IS2138B - Hýdroxýltenging kompaktíns við pravastatín með Micromonospora - Google Patents

Hýdroxýltenging kompaktíns við pravastatín með Micromonospora

Info

Publication number
IS2138B
IS2138B IS6227A IS6227A IS2138B IS 2138 B IS2138 B IS 2138B IS 6227 A IS6227 A IS 6227A IS 6227 A IS6227 A IS 6227A IS 2138 B IS2138 B IS 2138B
Authority
IS
Iceland
Prior art keywords
compactin
micromonospora
pravastatin
hydroxylation
Prior art date
Application number
IS6227A
Other languages
English (en)
Other versions
IS6227A (is
Inventor
Jekkel Antonia
Ambrus Gabor
Ilkoy Eva
Horvath Ildiko
Konya Attila
Szabo Istvan Mihaly
Nagy Zsuzsanna
Horvath Gyula
Mozes Julia
Barta Istvan
Gyoergy Somogyi
Salat Janos
Boros Sandor
Original Assignee
Ivax Drug Res Inst Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Drug Res Inst Ltd filed Critical Ivax Drug Res Inst Ltd
Publication of IS6227A publication Critical patent/IS6227A/is
Publication of IS2138B publication Critical patent/IS2138B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora
IS6227A 1999-07-12 2002-01-11 Hýdroxýltenging kompaktíns við pravastatín með Micromonospora IS2138B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902352A HUP9902352A1 (hu) 1999-07-12 1999-07-12 Eljárás pravasztatin mikrobiológiai előállítására
PCT/HU2000/000066 WO2001004340A1 (en) 1999-07-12 2000-06-29 Hydroxylation of compactin to pravastatin by micromonospora

Publications (2)

Publication Number Publication Date
IS6227A IS6227A (is) 2002-01-11
IS2138B true IS2138B (is) 2006-08-15

Family

ID=89998701

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6227A IS2138B (is) 1999-07-12 2002-01-11 Hýdroxýltenging kompaktíns við pravastatín með Micromonospora

Country Status (32)

Country Link
US (2) US6905851B1 (is)
EP (3) EP1190087B1 (is)
JP (2) JP4531315B2 (is)
KR (2) KR100479837B1 (is)
CN (2) CN1590555A (is)
AP (1) AP1405A (is)
AT (1) ATE243262T1 (is)
AU (2) AU773633B2 (is)
BG (1) BG65109B1 (is)
BR (1) BR0013156A (is)
CA (2) CA2379015A1 (is)
CZ (2) CZ297009B6 (is)
DE (1) DE60003424T2 (is)
DK (1) DK1190087T3 (is)
ES (1) ES2200891T3 (is)
HR (1) HRP20020028B1 (is)
HU (1) HUP9902352A1 (is)
IL (2) IL147583A0 (is)
IS (1) IS2138B (is)
MX (1) MXPA02000356A (is)
NO (1) NO20020119L (is)
NZ (1) NZ516563A (is)
OA (1) OA12150A (is)
PL (2) PL353493A1 (is)
PT (1) PT1190087E (is)
RU (2) RU2235780C2 (is)
SK (2) SK285726B6 (is)
TR (1) TR200200726T2 (is)
UA (1) UA67854C2 (is)
WO (2) WO2001004340A1 (is)
YU (1) YU2002A (is)
ZA (1) ZA200200273B (is)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
DE04010770T1 (de) 1999-11-30 2005-10-20 Biogal Gyogyszergyar Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe
AU779306B2 (en) 1999-12-14 2005-01-13 Teva Gyogyszergyar Reszvenytarsasag Novel forms of pravastatin sodium
JP3737801B2 (ja) * 2000-10-05 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
ATE356554T1 (de) * 2001-02-09 2007-04-15 Unilever Nv Nahrungsmittel enthaltend sojaprotein und statin
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
WO2005051372A2 (en) 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
MX2010008654A (es) * 2008-02-06 2010-10-06 Biocon Ltd Medios de fermentacion y procedimientos para los mismos.
RU2522806C1 (ru) * 2012-11-27 2014-07-20 Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук Усовершенствованный способ очистки правастатина
JP6441599B2 (ja) * 2014-07-14 2018-12-19 合同酒精株式会社 プラバスタチンの製造法
CN114031496A (zh) * 2021-11-30 2022-02-11 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5810572A (ja) 1981-07-07 1983-01-21 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製造法
JPS5889191A (ja) 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS59175450A (ja) * 1983-03-24 1984-10-04 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
JPH06253853A (ja) * 1993-03-09 1994-09-13 Asahi Chem Ind Co Ltd マクロライド抗生物質生合成遺伝子を含有するｄｎａ
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
JPH08149986A (ja) * 1994-09-28 1996-06-11 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
JPH0889277A (ja) * 1994-09-28 1996-04-09 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IN191580B (is) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
EP1198448A2 (en) 2002-04-24
AP2002002404A0 (en) 2002-03-31
PL353493A1 (en) 2003-11-17
ZA200200273B (en) 2003-06-25
SK285726B6 (sk) 2007-07-06
IS6227A (is) 2002-01-11
CN1399686A (zh) 2003-02-26
AU6349200A (en) 2001-01-30
CA2373544A1 (en) 2001-01-18
WO2001003647A2 (en) 2001-01-18
EP1190087A1 (en) 2002-03-27
US6905851B1 (en) 2005-06-14
EP1198448A4 (en) 2003-05-28
AU773633B2 (en) 2004-05-27
ES2200891T3 (es) 2004-03-16
BG106302A (en) 2002-10-31
HRP20020028B1 (en) 2005-04-30
EP1327689A1 (en) 2003-07-16
NZ516563A (en) 2002-11-26
AU5835500A (en) 2001-01-30
IL147583A0 (en) 2002-08-14
US20050124051A1 (en) 2005-06-09
KR20020060150A (ko) 2002-07-16
NO20020119L (no) 2002-02-21
HUP9902352A1 (hu) 2000-09-28
KR100479837B1 (ko) 2005-03-31
UA67854C2 (en) 2004-07-15
KR20020048927A (ko) 2002-06-24
DE60003424T2 (de) 2004-05-19
IL147588A0 (en) 2002-08-14
JP4531315B2 (ja) 2010-08-25
WO2001004340A1 (en) 2001-01-18
HU9902352D0 (en) 1999-09-28
ATE243262T1 (de) 2003-07-15
BR0013156A (pt) 2002-04-02
JP2003528576A (ja) 2003-09-30
AP1405A (en) 2005-04-28
EP1190087B1 (en) 2003-06-18
WO2001003647A3 (en) 2001-06-28
CZ2002119A3 (cs) 2003-02-12
RU2004114667A (ru) 2005-10-27
CZ297009B6 (cs) 2006-08-16
RU2235780C2 (ru) 2004-09-10
NO20020119D0 (no) 2002-01-10
HRP20020028A2 (en) 2003-06-30
YU2002A (sh) 2004-12-31
JP2003504071A (ja) 2003-02-04
CA2379015A1 (en) 2001-01-18
CZ2002127A3 (cs) 2003-06-18
SK612002A3 (en) 2002-12-03
OA12150A (en) 2006-05-05
SK492002A3 (sk) 2005-03-04
DE60003424D1 (de) 2003-07-24
CN1590555A (zh) 2005-03-09
PL364872A1 (en) 2004-12-27
BG65109B1 (bg) 2007-02-28
DK1190087T3 (da) 2003-10-13
TR200200726T2 (tr) 2002-06-21
MXPA02000356A (es) 2005-06-06
PT1190087E (pt) 2003-10-31

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