KR100656004B1 - 암의 치료를 위한 조합 요법 - Google Patents

암의 치료를 위한 조합 요법 Download PDF

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Publication number
KR100656004B1
KR100656004B1 KR1020047002183A KR20047002183A KR100656004B1 KR 100656004 B1 KR100656004 B1 KR 100656004B1 KR 1020047002183 A KR1020047002183 A KR 1020047002183A KR 20047002183 A KR20047002183 A KR 20047002183A KR 100656004 B1 KR100656004 B1 KR 100656004B1
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KR
South Korea
Prior art keywords
pyrrole
carboxylic acid
amide
oxo
dimethyl
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Expired - Fee Related
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KR1020047002183A
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English (en)
Korean (ko)
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KR20040043193A (ko
Inventor
제이미 마스퍼러
파룰 도시
줄리 셰링톤
Original Assignee
수젠, 인크.
파마시아 코포레이션
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Publication of KR20040043193A publication Critical patent/KR20040043193A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020047002183A 2001-08-15 2002-08-15 암의 치료를 위한 조합 요법 Expired - Fee Related KR100656004B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31241301P 2001-08-15 2001-08-15
US60/312,413 2001-08-15
PCT/US2002/025797 WO2003015608A2 (en) 2001-08-15 2002-08-15 Combination therapy for the treatment of cancer

Publications (2)

Publication Number Publication Date
KR20040043193A KR20040043193A (ko) 2004-05-22
KR100656004B1 true KR100656004B1 (ko) 2007-02-28

Family

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Application Number Title Priority Date Filing Date
KR1020047002183A Expired - Fee Related KR100656004B1 (ko) 2001-08-15 2002-08-15 암의 치료를 위한 조합 요법

Country Status (36)

Country Link
US (1) US7320996B2 (enExample)
EP (1) EP1427326B1 (enExample)
JP (1) JP2005501843A (enExample)
KR (1) KR100656004B1 (enExample)
CN (1) CN1541098A (enExample)
AP (1) AP2004002995A0 (enExample)
AR (1) AR038957A1 (enExample)
AT (1) ATE414512T1 (enExample)
AU (1) AU2002329744B2 (enExample)
BG (1) BG108622A (enExample)
BR (1) BR0211978A (enExample)
CA (1) CA2457745A1 (enExample)
CO (1) CO5560544A2 (enExample)
CZ (1) CZ2004356A3 (enExample)
DE (1) DE60229959D1 (enExample)
EA (1) EA008137B1 (enExample)
EC (1) ECSP045021A (enExample)
GE (1) GEP20063868B (enExample)
HR (1) HRP20040170A2 (enExample)
HU (1) HUP0500424A3 (enExample)
IL (1) IL159887A0 (enExample)
IS (1) IS7137A (enExample)
MA (1) MA27060A1 (enExample)
MX (1) MXPA04001464A (enExample)
NO (1) NO20040516L (enExample)
NZ (1) NZ530792A (enExample)
OA (1) OA12651A (enExample)
PE (1) PE20030332A1 (enExample)
PL (1) PL368921A1 (enExample)
RS (1) RS13204A (enExample)
SK (1) SK1412004A3 (enExample)
TN (1) TNSN04015A1 (enExample)
TW (1) TWI230609B (enExample)
UA (1) UA77002C2 (enExample)
WO (1) WO2003015608A2 (enExample)
ZA (1) ZA200400849B (enExample)

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JP2010502741A (ja) * 2006-09-11 2010-01-28 キュリス，インコーポレイテッド Ｐｔｋインヒビターとしての亜鉛結合部分を含む置換２−インドリノン
US20090004213A1 (en) * 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
WO2009030270A1 (en) * 2007-09-03 2009-03-12 Novartis Ag Dihydroindole derivatives useful in parkinson's disease
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EP2181991A1 (en) * 2008-10-28 2010-05-05 LEK Pharmaceuticals D.D. Novel salts of sunitinib
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WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
RU2495628C1 (ru) * 2012-04-18 2013-10-20 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ выбора тактики лечения актинического кератоза
TWI646091B (zh) * 2012-12-28 2019-01-01 日商衛斯克慧特股份有限公司 鹽類及晶形
US20160031888A1 (en) * 2013-03-13 2016-02-04 Boston Biomedical, Inc. 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer
CN103923014A (zh) * 2014-05-05 2014-07-16 宁夏宝马药业有限公司 环肌酸制备方法
EP3400218A4 (en) 2016-01-08 2019-09-18 Euclises Pharmaceuticals, Inc. COMBINATION OF A CHROME CONNECTION AND A SECOND ACTIVE SUBSTANCE
CN111759883B (zh) * 2020-07-23 2021-09-17 浙江农林大学 山核桃内果皮提取物在制备抗卵巢癌产品中的应用
CN114853736B (zh) * 2022-07-06 2022-10-21 北京鑫开元医药科技有限公司 具有trk抑制活性的化合物、制备方法、组合物及其用途

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