CA2309196C - Novel camptothecin derivatives - Google Patents

Novel camptothecin derivatives Download PDF

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Publication number
CA2309196C
CA2309196C CA002309196A CA2309196A CA2309196C CA 2309196 C CA2309196 C CA 2309196C CA 002309196 A CA002309196 A CA 002309196A CA 2309196 A CA2309196 A CA 2309196A CA 2309196 C CA2309196 C CA 2309196C
Authority
CA
Canada
Prior art keywords
compound
ch2ch3
group
och2
dimethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002309196A
Other languages
English (en)
French (fr)
Other versions
CA2309196A1 (en
Inventor
Takanori Ogawa
Takashi Yaegashi
Seigo Sawada
Tomio Furuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Publication of CA2309196A1 publication Critical patent/CA2309196A1/en
Application granted granted Critical
Publication of CA2309196C publication Critical patent/CA2309196C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CA002309196A 1997-11-06 1998-11-06 Novel camptothecin derivatives Expired - Fee Related CA2309196C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31918297A JP4094710B2 (ja) 1997-11-06 1997-11-06 新規なカンプトテシン誘導体
JP9/319182 1997-11-06
PCT/JP1998/005000 WO1999024430A1 (en) 1997-11-06 1998-11-06 Novel camptothecin derivatives

Publications (2)

Publication Number Publication Date
CA2309196A1 CA2309196A1 (en) 1999-05-20
CA2309196C true CA2309196C (en) 2007-09-11

Family

ID=18107341

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002309196A Expired - Fee Related CA2309196C (en) 1997-11-06 1998-11-06 Novel camptothecin derivatives

Country Status (15)

Country Link
US (1) US6310210B1 (https=)
EP (1) EP1029863B1 (https=)
JP (1) JP4094710B2 (https=)
KR (1) KR100563210B1 (https=)
CN (1) CN1114605C (https=)
AT (1) ATE240330T1 (https=)
AU (1) AU738823B2 (https=)
BR (1) BR9813972A (https=)
CA (1) CA2309196C (https=)
DE (1) DE69814667T2 (https=)
DK (1) DK1029863T3 (https=)
EA (1) EA002211B1 (https=)
ES (1) ES2193574T3 (https=)
PT (1) PT1029863E (https=)
WO (1) WO1999024430A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR027687A1 (es) 2000-03-22 2003-04-09 Yakult Honsha Kk Procedimiento para preparar camptotecina
KR20040039404A (ko) 2001-09-25 2004-05-10 닥터 레디스 레보러터리즈 리미티드 20(에스)-캄포테신의 약제학적으로 수용가능한 염
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
US6608076B1 (en) 2002-05-16 2003-08-19 Enzon, Inc. Camptothecin derivatives and polymeric conjugates thereof
EP1572242B1 (en) * 2002-12-13 2014-04-16 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
WO2005077370A1 (ja) * 2004-02-13 2005-08-25 Kabushiki Kaisha Yakult Honsha カンプトテシン類含有水溶液製剤

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134095A (ja) 1982-02-05 1983-08-10 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5839684A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd １０−置換カンプテシン誘導体の製造法
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5951287A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951289A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5122606A (en) 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US4939255A (en) 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
JP2540357B2 (ja) 1987-06-24 1996-10-02 第一製薬株式会社 六環性化合物
JP2538792B2 (ja) 1987-06-25 1996-10-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
WO1991004260A2 (en) 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5162532A (en) 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
JPH0873461A (ja) 1994-09-06 1996-03-19 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤

Also Published As

Publication number Publication date
DK1029863T3 (da) 2003-08-11
WO1999024430A1 (en) 1999-05-20
DE69814667D1 (en) 2003-06-18
KR100563210B1 (ko) 2006-03-22
KR20010031595A (ko) 2001-04-16
PT1029863E (pt) 2003-09-30
EP1029863A4 (en) 2001-05-02
CN1278261A (zh) 2000-12-27
US6310210B1 (en) 2001-10-30
JPH11140085A (ja) 1999-05-25
CN1114605C (zh) 2003-07-16
EP1029863B1 (en) 2003-05-14
DE69814667T2 (de) 2004-04-08
ATE240330T1 (de) 2003-05-15
BR9813972A (pt) 2000-09-26
EP1029863A1 (en) 2000-08-23
EA002211B1 (ru) 2002-02-28
AU9761998A (en) 1999-05-31
CA2309196A1 (en) 1999-05-20
EA200000491A1 (ru) 2000-10-30
AU738823B2 (en) 2001-09-27
JP4094710B2 (ja) 2008-06-04
ES2193574T3 (es) 2003-11-01

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Effective date: 20141106