KR100563210B1 - 신규한 캄프토테신 유도체 - Google Patents

신규한 캄프토테신 유도체 Download PDF

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Publication number
KR100563210B1
KR100563210B1 KR1020007004645A KR20007004645A KR100563210B1 KR 100563210 B1 KR100563210 B1 KR 100563210B1 KR 1020007004645 A KR1020007004645 A KR 1020007004645A KR 20007004645 A KR20007004645 A KR 20007004645A KR 100563210 B1 KR100563210 B1 KR 100563210B1
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KR
South Korea
Prior art keywords
compound
group
och
dimethylamino
ethylamide
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Expired - Fee Related
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KR1020007004645A
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English (en)
Korean (ko)
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KR20010031595A (ko
Inventor
오가와다카노리
야에가시다가시
사와다세이고
후루타토미오
Original Assignee
(주) 야쿠르트본사
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Publication of KR20010031595A publication Critical patent/KR20010031595A/ko
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Publication of KR100563210B1 publication Critical patent/KR100563210B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
KR1020007004645A 1997-11-06 1998-11-06 신규한 캄프토테신 유도체 Expired - Fee Related KR100563210B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31918297A JP4094710B2 (ja) 1997-11-06 1997-11-06 新規なカンプトテシン誘導体
JP9-319182 1997-11-06
PCT/JP1998/005000 WO1999024430A1 (en) 1997-11-06 1998-11-06 Novel camptothecin derivatives

Publications (2)

Publication Number Publication Date
KR20010031595A KR20010031595A (ko) 2001-04-16
KR100563210B1 true KR100563210B1 (ko) 2006-03-22

Family

ID=18107341

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007004645A Expired - Fee Related KR100563210B1 (ko) 1997-11-06 1998-11-06 신규한 캄프토테신 유도체

Country Status (15)

Country Link
US (1) US6310210B1 (https=)
EP (1) EP1029863B1 (https=)
JP (1) JP4094710B2 (https=)
KR (1) KR100563210B1 (https=)
CN (1) CN1114605C (https=)
AT (1) ATE240330T1 (https=)
AU (1) AU738823B2 (https=)
BR (1) BR9813972A (https=)
CA (1) CA2309196C (https=)
DE (1) DE69814667T2 (https=)
DK (1) DK1029863T3 (https=)
EA (1) EA002211B1 (https=)
ES (1) ES2193574T3 (https=)
PT (1) PT1029863E (https=)
WO (1) WO1999024430A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR027687A1 (es) 2000-03-22 2003-04-09 Yakult Honsha Kk Procedimiento para preparar camptotecina
KR20040039404A (ko) 2001-09-25 2004-05-10 닥터 레디스 레보러터리즈 리미티드 20(에스)-캄포테신의 약제학적으로 수용가능한 염
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
US6608076B1 (en) 2002-05-16 2003-08-19 Enzon, Inc. Camptothecin derivatives and polymeric conjugates thereof
EP1572242B1 (en) * 2002-12-13 2014-04-16 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
WO2005077370A1 (ja) * 2004-02-13 2005-08-25 Kabushiki Kaisha Yakult Honsha カンプトテシン類含有水溶液製剤

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0700914A1 (en) * 1994-09-06 1996-03-13 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives, preparations thereof and antitumor agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134095A (ja) 1982-02-05 1983-08-10 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5839684A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd １０−置換カンプテシン誘導体の製造法
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5951287A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951289A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5122606A (en) 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US4939255A (en) 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
JP2540357B2 (ja) 1987-06-24 1996-10-02 第一製薬株式会社 六環性化合物
JP2538792B2 (ja) 1987-06-25 1996-10-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
WO1991004260A2 (en) 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5162532A (en) 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0700914A1 (en) * 1994-09-06 1996-03-13 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives, preparations thereof and antitumor agents

Also Published As

Publication number Publication date
DK1029863T3 (da) 2003-08-11
WO1999024430A1 (en) 1999-05-20
DE69814667D1 (en) 2003-06-18
KR20010031595A (ko) 2001-04-16
PT1029863E (pt) 2003-09-30
EP1029863A4 (en) 2001-05-02
CA2309196C (en) 2007-09-11
CN1278261A (zh) 2000-12-27
US6310210B1 (en) 2001-10-30
JPH11140085A (ja) 1999-05-25
CN1114605C (zh) 2003-07-16
EP1029863B1 (en) 2003-05-14
DE69814667T2 (de) 2004-04-08
ATE240330T1 (de) 2003-05-15
BR9813972A (pt) 2000-09-26
EP1029863A1 (en) 2000-08-23
EA002211B1 (ru) 2002-02-28
AU9761998A (en) 1999-05-31
CA2309196A1 (en) 1999-05-20
EA200000491A1 (ru) 2000-10-30
AU738823B2 (en) 2001-09-27
JP4094710B2 (ja) 2008-06-04
ES2193574T3 (es) 2003-11-01

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