DK1190087T3 - Hydroxylering af compactin til pravastatin under anvendelse af Micromonostora-stammer - Google Patents

Hydroxylering af compactin til pravastatin under anvendelse af Micromonostora-stammer

Info

Publication number
DK1190087T3
DK1190087T3 DK00944121T DK00944121T DK1190087T3 DK 1190087 T3 DK1190087 T3 DK 1190087T3 DK 00944121 T DK00944121 T DK 00944121T DK 00944121 T DK00944121 T DK 00944121T DK 1190087 T3 DK1190087 T3 DK 1190087T3
Authority
DK
Denmark
Prior art keywords
micromonostora
compactin
pravastatin
hydroxylation
strains
Prior art date
Application number
DK00944121T
Other languages
English (en)
Inventor
Gabor Ambrus
Zsuzsanna Nagy
Istvan Barta
Gyoergy Somogyi
Antonia Jekkel
Eva Ilkoy
Ildiko Horvath
Attila Konya
Istvan Mihaly Szabo
Gyula Horvath
Julia Mozes
Janos Salat
Sandor Boros
Original Assignee
Ivax Drug Res Inst Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Drug Res Inst Ltd filed Critical Ivax Drug Res Inst Ltd
Application granted granted Critical
Publication of DK1190087T3 publication Critical patent/DK1190087T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora
DK00944121T 1999-07-12 2000-06-29 Hydroxylering af compactin til pravastatin under anvendelse af Micromonostora-stammer DK1190087T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902352A HUP9902352A1 (hu) 1999-07-12 1999-07-12 Eljárás pravasztatin mikrobiológiai előállítására
PCT/HU2000/000066 WO2001004340A1 (en) 1999-07-12 2000-06-29 Hydroxylation of compactin to pravastatin by micromonospora

Publications (1)

Publication Number Publication Date
DK1190087T3 true DK1190087T3 (da) 2003-10-13

Family

ID=89998701

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00944121T DK1190087T3 (da) 1999-07-12 2000-06-29 Hydroxylering af compactin til pravastatin under anvendelse af Micromonostora-stammer

Country Status (32)

Country Link
US (2) US6905851B1 (da)
EP (3) EP1190087B1 (da)
JP (2) JP4531315B2 (da)
KR (2) KR100479837B1 (da)
CN (2) CN1590555A (da)
AP (1) AP1405A (da)
AT (1) ATE243262T1 (da)
AU (2) AU773633B2 (da)
BG (1) BG65109B1 (da)
BR (1) BR0013156A (da)
CA (2) CA2379015A1 (da)
CZ (2) CZ297009B6 (da)
DE (1) DE60003424T2 (da)
DK (1) DK1190087T3 (da)
ES (1) ES2200891T3 (da)
HR (1) HRP20020028B1 (da)
HU (1) HUP9902352A1 (da)
IL (2) IL147583A0 (da)
IS (1) IS2138B (da)
MX (1) MXPA02000356A (da)
NO (1) NO20020119L (da)
NZ (1) NZ516563A (da)
OA (1) OA12150A (da)
PL (2) PL353493A1 (da)
PT (1) PT1190087E (da)
RU (2) RU2235780C2 (da)
SK (2) SK285726B6 (da)
TR (1) TR200200726T2 (da)
UA (1) UA67854C2 (da)
WO (2) WO2001004340A1 (da)
YU (1) YU2002A (da)
ZA (1) ZA200200273B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
DE04010770T1 (de) 1999-11-30 2005-10-20 Biogal Gyogyszergyar Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe
AU779306B2 (en) 1999-12-14 2005-01-13 Teva Gyogyszergyar Reszvenytarsasag Novel forms of pravastatin sodium
JP3737801B2 (ja) * 2000-10-05 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
ATE356554T1 (de) * 2001-02-09 2007-04-15 Unilever Nv Nahrungsmittel enthaltend sojaprotein und statin
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
WO2005051372A2 (en) 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
MX2010008654A (es) * 2008-02-06 2010-10-06 Biocon Ltd Medios de fermentacion y procedimientos para los mismos.
RU2522806C1 (ru) * 2012-11-27 2014-07-20 Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук Усовершенствованный способ очистки правастатина
JP6441599B2 (ja) * 2014-07-14 2018-12-19 合同酒精株式会社 プラバスタチンの製造法
CN114031496A (zh) * 2021-11-30 2022-02-11 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5810572A (ja) 1981-07-07 1983-01-21 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製造法
JPS5889191A (ja) 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS59175450A (ja) * 1983-03-24 1984-10-04 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
JPH06253853A (ja) * 1993-03-09 1994-09-13 Asahi Chem Ind Co Ltd マクロライド抗生物質生合成遺伝子を含有するｄｎａ
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
JPH08149986A (ja) * 1994-09-28 1996-06-11 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
JPH0889277A (ja) * 1994-09-28 1996-04-09 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IN191580B (da) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
EP1198448A2 (en) 2002-04-24
AP2002002404A0 (en) 2002-03-31
PL353493A1 (en) 2003-11-17
ZA200200273B (en) 2003-06-25
SK285726B6 (sk) 2007-07-06
IS6227A (is) 2002-01-11
CN1399686A (zh) 2003-02-26
AU6349200A (en) 2001-01-30
CA2373544A1 (en) 2001-01-18
WO2001003647A2 (en) 2001-01-18
EP1190087A1 (en) 2002-03-27
US6905851B1 (en) 2005-06-14
EP1198448A4 (en) 2003-05-28
AU773633B2 (en) 2004-05-27
ES2200891T3 (es) 2004-03-16
BG106302A (en) 2002-10-31
HRP20020028B1 (en) 2005-04-30
EP1327689A1 (en) 2003-07-16
NZ516563A (en) 2002-11-26
AU5835500A (en) 2001-01-30
IL147583A0 (en) 2002-08-14
US20050124051A1 (en) 2005-06-09
KR20020060150A (ko) 2002-07-16
NO20020119L (no) 2002-02-21
HUP9902352A1 (hu) 2000-09-28
KR100479837B1 (ko) 2005-03-31
UA67854C2 (en) 2004-07-15
KR20020048927A (ko) 2002-06-24
DE60003424T2 (de) 2004-05-19
IL147588A0 (en) 2002-08-14
JP4531315B2 (ja) 2010-08-25
WO2001004340A1 (en) 2001-01-18
HU9902352D0 (en) 1999-09-28
ATE243262T1 (de) 2003-07-15
BR0013156A (pt) 2002-04-02
JP2003528576A (ja) 2003-09-30
IS2138B (is) 2006-08-15
AP1405A (en) 2005-04-28
EP1190087B1 (en) 2003-06-18
WO2001003647A3 (en) 2001-06-28
CZ2002119A3 (cs) 2003-02-12
RU2004114667A (ru) 2005-10-27
CZ297009B6 (cs) 2006-08-16
RU2235780C2 (ru) 2004-09-10
NO20020119D0 (no) 2002-01-10
HRP20020028A2 (en) 2003-06-30
YU2002A (sh) 2004-12-31
JP2003504071A (ja) 2003-02-04
CA2379015A1 (en) 2001-01-18
CZ2002127A3 (cs) 2003-06-18
SK612002A3 (en) 2002-12-03
OA12150A (en) 2006-05-05
SK492002A3 (sk) 2005-03-04
DE60003424D1 (de) 2003-07-24
CN1590555A (zh) 2005-03-09
PL364872A1 (en) 2004-12-27
BG65109B1 (bg) 2007-02-28
TR200200726T2 (tr) 2002-06-21
MXPA02000356A (es) 2005-06-06
PT1190087E (pt) 2003-10-31

Similar Documents

Publication Publication Date Title
DK1190087T3 (da) Hydroxylering af compactin til pravastatin under anvendelse af Micromonostora-stammer
AU2002230429A1 (en) Reduction of spectral site to site variation
DK1173431T4 (da) Fremgangsmåde til fremstilling af citalopram
DK1105382T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1159274T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1150966T3 (da) Fremgangsmåde til fremstilling af 5-cyanophthalid
NO20013818D0 (no) Mikrobiell fremgangsmåte for fremstilling av pravastatin
NO20031739L (no) Fremgangsmåte for rensing av pravastatin
DK1228056T3 (da) Fremgangsmåde til fremstilling af citalopram
DK199901006A (da) Digital til analog konverteringsanordning
EA200300327A1 (ru) Способ преобразования энергии
HUP0202173A3 (en) Hydroxylation of compactin to pravastatin by micromonospora
EP1404313A4 (en) SIMVASTATIN METHYL ANALOGUES AS NEW HMG-CoA REDUCTASE INHIBITORS
NO20034376L (no) Anordning for omstilling av sporvekseltunger
DK1226125T3 (da) Fremgangsmåde til fremstilling af mavesårsmidler
NO20034639L (no) To-trinns-konvertering av beskyttet taxanester til paclitaxel
IDP000026456A (id) Senyawa-senyawa siklopropanakarboksilat ester
HU9900208V0 (en) Supporting device to support walking surfaces of buildings
TW481307U (en) Improved structure of optical mouse
DK1237864T3 (da) Fremgagsdmåde til fremstilling af amorft atorvastatin
TW439714U (en) Support structure for pedal of baby-stroller
FR2824971B1 (fr) Convertisseur analogique/numerique
DK1154979T3 (da) Mikrobiel proces til fremstilling af pravastatin
ITRM990799A0 (it) Composti di esteri ciclopropancarbossilici.
FR2830559B1 (fr) Aspirateur de bassin mu par la force hydraulique