KR100479837B1 - 마이크로모노스포라 균주를 이용한 프라바스타틴의 미생물적 제조방법 - Google Patents

마이크로모노스포라 균주를 이용한 프라바스타틴의 미생물적 제조방법 Download PDF

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Publication number
KR100479837B1
KR100479837B1 KR10-2002-7000475A KR20027000475A KR100479837B1 KR 100479837 B1 KR100479837 B1 KR 100479837B1 KR 20027000475 A KR20027000475 A KR 20027000475A KR 100479837 B1 KR100479837 B1 KR 100479837B1
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South Korea
Prior art keywords
formula
strain
compound
micromonospora
pravastatin
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Expired - Fee Related
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KR10-2002-7000475A
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English (en)
Korean (ko)
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KR20020048927A (ko
Inventor
젝켈안토니아
앰브루스가보르
일케이에바
호르바스일디코
코냐아틸라
사보이스트반미할리
네이지추즈잔나
호르바스지울라
모제스줄리아
바르타이스트반
소모지지에르지
살라트자노스
보로스산도르
Original Assignee
아이박스 드럭 리서치 인스티튜트 리미티드
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Publication of KR20020048927A publication Critical patent/KR20020048927A/ko
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Publication of KR100479837B1 publication Critical patent/KR100479837B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR10-2002-7000475A 1999-07-12 2000-06-29 마이크로모노스포라 균주를 이용한 프라바스타틴의 미생물적 제조방법 Expired - Fee Related KR100479837B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP9902352 1999-07-12
HU9902352A HUP9902352A1 (hu) 1999-07-12 1999-07-12 Eljárás pravasztatin mikrobiológiai előállítására

Publications (2)

Publication Number Publication Date
KR20020048927A KR20020048927A (ko) 2002-06-24
KR100479837B1 true KR100479837B1 (ko) 2005-03-31

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR10-2002-7000475A Expired - Fee Related KR100479837B1 (ko) 1999-07-12 2000-06-29 마이크로모노스포라 균주를 이용한 프라바스타틴의 미생물적 제조방법
KR1020027000486A Withdrawn KR20020060150A (ko) 1999-07-12 2000-07-11 프라바스타틴의 미생물적 제조 방법

Family Applications After (1)

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KR1020027000486A Withdrawn KR20020060150A (ko) 1999-07-12 2000-07-11 프라바스타틴의 미생물적 제조 방법

Country Status (32)

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US (2) US6905851B1 (enExample)
EP (3) EP1190087B1 (enExample)
JP (2) JP4531315B2 (enExample)
KR (2) KR100479837B1 (enExample)
CN (2) CN1399686A (enExample)
AP (1) AP1405A (enExample)
AT (1) ATE243262T1 (enExample)
AU (2) AU773633B2 (enExample)
BG (1) BG65109B1 (enExample)
BR (1) BR0013156A (enExample)
CA (2) CA2379015A1 (enExample)
CZ (2) CZ297009B6 (enExample)
DE (1) DE60003424T2 (enExample)
DK (1) DK1190087T3 (enExample)
ES (1) ES2200891T3 (enExample)
HR (1) HRP20020028B1 (enExample)
HU (1) HUP9902352A1 (enExample)
IL (2) IL147583A0 (enExample)
IS (1) IS2138B (enExample)
MX (1) MXPA02000356A (enExample)
NO (1) NO20020119L (enExample)
NZ (1) NZ516563A (enExample)
OA (1) OA12150A (enExample)
PL (2) PL353493A1 (enExample)
PT (1) PT1190087E (enExample)
RU (2) RU2235780C2 (enExample)
SK (2) SK285726B6 (enExample)
TR (1) TR200200726T2 (enExample)
UA (1) UA67854C2 (enExample)
WO (2) WO2001004340A1 (enExample)
YU (1) YU2002A (enExample)
ZA (1) ZA200200273B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
DE60037687D1 (de) 1999-11-30 2008-02-14 Biogal Gyogyszergyar Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe
SK8312002A3 (en) 1999-12-14 2003-05-02 Biogal Gyogyszergyar Novel forms of pravastatin sodium
PL361230A1 (en) * 2000-10-05 2004-10-04 Biogal Gyogyszergyar Rt. Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
EP1357807B1 (en) * 2001-02-09 2007-03-14 Unilever N.V. Food product comprising soy protein and statins
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
CN1244688C (zh) * 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
US7425644B2 (en) 2003-11-24 2008-09-16 TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság Method of purifying pravastatin
SG188126A1 (en) * 2008-02-06 2013-03-28 Biocon Ltd Fermentation media comprising urea-like nitrogen sources and its use for the production of secondary metabolits, enzymes and recombinant proteias
RU2522806C1 (ru) * 2012-11-27 2014-07-20 Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук Усовершенствованный способ очистки правастатина
JP6441599B2 (ja) * 2014-07-14 2018-12-19 合同酒精株式会社 プラバスタチンの製造法
CN114031496B (zh) * 2021-11-30 2024-09-27 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法
CN119330849A (zh) * 2022-12-25 2025-01-21 塔里木大学 一种化合物abagg及其用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5810572A (ja) 1981-07-07 1983-01-21 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製造法
JPS5889191A (ja) 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS59175450A (ja) * 1983-03-24 1984-10-04 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JPH06253853A (ja) * 1993-03-09 1994-09-13 Asahi Chem Ind Co Ltd マクロライド抗生物質生合成遺伝子を含有するｄｎａ
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
JPH08149986A (ja) * 1994-09-28 1996-06-11 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
JPH0889277A (ja) * 1994-09-28 1996-04-09 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IN191580B (enExample) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

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Publication number Publication date
WO2001003647A3 (en) 2001-06-28
UA67854C2 (en) 2004-07-15
CA2373544A1 (en) 2001-01-18
US20050124051A1 (en) 2005-06-09
AP1405A (en) 2005-04-28
CZ2002119A3 (cs) 2003-02-12
RU2004114667A (ru) 2005-10-27
CN1399686A (zh) 2003-02-26
ATE243262T1 (de) 2003-07-15
CZ297009B6 (cs) 2006-08-16
NO20020119L (no) 2002-02-21
KR20020048927A (ko) 2002-06-24
NO20020119D0 (no) 2002-01-10
NZ516563A (en) 2002-11-26
DK1190087T3 (da) 2003-10-13
EP1327689A1 (en) 2003-07-16
HUP9902352A1 (hu) 2000-09-28
AU773633B2 (en) 2004-05-27
JP2003504071A (ja) 2003-02-04
KR20020060150A (ko) 2002-07-16
HRP20020028B1 (en) 2005-04-30
IS6227A (is) 2002-01-11
HRP20020028A2 (en) 2003-06-30
YU2002A (sh) 2004-12-31
IL147588A0 (en) 2002-08-14
EP1190087A1 (en) 2002-03-27
ES2200891T3 (es) 2004-03-16
CN1590555A (zh) 2005-03-09
TR200200726T2 (tr) 2002-06-21
MXPA02000356A (es) 2005-06-06
PT1190087E (pt) 2003-10-31
AU6349200A (en) 2001-01-30
US6905851B1 (en) 2005-06-14
EP1190087B1 (en) 2003-06-18
BR0013156A (pt) 2002-04-02
JP4531315B2 (ja) 2010-08-25
WO2001004340A1 (en) 2001-01-18
ZA200200273B (en) 2003-06-25
PL353493A1 (en) 2003-11-17
DE60003424T2 (de) 2004-05-19
HU9902352D0 (en) 1999-09-28
CA2379015A1 (en) 2001-01-18
IS2138B (is) 2006-08-15
WO2001003647A2 (en) 2001-01-18
SK285726B6 (sk) 2007-07-06
OA12150A (en) 2006-05-05
PL364872A1 (en) 2004-12-27
JP2003528576A (ja) 2003-09-30
BG106302A (en) 2002-10-31
EP1198448A4 (en) 2003-05-28
AP2002002404A0 (en) 2002-03-31
SK612002A3 (en) 2002-12-03
SK492002A3 (sk) 2005-03-04
EP1198448A2 (en) 2002-04-24
CZ2002127A3 (cs) 2003-06-18
BG65109B1 (bg) 2007-02-28
AU5835500A (en) 2001-01-30
RU2235780C2 (ru) 2004-09-10
IL147583A0 (en) 2002-08-14
DE60003424D1 (de) 2003-07-24

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