFFFAOYSA-N CC(N(c(c(F)cc(N1CCN(C)CC1)c1)c1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(N(c(c(F)cc(N1CCN(C)CC1)c1)c1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl GQNDLBHAIXJGDR-UHFFFAOYSA-N 0.000 description 1
- LOAZSAQHNGGVGI-UHFFFAOYSA-N CC(N(c(c(F)cc(OCC(N)=O)c1)c1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(N(c(c(F)cc(OCC(N)=O)c1)c1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br LOAZSAQHNGGVGI-UHFFFAOYSA-N 0.000 description 1
- XCBLJZGLPCFIHU-UHFFFAOYSA-N CC(N(c(c(F)cc(OCCO)c1)c1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(N(c(c(F)cc(OCCO)c1)c1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br XCBLJZGLPCFIHU-UHFFFAOYSA-N 0.000 description 1
- YKLTZAXUEVSFGS-UHFFFAOYSA-N CC(N(c(c(F)ccc1)c1F)C1=O)=CC(OCc(cc2)c(CO)cc2F)=C1Br Chemical compound CC(N(c(c(F)ccc1)c1F)C1=O)=CC(OCc(cc2)c(CO)cc2F)=C1Br YKLTZAXUEVSFGS-UHFFFAOYSA-N 0.000 description 1
- BFQGTSKLUZCTMV-UHFFFAOYSA-N CC(N(c(c(N(C)CCO)cc(F)c1)c1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(N(c(c(N(C)CCO)cc(F)c1)c1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Br BFQGTSKLUZCTMV-UHFFFAOYSA-N 0.000 description 1
- WGLDCCKVFXUVGU-UHFFFAOYSA-N CC(N(c1cc(C(N)=O)ccc1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(N(c1cc(C(N)=O)ccc1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl WGLDCCKVFXUVGU-UHFFFAOYSA-N 0.000 description 1
- ZEBQLMNYFHEJDS-UHFFFAOYSA-N CC(N(c1cc(C(NC(CO)CO)=O)ccc1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(N(c1cc(C(NC(CO)CO)=O)ccc1F)C1=O)=CC(OCc(ccc(F)c2)c2F)=C1Cl ZEBQLMNYFHEJDS-UHFFFAOYSA-N 0.000 description 1
- RXGLLGXSOQVUKY-UHFFFAOYSA-N CC(N1Cc(cc2)ncc2C(OC)=O)=CC(OCc(c(F)c2)ccc2F)=CC1=O Chemical compound CC(N1Cc(cc2)ncc2C(OC)=O)=CC(OCc(c(F)c2)ccc2F)=CC1=O RXGLLGXSOQVUKY-UHFFFAOYSA-N 0.000 description 1
- QDAIABCHDQNBQS-UHFFFAOYSA-N CC(N1c(c(Cl)ccc2)c2Cl)=CC(O)=CC1=O Chemical compound CC(N1c(c(Cl)ccc2)c2Cl)=CC(O)=CC1=O QDAIABCHDQNBQS-UHFFFAOYSA-N 0.000 description 1
- LDXXNIVSGDRDBR-UHFFFAOYSA-N CC(N1c(cc(cc2)C(OC)=O)c2F)=CC(OCc(ccc(F)c2)c2F)=CC1=O Chemical compound CC(N1c(cc(cc2)C(OC)=O)c2F)=CC(OCc(ccc(F)c2)c2F)=CC1=O LDXXNIVSGDRDBR-UHFFFAOYSA-N 0.000 description 1
- FIHUBDCZJSWKIN-UHFFFAOYSA-N CC(N1c2c(C)c(C(O)=O)ccc2)=CC(OCc(ccc(F)c2)c2F)=CC1=O Chemical compound CC(N1c2c(C)c(C(O)=O)ccc2)=CC(OCc(ccc(F)c2)c2F)=CC1=O FIHUBDCZJSWKIN-UHFFFAOYSA-N 0.000 description 1
- FVNGECFANCUOBP-UHFFFAOYSA-N CC(N1c2cccc(CO)c2)=CC(OCc(ccc(F)c2)c2F)=CC1=O Chemical compound CC(N1c2cccc(CO)c2)=CC(OCc(ccc(F)c2)c2F)=CC1=O FVNGECFANCUOBP-UHFFFAOYSA-N 0.000 description 1
- UXQKGGZFJSERMQ-UHFFFAOYSA-N CC(OCC(N(c1c(C)ccc(C(OC)=O)c1)C1=O)=CC(O)=C1Br)=O Chemical compound CC(OCC(N(c1c(C)ccc(C(OC)=O)c1)C1=O)=CC(O)=C1Br)=O UXQKGGZFJSERMQ-UHFFFAOYSA-N 0.000 description 1
- NEJDZPQAXRTMKH-UHFFFAOYSA-N CC(OCC(Nc(cc1)cc(N(C(C)=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)c1F)=O)=O Chemical compound CC(OCC(Nc(cc1)cc(N(C(C)=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)c1F)=O)=O NEJDZPQAXRTMKH-UHFFFAOYSA-N 0.000 description 1
- NQPFMONIPUXOKU-UHFFFAOYSA-N CC1C=CC(CC#N)=CC1CN(C=CC(OCc(ccc(F)c1)c1F)=C1Br)C1=N Chemical compound CC1C=CC(CC#N)=CC1CN(C=CC(OCc(ccc(F)c1)c1F)=C1Br)C1=N NQPFMONIPUXOKU-UHFFFAOYSA-N 0.000 description 1
- QAVSJZMOKLNHPL-UHFFFAOYSA-N CCOC(c1cnc(CN(C(C)=CC(OCc(c(F)c2)ccc2F)=C2Cl)C2=O)cn1)=O Chemical compound CCOC(c1cnc(CN(C(C)=CC(OCc(c(F)c2)ccc2F)=C2Cl)C2=O)cn1)=O QAVSJZMOKLNHPL-UHFFFAOYSA-N 0.000 description 1
- NVZQSVNOSIYFHZ-UHFFFAOYSA-N COC(c(cc1)ccc1N(C=CC(OCc1ccccc1)=C1Br)C1=O)=O Chemical compound COC(c(cc1)ccc1N(C=CC(OCc1ccccc1)=C1Br)C1=O)=O NVZQSVNOSIYFHZ-UHFFFAOYSA-N 0.000 description 1
- ZCILFMOQBYTARB-UHFFFAOYSA-N COC(c1cccc(CN(C=CC(OCc2ccccc2)=C2Br)C2=O)c1)=O Chemical compound COC(c1cccc(CN(C=CC(OCc2ccccc2)=C2Br)C2=O)c1)=O ZCILFMOQBYTARB-UHFFFAOYSA-N 0.000 description 1
- WUGLLOYKIJQUIP-UHFFFAOYSA-N Cc(c(N(C(CO)=CC(OCc(ccc(F)c1)c1F)=C1Br)C1=O)c1)ccc1C(N)=O Chemical compound Cc(c(N(C(CO)=CC(OCc(ccc(F)c1)c1F)=C1Br)C1=O)c1)ccc1C(N)=O WUGLLOYKIJQUIP-UHFFFAOYSA-N 0.000 description 1
- RXOUUNWVHITAFT-UHFFFAOYSA-N Cc(ccc(C(O)=O)c1)c1N(C(C)=CC(OCc(cc1)c(CNC(NC2CC2)=O)cc1F)=C1)C1=O Chemical compound Cc(ccc(C(O)=O)c1)c1N(C(C)=CC(OCc(cc1)c(CNC(NC2CC2)=O)cc1F)=C1)C1=O RXOUUNWVHITAFT-UHFFFAOYSA-N 0.000 description 1
- PMDTZNQTKJBYLX-UHFFFAOYSA-N Cc(ccc(C(O)=O)c1)c1N(C(C)=CC(OCc(cc1)c(CNC(OC)=O)cc1F)=C1Br)C1=O Chemical compound Cc(ccc(C(O)=O)c1)c1N(C(C)=CC(OCc(cc1)c(CNC(OC)=O)cc1F)=C1Br)C1=O PMDTZNQTKJBYLX-UHFFFAOYSA-N 0.000 description 1
- YRNQKUDVZTWVLG-UHFFFAOYSA-N Cc1cccc(C)c1N(C(C)=CC(O)=C1Br)C1=O Chemical compound Cc1cccc(C)c1N(C(C)=CC(O)=C1Br)C1=O YRNQKUDVZTWVLG-UHFFFAOYSA-N 0.000 description 1
- AAPGLAOEPKHVDC-UHFFFAOYSA-N N#Cc(cc1)ccc1N(C=CC(OCc1ccccc1)=C1)C1=O Chemical compound N#Cc(cc1)ccc1N(C=CC(OCc1ccccc1)=C1)C1=O AAPGLAOEPKHVDC-UHFFFAOYSA-N 0.000 description 1
- OAKKPWHRCJZENL-UHFFFAOYSA-N NC(C=CN(Cc1cc(F)ccc1)C1=O)=C1Br Chemical compound NC(C=CN(Cc1cc(F)ccc1)C1=O)=C1Br OAKKPWHRCJZENL-UHFFFAOYSA-N 0.000 description 1
- GUXWLLGWCROLES-UHFFFAOYSA-N NC(C=CN1Cc2cccc(F)c2)=CC1=O Chemical compound NC(C=CN1Cc2cccc(F)c2)=CC1=O GUXWLLGWCROLES-UHFFFAOYSA-N 0.000 description 1
- BAYKQGHVLAQWKB-UHFFFAOYSA-N NCc1c(CN(C=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)cccc1 Chemical compound NCc1c(CN(C=CC(OCc(ccc(F)c2)c2F)=C2Br)C2=O)cccc1 BAYKQGHVLAQWKB-UHFFFAOYSA-N 0.000 description 1
- NAMAXYKTZDVQIQ-UHFFFAOYSA-N NCc1ccc(CN(C=CC(OCc2ccccc2)=C2Br)C2=O)cc1 Chemical compound NCc1ccc(CN(C=CC(OCc2ccccc2)=C2Br)C2=O)cc1 NAMAXYKTZDVQIQ-UHFFFAOYSA-N 0.000 description 1
- REROQYYZGYOCBU-UHFFFAOYSA-N Nc1cc(CO)ccc1F Chemical compound Nc1cc(CO)ccc1F REROQYYZGYOCBU-UHFFFAOYSA-N 0.000 description 1
- LWYGVHRXLKVPCE-UHFFFAOYSA-N O=C(c(cc1)ccc1N(C=CC(OCc1ccccc1)=C1Br)C1=O)N1CCNCC1 Chemical compound O=C(c(cc1)ccc1N(C=CC(OCc1ccccc1)=C1Br)C1=O)N1CCNCC1 LWYGVHRXLKVPCE-UHFFFAOYSA-N 0.000 description 1
- SLVBVJHGSQRBPU-UHFFFAOYSA-N O=C1N(CC2CNCCC2)C=CC(OCc2ccccc2)=C1Br Chemical compound O=C1N(CC2CNCCC2)C=CC(OCc2ccccc2)=C1Br SLVBVJHGSQRBPU-UHFFFAOYSA-N 0.000 description 1
- UMDIOJBZAHPYJK-UHFFFAOYSA-N O=C1N(CCc2c[s]cc2)C=CC(OCc2ccccc2)=C1Br Chemical compound O=C1N(CCc2c[s]cc2)C=CC(OCc2ccccc2)=C1Br UMDIOJBZAHPYJK-UHFFFAOYSA-N 0.000 description 1
- XANHTUXHYAKYBP-UHFFFAOYSA-N O=C1N(Cc2cc(F)ccc2)C=CC(NCc2cc(F)ccc2)=C1Br Chemical compound O=C1N(Cc2cc(F)ccc2)C=CC(NCc2cc(F)ccc2)=C1Br XANHTUXHYAKYBP-UHFFFAOYSA-N 0.000 description 1
- MIVUUTUPXVADIU-UHFFFAOYSA-N O=C1N(Cc2cc(F)ccc2)C=CC(NCc2ccccc2)=C1 Chemical compound O=C1N(Cc2cc(F)ccc2)C=CC(NCc2ccccc2)=C1 MIVUUTUPXVADIU-UHFFFAOYSA-N 0.000 description 1
- KWCYFVAUNPVYIU-UHFFFAOYSA-N O=C1N(Cc2cc(F)ccc2)C=CC(OCc(ccc(F)c2F)c2F)=C1Br Chemical compound O=C1N(Cc2cc(F)ccc2)C=CC(OCc(ccc(F)c2F)c2F)=C1Br KWCYFVAUNPVYIU-UHFFFAOYSA-N 0.000 description 1
- WJZJLEYMWNOJNQ-UHFFFAOYSA-N O=C1N(Cc2cccc(F)c2)C=CC(OCc2cc(F)ccc2)=C1Br Chemical compound O=C1N(Cc2cccc(F)c2)C=CC(OCc2cc(F)ccc2)=C1Br WJZJLEYMWNOJNQ-UHFFFAOYSA-N 0.000 description 1
- HEUVJEJFDFOAGJ-UHFFFAOYSA-N O=C1N(Cc2ccccc2)C=CC(OCc(cccc2)c2Cl)=C1 Chemical compound O=C1N(Cc2ccccc2)C=CC(OCc(cccc2)c2Cl)=C1 HEUVJEJFDFOAGJ-UHFFFAOYSA-N 0.000 description 1
- XMNRIBBTZMOLDH-UHFFFAOYSA-N O=C1NC=CC(OCc(c(F)c2)ccc2F)=C1 Chemical compound O=C1NC=CC(OCc(c(F)c2)ccc2F)=C1 XMNRIBBTZMOLDH-UHFFFAOYSA-N 0.000 description 1
- VDHZYXSYNYXMEP-UHFFFAOYSA-N O=C1NC=CC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound O=C1NC=CC(OCc(ccc(F)c2)c2F)=C1Br VDHZYXSYNYXMEP-UHFFFAOYSA-N 0.000 description 1
- FTJSPMAXTZOMIY-UHFFFAOYSA-N O=CC(N(c(c(F)ccc1)c1F)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br Chemical compound O=CC(N(c(c(F)ccc1)c1F)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br FTJSPMAXTZOMIY-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N OC(C(F)(F)F)=O Chemical compound OC(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- SXWDWSQMOZDMFF-UHFFFAOYSA-N OC(C(N(c(c(F)ccc1)c1F)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br)=O Chemical compound OC(C(N(c(c(F)ccc1)c1F)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Br)=O SXWDWSQMOZDMFF-UHFFFAOYSA-N 0.000 description 1
- WJDXDEDMFQVYID-UHFFFAOYSA-N OC(C=CN1Cc2cc(F)ccc2)=CC1=O Chemical compound OC(C=CN1Cc2cc(F)ccc2)=CC1=O WJDXDEDMFQVYID-UHFFFAOYSA-N 0.000 description 1
- FLFQSJTVQZCKBB-UHFFFAOYSA-N OCC(N(c(c(F)ccc1)c1F)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Cl Chemical compound OCC(N(c(c(F)ccc1)c1F)C1=O)=CC(OCc(c(F)c2)ccc2F)=C1Cl FLFQSJTVQZCKBB-UHFFFAOYSA-N 0.000 description 1
- HZWGPERGVBIRCQ-UHFFFAOYSA-N ONC(c(cc1)ccc1N(C=CC(OCc1ccccc1)=C1Br)C1=O)=O Chemical compound ONC(c(cc1)ccc1N(C=CC(OCc1ccccc1)=C1Br)C1=O)=O HZWGPERGVBIRCQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35702902P | 2002-02-14 | 2002-02-14 | |
| US60/357,029 | 2002-02-14 | ||
| US43691502P | 2002-12-30 | 2002-12-30 | |
| US60/436,915 | 2002-12-30 | ||
| PCT/US2003/004634 WO2003068230A1 (en) | 2002-02-14 | 2003-02-14 | Substituted pyridinones as modulators of p38 map kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077001895A Division KR100901931B1 (ko) | 2002-02-14 | 2003-02-14 | P38 map 키나제의 조절제로서의 치환된 피리디논 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20040084914A KR20040084914A (ko) | 2004-10-06 |
| KR100705519B1 true KR100705519B1 (ko) | 2007-04-10 |
Family
ID=27737560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047012622A Expired - Fee Related KR100705519B1 (ko) | 2002-02-14 | 2003-02-14 | P38 map 키나제의 조절제로서의 치환된 피리디논 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US7067540B2 (enExample) |
| EP (1) | EP1490064B1 (enExample) |
| JP (2) | JP4164031B2 (enExample) |
| KR (1) | KR100705519B1 (enExample) |
| CN (1) | CN100486576C (enExample) |
| AP (1) | AP1822A (enExample) |
| AT (1) | ATE448784T1 (enExample) |
| BR (1) | BR0307631A (enExample) |
| CA (1) | CA2476012C (enExample) |
| CO (1) | CO5640132A2 (enExample) |
| CY (1) | CY1109680T1 (enExample) |
| DE (1) | DE60330126D1 (enExample) |
| DK (1) | DK1490064T3 (enExample) |
| EA (1) | EA008008B1 (enExample) |
| EC (1) | ECSP045229A (enExample) |
| ES (1) | ES2334990T3 (enExample) |
| GE (1) | GEP20063937B (enExample) |
| HR (1) | HRP20040707B1 (enExample) |
| IL (1) | IL163162A (enExample) |
| IS (1) | IS2735B (enExample) |
| MA (1) | MA27268A1 (enExample) |
| MX (1) | MXPA04007470A (enExample) |
| NO (1) | NO327984B1 (enExample) |
| NZ (1) | NZ534395A (enExample) |
| OA (1) | OA12771A (enExample) |
| PL (1) | PL218749B1 (enExample) |
| PT (1) | PT1490064E (enExample) |
| RS (1) | RS52392B (enExample) |
| SI (1) | SI1490064T1 (enExample) |
| TN (1) | TNSN04156A1 (enExample) |
| WO (1) | WO2003068230A1 (enExample) |
| ZA (1) | ZA200406275B (enExample) |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60330126D1 (de) * | 2002-02-14 | 2009-12-31 | Pharmacia Corp | Substituierte pyridinone als modulatoren für p38 map kinase |
| US7456222B2 (en) * | 2002-05-17 | 2008-11-25 | Sequella, Inc. | Anti tubercular drug: compositions and methods |
| US20040033986A1 (en) * | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
| US7652039B2 (en) * | 2002-05-17 | 2010-01-26 | Sequella, Inc. | Methods of use and compositions for the diagnosis and treatment of infectious disease |
| EP1405849A1 (en) * | 2002-10-04 | 2004-04-07 | Corning Incorporated | Halogenated styrene compounds and low-absorption-loss polymers obtainable therefrom |
| NL1026826C2 (nl) * | 2003-08-13 | 2007-01-04 | Pharmacia Corp | Gesubstitueerde pyridinonen. |
| WO2005034857A2 (en) * | 2003-09-05 | 2005-04-21 | Sequella, Inc. | Methods and compositions comprising diamines as new anti-tubercular therapeutics |
| AU2003284808B2 (en) * | 2003-11-14 | 2009-01-22 | Catalyst Biosciences, Inc. | The derivatives of pyridone and the use of them |
| ATE495155T1 (de) * | 2003-11-19 | 2011-01-15 | Array Biopharma Inc | Heterocyclische inhibitoren von mek |
| MXPA06007326A (es) | 2003-12-23 | 2007-01-26 | Astex Therapeutics Ltd | Derivados de pirazol como moduladores de proteina cinasa. |
| AU2005219784B2 (en) * | 2004-03-05 | 2010-09-02 | Msd K.K. | Pyridone derivative |
| US20080081825A1 (en) * | 2004-04-28 | 2008-04-03 | Hisao Nakai | Nitrogen-Containing Heterocyclic Compounds and Medicinal Use Thereof |
| TWI355380B (en) * | 2004-05-27 | 2012-01-01 | Nihon Nohyaku Co Ltd | Substituted pyrazinecarboxanilide derivatives or s |
| JP4853759B2 (ja) * | 2004-05-27 | 2012-01-11 | 日本農薬株式会社 | 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法 |
| HRP20080608T3 (hr) | 2004-08-12 | 2008-12-31 | Pfizer Inc. | Triazolopiridinilsulfanilni derivati kao inhibitori p38 map kinaze |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| CA2580497A1 (en) * | 2004-10-13 | 2006-04-20 | Pharmacia & Upjohn Company Llc | Substituted n-alkylpyrimidinones |
| EP1810972B1 (en) | 2004-11-10 | 2012-01-25 | Ono Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic compound and pharmaceutical use thereof |
| US20070293544A1 (en) * | 2004-11-24 | 2007-12-20 | Ulrich Abel | Novel 4-Arylamino Pyridone Derivatives as Mek Inhibitors for the Treatment of Hyper-Proliferative Disorders |
| EA012266B1 (ru) | 2004-12-21 | 2009-08-28 | Лаборатуар Сероно С.А. | Сульфониламиноциклические соединения и их применение |
| JP4950070B2 (ja) | 2005-01-31 | 2012-06-13 | メルク セローノ ソシエテ アノニム | N−ヒドロキシアミド誘導体及びその使用 |
| PH12012502411A1 (en) * | 2005-05-10 | 2019-07-17 | Intermune Inc | Method of modulating stress-activated protein kinase system |
| US8343953B2 (en) | 2005-06-22 | 2013-01-01 | Astex Therapeutics Limited | Pharmaceutical compounds |
| JP5345842B2 (ja) | 2005-06-23 | 2013-11-20 | アステックス・セラピューティクス・リミテッド | プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ |
| TW200740755A (en) * | 2005-07-13 | 2007-11-01 | Bayer Cropscience Sa | Dihalogenation of N,O-disubstituted hydroxypyridones and their uses |
| US20100216758A1 (en) | 2005-08-10 | 2010-08-26 | Makoto Ando | Pyridone Compounds |
| CA2619770A1 (en) | 2005-08-24 | 2007-03-01 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
| CA2620631A1 (en) * | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases |
| ATE548363T1 (de) | 2005-08-29 | 2012-03-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen |
| AU2006284900A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases |
| EA013816B1 (ru) | 2005-09-01 | 2010-08-30 | Арес Трейдинг С.А. | Лечение неврита зрительного нерва |
| CA2621470A1 (en) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | Bicyclic aromatic substituted pyridone derivative |
| US7973060B2 (en) * | 2005-10-13 | 2011-07-05 | Crystalgenomics, Inc. | Fab I inhibitor and process for preparing same |
| AR059898A1 (es) * | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| US7618966B2 (en) | 2006-04-24 | 2009-11-17 | Allergan, Inc. | Abnormal Cannabidiols as agents for lowering intraocular pressure |
| BRPI0710732A2 (pt) | 2006-04-24 | 2011-11-08 | Allergan Inc | canabidióis anormais como agentes para redução da pressão intraocular |
| US7718830B2 (en) | 2006-04-24 | 2010-05-18 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
| UY30378A1 (es) * | 2006-06-02 | 2008-01-02 | Janssen Pharmaceutica Nv | Nuevos derivados de piridinona n-aril y n-heteroaril sustituidos para usar en enfermedades mediadas por mch-1 |
| BRPI0712902A2 (pt) * | 2006-06-05 | 2018-10-30 | Novartis Ag | compostos orgânicos |
| CA2656535C (en) * | 2006-07-14 | 2011-08-23 | Amgen Inc. | Alkyne-substituted pyridone compounds and methods of use |
| NZ575520A (en) | 2006-08-25 | 2012-03-30 | Boehringer Ingelheim Int | New pyridone derivatives with mch antagonistic activity and medicaments comprising these compounds |
| WO2008041090A1 (en) * | 2006-10-06 | 2008-04-10 | Pfizer Limited | Malanin concentrating hormone receptor-1 antagonist pyridinones |
| TW200831485A (en) | 2006-12-11 | 2008-08-01 | Boehringer Ingelheim Int | New pyridazine derivatives with MCH antagonistic activity and medicaments comprising these compounds |
| MX2009006266A (es) | 2006-12-13 | 2009-06-22 | Pfizer Prod Inc | Procedimientos de preparacion de 3-(4-(2,4-difluorobenciloxi)-3-br omo-6-metil-2-oxopiridin-1 (2h)-il)-n,4-dimetilbenzamida. |
| US20100210649A1 (en) * | 2006-12-21 | 2010-08-19 | Sloan-Kettering Institute For Cancer Research | Pyridazinones and furan-containing compounds |
| US8101632B2 (en) | 2007-01-10 | 2012-01-24 | Albany Molecular Research, Inc. | 5-furopyridinone substituted indazoles |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| GB0704932D0 (en) | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| WO2008157786A1 (en) | 2007-06-20 | 2008-12-24 | Auspex Pharmaceutical, Inc. | Substituted n-aryl pyridinones as fibrotic inhibitors |
| JP5301539B2 (ja) * | 2007-07-17 | 2013-09-25 | ブリストル−マイヤーズ スクイブ カンパニー | Gpr119gタンパク質共役受容体の調節方法および選択された化合物 |
| MX2010002536A (es) | 2007-09-14 | 2010-08-10 | Ortho Mcneil Janssen Pharm | 4-fenil-3,4,5,6-tetrahidro-2h, 1'h-[1,4]bipiridinil-2'-onas 1',3'-disubstituidas. |
| KR20100065191A (ko) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 1,3-이치환된 4-(아릴-x-페닐)-1h-피리딘-2-온 |
| EP2205565B1 (en) | 2007-09-14 | 2013-04-17 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones |
| AU2008319397B2 (en) * | 2007-11-01 | 2013-01-31 | Acucela, Inc. | Amine derivative compounds for treating ophthalmic diseases and disorders |
| EP2220083B1 (en) | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MX2010005483A (es) * | 2007-11-20 | 2010-06-11 | Merck Sharp & Dohme | Inhibidores de transcriptasa inversa no nucleosidos. |
| WO2009136965A1 (en) * | 2008-05-06 | 2009-11-12 | Sequella, Inc. | Compositions and methods comprising capuramycin analogues |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| MX2011002042A (es) | 2008-09-02 | 2011-06-20 | Ortho Mcneil Janssen Pharm | Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico. |
| EA201100311A1 (ru) | 2008-09-11 | 2011-10-31 | Пфайзер Инк. | Амидные производные гетероарилов и их применение в качестве активаторов глюкокиназы |
| AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
| JP2012515760A (ja) | 2009-01-20 | 2012-07-12 | ファイザー・インク | 置換ピラジノンアミド |
| EP2604604A1 (en) | 2009-03-11 | 2013-06-19 | Pfizer Inc | Benzofuranyl derivatives used as glucokinase inhibitors |
| EA020672B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалс, Инк. | Производные 1,2,4-триазоло[4,3-a]пиридина и их применение для лечения или предупреждения неврологических и психиатрических расстройств |
| SG176018A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102149682B (zh) | 2009-05-25 | 2012-12-05 | 中南大学 | 1-(取代芳基)-5-三氟甲基-2-(1h)吡啶酮化合物及其盐的制备方法及其用途 |
| DK2474533T3 (en) | 2009-05-25 | 2015-05-18 | Univ Central South | Preparation of 1- (substituted benzyl) -5-TRIFLUOROMETYL-2- (1H) pyridone compounds and their salts and their use |
| US20110021570A1 (en) | 2009-07-23 | 2011-01-27 | Nancy-Ellen Haynes | Pyridone glucokinase activators |
| CN101973936B (zh) * | 2010-09-28 | 2012-02-08 | 太原理工大学 | 一种吡啶酮衍生物的制备方法 |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| WO2012078674A1 (en) | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted indole/indazole-pyrimidinyl compounds |
| EP3469907B1 (en) * | 2010-12-06 | 2021-03-03 | Aclaris Therapeutics, Inc. | Substituted pyridinone-pyridinyl compounds |
| US8563558B2 (en) | 2010-12-06 | 2013-10-22 | Confluence Life Sciences, Inc. | Substituted pyridine urea compounds |
| EP2683689B1 (en) * | 2011-03-07 | 2017-04-12 | Pfizer Inc | Fluoro-pyridinone derivatives useful as antibacterial agents |
| US9018232B2 (en) | 2011-03-08 | 2015-04-28 | Auspex Pharmaceuticals, Inc. | Substituted N-aryl pyridinones |
| US9650395B2 (en) * | 2011-08-29 | 2017-05-16 | Ptc Therapeutics, Inc. | Antibacterial compounds and methods for use |
| CA2846663A1 (en) * | 2011-08-29 | 2013-03-07 | Ptc Therapeutics, Inc. | Antibacterial compounds and methods for use |
| WO2013057101A1 (de) | 2011-10-17 | 2013-04-25 | Bayer Intellectual Property Gmbh | Substituierte oxadiazolylpyridinone und - pyridazinone als hif - hemmer |
| MX2014006130A (es) | 2011-11-22 | 2015-04-13 | Intermune Inc | Metodos de diagnostico y tratamiento de la fibrosis pulmonar idiopatica. |
| WO2013086208A1 (en) * | 2011-12-06 | 2013-06-13 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
| IN2014CN04676A (enExample) | 2011-12-21 | 2015-09-18 | Ono Pharmaceutical Co | |
| EP2802571A1 (en) * | 2012-01-12 | 2014-11-19 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as mch receptor antagonists |
| PT2820009T (pt) * | 2012-03-01 | 2018-04-12 | Array Biopharma Inc | Inibidores de serina/treonina quinases |
| CN103288719A (zh) * | 2012-03-05 | 2013-09-11 | 苏州欧凯医药技术有限公司 | 非核甘艾滋病毒抑制物-吡啶酮类先导体的合成 |
| JP5924984B2 (ja) * | 2012-03-06 | 2016-05-25 | 国立大学法人東京農工大学 | トリフルオロメチルピリジノン化合物およびその製造方法 |
| KR102057877B1 (ko) | 2012-07-18 | 2019-12-20 | 노스 앤드 사우스 브라더 파마시 인베스트먼트 컴파니 리미티드 | 질소함유 헤테로고리 유도체 및 그의 약물에서의 용도 |
| WO2014031928A2 (en) * | 2012-08-24 | 2014-02-27 | Philip Jones | Heterocyclic modulators of hif activity for treatment of disease |
| WO2014031936A2 (en) | 2012-08-24 | 2014-02-27 | Philip Jones | Heterocyclic modulators of hif activity for treatment of disease |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| PL2931716T3 (pl) | 2012-12-13 | 2017-04-28 | Novartis Ag | Pochodne pirydonu i ich zastosowanie w leczeniu gruźlicy |
| RS56015B1 (sr) * | 2013-01-31 | 2017-09-29 | Vertex Pharma | Piridon amidi kao modulatori natrijumovih kanala |
| WO2014181213A1 (en) | 2013-05-10 | 2014-11-13 | Pfizer Inc. | Crystalline form of (sa)-(-)-3-(3-bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1 (2h)-yl)-n,4-dimethylbenzamide |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| US9115089B2 (en) | 2013-06-07 | 2015-08-25 | Confluence Life Sciences, Inc. | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| CN105358544A (zh) | 2013-07-09 | 2016-02-24 | 武田药品工业株式会社 | 杂环化合物 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| SI3080134T1 (sl) | 2013-12-13 | 2018-11-30 | Vertex Pharmaceuticals Incorporated | Predzdravila piridon amidov uporabna kot modulatorji natrijevih kanalov |
| UA121965C2 (uk) | 2014-01-21 | 2020-08-25 | Янссен Фармацевтика Нв | Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування |
| KR102502485B1 (ko) | 2014-01-21 | 2023-02-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| US9663504B2 (en) | 2014-02-25 | 2017-05-30 | Board Of Regents, The University Of Texas System | Salts of heterocyclic modulators of HIF activity for treatment of disease |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| CA2955559A1 (en) * | 2014-07-30 | 2016-02-04 | ABAC Therapeutics, S.L. | Arylhydrazides containing a 2-pyridone moiety as selective antibacterial agents |
| DK3231803T3 (da) | 2014-12-10 | 2020-08-24 | Ono Pharmaceutical Co | Dihydroindolizinonderivat |
| PE20180506A1 (es) * | 2015-06-03 | 2018-03-09 | Bristol Myers Squibb Co | Agonistas de receptor de apelina (apj) de 4-hidroxi-3-(heteroaril) piridin-2-ona como para uso en el tratamiento de trastornos cardiovasculares |
| CN105153027A (zh) * | 2015-07-21 | 2015-12-16 | 东华大学 | 一种3-氰基-4-羟基-2-吡啶酮类化合物及其制备和应用 |
| CN106466318B (zh) * | 2015-08-21 | 2019-01-01 | 中南大学 | 1-杂环取代苄基吡啶酮类化合物在制备治疗糖尿病肾病药物中的应用 |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| US11358977B2 (en) | 2017-05-16 | 2022-06-14 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
| KR102236356B1 (ko) | 2017-11-24 | 2021-04-05 | 주식회사 종근당 | 루푸스의 예방 또는 치료를 위한 조성물 |
| US11529337B2 (en) | 2018-02-12 | 2022-12-20 | Vertex Pharmaceuticals Incorporated | Method of treating pain |
| KR20190099952A (ko) * | 2018-02-20 | 2019-08-28 | 주식회사 종근당 | 포도막염의 예방 또는 치료를 위한 조성물 |
| JP7646643B2 (ja) * | 2019-10-04 | 2025-03-17 | アンスティトゥート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシャルシュ・メディカル・(インセルム) | 新規なピリジン-2(1h)オン誘導体、その調製、及び疼痛を処置するためのその使用 |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| GB201918413D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
| CN115666566A (zh) | 2020-03-27 | 2023-01-31 | 阿克拉瑞斯治疗股份有限公司 | 用于免疫病况的治疗的mk2途径抑制剂的口服组合物 |
| CN112552232B (zh) * | 2020-12-16 | 2022-11-25 | 浙江工业大学 | 一种吡啶酮六位炔胺修饰衍生物及其制备方法与应用 |
| CA3206499A1 (en) | 2021-02-02 | 2022-08-11 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
| AU2022252242A1 (en) * | 2021-03-31 | 2023-10-05 | Xinthera, Inc. | Mk2 inhibitors and uses thereof |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| AU2022307534B2 (en) * | 2021-07-09 | 2025-12-04 | Xinthera, Inc. | Pyridinone mk2 inhibitors and uses thereof |
| WO2023134765A1 (zh) * | 2022-01-14 | 2023-07-20 | 上海翰森生物医药科技有限公司 | 含五元环类衍生物、其制备方法和应用 |
| CN119546296A (zh) * | 2022-07-28 | 2025-02-28 | 深圳信立泰药业股份有限公司 | 一种式(i)所示的三联吡啶二酮化合物晶型及其制备方法与应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986001815A1 (en) * | 1984-09-22 | 1986-03-27 | Sandoz Ag | Improvements in or relating to organic compounds |
| WO1997010712A1 (en) * | 1995-09-19 | 1997-03-27 | Margolin Solomon B | Inhibition of tumor necrosis factor alpha |
| WO2000067746A1 (en) * | 1999-05-07 | 2000-11-16 | Texas Biotechnology Corporation | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE267045C (enExample) | ||||
| NL6816241A (enExample) * | 1967-12-01 | 1969-06-03 | ||
| BE758759A (fr) * | 1969-11-12 | 1971-05-10 | Merck & Co Inc | Pyridones anti-inflammatoires |
| US3644626A (en) * | 1969-11-25 | 1972-02-22 | Merck & Co Inc | Novel pyridones in compositions and methods for treating inflammation pain and fever |
| NL7016899A (enExample) | 1969-12-03 | 1971-06-07 | ||
| JPH01305081A (ja) | 1988-04-04 | 1989-12-08 | E R Squibb & Sons Inc | 3―アシルアミノ―1―[[[(置換スルホニル)アミノ〕カルボニル〕アミノ〕―2―アゼチジノン類 |
| US5032602A (en) * | 1988-12-14 | 1991-07-16 | Bayer Aktiengesellschaft | Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and pyrid-2-thiones |
| US5164506A (en) * | 1988-12-14 | 1992-11-17 | Bayer Aktiengesellschaft | Substituted 2-pyridones and pyrid-2-thiones compounds |
| US5308854A (en) * | 1990-06-18 | 1994-05-03 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
| IL100917A0 (en) | 1991-02-16 | 1992-11-15 | Fisons Plc | Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them |
| DE4221583A1 (de) * | 1991-11-12 | 1993-05-13 | Bayer Ag | Substituierte biphenylpyridone |
| DE4141788A1 (de) * | 1991-12-18 | 1993-06-24 | Merck Patent Gmbh | Imidazopyridine |
| AU668694B2 (en) | 1991-12-19 | 1996-05-16 | Sanofi-Synthelabo | Saccharin derivative proteolytic enzyme inhibitors |
| US5378720A (en) * | 1991-12-19 | 1995-01-03 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
| DE4206045A1 (de) * | 1992-02-27 | 1993-09-02 | Bayer Ag | Sulfonylbenzyl substituierte pyridone |
| NZ262942A (en) | 1993-03-29 | 1997-07-27 | Zeneca Ltd | Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions |
| DE4314964A1 (de) * | 1993-05-06 | 1994-11-10 | Bayer Ag | Pyridinylmethyl-substiutierte Pyridine und Pyridone |
| DE4316077A1 (de) * | 1993-05-13 | 1994-11-17 | Bayer Ag | Substituierte Mono- und Bihydridylmethylpyridone |
| US5744605A (en) * | 1993-06-30 | 1998-04-28 | University Of Pittsburgh | Intermediates in the synthesis of (+) camptothecin and related compounds and synthesis thereof |
| DE4341453A1 (de) * | 1993-12-06 | 1995-06-08 | Merck Patent Gmbh | Imidazopyridine |
| US5789426A (en) | 1995-01-20 | 1998-08-04 | Cornell Research Foundation, Inc. | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation |
| TW324008B (en) | 1995-03-13 | 1998-01-01 | Ishihara Sangyo Kaisha | Pyridone sulfonylurea compound, its production process and weed killer containing such compound |
| US5849587A (en) | 1995-06-09 | 1998-12-15 | Cornell Research Foundation, Inc. | Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells |
| JP2000512616A (ja) | 1996-02-22 | 2000-09-26 | メルク エンド カンパニー インコーポレーテッド | ピリジノントロンビンインヒビター |
| DE19619950A1 (de) * | 1996-04-17 | 1997-10-23 | Bayer Ag | Heterocyclisch-substituierte Phenylglycinolamide |
| EE9800353A (et) | 1996-04-23 | 1999-04-15 | Merck & Co., Inc. | Pürasinoonidest trombiini inhibiitorid |
| JPH09315008A (ja) | 1996-05-31 | 1997-12-09 | Fuji Photo Film Co Ltd | 感熱記録材料 |
| AU4808997A (en) * | 1996-09-30 | 1998-04-24 | Brigham And Women's Hospital | Methods and compounds for treatment of abnormal uterine bleeding |
| JP2001508796A (ja) | 1997-01-22 | 2001-07-03 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害薬 |
| AU718048B2 (en) | 1997-03-21 | 2000-04-06 | Novartis Ag | Pyrazole derivatives as herbicides |
| US6514977B1 (en) * | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| AU738222B2 (en) | 1998-04-08 | 2001-09-13 | Novartis Ag | N-pyridonyl herbicides |
| DE19826671A1 (de) * | 1998-06-16 | 1999-12-23 | Hoechst Schering Agrevo Gmbh | 1,3-Oxazolin- und 1,3-Thiazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| US6344323B1 (en) | 1998-09-16 | 2002-02-05 | Vitagenix, Inc. | Compositions and methods for inhibiting cox-2 expression and treating cox-2 associated disorders by using cox-2 antisense oligonucleotides |
| DK1124804T3 (da) | 1998-10-27 | 2005-12-12 | Abbott Lab | Inhibitorer for biosyntesen af prostaglandin-endoperoxid-H-syntase |
| JP2000128878A (ja) | 1998-10-28 | 2000-05-09 | Teijin Ltd | ベンゾフリル−α−ピリドン誘導体 |
| CA2320730A1 (en) | 1998-12-23 | 2000-07-06 | Renhua Li | Thrombin or factor xa inhibitors |
| EP1363910B1 (en) | 2000-11-17 | 2006-03-01 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| DE60330126D1 (de) * | 2002-02-14 | 2009-12-31 | Pharmacia Corp | Substituierte pyridinone als modulatoren für p38 map kinase |
| ES2291630T3 (es) | 2002-04-19 | 2008-03-01 | Smithkline Beecham Corporation | Nuevos compuestos. |
| NL1026826C2 (nl) * | 2003-08-13 | 2007-01-04 | Pharmacia Corp | Gesubstitueerde pyridinonen. |
| WO2007091176A1 (en) * | 2006-02-10 | 2007-08-16 | Pfizer Products Inc. | Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives |
-
2003
- 2003-02-14 DE DE60330126T patent/DE60330126D1/de not_active Expired - Lifetime
- 2003-02-14 PL PL371943A patent/PL218749B1/pl unknown
- 2003-02-14 DK DK03713478T patent/DK1490064T3/da active
- 2003-02-14 MX MXPA04007470A patent/MXPA04007470A/es active IP Right Grant
- 2003-02-14 GE GEAP8358A patent/GEP20063937B/en unknown
- 2003-02-14 RS YU74904A patent/RS52392B/sr unknown
- 2003-02-14 EA EA200400953A patent/EA008008B1/ru not_active IP Right Cessation
- 2003-02-14 AP APAP/P/2004/003105A patent/AP1822A/en active
- 2003-02-14 CA CA2476012A patent/CA2476012C/en not_active Expired - Fee Related
- 2003-02-14 AT AT03713478T patent/ATE448784T1/de active
- 2003-02-14 OA OA1200400210A patent/OA12771A/en unknown
- 2003-02-14 HR HRP20040707AA patent/HRP20040707B1/hr not_active IP Right Cessation
- 2003-02-14 SI SI200331709T patent/SI1490064T1/sl unknown
- 2003-02-14 CN CNB038080427A patent/CN100486576C/zh not_active Expired - Fee Related
- 2003-02-14 ES ES03713478T patent/ES2334990T3/es not_active Expired - Lifetime
- 2003-02-14 KR KR1020047012622A patent/KR100705519B1/ko not_active Expired - Fee Related
- 2003-02-14 JP JP2003567412A patent/JP4164031B2/ja not_active Expired - Fee Related
- 2003-02-14 PT PT03713478T patent/PT1490064E/pt unknown
- 2003-02-14 EP EP03713478A patent/EP1490064B1/en not_active Expired - Lifetime
- 2003-02-14 US US10/367,987 patent/US7067540B2/en not_active Expired - Lifetime
- 2003-02-14 WO PCT/US2003/004634 patent/WO2003068230A1/en not_active Ceased
- 2003-02-14 NZ NZ534395A patent/NZ534395A/en not_active IP Right Cessation
- 2003-02-14 BR BR0307631-8A patent/BR0307631A/pt not_active IP Right Cessation
-
2004
- 2004-07-22 IL IL163162A patent/IL163162A/en not_active IP Right Cessation
- 2004-07-26 IS IS7374A patent/IS2735B/is unknown
- 2004-08-05 ZA ZA2004/06275A patent/ZA200406275B/en unknown
- 2004-08-06 CO CO04076760A patent/CO5640132A2/es active IP Right Grant
- 2004-08-09 MA MA27818A patent/MA27268A1/fr unknown
- 2004-08-12 TN TNP2004000156A patent/TNSN04156A1/fr unknown
- 2004-08-12 EC EC2004005229A patent/ECSP045229A/es unknown
- 2004-09-13 NO NO20043820A patent/NO327984B1/no not_active IP Right Cessation
-
2005
- 2005-09-14 US US11/226,556 patent/US7629363B2/en not_active Expired - Fee Related
-
2006
- 2006-09-13 US US11/531,492 patent/US20070088033A1/en not_active Abandoned
- 2006-09-28 JP JP2006263778A patent/JP5325380B2/ja not_active Expired - Fee Related
-
2009
- 2009-12-30 CY CY20091101348T patent/CY1109680T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986001815A1 (en) * | 1984-09-22 | 1986-03-27 | Sandoz Ag | Improvements in or relating to organic compounds |
| WO1997010712A1 (en) * | 1995-09-19 | 1997-03-27 | Margolin Solomon B | Inhibition of tumor necrosis factor alpha |
| WO2000067746A1 (en) * | 1999-05-07 | 2000-11-16 | Texas Biotechnology Corporation | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100705519B1 (ko) | P38 map 키나제의 조절제로서의 치환된 피리디논 | |
| US20050176775A1 (en) | Substituted pyridinones | |
| JP6759100B2 (ja) | 治療用阻害化合物 | |
| JP5335932B2 (ja) | 制癌剤である二置換ピリジン誘導体 | |
| AU2001289873A1 (en) | Pyridine derivatives with IKB-kinase (IKK-Beta) inhibiting activity | |
| AU2004226165A1 (en) | Pyrimidin-4-one derivatives and their use as p38 kinase modulators | |
| KR20240069725A (ko) | 피리딘 유도체 및 이의 용도 | |
| WO2015163472A1 (ja) | トリアゾリルで置換されたヘテロアリール化合物 | |
| JP2013047223A (ja) | 医薬 | |
| KR100901931B1 (ko) | P38 map 키나제의 조절제로서의 치환된 피리디논 | |
| AU2003217433B2 (en) | Substituted pyridinones as modulators of p38 MAP Kinase | |
| AU2007202607B2 (en) | Substituted Pyridinones as Modulators of p38 MAP Kinase | |
| JP2009539998A (ja) | プロテインキナーゼ阻害剤としての置換3−シアノピリジン | |
| HK1074992B (en) | Substituted pyridinones as modulators of p38 map kinase | |
| HK1135382B (en) | Substituted pyridinones as modulators of p38 map kinase | |
| EP4612134A1 (en) | Diaryl diazole and diaryl triazole derivatives for use in treating a disease associated with kcnk13 activity | |
| CN120398872A (zh) | 用于预防或治疗癌症的新型杂环化合物和包括与DNA聚合酶θ抑制剂相同的杂环化合物的药物组合物 | |
| CN101531631A (zh) | 作为p38map激酶调节剂的取代吡啶酮类 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| AMND | Amendment | ||
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| AMND | Amendment | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
St.27 status event code: N-2-6-B10-B15-exm-PE0601 |
|
| J201 | Request for trial against refusal decision | ||
| PJ0201 | Trial against decision of rejection |
St.27 status event code: A-3-3-V10-V11-apl-PJ0201 |
|
| A107 | Divisional application of patent | ||
| AMND | Amendment | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0104 | Divisional application for international application |
St.27 status event code: A-0-1-A10-A18-div-PA0104 St.27 status event code: A-0-1-A10-A16-div-PA0104 |
|
| PB0901 | Examination by re-examination before a trial |
St.27 status event code: A-6-3-E10-E12-rex-PB0901 |
|
| B701 | Decision to grant | ||
| PB0701 | Decision of registration after re-examination before a trial |
St.27 status event code: A-3-4-F10-F13-rex-PB0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| FPAY | Annual fee payment |
Payment date: 20120329 Year of fee payment: 6 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 6 |
|
| FPAY | Annual fee payment |
Payment date: 20130329 Year of fee payment: 7 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 7 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 8 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 9 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20160404 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20160404 |